Amino acid dipepetide frequency for Oscillatoria nigro-viridis PCC 7112

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.932AlaAla: 8.932 ± 0.097	0.863AlaCys: 0.863 ± 0.024	4.49AlaAsp: 4.49 ± 0.056	6.007AlaGlu: 6.007 ± 0.064	2.863AlaPhe: 2.863 ± 0.044	6.299AlaGly: 6.299 ± 0.072	1.158AlaHis: 1.158 ± 0.025	7.141AlaIle: 7.141 ± 0.072	4.421AlaLys: 4.421 ± 0.051	8.544AlaLeu: 8.544 ± 0.085	1.664AlaMet: 1.664 ± 0.03	3.774AlaAsn: 3.774 ± 0.075	3.317AlaPro: 3.317 ± 0.069	3.955AlaGln: 3.955 ± 0.049	3.892AlaArg: 3.892 ± 0.051	5.331AlaSer: 5.331 ± 0.059	4.735AlaThr: 4.735 ± 0.07	6.368AlaVal: 6.368 ± 0.07	1.012AlaTrp: 1.012 ± 0.025	2.158AlaTyr: 2.158 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.717CysAla: 0.717 ± 0.021	0.193CysCys: 0.193 ± 0.011	0.644CysAsp: 0.644 ± 0.017	0.632CysGlu: 0.632 ± 0.021	0.427CysPhe: 0.427 ± 0.016	0.869CysGly: 0.869 ± 0.022	0.29CysHis: 0.29 ± 0.012	0.573CysIle: 0.573 ± 0.018	0.411CysLys: 0.411 ± 0.012	1.148CysLeu: 1.148 ± 0.026	0.152CysMet: 0.152 ± 0.008	0.355CysAsn: 0.355 ± 0.014	0.517CysPro: 0.517 ± 0.018	0.593CysGln: 0.593 ± 0.018	0.59CysArg: 0.59 ± 0.019	0.664CysSer: 0.664 ± 0.02	0.504CysThr: 0.504 ± 0.016	0.627CysVal: 0.627 ± 0.018	0.165CysTrp: 0.165 ± 0.009	0.41CysTyr: 0.41 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	4.143AspAla: 4.143 ± 0.049	0.636AspCys: 0.636 ± 0.022	2.406AspAsp: 2.406 ± 0.054	3.001AspGlu: 3.001 ± 0.044	2.452AspPhe: 2.452 ± 0.04	3.602AspGly: 3.602 ± 0.063	0.495AspHis: 0.495 ± 0.019	3.377AspIle: 3.377 ± 0.045	2.282AspLys: 2.282 ± 0.042	5.779AspLeu: 5.779 ± 0.058	0.809AspMet: 0.809 ± 0.02	2.0AspAsn: 2.0 ± 0.041	2.398AspPro: 2.398 ± 0.05	1.182AspGln: 1.182 ± 0.024	4.691AspArg: 4.691 ± 0.056	3.374AspSer: 3.374 ± 0.05	2.578AspThr: 2.578 ± 0.056	2.926AspVal: 2.926 ± 0.038	0.888AspTrp: 0.888 ± 0.02	1.78AspTyr: 1.78 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	5.875GluAla: 5.875 ± 0.063	0.585GluCys: 0.585 ± 0.017	2.739GluAsp: 2.739 ± 0.044	4.074GluGlu: 4.074 ± 0.061	2.632GluPhe: 2.632 ± 0.038	3.496GluGly: 3.496 ± 0.042	0.992GluHis: 0.992 ± 0.026	4.991GluIle: 4.991 ± 0.063	3.613GluLys: 3.613 ± 0.052	7.174GluLeu: 7.174 ± 0.076	1.4GluMet: 1.4 ± 0.028	2.916GluAsn: 2.916 ± 0.038	2.633GluPro: 2.633 ± 0.054	3.322GluGln: 3.322 ± 0.048	3.356GluArg: 3.356 ± 0.058	4.012GluSer: 4.012 ± 0.05	3.823GluThr: 3.823 ± 0.047	4.468GluVal: 4.468 ± 0.048	0.838GluTrp: 0.838 ± 0.024	1.938GluTyr: 1.938 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.176PheAla: 3.176 ± 0.047	0.555PheCys: 0.555 ± 0.016	2.439PheAsp: 2.439 ± 0.044	2.321PheGlu: 2.321 ± 0.039	1.623PhePhe: 1.623 ± 0.032	2.917PheGly: 2.917 ± 0.043	0.665PheHis: 0.665 ± 0.019	2.133PheIle: 2.133 ± 0.033	1.631PheLys: 1.631 ± 0.029	3.906PheLeu: 3.906 ± 0.045	0.702PheMet: 0.702 ± 0.017	1.734PheAsn: 1.734 ± 0.031	1.868PhePro: 1.868 ± 0.028	1.697PheGln: 1.697 ± 0.029	1.813PheArg: 1.813 ± 0.029	2.874PheSer: 2.874 ± 0.042	2.161PheThr: 2.161 ± 0.04	2.507PheVal: 2.507 ± 0.039	0.674PheTrp: 0.674 ± 0.017	1.398PheTyr: 1.398 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	5.068GlyAla: 5.068 ± 0.064	0.833GlyCys: 0.833 ± 0.021	3.719GlyAsp: 3.719 ± 0.068	4.421GlyGlu: 4.421 ± 0.048	2.936GlyPhe: 2.936 ± 0.044	5.281GlyGly: 5.281 ± 0.097	1.13GlyHis: 1.13 ± 0.025	4.937GlyIle: 4.937 ± 0.046	4.356GlyLys: 4.356 ± 0.049	6.618GlyLeu: 6.618 ± 0.074	1.505GlyMet: 1.505 ± 0.03	3.482GlyAsn: 3.482 ± 0.085	1.534GlyPro: 1.534 ± 0.033	2.962GlyGln: 2.962 ± 0.049	3.442GlyArg: 3.442 ± 0.04	4.35GlySer: 4.35 ± 0.063	4.166GlyThr: 4.166 ± 0.082	4.544GlyVal: 4.544 ± 0.05	1.108GlyTrp: 1.108 ± 0.025	2.309GlyTyr: 2.309 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	0.992HisAla: 0.992 ± 0.022	0.255HisCys: 0.255 ± 0.01	0.678HisAsp: 0.678 ± 0.02	0.915HisGlu: 0.915 ± 0.027	0.747HisPhe: 0.747 ± 0.022	0.974HisGly: 0.974 ± 0.025	0.466HisHis: 0.466 ± 0.018	0.934HisIle: 0.934 ± 0.022	0.772HisLys: 0.772 ± 0.018	2.059HisLeu: 2.059 ± 0.034	0.219HisMet: 0.219 ± 0.01	0.674HisAsn: 0.674 ± 0.017	1.245HisPro: 1.245 ± 0.027	0.932HisGln: 0.932 ± 0.02	1.032HisArg: 1.032 ± 0.026	1.136HisSer: 1.136 ± 0.027	0.774HisThr: 0.774 ± 0.02	0.703HisVal: 0.703 ± 0.022	0.288HisTrp: 0.288 ± 0.012	0.574HisTyr: 0.574 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	7.149IleAla: 7.149 ± 0.067	0.786IleCys: 0.786 ± 0.022	3.798IleAsp: 3.798 ± 0.046	4.419IleGlu: 4.419 ± 0.062	2.451IlePhe: 2.451 ± 0.036	4.473IleGly: 4.473 ± 0.049	1.083IleHis: 1.083 ± 0.024	3.214IleIle: 3.214 ± 0.051	2.873IleLys: 2.873 ± 0.043	6.317IleLeu: 6.317 ± 0.067	0.831IleMet: 0.831 ± 0.02	2.685IleAsn: 2.685 ± 0.041	3.411IlePro: 3.411 ± 0.05	2.653IleGln: 2.653 ± 0.04	2.984IleArg: 2.984 ± 0.045	4.407IleSer: 4.407 ± 0.056	3.209IleThr: 3.209 ± 0.045	4.493IleVal: 4.493 ± 0.056	0.835IleTrp: 0.835 ± 0.023	1.866IleTyr: 1.866 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	4.132LysAla: 4.132 ± 0.059	0.38LysCys: 0.38 ± 0.014	2.167LysAsp: 2.167 ± 0.036	2.806LysGlu: 2.806 ± 0.044	1.844LysPhe: 1.844 ± 0.031	2.912LysGly: 2.912 ± 0.045	0.813LysHis: 0.813 ± 0.023	3.58LysIle: 3.58 ± 0.048	2.559LysLys: 2.559 ± 0.05	5.462LysLeu: 5.462 ± 0.061	1.066LysMet: 1.066 ± 0.023	2.256LysAsn: 2.256 ± 0.038	2.56LysPro: 2.56 ± 0.042	2.726LysGln: 2.726 ± 0.036	2.368LysArg: 2.368 ± 0.036	3.231LysSer: 3.231 ± 0.046	3.018LysThr: 3.018 ± 0.047	3.239LysVal: 3.239 ± 0.038	0.529LysTrp: 0.529 ± 0.016	1.486LysTyr: 1.486 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	9.805LeuAla: 9.805 ± 0.087	1.048LeuCys: 1.048 ± 0.026	5.365LeuAsp: 5.365 ± 0.055	7.283LeuGlu: 7.283 ± 0.08	3.56LeuPhe: 3.56 ± 0.047	7.482LeuGly: 7.482 ± 0.076	1.784LeuHis: 1.784 ± 0.032	6.205LeuIle: 6.205 ± 0.073	5.575LeuLys: 5.575 ± 0.068	10.784LeuLeu: 10.784 ± 0.112	2.033LeuMet: 2.033 ± 0.034	4.55LeuAsn: 4.55 ± 0.047	5.584LeuPro: 5.584 ± 0.073	5.278LeuGln: 5.278 ± 0.061	5.551LeuArg: 5.551 ± 0.063	7.464LeuSer: 7.464 ± 0.065	6.166LeuThr: 6.166 ± 0.066	6.73LeuVal: 6.73 ± 0.064	1.334LeuTrp: 1.334 ± 0.029	2.655LeuTyr: 2.655 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	1.724MetAla: 1.724 ± 0.029	0.128MetCys: 0.128 ± 0.008	0.72MetAsp: 0.72 ± 0.018	1.027MetGlu: 1.027 ± 0.021	0.569MetPhe: 0.569 ± 0.017	1.311MetGly: 1.311 ± 0.031	0.251MetHis: 0.251 ± 0.011	0.914MetIle: 0.914 ± 0.024	0.99MetLys: 0.99 ± 0.023	1.94MetLeu: 1.94 ± 0.035	0.448MetMet: 0.448 ± 0.013	0.884MetAsn: 0.884 ± 0.021	1.058MetPro: 1.058 ± 0.023	0.923MetGln: 0.923 ± 0.025	0.964MetArg: 0.964 ± 0.021	1.354MetSer: 1.354 ± 0.024	1.289MetThr: 1.289 ± 0.025	1.231MetVal: 1.231 ± 0.024	0.172MetTrp: 0.172 ± 0.01	0.356MetTyr: 0.356 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.122AsnAla: 3.122 ± 0.052	0.536AsnCys: 0.536 ± 0.017	1.809AsnAsp: 1.809 ± 0.053	1.783AsnGlu: 1.783 ± 0.033	2.021AsnPhe: 2.021 ± 0.033	2.789AsnGly: 2.789 ± 0.062	0.704AsnHis: 0.704 ± 0.018	2.558AsnIle: 2.558 ± 0.045	1.687AsnLys: 1.687 ± 0.029	5.652AsnLeu: 5.652 ± 0.083	0.646AsnMet: 0.646 ± 0.017	1.993AsnAsn: 1.993 ± 0.056	3.07AsnPro: 3.07 ± 0.053	2.503AsnGln: 2.503 ± 0.038	2.529AsnArg: 2.529 ± 0.04	3.411AsnSer: 3.411 ± 0.059	2.129AsnThr: 2.129 ± 0.044	2.201AsnVal: 2.201 ± 0.037	0.789AsnTrp: 0.789 ± 0.019	1.484AsnTyr: 1.484 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	4.245ProAla: 4.245 ± 0.065	0.346ProCys: 0.346 ± 0.014	3.287ProAsp: 3.287 ± 0.043	4.11ProGlu: 4.11 ± 0.053	1.649ProPhe: 1.649 ± 0.034	3.138ProGly: 3.138 ± 0.047	0.823ProHis: 0.823 ± 0.02	2.94ProIle: 2.94 ± 0.043	2.215ProLys: 2.215 ± 0.037	4.631ProLeu: 4.631 ± 0.06	0.762ProMet: 0.762 ± 0.022	2.335ProAsn: 2.335 ± 0.045	2.647ProPro: 2.647 ± 0.059	2.446ProGln: 2.446 ± 0.039	1.775ProArg: 1.775 ± 0.03	2.937ProSer: 2.937 ± 0.044	3.364ProThr: 3.364 ± 0.14	3.543ProVal: 3.543 ± 0.046	0.546ProTrp: 0.546 ± 0.018	1.207ProTyr: 1.207 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	4.335GlnAla: 4.335 ± 0.051	0.355GlnCys: 0.355 ± 0.015	1.854GlnAsp: 1.854 ± 0.036	3.229GlnGlu: 3.229 ± 0.043	1.792GlnPhe: 1.792 ± 0.03	2.864GlnGly: 2.864 ± 0.038	0.828GlnHis: 0.828 ± 0.023	3.461GlnIle: 3.461 ± 0.041	2.704GlnLys: 2.704 ± 0.037	5.81GlnLeu: 5.81 ± 0.072	1.037GlnMet: 1.037 ± 0.023	2.011GlnAsn: 2.011 ± 0.034	2.425GlnPro: 2.425 ± 0.041	3.431GlnGln: 3.431 ± 0.065	2.615GlnArg: 2.615 ± 0.042	2.85GlnSer: 2.85 ± 0.047	2.828GlnThr: 2.828 ± 0.043	3.426GlnVal: 3.426 ± 0.04	0.572GlnTrp: 0.572 ± 0.018	1.162GlnTyr: 1.162 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	3.798ArgAla: 3.798 ± 0.046	0.584ArgCys: 0.584 ± 0.019	2.808ArgAsp: 2.808 ± 0.04	3.701ArgGlu: 3.701 ± 0.054	2.165ArgPhe: 2.165 ± 0.033	3.188ArgGly: 3.188 ± 0.043	0.987ArgHis: 0.987 ± 0.025	3.422ArgIle: 3.422 ± 0.042	2.467ArgLys: 2.467 ± 0.04	5.82ArgLeu: 5.82 ± 0.066	1.004ArgMet: 1.004 ± 0.021	2.078ArgAsn: 2.078 ± 0.035	2.135ArgPro: 2.135 ± 0.036	3.136ArgGln: 3.136 ± 0.052	3.03ArgArg: 3.03 ± 0.052	3.704ArgSer: 3.704 ± 0.049	2.762ArgThr: 2.762 ± 0.036	3.512ArgVal: 3.512 ± 0.047	0.82ArgTrp: 0.82 ± 0.024	1.771ArgTyr: 1.771 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	5.319SerAla: 5.319 ± 0.052	0.684SerCys: 0.684 ± 0.019	3.46SerAsp: 3.46 ± 0.049	4.407SerGlu: 4.407 ± 0.056	2.492SerPhe: 2.492 ± 0.038	5.247SerGly: 5.247 ± 0.076	1.205SerHis: 1.205 ± 0.03	3.893SerIle: 3.893 ± 0.053	2.802SerLys: 2.802 ± 0.039	7.076SerLeu: 7.076 ± 0.066	1.137SerMet: 1.137 ± 0.025	2.748SerAsn: 2.748 ± 0.048	3.694SerPro: 3.694 ± 0.055	3.723SerGln: 3.723 ± 0.051	3.44SerArg: 3.44 ± 0.042	4.569SerSer: 4.569 ± 0.071	3.425SerThr: 3.425 ± 0.057	4.115SerVal: 4.115 ± 0.045	0.888SerTrp: 0.888 ± 0.021	1.795SerTyr: 1.795 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	5.364ThrAla: 5.364 ± 0.067	0.453ThrCys: 0.453 ± 0.014	2.821ThrAsp: 2.821 ± 0.047	3.347ThrGlu: 3.347 ± 0.045	2.161ThrPhe: 2.161 ± 0.041	4.471ThrGly: 4.471 ± 0.076	0.872ThrHis: 0.872 ± 0.02	3.586ThrIle: 3.586 ± 0.048	2.222ThrLys: 2.222 ± 0.038	5.917ThrLeu: 5.917 ± 0.061	0.736ThrMet: 0.736 ± 0.018	2.259ThrAsn: 2.259 ± 0.047	3.896ThrPro: 3.896 ± 0.154	2.451ThrGln: 2.451 ± 0.04	2.321ThrArg: 2.321 ± 0.036	3.293ThrSer: 3.293 ± 0.06	3.031ThrThr: 3.031 ± 0.071	4.402ThrVal: 4.402 ± 0.07	0.655ThrTrp: 0.655 ± 0.019	1.544ThrTyr: 1.544 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	6.076ValAla: 6.076 ± 0.064	0.722ValCys: 0.722 ± 0.02	3.382ValAsp: 3.382 ± 0.044	4.725ValGlu: 4.725 ± 0.056	2.561ValPhe: 2.561 ± 0.039	4.499ValGly: 4.499 ± 0.053	0.968ValHis: 0.968 ± 0.024	3.768ValIle: 3.768 ± 0.046	3.671ValLys: 3.671 ± 0.046	6.534ValLeu: 6.534 ± 0.063	1.346ValMet: 1.346 ± 0.027	2.842ValAsn: 2.842 ± 0.034	3.072ValPro: 3.072 ± 0.041	2.826ValGln: 2.826 ± 0.043	3.594ValArg: 3.594 ± 0.053	4.419ValSer: 4.419 ± 0.052	3.798ValThr: 3.798 ± 0.071	4.421ValVal: 4.421 ± 0.05	0.892ValTrp: 0.892 ± 0.021	1.775ValTyr: 1.775 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	0.912TrpAla: 0.912 ± 0.023	0.148TrpCys: 0.148 ± 0.008	0.627TrpAsp: 0.627 ± 0.018	0.997TrpGlu: 0.997 ± 0.025	0.541TrpPhe: 0.541 ± 0.017	0.897TrpGly: 0.897 ± 0.024	0.301TrpHis: 0.301 ± 0.013	0.802TrpIle: 0.802 ± 0.021	0.65TrpLys: 0.65 ± 0.02	1.691TrpLeu: 1.691 ± 0.033	0.364TrpMet: 0.364 ± 0.013	0.628TrpAsn: 0.628 ± 0.02	0.386TrpPro: 0.386 ± 0.015	1.037TrpGln: 1.037 ± 0.02	0.831TrpArg: 0.831 ± 0.022	0.764TrpSer: 0.764 ± 0.017	0.579TrpThr: 0.579 ± 0.018	0.917TrpVal: 0.917 ± 0.022	0.224TrpTrp: 0.224 ± 0.011	0.428TrpTyr: 0.428 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.042TyrAla: 2.042 ± 0.031	0.392TyrCys: 0.392 ± 0.015	1.582TyrAsp: 1.582 ± 0.05	1.672TyrGlu: 1.672 ± 0.033	1.306TyrPhe: 1.306 ± 0.028	1.995TyrGly: 1.995 ± 0.038	0.552TyrHis: 0.552 ± 0.02	1.507TyrIle: 1.507 ± 0.028	1.237TyrLys: 1.237 ± 0.029	3.376TyrLeu: 3.376 ± 0.046	0.389TyrMet: 0.389 ± 0.011	1.21TyrAsn: 1.21 ± 0.034	1.496TyrPro: 1.496 ± 0.025	1.812TyrGln: 1.812 ± 0.032	2.072TyrArg: 2.072 ± 0.032	1.975TyrSer: 1.975 ± 0.04	1.465TyrThr: 1.465 ± 0.033	1.519TyrVal: 1.519 ± 0.028	0.495TyrTrp: 0.495 ± 0.015	1.014TyrTyr: 1.014 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6276 proteins (2109055 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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