Amino acid dipepetide frequency for Mycoplasma phocidae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.452AlaAla: 3.452 ± 0.182
0.41AlaCys: 0.41 ± 0.042
2.407AlaAsp: 2.407 ± 0.184
2.663AlaGlu: 2.663 ± 0.12
2.614AlaPhe: 2.614 ± 0.121
2.275AlaGly: 2.275 ± 0.113
0.794AlaHis: 0.794 ± 0.069
6.097AlaIle: 6.097 ± 0.221
6.344AlaLys: 6.344 ± 0.213
4.748AlaLeu: 4.748 ± 0.185
1.067AlaMet: 1.067 ± 0.083
4.171AlaAsn: 4.171 ± 0.193
1.279AlaPro: 1.279 ± 0.08
1.521AlaGln: 1.521 ± 0.081
1.741AlaArg: 1.741 ± 0.103
3.262AlaSer: 3.262 ± 0.115
2.711AlaThr: 2.711 ± 0.11
2.328AlaVal: 2.328 ± 0.115
0.304AlaTrp: 0.304 ± 0.041
2.028AlaTyr: 2.028 ± 0.102
0.0AlaXaa: 0.0 ± 0.0
Cys
0.282CysAla: 0.282 ± 0.039
0.057CysCys: 0.057 ± 0.016
0.339CysAsp: 0.339 ± 0.052
0.339CysGlu: 0.339 ± 0.045
0.287CysPhe: 0.287 ± 0.038
0.357CysGly: 0.357 ± 0.045
0.066CysHis: 0.066 ± 0.018
0.406CysIle: 0.406 ± 0.046
0.287CysLys: 0.287 ± 0.038
0.498CysLeu: 0.498 ± 0.05
0.044CysMet: 0.044 ± 0.015
0.326CysAsn: 0.326 ± 0.033
0.159CysPro: 0.159 ± 0.027
0.22CysGln: 0.22 ± 0.031
0.119CysArg: 0.119 ± 0.026
0.309CysSer: 0.309 ± 0.043
0.207CysThr: 0.207 ± 0.029
0.194CysVal: 0.194 ± 0.033
0.026CysTrp: 0.026 ± 0.011
0.141CysTyr: 0.141 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
2.76AspAla: 2.76 ± 0.111
0.15AspCys: 0.15 ± 0.024
3.346AspAsp: 3.346 ± 0.182
4.594AspGlu: 4.594 ± 0.188
3.986AspPhe: 3.986 ± 0.161
2.641AspGly: 2.641 ± 0.12
0.749AspHis: 0.749 ± 0.052
5.105AspIle: 5.105 ± 0.167
6.309AspLys: 6.309 ± 0.18
5.665AspLeu: 5.665 ± 0.174
0.891AspMet: 0.891 ± 0.06
4.365AspAsn: 4.365 ± 0.165
1.812AspPro: 1.812 ± 0.092
1.671AspGln: 1.671 ± 0.093
1.543AspArg: 1.543 ± 0.1
3.62AspSer: 3.62 ± 0.153
2.037AspThr: 2.037 ± 0.103
3.17AspVal: 3.17 ± 0.127
0.604AspTrp: 0.604 ± 0.086
2.778AspTyr: 2.778 ± 0.139
0.0AspXaa: 0.0 ± 0.0
Glu
3.483GluAla: 3.483 ± 0.179
0.242GluCys: 0.242 ± 0.04
3.681GluAsp: 3.681 ± 0.158
5.524GluGlu: 5.524 ± 0.248
3.637GluPhe: 3.637 ± 0.162
2.584GluGly: 2.584 ± 0.131
0.851GluHis: 0.851 ± 0.065
8.28GluIle: 8.28 ± 0.245
8.346GluLys: 8.346 ± 0.266
6.534GluLeu: 6.534 ± 0.195
1.574GluMet: 1.574 ± 0.092
6.684GluAsn: 6.684 ± 0.217
1.23GluPro: 1.23 ± 0.085
2.24GluGln: 2.24 ± 0.105
1.821GluArg: 1.821 ± 0.111
3.65GluSer: 3.65 ± 0.139
2.949GluThr: 2.949 ± 0.11
3.073GluVal: 3.073 ± 0.119
0.463GluTrp: 0.463 ± 0.045
3.121GluTyr: 3.121 ± 0.149
0.0GluXaa: 0.0 ± 0.0
Phe
2.711PheAla: 2.711 ± 0.136
0.3PheCys: 0.3 ± 0.044
3.827PheAsp: 3.827 ± 0.15
3.761PheGlu: 3.761 ± 0.136
2.641PhePhe: 2.641 ± 0.145
2.632PheGly: 2.632 ± 0.118
0.63PheHis: 0.63 ± 0.054
5.502PheIle: 5.502 ± 0.223
5.775PheLys: 5.775 ± 0.173
4.761PheLeu: 4.761 ± 0.174
0.789PheMet: 0.789 ± 0.062
4.373PheAsn: 4.373 ± 0.171
1.186PhePro: 1.186 ± 0.082
1.362PheGln: 1.362 ± 0.092
1.477PheArg: 1.477 ± 0.084
4.347PheSer: 4.347 ± 0.161
2.658PheThr: 2.658 ± 0.162
2.985PheVal: 2.985 ± 0.142
0.507PheTrp: 0.507 ± 0.054
2.112PheTyr: 2.112 ± 0.108
0.0PheXaa: 0.0 ± 0.0
Gly
2.341GlyAla: 2.341 ± 0.124
0.172GlyCys: 0.172 ± 0.03
2.442GlyAsp: 2.442 ± 0.11
2.606GlyGlu: 2.606 ± 0.126
2.764GlyPhe: 2.764 ± 0.13
2.738GlyGly: 2.738 ± 0.201
0.794GlyHis: 0.794 ± 0.062
4.687GlyIle: 4.687 ± 0.155
4.404GlyLys: 4.404 ± 0.152
3.924GlyLeu: 3.924 ± 0.13
0.935GlyMet: 0.935 ± 0.075
2.844GlyAsn: 2.844 ± 0.106
0.979GlyPro: 0.979 ± 0.063
1.473GlyGln: 1.473 ± 0.103
1.578GlyArg: 1.578 ± 0.098
3.06GlySer: 3.06 ± 0.132
2.341GlyThr: 2.341 ± 0.146
2.491GlyVal: 2.491 ± 0.119
0.423GlyTrp: 0.423 ± 0.049
2.041GlyTyr: 2.041 ± 0.103
0.0GlyXaa: 0.0 ± 0.0
His
0.798HisAla: 0.798 ± 0.064
0.075HisCys: 0.075 ± 0.017
0.723HisAsp: 0.723 ± 0.058
0.908HisGlu: 0.908 ± 0.065
0.816HisPhe: 0.816 ± 0.062
0.758HisGly: 0.758 ± 0.062
0.322HisHis: 0.322 ± 0.036
1.177HisIle: 1.177 ± 0.069
1.063HisLys: 1.063 ± 0.075
1.204HisLeu: 1.204 ± 0.073
0.247HisMet: 0.247 ± 0.032
1.018HisAsn: 1.018 ± 0.072
0.547HisPro: 0.547 ± 0.055
0.516HisGln: 0.516 ± 0.057
0.489HisArg: 0.489 ± 0.042
0.895HisSer: 0.895 ± 0.069
0.525HisThr: 0.525 ± 0.046
0.661HisVal: 0.661 ± 0.062
0.11HisTrp: 0.11 ± 0.022
0.63HisTyr: 0.63 ± 0.046
0.0HisXaa: 0.0 ± 0.0
Ile
6.177IleAla: 6.177 ± 0.169
0.52IleCys: 0.52 ± 0.051
6.225IleAsp: 6.225 ± 0.192
6.71IleGlu: 6.71 ± 0.212
5.559IlePhe: 5.559 ± 0.23
4.171IleGly: 4.171 ± 0.15
1.217IleHis: 1.217 ± 0.074
9.391IleIle: 9.391 ± 0.243
10.599IleLys: 10.599 ± 0.243
8.588IleLeu: 8.588 ± 0.274
1.662IleMet: 1.662 ± 0.101
8.478IleAsn: 8.478 ± 0.268
2.751IlePro: 2.751 ± 0.124
2.764IleGln: 2.764 ± 0.108
3.068IleArg: 3.068 ± 0.133
8.557IleSer: 8.557 ± 0.342
4.964IleThr: 4.964 ± 0.173
5.458IleVal: 5.458 ± 0.177
0.697IleTrp: 0.697 ± 0.059
3.553IleTyr: 3.553 ± 0.134
0.0IleXaa: 0.0 ± 0.0
Lys
4.735LysAla: 4.735 ± 0.164
0.392LysCys: 0.392 ± 0.054
5.828LysAsp: 5.828 ± 0.203
7.905LysGlu: 7.905 ± 0.232
4.951LysPhe: 4.951 ± 0.166
3.492LysGly: 3.492 ± 0.132
1.393LysHis: 1.393 ± 0.078
12.173LysIle: 12.173 ± 0.249
11.688LysLys: 11.688 ± 0.275
9.426LysLeu: 9.426 ± 0.248
2.42LysMet: 2.42 ± 0.106
10.678LysAsn: 10.678 ± 0.271
2.866LysPro: 2.866 ± 0.132
3.13LysGln: 3.13 ± 0.12
3.337LysArg: 3.337 ± 0.144
6.203LysSer: 6.203 ± 0.195
5.423LysThr: 5.423 ± 0.144
4.889LysVal: 4.889 ± 0.193
1.093LysTrp: 1.093 ± 0.077
5.268LysTyr: 5.268 ± 0.175
0.0LysXaa: 0.0 ± 0.0
Leu
5.449LeuAla: 5.449 ± 0.2
0.414LeuCys: 0.414 ± 0.047
5.573LeuAsp: 5.573 ± 0.172
6.662LeuGlu: 6.662 ± 0.221
4.867LeuPhe: 4.867 ± 0.171
4.396LeuGly: 4.396 ± 0.149
1.089LeuHis: 1.089 ± 0.074
9.192LeuIle: 9.192 ± 0.285
9.695LeuLys: 9.695 ± 0.274
7.654LeuLeu: 7.654 ± 0.235
1.543LeuMet: 1.543 ± 0.078
7.543LeuAsn: 7.543 ± 0.225
2.883LeuPro: 2.883 ± 0.107
2.165LeuGln: 2.165 ± 0.097
2.742LeuArg: 2.742 ± 0.118
6.701LeuSer: 6.701 ± 0.201
4.206LeuThr: 4.206 ± 0.125
4.911LeuVal: 4.911 ± 0.151
0.661LeuTrp: 0.661 ± 0.058
2.932LeuTyr: 2.932 ± 0.106
0.0LeuXaa: 0.0 ± 0.0
Met
1.04MetAla: 1.04 ± 0.075
0.057MetCys: 0.057 ± 0.017
0.869MetAsp: 0.869 ± 0.066
1.01MetGlu: 1.01 ± 0.085
1.023MetPhe: 1.023 ± 0.127
0.798MetGly: 0.798 ± 0.064
0.26MetHis: 0.26 ± 0.031
1.764MetIle: 1.764 ± 0.113
2.213MetLys: 2.213 ± 0.104
1.631MetLeu: 1.631 ± 0.112
0.436MetMet: 0.436 ± 0.074
1.376MetAsn: 1.376 ± 0.075
0.714MetPro: 0.714 ± 0.051
0.516MetGln: 0.516 ± 0.046
0.586MetArg: 0.586 ± 0.057
1.177MetSer: 1.177 ± 0.082
0.798MetThr: 0.798 ± 0.07
0.886MetVal: 0.886 ± 0.069
0.132MetTrp: 0.132 ± 0.024
0.467MetTyr: 0.467 ± 0.043
0.0MetXaa: 0.0 ± 0.0
Asn
3.743AsnAla: 3.743 ± 0.18
0.238AsnCys: 0.238 ± 0.04
4.938AsnAsp: 4.938 ± 0.2
5.983AsnGlu: 5.983 ± 0.202
4.775AsnPhe: 4.775 ± 0.155
3.562AsnGly: 3.562 ± 0.172
1.151AsnHis: 1.151 ± 0.08
7.319AsnIle: 7.319 ± 0.213
9.166AsnLys: 9.166 ± 0.269
8.09AsnLeu: 8.09 ± 0.231
1.256AsnMet: 1.256 ± 0.082
7.252AsnAsn: 7.252 ± 0.265
2.65AsnPro: 2.65 ± 0.134
3.174AsnGln: 3.174 ± 0.176
2.271AsnArg: 2.271 ± 0.125
6.022AsnSer: 6.022 ± 0.2
2.941AsnThr: 2.941 ± 0.124
3.884AsnVal: 3.884 ± 0.148
0.71AsnTrp: 0.71 ± 0.058
3.822AsnTyr: 3.822 ± 0.139
0.0AsnXaa: 0.0 ± 0.0
Pro
1.252ProAla: 1.252 ± 0.096
0.137ProCys: 0.137 ± 0.022
1.583ProAsp: 1.583 ± 0.111
2.151ProGlu: 2.151 ± 0.108
1.468ProPhe: 1.468 ± 0.075
1.327ProGly: 1.327 ± 0.087
0.498ProHis: 0.498 ± 0.045
2.83ProIle: 2.83 ± 0.13
2.703ProLys: 2.703 ± 0.132
2.266ProLeu: 2.266 ± 0.096
0.463ProMet: 0.463 ± 0.051
2.275ProAsn: 2.275 ± 0.101
0.6ProPro: 0.6 ± 0.067
0.921ProGln: 0.921 ± 0.076
0.794ProArg: 0.794 ± 0.063
1.662ProSer: 1.662 ± 0.085
1.671ProThr: 1.671 ± 0.112
1.186ProVal: 1.186 ± 0.09
0.287ProTrp: 0.287 ± 0.036
1.049ProTyr: 1.049 ± 0.071
0.0ProXaa: 0.0 ± 0.0
Gln
1.45GlnAla: 1.45 ± 0.083
0.088GlnCys: 0.088 ± 0.021
1.671GlnAsp: 1.671 ± 0.096
2.394GlnGlu: 2.394 ± 0.12
1.455GlnPhe: 1.455 ± 0.094
1.23GlnGly: 1.23 ± 0.067
0.384GlnHis: 0.384 ± 0.046
3.359GlnIle: 3.359 ± 0.11
3.628GlnLys: 3.628 ± 0.139
2.76GlnLeu: 2.76 ± 0.123
0.626GlnMet: 0.626 ± 0.06
2.742GlnAsn: 2.742 ± 0.105
0.679GlnPro: 0.679 ± 0.064
1.054GlnGln: 1.054 ± 0.074
1.023GlnArg: 1.023 ± 0.068
1.609GlnSer: 1.609 ± 0.087
1.552GlnThr: 1.552 ± 0.09
1.243GlnVal: 1.243 ± 0.07
0.242GlnTrp: 0.242 ± 0.04
1.217GlnTyr: 1.217 ± 0.084
0.0GlnXaa: 0.0 ± 0.0
Arg
1.473ArgAla: 1.473 ± 0.08
0.145ArgCys: 0.145 ± 0.028
1.794ArgAsp: 1.794 ± 0.096
2.337ArgGlu: 2.337 ± 0.109
1.477ArgPhe: 1.477 ± 0.077
1.464ArgGly: 1.464 ± 0.1
0.441ArgHis: 0.441 ± 0.047
3.192ArgIle: 3.192 ± 0.119
3.218ArgLys: 3.218 ± 0.125
2.526ArgLeu: 2.526 ± 0.117
0.604ArgMet: 0.604 ± 0.048
2.368ArgAsn: 2.368 ± 0.096
0.767ArgPro: 0.767 ± 0.064
1.089ArgGln: 1.089 ± 0.072
1.243ArgArg: 1.243 ± 0.081
1.799ArgSer: 1.799 ± 0.107
1.243ArgThr: 1.243 ± 0.076
1.711ArgVal: 1.711 ± 0.113
0.309ArgTrp: 0.309 ± 0.04
1.287ArgTyr: 1.287 ± 0.078
0.0ArgXaa: 0.0 ± 0.0
Ser
3.139SerAla: 3.139 ± 0.152
0.485SerCys: 0.485 ± 0.058
3.633SerAsp: 3.633 ± 0.144
4.651SerGlu: 4.651 ± 0.165
3.981SerPhe: 3.981 ± 0.182
3.487SerGly: 3.487 ± 0.146
0.974SerHis: 0.974 ± 0.068
6.446SerIle: 6.446 ± 0.201
7.42SerLys: 7.42 ± 0.211
6.759SerLeu: 6.759 ± 0.235
1.054SerMet: 1.054 ± 0.106
5.18SerAsn: 5.18 ± 0.186
1.746SerPro: 1.746 ± 0.079
2.31SerGln: 2.31 ± 0.129
2.072SerArg: 2.072 ± 0.091
5.154SerSer: 5.154 ± 0.176
3.064SerThr: 3.064 ± 0.124
2.972SerVal: 2.972 ± 0.112
0.6SerTrp: 0.6 ± 0.062
2.852SerTyr: 2.852 ± 0.133
0.0SerXaa: 0.0 ± 0.0
Thr
2.103ThrAla: 2.103 ± 0.104
0.176ThrCys: 0.176 ± 0.029
2.107ThrAsp: 2.107 ± 0.115
2.778ThrGlu: 2.778 ± 0.139
2.588ThrPhe: 2.588 ± 0.113
2.222ThrGly: 2.222 ± 0.113
0.626ThrHis: 0.626 ± 0.059
5.097ThrIle: 5.097 ± 0.271
4.858ThrLys: 4.858 ± 0.18
4.501ThrLeu: 4.501 ± 0.15
0.648ThrMet: 0.648 ± 0.061
4.105ThrAsn: 4.105 ± 0.155
1.711ThrPro: 1.711 ± 0.111
1.279ThrGln: 1.279 ± 0.077
1.512ThrArg: 1.512 ± 0.086
3.201ThrSer: 3.201 ± 0.144
2.456ThrThr: 2.456 ± 0.112
2.319ThrVal: 2.319 ± 0.149
0.37ThrTrp: 0.37 ± 0.045
1.777ThrTyr: 1.777 ± 0.086
0.0ThrXaa: 0.0 ± 0.0
Val
3.426ValAla: 3.426 ± 0.145
0.335ValCys: 0.335 ± 0.039
3.346ValAsp: 3.346 ± 0.127
3.58ValGlu: 3.58 ± 0.147
2.592ValPhe: 2.592 ± 0.127
2.689ValGly: 2.689 ± 0.13
0.573ValHis: 0.573 ± 0.051
4.894ValIle: 4.894 ± 0.166
4.969ValLys: 4.969 ± 0.148
4.272ValLeu: 4.272 ± 0.132
0.807ValMet: 0.807 ± 0.06
3.62ValAsn: 3.62 ± 0.131
1.226ValPro: 1.226 ± 0.076
1.234ValGln: 1.234 ± 0.083
1.327ValArg: 1.327 ± 0.078
3.461ValSer: 3.461 ± 0.14
2.478ValThr: 2.478 ± 0.125
2.755ValVal: 2.755 ± 0.141
0.432ValTrp: 0.432 ± 0.05
1.843ValTyr: 1.843 ± 0.093
0.0ValXaa: 0.0 ± 0.0
Trp
0.406TrpAla: 0.406 ± 0.041
0.035TrpCys: 0.035 ± 0.012
0.569TrpAsp: 0.569 ± 0.067
0.489TrpGlu: 0.489 ± 0.038
0.454TrpPhe: 0.454 ± 0.045
0.322TrpGly: 0.322 ± 0.039
0.093TrpHis: 0.093 ± 0.021
0.921TrpIle: 0.921 ± 0.061
0.904TrpLys: 0.904 ± 0.074
0.798TrpLeu: 0.798 ± 0.062
0.194TrpMet: 0.194 ± 0.03
0.701TrpAsn: 0.701 ± 0.069
0.198TrpPro: 0.198 ± 0.031
0.216TrpGln: 0.216 ± 0.032
0.287TrpArg: 0.287 ± 0.038
0.595TrpSer: 0.595 ± 0.086
0.428TrpThr: 0.428 ± 0.038
0.467TrpVal: 0.467 ± 0.06
0.145TrpTrp: 0.145 ± 0.027
0.397TrpTyr: 0.397 ± 0.046
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.997TyrAla: 1.997 ± 0.109
0.234TyrCys: 0.234 ± 0.03
2.892TyrAsp: 2.892 ± 0.126
2.923TyrGlu: 2.923 ± 0.111
2.403TyrPhe: 2.403 ± 0.107
1.891TyrGly: 1.891 ± 0.094
0.578TyrHis: 0.578 ± 0.049
3.285TyrIle: 3.285 ± 0.118
3.703TyrLys: 3.703 ± 0.16
4.673TyrLeu: 4.673 ± 0.172
0.489TyrMet: 0.489 ± 0.04
2.848TyrAsn: 2.848 ± 0.109
1.142TyrPro: 1.142 ± 0.064
1.552TyrGln: 1.552 ± 0.098
1.455TyrArg: 1.455 ± 0.096
2.694TyrSer: 2.694 ± 0.117
1.781TyrThr: 1.781 ± 0.099
2.275TyrVal: 2.275 ± 0.104
0.503TyrTrp: 0.503 ± 0.05
1.896TyrTyr: 1.896 ± 0.115
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 608 proteins (226822 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski