Amino acid dipepetide frequency for Cannes 8 virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.194AlaAla: 3.194 ± 0.253
1.307AlaCys: 1.307 ± 0.108
2.15AlaAsp: 2.15 ± 0.156
4.089AlaGlu: 4.089 ± 0.191
3.01AlaPhe: 3.01 ± 0.17
2.483AlaGly: 2.483 ± 0.172
0.763AlaHis: 0.763 ± 0.077
2.527AlaIle: 2.527 ± 0.179
4.712AlaLys: 4.712 ± 0.289
5.177AlaLeu: 5.177 ± 0.255
1.228AlaMet: 1.228 ± 0.097
1.825AlaAsn: 1.825 ± 0.166
1.886AlaPro: 1.886 ± 0.115
1.614AlaGln: 1.614 ± 0.116
2.729AlaArg: 2.729 ± 0.149
4.405AlaSer: 4.405 ± 0.26
2.738AlaThr: 2.738 ± 0.214
3.255AlaVal: 3.255 ± 0.189
0.535AlaTrp: 0.535 ± 0.071
1.342AlaTyr: 1.342 ± 0.12
0.0AlaXaa: 0.0 ± 0.0
Cys
1.193CysAla: 1.193 ± 0.113
0.711CysCys: 0.711 ± 0.085
1.202CysAsp: 1.202 ± 0.113
2.211CysGlu: 2.211 ± 0.17
1.843CysPhe: 1.843 ± 0.175
2.158CysGly: 2.158 ± 0.184
0.43CysHis: 0.43 ± 0.063
0.939CysIle: 0.939 ± 0.094
2.15CysLys: 2.15 ± 0.192
2.36CysLeu: 2.36 ± 0.147
0.412CysMet: 0.412 ± 0.066
0.684CysAsn: 0.684 ± 0.08
1.562CysPro: 1.562 ± 0.171
0.649CysGln: 0.649 ± 0.077
1.378CysArg: 1.378 ± 0.118
2.632CysSer: 2.632 ± 0.21
0.948CysThr: 0.948 ± 0.085
1.518CysVal: 1.518 ± 0.116
0.263CysTrp: 0.263 ± 0.051
0.693CysTyr: 0.693 ± 0.077
0.0CysXaa: 0.0 ± 0.0
Asp
2.641AspAla: 2.641 ± 0.17
1.272AspCys: 1.272 ± 0.117
2.115AspAsp: 2.115 ± 0.142
3.764AspGlu: 3.764 ± 0.2
2.948AspPhe: 2.948 ± 0.145
3.992AspGly: 3.992 ± 0.194
0.588AspHis: 0.588 ± 0.076
3.773AspIle: 3.773 ± 0.203
3.185AspLys: 3.185 ± 0.204
3.299AspLeu: 3.299 ± 0.19
1.035AspMet: 1.035 ± 0.097
1.544AspAsn: 1.544 ± 0.122
1.878AspPro: 1.878 ± 0.149
0.913AspGln: 0.913 ± 0.086
2.237AspArg: 2.237 ± 0.146
3.053AspSer: 3.053 ± 0.144
1.834AspThr: 1.834 ± 0.158
3.624AspVal: 3.624 ± 0.197
0.772AspTrp: 0.772 ± 0.078
1.342AspTyr: 1.342 ± 0.112
0.0AspXaa: 0.0 ± 0.0
Glu
4.431GluAla: 4.431 ± 0.202
1.834GluCys: 1.834 ± 0.198
4.063GluAsp: 4.063 ± 0.223
9.81GluGlu: 9.81 ± 0.57
4.817GluPhe: 4.817 ± 0.238
5.072GluGly: 5.072 ± 0.205
1.834GluHis: 1.834 ± 0.145
4.536GluIle: 4.536 ± 0.181
10.845GluLys: 10.845 ± 0.359
6.932GluLeu: 6.932 ± 0.266
2.264GluMet: 2.264 ± 0.167
4.115GluAsn: 4.115 ± 0.211
2.018GluPro: 2.018 ± 0.135
3.141GluGln: 3.141 ± 0.176
6.019GluArg: 6.019 ± 0.299
4.045GluSer: 4.045 ± 0.225
5.335GluThr: 5.335 ± 0.196
4.238GluVal: 4.238 ± 0.195
1.176GluTrp: 1.176 ± 0.097
2.65GluTyr: 2.65 ± 0.169
0.0GluXaa: 0.0 ± 0.0
Phe
3.659PheAla: 3.659 ± 0.176
2.36PheCys: 2.36 ± 0.185
3.097PheAsp: 3.097 ± 0.192
5.238PheGlu: 5.238 ± 0.288
3.246PhePhe: 3.246 ± 0.189
3.887PheGly: 3.887 ± 0.206
1.0PheHis: 1.0 ± 0.09
2.071PheIle: 2.071 ± 0.123
2.562PheLys: 2.562 ± 0.147
6.8PheLeu: 6.8 ± 0.26
1.123PheMet: 1.123 ± 0.096
1.018PheAsn: 1.018 ± 0.108
2.518PhePro: 2.518 ± 0.173
1.439PheGln: 1.439 ± 0.103
3.106PheArg: 3.106 ± 0.166
5.668PheSer: 5.668 ± 0.264
1.772PheThr: 1.772 ± 0.133
4.782PheVal: 4.782 ± 0.224
1.693PheTrp: 1.693 ± 0.169
1.781PheTyr: 1.781 ± 0.128
0.0PheXaa: 0.0 ± 0.0
Gly
3.308GlyAla: 3.308 ± 0.192
1.571GlyCys: 1.571 ± 0.143
2.632GlyAsp: 2.632 ± 0.152
5.651GlyGlu: 5.651 ± 0.265
2.869GlyPhe: 2.869 ± 0.147
3.457GlyGly: 3.457 ± 0.201
1.228GlyHis: 1.228 ± 0.129
3.791GlyIle: 3.791 ± 0.201
6.826GlyLys: 6.826 ± 0.259
4.291GlyLeu: 4.291 ± 0.23
1.316GlyMet: 1.316 ± 0.112
2.72GlyAsn: 2.72 ± 0.155
1.658GlyPro: 1.658 ± 0.125
1.895GlyGln: 1.895 ± 0.166
3.948GlyArg: 3.948 ± 0.203
4.194GlySer: 4.194 ± 0.22
3.747GlyThr: 3.747 ± 0.216
4.115GlyVal: 4.115 ± 0.223
0.93GlyTrp: 0.93 ± 0.087
2.334GlyTyr: 2.334 ± 0.138
0.0GlyXaa: 0.0 ± 0.0
His
0.79HisAla: 0.79 ± 0.084
0.491HisCys: 0.491 ± 0.062
0.57HisAsp: 0.57 ± 0.08
1.404HisGlu: 1.404 ± 0.111
1.299HisPhe: 1.299 ± 0.109
1.544HisGly: 1.544 ± 0.161
0.29HisHis: 0.29 ± 0.045
1.29HisIle: 1.29 ± 0.116
1.781HisLys: 1.781 ± 0.139
1.834HisLeu: 1.834 ± 0.146
0.325HisMet: 0.325 ± 0.05
0.728HisAsn: 0.728 ± 0.082
0.86HisPro: 0.86 ± 0.093
0.623HisGln: 0.623 ± 0.07
0.93HisArg: 0.93 ± 0.091
1.536HisSer: 1.536 ± 0.122
0.553HisThr: 0.553 ± 0.066
1.079HisVal: 1.079 ± 0.09
0.263HisTrp: 0.263 ± 0.056
0.544HisTyr: 0.544 ± 0.069
0.0HisXaa: 0.0 ± 0.0
Ile
2.457IleAla: 2.457 ± 0.153
1.202IleCys: 1.202 ± 0.093
2.185IleAsp: 2.185 ± 0.134
3.352IleGlu: 3.352 ± 0.176
3.334IlePhe: 3.334 ± 0.222
2.65IleGly: 2.65 ± 0.187
1.106IleHis: 1.106 ± 0.105
2.255IleIle: 2.255 ± 0.158
2.834IleLys: 2.834 ± 0.154
5.37IleLeu: 5.37 ± 0.207
0.693IleMet: 0.693 ± 0.079
1.167IleAsn: 1.167 ± 0.108
2.79IlePro: 2.79 ± 0.176
1.904IleGln: 1.904 ± 0.151
2.562IleArg: 2.562 ± 0.135
5.344IleSer: 5.344 ± 0.241
2.018IleThr: 2.018 ± 0.146
3.282IleVal: 3.282 ± 0.175
0.772IleTrp: 0.772 ± 0.107
1.211IleTyr: 1.211 ± 0.104
0.0IleXaa: 0.0 ± 0.0
Lys
4.194LysAla: 4.194 ± 0.264
1.65LysCys: 1.65 ± 0.169
4.124LysAsp: 4.124 ± 0.175
8.73LysGlu: 8.73 ± 0.381
4.65LysPhe: 4.65 ± 0.242
5.308LysGly: 5.308 ± 0.224
2.044LysHis: 2.044 ± 0.144
4.747LysIle: 4.747 ± 0.243
11.644LysLys: 11.644 ± 0.661
6.098LysLeu: 6.098 ± 0.266
1.992LysMet: 1.992 ± 0.135
4.835LysAsn: 4.835 ± 0.241
2.176LysPro: 2.176 ± 0.144
2.878LysGln: 2.878 ± 0.177
5.826LysArg: 5.826 ± 0.234
4.475LysSer: 4.475 ± 0.208
5.151LysThr: 5.151 ± 0.231
4.536LysVal: 4.536 ± 0.178
0.895LysTrp: 0.895 ± 0.092
3.203LysTyr: 3.203 ± 0.169
0.0LysXaa: 0.0 ± 0.0
Leu
4.378LeuAla: 4.378 ± 0.216
3.045LeuCys: 3.045 ± 0.197
4.352LeuAsp: 4.352 ± 0.19
8.362LeuGlu: 8.362 ± 0.358
5.256LeuPhe: 5.256 ± 0.246
5.159LeuGly: 5.159 ± 0.247
1.562LeuHis: 1.562 ± 0.129
2.878LeuIle: 2.878 ± 0.148
5.51LeuLys: 5.51 ± 0.244
8.713LeuLeu: 8.713 ± 0.339
1.623LeuMet: 1.623 ± 0.112
2.702LeuAsn: 2.702 ± 0.147
4.387LeuPro: 4.387 ± 0.223
3.501LeuGln: 3.501 ± 0.234
4.966LeuArg: 4.966 ± 0.208
8.608LeuSer: 8.608 ± 0.33
3.264LeuThr: 3.264 ± 0.188
5.931LeuVal: 5.931 ± 0.274
1.825LeuTrp: 1.825 ± 0.138
2.43LeuTyr: 2.43 ± 0.131
0.0LeuXaa: 0.0 ± 0.0
Met
1.264MetAla: 1.264 ± 0.107
0.588MetCys: 0.588 ± 0.077
1.185MetAsp: 1.185 ± 0.102
2.308MetGlu: 2.308 ± 0.145
1.062MetPhe: 1.062 ± 0.089
1.176MetGly: 1.176 ± 0.117
0.342MetHis: 0.342 ± 0.053
0.526MetIle: 0.526 ± 0.066
1.439MetLys: 1.439 ± 0.106
1.439MetLeu: 1.439 ± 0.115
0.491MetMet: 0.491 ± 0.066
1.035MetAsn: 1.035 ± 0.097
0.597MetPro: 0.597 ± 0.07
0.825MetGln: 0.825 ± 0.081
0.956MetArg: 0.956 ± 0.111
2.027MetSer: 2.027 ± 0.129
1.123MetThr: 1.123 ± 0.109
1.079MetVal: 1.079 ± 0.112
0.307MetTrp: 0.307 ± 0.057
0.518MetTyr: 0.518 ± 0.064
0.0MetXaa: 0.0 ± 0.0
Asn
1.948AsnAla: 1.948 ± 0.139
0.79AsnCys: 0.79 ± 0.1
1.325AsnAsp: 1.325 ± 0.121
2.15AsnGlu: 2.15 ± 0.125
2.641AsnPhe: 2.641 ± 0.149
3.045AsnGly: 3.045 ± 0.203
0.465AsnHis: 0.465 ± 0.061
3.036AsnIle: 3.036 ± 0.211
3.58AsnLys: 3.58 ± 0.27
3.246AsnLeu: 3.246 ± 0.136
0.834AsnMet: 0.834 ± 0.101
1.579AsnAsn: 1.579 ± 0.135
2.202AsnPro: 2.202 ± 0.179
0.781AsnGln: 0.781 ± 0.076
1.623AsnArg: 1.623 ± 0.124
3.045AsnSer: 3.045 ± 0.188
2.036AsnThr: 2.036 ± 0.233
2.553AsnVal: 2.553 ± 0.175
0.562AsnTrp: 0.562 ± 0.07
1.088AsnTyr: 1.088 ± 0.1
0.0AsnXaa: 0.0 ± 0.0
Pro
1.378ProAla: 1.378 ± 0.122
0.79ProCys: 0.79 ± 0.092
1.86ProAsp: 1.86 ± 0.129
4.141ProGlu: 4.141 ± 0.195
2.334ProPhe: 2.334 ± 0.169
2.36ProGly: 2.36 ± 0.159
0.825ProHis: 0.825 ± 0.09
1.693ProIle: 1.693 ± 0.14
3.615ProLys: 3.615 ± 0.226
3.65ProLeu: 3.65 ± 0.172
0.684ProMet: 0.684 ± 0.085
1.729ProAsn: 1.729 ± 0.143
1.843ProPro: 1.843 ± 0.153
1.518ProGln: 1.518 ± 0.128
2.132ProArg: 2.132 ± 0.152
2.869ProSer: 2.869 ± 0.172
1.957ProThr: 1.957 ± 0.149
1.965ProVal: 1.965 ± 0.125
0.597ProTrp: 0.597 ± 0.081
1.299ProTyr: 1.299 ± 0.117
0.0ProXaa: 0.0 ± 0.0
Gln
1.439GlnAla: 1.439 ± 0.131
0.509GlnCys: 0.509 ± 0.067
1.202GlnAsp: 1.202 ± 0.098
3.475GlnGlu: 3.475 ± 0.174
0.983GlnPhe: 0.983 ± 0.08
2.141GlnGly: 2.141 ± 0.169
0.79GlnHis: 0.79 ± 0.078
1.483GlnIle: 1.483 ± 0.116
4.326GlnLys: 4.326 ± 0.231
2.194GlnLeu: 2.194 ± 0.144
0.798GlnMet: 0.798 ± 0.092
1.764GlnAsn: 1.764 ± 0.13
0.79GlnPro: 0.79 ± 0.098
1.579GlnGln: 1.579 ± 0.147
2.624GlnArg: 2.624 ± 0.159
1.781GlnSer: 1.781 ± 0.113
2.071GlnThr: 2.071 ± 0.148
1.904GlnVal: 1.904 ± 0.168
0.465GlnTrp: 0.465 ± 0.06
0.772GlnTyr: 0.772 ± 0.085
0.0GlnXaa: 0.0 ± 0.0
Arg
2.606ArgAla: 2.606 ± 0.151
1.141ArgCys: 1.141 ± 0.108
2.852ArgAsp: 2.852 ± 0.16
6.405ArgGlu: 6.405 ± 0.242
2.65ArgPhe: 2.65 ± 0.144
3.483ArgGly: 3.483 ± 0.169
1.228ArgHis: 1.228 ± 0.118
2.992ArgIle: 2.992 ± 0.164
6.247ArgLys: 6.247 ± 0.236
4.633ArgLeu: 4.633 ± 0.205
1.255ArgMet: 1.255 ± 0.1
2.755ArgAsn: 2.755 ± 0.184
1.579ArgPro: 1.579 ± 0.128
1.913ArgGln: 1.913 ± 0.129
3.106ArgArg: 3.106 ± 0.189
2.974ArgSer: 2.974 ± 0.153
2.878ArgThr: 2.878 ± 0.153
3.527ArgVal: 3.527 ± 0.209
0.737ArgTrp: 0.737 ± 0.071
1.895ArgTyr: 1.895 ± 0.108
0.0ArgXaa: 0.0 ± 0.0
Ser
3.843SerAla: 3.843 ± 0.19
2.167SerCys: 2.167 ± 0.182
3.325SerAsp: 3.325 ± 0.188
5.642SerGlu: 5.642 ± 0.258
5.659SerPhe: 5.659 ± 0.294
5.466SerGly: 5.466 ± 0.243
1.5SerHis: 1.5 ± 0.147
2.904SerIle: 2.904 ± 0.144
5.888SerLys: 5.888 ± 0.247
7.634SerLeu: 7.634 ± 0.275
1.237SerMet: 1.237 ± 0.115
2.632SerAsn: 2.632 ± 0.195
3.466SerPro: 3.466 ± 0.178
2.781SerGln: 2.781 ± 0.183
4.001SerArg: 4.001 ± 0.2
7.107SerSer: 7.107 ± 0.335
3.15SerThr: 3.15 ± 0.177
5.265SerVal: 5.265 ± 0.277
1.439SerTrp: 1.439 ± 0.106
1.974SerTyr: 1.974 ± 0.125
0.0SerXaa: 0.0 ± 0.0
Thr
2.466ThrAla: 2.466 ± 0.145
1.404ThrCys: 1.404 ± 0.13
1.957ThrAsp: 1.957 ± 0.132
3.764ThrGlu: 3.764 ± 0.202
2.781ThrPhe: 2.781 ± 0.148
2.86ThrGly: 2.86 ± 0.198
0.825ThrHis: 0.825 ± 0.079
2.167ThrIle: 2.167 ± 0.142
4.361ThrLys: 4.361 ± 0.225
4.475ThrLeu: 4.475 ± 0.297
1.009ThrMet: 1.009 ± 0.112
2.106ThrAsn: 2.106 ± 0.226
2.387ThrPro: 2.387 ± 0.139
1.878ThrGln: 1.878 ± 0.142
2.825ThrArg: 2.825 ± 0.167
3.229ThrSer: 3.229 ± 0.187
2.948ThrThr: 2.948 ± 0.205
2.869ThrVal: 2.869 ± 0.148
0.693ThrTrp: 0.693 ± 0.079
1.342ThrTyr: 1.342 ± 0.097
0.0ThrXaa: 0.0 ± 0.0
Val
3.519ValAla: 3.519 ± 0.221
1.755ValCys: 1.755 ± 0.145
3.132ValAsp: 3.132 ± 0.162
4.966ValGlu: 4.966 ± 0.25
4.352ValPhe: 4.352 ± 0.196
3.282ValGly: 3.282 ± 0.171
1.176ValHis: 1.176 ± 0.097
2.527ValIle: 2.527 ± 0.163
4.229ValLys: 4.229 ± 0.204
6.309ValLeu: 6.309 ± 0.203
1.114ValMet: 1.114 ± 0.107
1.755ValAsn: 1.755 ± 0.129
3.15ValPro: 3.15 ± 0.145
1.948ValGln: 1.948 ± 0.124
3.176ValArg: 3.176 ± 0.173
6.002ValSer: 6.002 ± 0.245
2.474ValThr: 2.474 ± 0.166
4.922ValVal: 4.922 ± 0.233
1.149ValTrp: 1.149 ± 0.1
2.001ValTyr: 2.001 ± 0.139
0.0ValXaa: 0.0 ± 0.0
Trp
0.623TrpAla: 0.623 ± 0.072
0.641TrpCys: 0.641 ± 0.102
0.737TrpAsp: 0.737 ± 0.088
1.246TrpGlu: 1.246 ± 0.113
1.457TrpPhe: 1.457 ± 0.131
0.605TrpGly: 0.605 ± 0.093
0.237TrpHis: 0.237 ± 0.044
0.728TrpIle: 0.728 ± 0.084
1.404TrpLys: 1.404 ± 0.126
1.386TrpLeu: 1.386 ± 0.13
0.316TrpMet: 0.316 ± 0.057
0.702TrpAsn: 0.702 ± 0.081
0.254TrpPro: 0.254 ± 0.046
0.351TrpGln: 0.351 ± 0.052
1.053TrpArg: 1.053 ± 0.1
1.614TrpSer: 1.614 ± 0.121
0.904TrpThr: 0.904 ± 0.095
0.886TrpVal: 0.886 ± 0.086
0.29TrpTrp: 0.29 ± 0.051
0.535TrpTyr: 0.535 ± 0.071
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.641TyrAla: 1.641 ± 0.133
0.711TyrCys: 0.711 ± 0.081
1.746TyrAsp: 1.746 ± 0.135
2.466TyrGlu: 2.466 ± 0.152
1.632TyrPhe: 1.632 ± 0.129
2.352TyrGly: 2.352 ± 0.163
0.5TyrHis: 0.5 ± 0.06
1.623TyrIle: 1.623 ± 0.127
2.018TyrLys: 2.018 ± 0.124
2.615TyrLeu: 2.615 ± 0.16
0.526TyrMet: 0.526 ± 0.073
1.132TyrAsn: 1.132 ± 0.096
1.237TyrPro: 1.237 ± 0.106
0.965TyrGln: 0.965 ± 0.102
1.658TyrArg: 1.658 ± 0.113
2.474TyrSer: 2.474 ± 0.151
1.448TyrThr: 1.448 ± 0.114
1.606TyrVal: 1.606 ± 0.117
0.605TyrTrp: 0.605 ± 0.082
0.684TyrTyr: 0.684 ± 0.078
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 483 proteins (113970 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski