Amino acid dipepetide frequency for Punta toro phlebovirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.085AlaAla: 3.085 ± 2.987
1.285AlaCys: 1.285 ± 0.407
2.314AlaAsp: 2.314 ± 1.456
3.599AlaGlu: 3.599 ± 1.284
3.085AlaPhe: 3.085 ± 0.541
2.314AlaGly: 2.314 ± 2.25
1.799AlaHis: 1.799 ± 0.782
5.141AlaIle: 5.141 ± 0.773
2.828AlaLys: 2.828 ± 1.479
3.342AlaLeu: 3.342 ± 1.692
1.285AlaMet: 1.285 ± 3.444
0.514AlaAsn: 0.514 ± 0.838
1.542AlaPro: 1.542 ± 0.482
1.028AlaGln: 1.028 ± 0.661
2.828AlaArg: 2.828 ± 1.038
4.37AlaSer: 4.37 ± 0.653
2.571AlaThr: 2.571 ± 0.764
4.113AlaVal: 4.113 ± 1.053
0.0AlaTrp: 0.0 ± 0.0
2.571AlaTyr: 2.571 ± 0.591
0.0AlaXaa: 0.0 ± 0.0
Cys
1.028CysAla: 1.028 ± 0.352
0.257CysCys: 0.257 ± 0.627
1.542CysAsp: 1.542 ± 0.643
1.542CysGlu: 1.542 ± 0.482
1.799CysPhe: 1.799 ± 1.258
1.285CysGly: 1.285 ± 0.809
0.514CysHis: 0.514 ± 0.452
1.285CysIle: 1.285 ± 0.809
1.799CysLys: 1.799 ± 0.703
2.057CysLeu: 2.057 ± 0.662
0.771CysMet: 0.771 ± 0.496
0.514CysAsn: 0.514 ± 0.33
1.542CysPro: 1.542 ± 0.511
2.057CysGln: 2.057 ± 0.703
2.057CysArg: 2.057 ± 0.71
2.828CysSer: 2.828 ± 1.048
1.542CysThr: 1.542 ± 0.511
1.542CysVal: 1.542 ± 1.356
0.0CysTrp: 0.0 ± 0.0
1.285CysTyr: 1.285 ± 0.533
0.0CysXaa: 0.0 ± 0.0
Asp
2.314AspAla: 2.314 ± 0.752
2.057AspCys: 2.057 ± 0.992
5.141AspAsp: 5.141 ± 1.63
3.599AspGlu: 3.599 ± 1.563
3.342AspPhe: 3.342 ± 1.016
2.571AspGly: 2.571 ± 1.355
1.799AspHis: 1.799 ± 0.703
4.884AspIle: 4.884 ± 1.403
3.599AspLys: 3.599 ± 0.206
5.656AspLeu: 5.656 ± 2.134
1.028AspMet: 1.028 ± 0.661
2.828AspAsn: 2.828 ± 0.497
2.314AspPro: 2.314 ± 1.191
1.542AspGln: 1.542 ± 0.833
1.799AspArg: 1.799 ± 0.865
4.627AspSer: 4.627 ± 1.115
1.285AspThr: 1.285 ± 0.648
3.342AspVal: 3.342 ± 1.573
1.028AspTrp: 1.028 ± 0.743
1.542AspTyr: 1.542 ± 0.916
0.0AspXaa: 0.0 ± 0.0
Glu
2.571GluAla: 2.571 ± 1.092
1.285GluCys: 1.285 ± 0.533
4.37GluAsp: 4.37 ± 1.445
4.627GluGlu: 4.627 ± 1.601
2.828GluPhe: 2.828 ± 0.899
4.113GluGly: 4.113 ± 1.22
1.542GluHis: 1.542 ± 0.643
5.141GluIle: 5.141 ± 2.03
3.342GluLys: 3.342 ± 0.893
6.941GluLeu: 6.941 ± 2.873
0.771GluMet: 0.771 ± 0.37
3.599GluAsn: 3.599 ± 1.144
1.799GluPro: 1.799 ± 0.488
2.314GluGln: 2.314 ± 0.752
3.856GluArg: 3.856 ± 1.022
5.913GluSer: 5.913 ± 1.351
3.085GluThr: 3.085 ± 0.977
3.856GluVal: 3.856 ± 1.014
0.514GluTrp: 0.514 ± 0.575
1.285GluTyr: 1.285 ± 0.852
0.0GluXaa: 0.0 ± 0.0
Phe
3.085PheAla: 3.085 ± 3.155
1.028PheCys: 1.028 ± 0.352
2.057PheAsp: 2.057 ± 0.762
3.085PheGlu: 3.085 ± 0.322
2.828PhePhe: 2.828 ± 1.038
2.057PheGly: 2.057 ± 1.049
0.514PheHis: 0.514 ± 0.33
3.342PheIle: 3.342 ± 1.222
3.342PheLys: 3.342 ± 0.778
5.141PheLeu: 5.141 ± 0.499
1.542PheMet: 1.542 ± 0.585
2.571PheAsn: 2.571 ± 0.895
1.285PhePro: 1.285 ± 0.546
1.028PheGln: 1.028 ± 0.393
2.571PheArg: 2.571 ± 1.055
4.113PheSer: 4.113 ± 0.149
3.085PheThr: 3.085 ± 0.972
3.085PheVal: 3.085 ± 1.043
1.285PheTrp: 1.285 ± 0.546
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
2.571GlyAla: 2.571 ± 0.813
2.057GlyCys: 2.057 ± 0.704
2.314GlyAsp: 2.314 ± 0.742
1.285GlyGlu: 1.285 ± 0.648
3.599GlyPhe: 3.599 ± 0.597
3.599GlyGly: 3.599 ± 0.597
1.028GlyHis: 1.028 ± 0.393
2.828GlyIle: 2.828 ± 0.497
3.085GlyLys: 3.085 ± 0.92
5.913GlyLeu: 5.913 ± 1.373
1.542GlyMet: 1.542 ± 0.541
2.314GlyAsn: 2.314 ± 1.485
2.571GlyPro: 2.571 ± 1.067
2.314GlyGln: 2.314 ± 0.891
3.085GlyArg: 3.085 ± 0.729
5.141GlySer: 5.141 ± 1.759
3.342GlyThr: 3.342 ± 1.694
4.37GlyVal: 4.37 ± 1.437
1.028GlyTrp: 1.028 ± 1.676
1.799GlyTyr: 1.799 ± 1.324
0.0GlyXaa: 0.0 ± 0.0
His
1.285HisAla: 1.285 ± 0.533
0.514HisCys: 0.514 ± 0.822
2.571HisAsp: 2.571 ± 0.597
0.771HisGlu: 0.771 ± 0.256
1.542HisPhe: 1.542 ± 0.686
1.542HisGly: 1.542 ± 0.511
0.257HisHis: 0.257 ± 0.226
2.314HisIle: 2.314 ± 0.767
1.285HisLys: 1.285 ± 0.407
1.542HisLeu: 1.542 ± 0.528
0.514HisMet: 0.514 ± 0.176
1.028HisAsn: 1.028 ± 1.291
1.028HisPro: 1.028 ± 0.809
1.285HisGln: 1.285 ± 0.407
1.542HisArg: 1.542 ± 0.74
1.542HisSer: 1.542 ± 0.511
1.285HisThr: 1.285 ± 0.407
1.542HisVal: 1.542 ± 0.704
0.0HisTrp: 0.0 ± 0.0
0.771HisTyr: 0.771 ± 0.256
0.0HisXaa: 0.0 ± 0.0
Ile
3.856IleAla: 3.856 ± 1.948
1.799IleCys: 1.799 ± 0.563
3.599IleAsp: 3.599 ± 1.483
3.856IleGlu: 3.856 ± 0.891
2.571IlePhe: 2.571 ± 0.813
5.656IleGly: 5.656 ± 1.521
1.799IleHis: 1.799 ± 0.572
3.856IleIle: 3.856 ± 0.681
5.913IleLys: 5.913 ± 2.496
5.141IleLeu: 5.141 ± 1.759
1.799IleMet: 1.799 ± 0.495
4.113IleAsn: 4.113 ± 2.009
3.342IlePro: 3.342 ± 1.024
2.571IleGln: 2.571 ± 0.591
4.37IleArg: 4.37 ± 1.428
7.198IleSer: 7.198 ± 1.562
3.856IleThr: 3.856 ± 1.128
4.113IleVal: 4.113 ± 1.183
0.514IleTrp: 0.514 ± 0.33
1.799IleTyr: 1.799 ± 0.572
0.0IleXaa: 0.0 ± 0.0
Lys
3.599LysAla: 3.599 ± 0.74
2.571LysCys: 2.571 ± 1.089
3.342LysAsp: 3.342 ± 0.815
4.627LysGlu: 4.627 ± 1.225
1.799LysPhe: 1.799 ± 0.488
3.856LysGly: 3.856 ± 2.126
1.028LysHis: 1.028 ± 0.393
5.398LysIle: 5.398 ± 1.717
4.884LysLys: 4.884 ± 0.92
4.113LysLeu: 4.113 ± 0.503
3.599LysMet: 3.599 ± 2.015
3.599LysAsn: 3.599 ± 0.882
2.571LysPro: 2.571 ± 1.268
2.828LysGln: 2.828 ± 0.602
3.856LysArg: 3.856 ± 2.07
4.884LysSer: 4.884 ± 0.287
5.398LysThr: 5.398 ± 1.535
3.856LysVal: 3.856 ± 1.448
1.542LysTrp: 1.542 ± 0.791
3.085LysTyr: 3.085 ± 0.553
0.0LysXaa: 0.0 ± 0.0
Leu
2.571LeuAla: 2.571 ± 1.355
2.057LeuCys: 2.057 ± 1.028
3.085LeuAsp: 3.085 ± 0.964
4.884LeuGlu: 4.884 ± 1.124
4.37LeuPhe: 4.37 ± 1.006
4.37LeuGly: 4.37 ± 0.671
2.314LeuHis: 2.314 ± 0.889
4.627LeuIle: 4.627 ± 1.023
9.254LeuLys: 9.254 ± 2.759
6.684LeuLeu: 6.684 ± 1.746
3.856LeuMet: 3.856 ± 0.764
4.37LeuAsn: 4.37 ± 1.466
3.085LeuPro: 3.085 ± 2.165
2.571LeuGln: 2.571 ± 1.031
4.884LeuArg: 4.884 ± 0.633
11.054LeuSer: 11.054 ± 1.235
5.656LeuThr: 5.656 ± 1.694
4.627LeuVal: 4.627 ± 1.761
0.514LeuTrp: 0.514 ± 0.575
3.342LeuTyr: 3.342 ± 0.893
0.0LeuXaa: 0.0 ± 0.0
Met
2.571MetAla: 2.571 ± 1.355
0.0MetCys: 0.0 ± 0.0
1.542MetAsp: 1.542 ± 0.686
3.342MetGlu: 3.342 ± 1.192
0.771MetPhe: 0.771 ± 0.568
1.285MetGly: 1.285 ± 0.533
0.771MetHis: 0.771 ± 0.798
2.571MetIle: 2.571 ± 1.415
2.057MetLys: 2.057 ± 1.028
3.085MetLeu: 3.085 ± 0.92
2.571MetMet: 2.571 ± 0.85
1.799MetAsn: 1.799 ± 0.865
0.0MetPro: 0.0 ± 0.0
0.771MetGln: 0.771 ± 0.798
1.285MetArg: 1.285 ± 0.499
3.085MetSer: 3.085 ± 1.665
2.057MetThr: 2.057 ± 0.547
2.057MetVal: 2.057 ± 1.382
0.0MetTrp: 0.0 ± 0.0
1.285MetTyr: 1.285 ± 0.407
0.0MetXaa: 0.0 ± 0.0
Asn
2.314AsnAla: 2.314 ± 0.538
0.514AsnCys: 0.514 ± 0.452
2.828AsnAsp: 2.828 ± 0.854
3.599AsnGlu: 3.599 ± 0.995
2.314AsnPhe: 2.314 ± 1.487
1.799AsnGly: 1.799 ± 0.572
1.285AsnHis: 1.285 ± 0.533
2.571AsnIle: 2.571 ± 1.868
4.627AsnLys: 4.627 ± 1.009
4.113AsnLeu: 4.113 ± 0.858
1.285AsnMet: 1.285 ± 0.403
1.799AsnAsn: 1.799 ± 0.488
2.828AsnPro: 2.828 ± 1.236
2.057AsnGln: 2.057 ± 0.525
1.799AsnArg: 1.799 ± 1.324
3.085AsnSer: 3.085 ± 1.235
1.028AsnThr: 1.028 ± 0.352
2.057AsnVal: 2.057 ± 1.175
1.285AsnTrp: 1.285 ± 0.751
1.542AsnTyr: 1.542 ± 1.064
0.0AsnXaa: 0.0 ± 0.0
Pro
2.057ProAla: 2.057 ± 0.762
0.0ProCys: 0.0 ± 0.0
2.828ProAsp: 2.828 ± 0.692
2.828ProGlu: 2.828 ± 1.519
2.314ProPhe: 2.314 ± 0.538
2.571ProGly: 2.571 ± 0.895
0.514ProHis: 0.514 ± 0.176
1.028ProIle: 1.028 ± 0.587
1.542ProLys: 1.542 ± 0.643
3.599ProLeu: 3.599 ± 1.668
1.799ProMet: 1.799 ± 0.782
1.799ProAsn: 1.799 ± 0.955
1.285ProPro: 1.285 ± 0.407
1.285ProGln: 1.285 ± 0.407
1.799ProArg: 1.799 ± 0.582
3.342ProSer: 3.342 ± 3.041
1.799ProThr: 1.799 ± 0.641
2.057ProVal: 2.057 ± 1.225
0.514ProTrp: 0.514 ± 0.176
0.771ProTyr: 0.771 ± 0.256
0.0ProXaa: 0.0 ± 0.0
Gln
2.314GlnAla: 2.314 ± 3.331
1.028GlnCys: 1.028 ± 0.587
1.799GlnAsp: 1.799 ± 0.725
3.085GlnGlu: 3.085 ± 1.219
1.028GlnPhe: 1.028 ± 1.643
2.057GlnGly: 2.057 ± 0.762
1.285GlnHis: 1.285 ± 0.826
3.342GlnIle: 3.342 ± 1.192
2.571GlnLys: 2.571 ± 1.067
3.085GlnLeu: 3.085 ± 1.55
0.257GlnMet: 0.257 ± 0.165
1.028GlnAsn: 1.028 ± 0.393
0.771GlnPro: 0.771 ± 0.256
1.285GlnGln: 1.285 ± 0.533
0.771GlnArg: 0.771 ± 0.256
2.828GlnSer: 2.828 ± 1.156
2.057GlnThr: 2.057 ± 0.656
2.057GlnVal: 2.057 ± 0.901
0.0GlnTrp: 0.0 ± 0.0
0.771GlnTyr: 0.771 ± 0.568
0.0GlnXaa: 0.0 ± 0.0
Arg
3.856ArgAla: 3.856 ± 2.288
2.057ArgCys: 2.057 ± 0.656
3.599ArgAsp: 3.599 ± 0.263
3.342ArgGlu: 3.342 ± 1.024
1.542ArgPhe: 1.542 ± 0.704
3.085ArgGly: 3.085 ± 2.139
1.028ArgHis: 1.028 ± 0.501
4.113ArgIle: 4.113 ± 0.791
1.799ArgLys: 1.799 ± 0.641
3.085ArgLeu: 3.085 ± 1.536
2.571ArgMet: 2.571 ± 1.652
3.856ArgAsn: 3.856 ± 1.541
1.285ArgPro: 1.285 ± 0.648
1.028ArgGln: 1.028 ± 0.607
2.057ArgArg: 2.057 ± 0.662
5.141ArgSer: 5.141 ± 2.89
1.542ArgThr: 1.542 ± 0.991
3.342ArgVal: 3.342 ± 1.02
0.257ArgTrp: 0.257 ± 0.165
1.028ArgTyr: 1.028 ± 0.352
0.0ArgXaa: 0.0 ± 0.0
Ser
4.37SerAla: 4.37 ± 1.22
3.599SerCys: 3.599 ± 2.516
5.141SerAsp: 5.141 ± 0.984
8.483SerGlu: 8.483 ± 0.773
4.884SerPhe: 4.884 ± 0.979
4.113SerGly: 4.113 ± 1.324
2.057SerHis: 2.057 ± 0.786
5.913SerIle: 5.913 ± 0.732
7.198SerLys: 7.198 ± 1.806
10.026SerLeu: 10.026 ± 1.282
1.799SerMet: 1.799 ± 1.047
3.342SerAsn: 3.342 ± 0.759
3.342SerPro: 3.342 ± 1.183
1.542SerGln: 1.542 ± 0.511
3.599SerArg: 3.599 ± 1.269
11.311SerSer: 11.311 ± 2.822
5.141SerThr: 5.141 ± 1.437
5.141SerVal: 5.141 ± 1.355
2.057SerTrp: 2.057 ± 0.547
2.571SerTyr: 2.571 ± 0.539
0.0SerXaa: 0.0 ± 0.0
Thr
2.571ThrAla: 2.571 ± 0.859
1.542ThrCys: 1.542 ± 0.916
2.571ThrAsp: 2.571 ± 1.092
1.542ThrGlu: 1.542 ± 0.704
2.828ThrPhe: 2.828 ± 0.418
3.856ThrGly: 3.856 ± 0.709
0.771ThrHis: 0.771 ± 0.75
5.398ThrIle: 5.398 ± 0.724
2.571ThrLys: 2.571 ± 0.895
5.913ThrLeu: 5.913 ± 0.765
2.057ThrMet: 2.057 ± 0.757
2.828ThrAsn: 2.828 ± 1.048
1.285ThrPro: 1.285 ± 0.407
1.542ThrGln: 1.542 ± 0.833
3.342ThrArg: 3.342 ± 0.552
5.913ThrSer: 5.913 ± 0.685
2.057ThrThr: 2.057 ± 0.901
2.828ThrVal: 2.828 ± 1.007
1.028ThrTrp: 1.028 ± 0.352
0.771ThrTyr: 0.771 ± 1.192
0.0ThrXaa: 0.0 ± 0.0
Val
2.314ValAla: 2.314 ± 0.502
2.314ValCys: 2.314 ± 1.11
2.828ValAsp: 2.828 ± 1.001
2.828ValGlu: 2.828 ± 0.899
2.314ValPhe: 2.314 ± 0.79
3.599ValGly: 3.599 ± 1.91
2.828ValHis: 2.828 ± 0.915
4.627ValIle: 4.627 ± 0.574
4.884ValLys: 4.884 ± 1.06
5.141ValLeu: 5.141 ± 2.591
1.799ValMet: 1.799 ± 0.488
1.799ValAsn: 1.799 ± 0.582
1.542ValPro: 1.542 ± 0.643
3.085ValGln: 3.085 ± 1.169
2.571ValArg: 2.571 ± 1.355
5.656ValSer: 5.656 ± 0.778
4.627ValThr: 4.627 ± 1.879
2.314ValVal: 2.314 ± 1.11
0.514ValTrp: 0.514 ± 0.33
1.542ValTyr: 1.542 ± 0.528
0.0ValXaa: 0.0 ± 0.0
Trp
0.257TrpAla: 0.257 ± 0.165
0.771TrpCys: 0.771 ± 0.568
0.771TrpAsp: 0.771 ± 0.256
0.771TrpGlu: 0.771 ± 0.553
0.514TrpPhe: 0.514 ± 0.176
0.771TrpGly: 0.771 ± 0.553
0.0TrpHis: 0.0 ± 0.0
1.028TrpIle: 1.028 ± 0.393
0.514TrpLys: 0.514 ± 0.822
1.542TrpLeu: 1.542 ± 0.643
0.257TrpMet: 0.257 ± 0.165
0.257TrpAsn: 0.257 ± 0.165
0.771TrpPro: 0.771 ± 0.553
0.0TrpGln: 0.0 ± 0.0
1.028TrpArg: 1.028 ± 0.393
0.771TrpSer: 0.771 ± 0.256
1.028TrpThr: 1.028 ± 0.691
1.028TrpVal: 1.028 ± 0.743
0.257TrpTrp: 0.257 ± 0.165
0.257TrpTyr: 0.257 ± 0.165
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.028TyrAla: 1.028 ± 0.607
0.514TyrCys: 0.514 ± 0.176
2.057TyrAsp: 2.057 ± 0.71
2.057TyrGlu: 2.057 ± 1.32
0.771TyrPhe: 0.771 ± 0.496
1.285TyrGly: 1.285 ± 0.407
1.028TyrHis: 1.028 ± 0.393
2.571TyrIle: 2.571 ± 1.089
3.342TyrLys: 3.342 ± 0.865
2.057TyrLeu: 2.057 ± 0.827
1.542TyrMet: 1.542 ± 0.704
0.771TyrAsn: 0.771 ± 0.496
1.542TyrPro: 1.542 ± 0.99
1.285TyrGln: 1.285 ± 0.957
0.514TyrArg: 0.514 ± 0.33
2.828TyrSer: 2.828 ± 0.915
0.771TyrThr: 0.771 ± 0.256
1.799TyrVal: 1.799 ± 0.582
0.257TyrTrp: 0.257 ± 0.226
0.771TyrTyr: 0.771 ± 0.553
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (3891 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski