Amino acid dipepetide frequency for Burkholderia virus Bcepil02

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
21.323AlaAla: 21.323 ± 1.396
0.706AlaCys: 0.706 ± 0.249
6.704AlaAsp: 6.704 ± 0.731
7.511AlaGlu: 7.511 ± 0.791
4.285AlaPhe: 4.285 ± 0.433
10.586AlaGly: 10.586 ± 0.864
1.865AlaHis: 1.865 ± 0.424
5.142AlaIle: 5.142 ± 0.496
5.242AlaLys: 5.242 ± 0.702
11.09AlaLeu: 11.09 ± 0.823
3.327AlaMet: 3.327 ± 0.411
4.285AlaAsn: 4.285 ± 0.539
8.368AlaPro: 8.368 ± 1.281
5.293AlaGln: 5.293 ± 0.812
9.527AlaArg: 9.527 ± 0.864
6.755AlaSer: 6.755 ± 0.646
7.057AlaThr: 7.057 ± 0.548
5.948AlaVal: 5.948 ± 0.667
1.663AlaTrp: 1.663 ± 0.248
2.722AlaTyr: 2.722 ± 0.369
0.0AlaXaa: 0.0 ± 0.0
Cys
0.807CysAla: 0.807 ± 0.301
0.302CysCys: 0.302 ± 0.127
0.605CysAsp: 0.605 ± 0.238
0.504CysGlu: 0.504 ± 0.187
0.252CysPhe: 0.252 ± 0.126
0.504CysGly: 0.504 ± 0.203
0.0CysHis: 0.0 ± 0.0
0.403CysIle: 0.403 ± 0.178
0.252CysLys: 0.252 ± 0.122
0.504CysLeu: 0.504 ± 0.192
0.353CysMet: 0.353 ± 0.148
0.353CysAsn: 0.353 ± 0.151
0.554CysPro: 0.554 ± 0.218
0.403CysGln: 0.403 ± 0.186
0.756CysArg: 0.756 ± 0.243
0.403CysSer: 0.403 ± 0.158
0.403CysThr: 0.403 ± 0.144
0.202CysVal: 0.202 ± 0.113
0.101CysTrp: 0.101 ± 0.077
0.302CysTyr: 0.302 ± 0.145
0.0CysXaa: 0.0 ± 0.0
Asp
9.376AspAla: 9.376 ± 0.828
0.403AspCys: 0.403 ± 0.168
4.688AspAsp: 4.688 ± 0.834
4.486AspGlu: 4.486 ± 0.581
1.865AspPhe: 1.865 ± 0.343
6.856AspGly: 6.856 ± 0.676
1.462AspHis: 1.462 ± 0.303
2.42AspIle: 2.42 ± 0.293
2.268AspLys: 2.268 ± 0.439
4.285AspLeu: 4.285 ± 0.515
1.411AspMet: 1.411 ± 0.25
2.067AspAsn: 2.067 ± 0.288
3.277AspPro: 3.277 ± 0.396
1.966AspGln: 1.966 ± 0.325
5.343AspArg: 5.343 ± 0.576
2.47AspSer: 2.47 ± 0.327
2.772AspThr: 2.772 ± 0.288
4.033AspVal: 4.033 ± 0.395
1.411AspTrp: 1.411 ± 0.378
1.159AspTyr: 1.159 ± 0.199
0.0AspXaa: 0.0 ± 0.0
Glu
7.511GluAla: 7.511 ± 0.667
0.454GluCys: 0.454 ± 0.189
2.42GluAsp: 2.42 ± 0.389
3.982GluGlu: 3.982 ± 0.512
2.42GluPhe: 2.42 ± 0.395
3.932GluGly: 3.932 ± 0.447
1.764GluHis: 1.764 ± 0.31
3.68GluIle: 3.68 ± 0.339
2.924GluLys: 2.924 ± 0.319
6.351GluLeu: 6.351 ± 0.667
1.966GluMet: 1.966 ± 0.318
2.168GluAsn: 2.168 ± 0.282
2.823GluPro: 2.823 ± 0.35
3.68GluGln: 3.68 ± 0.798
6.049GluArg: 6.049 ± 0.678
2.319GluSer: 2.319 ± 0.293
3.478GluThr: 3.478 ± 0.407
3.327GluVal: 3.327 ± 0.37
1.159GluTrp: 1.159 ± 0.273
1.865GluTyr: 1.865 ± 0.262
0.0GluXaa: 0.0 ± 0.0
Phe
3.68PheAla: 3.68 ± 0.422
0.353PheCys: 0.353 ± 0.166
2.52PheAsp: 2.52 ± 0.31
2.117PheGlu: 2.117 ± 0.411
1.059PhePhe: 1.059 ± 0.297
2.42PheGly: 2.42 ± 0.428
0.655PheHis: 0.655 ± 0.167
1.462PheIle: 1.462 ± 0.292
1.411PheLys: 1.411 ± 0.297
1.663PheLeu: 1.663 ± 0.301
1.159PheMet: 1.159 ± 0.239
1.361PheAsn: 1.361 ± 0.19
1.563PhePro: 1.563 ± 0.257
1.311PheGln: 1.311 ± 0.261
2.319PheArg: 2.319 ± 0.546
1.663PheSer: 1.663 ± 0.316
1.916PheThr: 1.916 ± 0.243
2.168PheVal: 2.168 ± 0.328
0.454PheTrp: 0.454 ± 0.136
0.706PheTyr: 0.706 ± 0.205
0.0PheXaa: 0.0 ± 0.0
Gly
9.93GlyAla: 9.93 ± 0.923
0.807GlyCys: 0.807 ± 0.282
6.2GlyAsp: 6.2 ± 0.628
5.495GlyGlu: 5.495 ± 0.626
2.823GlyPhe: 2.823 ± 0.474
6.956GlyGly: 6.956 ± 0.826
1.966GlyHis: 1.966 ± 0.413
4.033GlyIle: 4.033 ± 0.546
4.436GlyLys: 4.436 ± 0.473
4.738GlyLeu: 4.738 ± 0.482
2.52GlyMet: 2.52 ± 0.597
2.924GlyAsn: 2.924 ± 0.407
2.873GlyPro: 2.873 ± 0.293
3.327GlyGln: 3.327 ± 0.423
4.839GlyArg: 4.839 ± 0.601
3.781GlySer: 3.781 ± 0.513
5.696GlyThr: 5.696 ± 0.659
5.646GlyVal: 5.646 ± 0.455
1.462GlyTrp: 1.462 ± 0.264
1.714GlyTyr: 1.714 ± 0.242
0.0GlyXaa: 0.0 ± 0.0
His
1.865HisAla: 1.865 ± 0.333
0.353HisCys: 0.353 ± 0.148
1.26HisAsp: 1.26 ± 0.228
1.865HisGlu: 1.865 ± 0.43
0.857HisPhe: 0.857 ± 0.23
2.016HisGly: 2.016 ± 0.422
0.554HisHis: 0.554 ± 0.204
0.756HisIle: 0.756 ± 0.176
0.655HisLys: 0.655 ± 0.169
1.462HisLeu: 1.462 ± 0.261
0.252HisMet: 0.252 ± 0.1
0.756HisAsn: 0.756 ± 0.245
0.706HisPro: 0.706 ± 0.178
0.605HisGln: 0.605 ± 0.191
1.462HisArg: 1.462 ± 0.311
1.008HisSer: 1.008 ± 0.273
0.706HisThr: 0.706 ± 0.178
1.21HisVal: 1.21 ± 0.245
0.202HisTrp: 0.202 ± 0.097
0.605HisTyr: 0.605 ± 0.167
0.0HisXaa: 0.0 ± 0.0
Ile
5.394IleAla: 5.394 ± 0.507
0.504IleCys: 0.504 ± 0.23
2.924IleAsp: 2.924 ± 0.307
4.083IleGlu: 4.083 ± 0.514
1.361IlePhe: 1.361 ± 0.214
4.285IleGly: 4.285 ± 0.482
0.454IleHis: 0.454 ± 0.149
2.067IleIle: 2.067 ± 0.334
2.016IleLys: 2.016 ± 0.235
1.966IleLeu: 1.966 ± 0.252
0.605IleMet: 0.605 ± 0.196
1.865IleAsn: 1.865 ± 0.305
1.966IlePro: 1.966 ± 0.381
1.26IleGln: 1.26 ± 0.347
2.772IleArg: 2.772 ± 0.393
2.067IleSer: 2.067 ± 0.353
1.966IleThr: 1.966 ± 0.27
3.529IleVal: 3.529 ± 0.381
0.706IleTrp: 0.706 ± 0.19
0.907IleTyr: 0.907 ± 0.175
0.0IleXaa: 0.0 ± 0.0
Lys
6.099LysAla: 6.099 ± 0.783
0.101LysCys: 0.101 ± 0.077
2.722LysAsp: 2.722 ± 0.343
2.772LysGlu: 2.772 ± 0.361
1.008LysPhe: 1.008 ± 0.246
3.125LysGly: 3.125 ± 0.494
0.857LysHis: 0.857 ± 0.213
1.764LysIle: 1.764 ± 0.369
2.42LysLys: 2.42 ± 0.481
3.327LysLeu: 3.327 ± 0.392
1.311LysMet: 1.311 ± 0.245
1.613LysAsn: 1.613 ± 0.369
3.125LysPro: 3.125 ± 0.452
2.117LysGln: 2.117 ± 0.312
3.075LysArg: 3.075 ± 0.429
2.218LysSer: 2.218 ± 0.305
2.168LysThr: 2.168 ± 0.367
3.629LysVal: 3.629 ± 0.503
0.554LysTrp: 0.554 ± 0.173
0.756LysTyr: 0.756 ± 0.211
0.0LysXaa: 0.0 ± 0.0
Leu
9.225LeuAla: 9.225 ± 0.687
0.554LeuCys: 0.554 ± 0.216
6.2LeuAsp: 6.2 ± 0.556
4.486LeuGlu: 4.486 ± 0.366
1.714LeuPhe: 1.714 ± 0.24
5.192LeuGly: 5.192 ± 0.5
1.764LeuHis: 1.764 ± 0.325
2.621LeuIle: 2.621 ± 0.435
4.184LeuLys: 4.184 ± 0.436
5.293LeuLeu: 5.293 ± 0.622
1.361LeuMet: 1.361 ± 0.213
3.125LeuAsn: 3.125 ± 0.407
4.083LeuPro: 4.083 ± 0.462
2.42LeuGln: 2.42 ± 0.317
5.948LeuArg: 5.948 ± 0.707
4.234LeuSer: 4.234 ± 0.45
5.192LeuThr: 5.192 ± 0.464
4.033LeuVal: 4.033 ± 0.384
0.807LeuTrp: 0.807 ± 0.185
2.067LeuTyr: 2.067 ± 0.295
0.0LeuXaa: 0.0 ± 0.0
Met
2.47MetAla: 2.47 ± 0.368
0.05MetCys: 0.05 ± 0.056
1.411MetAsp: 1.411 ± 0.251
0.907MetGlu: 0.907 ± 0.175
0.504MetPhe: 0.504 ± 0.148
1.865MetGly: 1.865 ± 0.367
0.504MetHis: 0.504 ± 0.121
0.958MetIle: 0.958 ± 0.193
1.411MetLys: 1.411 ± 0.266
2.268MetLeu: 2.268 ± 0.309
0.706MetMet: 0.706 ± 0.226
0.807MetAsn: 0.807 ± 0.214
1.462MetPro: 1.462 ± 0.266
1.059MetGln: 1.059 ± 0.185
2.52MetArg: 2.52 ± 0.341
2.016MetSer: 2.016 ± 0.398
1.512MetThr: 1.512 ± 0.302
1.764MetVal: 1.764 ± 0.341
0.605MetTrp: 0.605 ± 0.211
0.353MetTyr: 0.353 ± 0.186
0.0MetXaa: 0.0 ± 0.0
Asn
4.638AsnAla: 4.638 ± 0.561
0.252AsnCys: 0.252 ± 0.113
2.52AsnAsp: 2.52 ± 0.331
2.016AsnGlu: 2.016 ± 0.387
0.706AsnPhe: 0.706 ± 0.204
3.68AsnGly: 3.68 ± 0.458
0.857AsnHis: 0.857 ± 0.195
1.714AsnIle: 1.714 ± 0.282
1.26AsnLys: 1.26 ± 0.274
2.369AsnLeu: 2.369 ± 0.294
0.706AsnMet: 0.706 ± 0.15
1.159AsnAsn: 1.159 ± 0.242
2.168AsnPro: 2.168 ± 0.314
1.361AsnGln: 1.361 ± 0.266
2.218AsnArg: 2.218 ± 0.355
1.815AsnSer: 1.815 ± 0.308
1.663AsnThr: 1.663 ± 0.286
2.571AsnVal: 2.571 ± 0.283
0.454AsnTrp: 0.454 ± 0.111
0.907AsnTyr: 0.907 ± 0.19
0.0AsnXaa: 0.0 ± 0.0
Pro
9.326ProAla: 9.326 ± 1.152
0.554ProCys: 0.554 ± 0.217
3.428ProAsp: 3.428 ± 0.391
4.486ProGlu: 4.486 ± 0.46
1.512ProPhe: 1.512 ± 0.304
4.587ProGly: 4.587 ± 0.611
0.706ProHis: 0.706 ± 0.205
1.865ProIle: 1.865 ± 0.299
1.916ProLys: 1.916 ± 0.3
3.579ProLeu: 3.579 ± 0.476
1.311ProMet: 1.311 ± 0.287
1.613ProAsn: 1.613 ± 0.276
3.629ProPro: 3.629 ± 0.82
1.916ProGln: 1.916 ± 0.398
3.327ProArg: 3.327 ± 0.637
3.478ProSer: 3.478 ± 0.457
2.772ProThr: 2.772 ± 0.279
3.781ProVal: 3.781 ± 0.317
0.353ProTrp: 0.353 ± 0.11
1.311ProTyr: 1.311 ± 0.363
0.0ProXaa: 0.0 ± 0.0
Gln
4.839GlnAla: 4.839 ± 0.682
0.202GlnCys: 0.202 ± 0.113
2.117GlnAsp: 2.117 ± 0.292
2.722GlnGlu: 2.722 ± 0.327
1.512GlnPhe: 1.512 ± 0.217
2.924GlnGly: 2.924 ± 0.517
0.655GlnHis: 0.655 ± 0.214
1.815GlnIle: 1.815 ± 0.475
1.563GlnLys: 1.563 ± 0.247
2.772GlnLeu: 2.772 ± 0.361
1.411GlnMet: 1.411 ± 0.332
1.411GlnAsn: 1.411 ± 0.425
2.672GlnPro: 2.672 ± 0.426
3.831GlnGln: 3.831 ± 0.652
3.73GlnArg: 3.73 ± 0.475
2.52GlnSer: 2.52 ± 0.464
1.462GlnThr: 1.462 ± 0.248
2.218GlnVal: 2.218 ± 0.348
0.202GlnTrp: 0.202 ± 0.083
1.008GlnTyr: 1.008 ± 0.19
0.0GlnXaa: 0.0 ± 0.0
Arg
9.477ArgAla: 9.477 ± 0.73
0.605ArgCys: 0.605 ± 0.212
5.343ArgAsp: 5.343 ± 0.567
4.486ArgGlu: 4.486 ± 0.586
3.428ArgPhe: 3.428 ± 0.42
4.486ArgGly: 4.486 ± 0.473
1.815ArgHis: 1.815 ± 0.553
3.428ArgIle: 3.428 ± 0.32
3.176ArgLys: 3.176 ± 0.477
6.704ArgLeu: 6.704 ± 0.391
1.916ArgMet: 1.916 ± 0.361
2.47ArgAsn: 2.47 ± 0.274
3.831ArgPro: 3.831 ± 0.663
3.478ArgGln: 3.478 ± 0.547
6.2ArgArg: 6.2 ± 0.891
3.377ArgSer: 3.377 ± 0.516
3.125ArgThr: 3.125 ± 0.377
5.444ArgVal: 5.444 ± 0.581
1.109ArgTrp: 1.109 ± 0.259
2.42ArgTyr: 2.42 ± 0.341
0.0ArgXaa: 0.0 ± 0.0
Ser
5.545SerAla: 5.545 ± 0.588
0.151SerCys: 0.151 ± 0.104
3.327SerAsp: 3.327 ± 0.442
2.772SerGlu: 2.772 ± 0.337
1.411SerPhe: 1.411 ± 0.217
6.251SerGly: 6.251 ± 0.669
0.807SerHis: 0.807 ± 0.177
2.067SerIle: 2.067 ± 0.326
2.672SerLys: 2.672 ± 0.305
4.033SerLeu: 4.033 ± 0.391
1.109SerMet: 1.109 ± 0.23
2.016SerAsn: 2.016 ± 0.31
2.571SerPro: 2.571 ± 0.466
1.663SerGln: 1.663 ± 0.449
4.033SerArg: 4.033 ± 0.431
2.621SerSer: 2.621 ± 0.432
3.024SerThr: 3.024 ± 0.478
3.176SerVal: 3.176 ± 0.31
0.554SerTrp: 0.554 ± 0.147
1.109SerTyr: 1.109 ± 0.213
0.0SerXaa: 0.0 ± 0.0
Thr
6.603ThrAla: 6.603 ± 0.664
0.504ThrCys: 0.504 ± 0.178
3.125ThrAsp: 3.125 ± 0.378
3.075ThrGlu: 3.075 ± 0.41
2.067ThrPhe: 2.067 ± 0.291
5.192ThrGly: 5.192 ± 0.759
0.907ThrHis: 0.907 ± 0.211
2.772ThrIle: 2.772 ± 0.465
2.067ThrLys: 2.067 ± 0.243
3.932ThrLeu: 3.932 ± 0.359
1.26ThrMet: 1.26 ± 0.208
1.512ThrAsn: 1.512 ± 0.255
4.436ThrPro: 4.436 ± 0.44
2.47ThrGln: 2.47 ± 0.337
3.377ThrArg: 3.377 ± 0.527
2.218ThrSer: 2.218 ± 0.233
2.42ThrThr: 2.42 ± 0.31
4.184ThrVal: 4.184 ± 0.463
0.605ThrTrp: 0.605 ± 0.218
1.159ThrTyr: 1.159 ± 0.203
0.0ThrXaa: 0.0 ± 0.0
Val
7.864ValAla: 7.864 ± 0.55
0.605ValCys: 0.605 ± 0.235
3.982ValAsp: 3.982 ± 0.425
4.486ValGlu: 4.486 ± 0.499
1.714ValPhe: 1.714 ± 0.362
4.436ValGly: 4.436 ± 0.585
0.857ValHis: 0.857 ± 0.304
2.42ValIle: 2.42 ± 0.361
3.932ValLys: 3.932 ± 0.489
4.486ValLeu: 4.486 ± 0.423
1.26ValMet: 1.26 ± 0.221
1.663ValAsn: 1.663 ± 0.39
3.831ValPro: 3.831 ± 0.361
2.117ValGln: 2.117 ± 0.327
5.242ValArg: 5.242 ± 0.676
4.133ValSer: 4.133 ± 0.419
4.033ValThr: 4.033 ± 0.388
4.285ValVal: 4.285 ± 0.599
0.655ValTrp: 0.655 ± 0.196
1.563ValTyr: 1.563 ± 0.29
0.0ValXaa: 0.0 ± 0.0
Trp
1.159TrpAla: 1.159 ± 0.246
0.302TrpCys: 0.302 ± 0.137
0.655TrpAsp: 0.655 ± 0.195
0.655TrpGlu: 0.655 ± 0.154
0.655TrpPhe: 0.655 ± 0.158
0.958TrpGly: 0.958 ± 0.224
0.353TrpHis: 0.353 ± 0.149
0.605TrpIle: 0.605 ± 0.148
0.302TrpLys: 0.302 ± 0.097
1.663TrpLeu: 1.663 ± 0.341
0.454TrpMet: 0.454 ± 0.154
0.756TrpAsn: 0.756 ± 0.169
0.101TrpPro: 0.101 ± 0.069
0.605TrpGln: 0.605 ± 0.168
1.512TrpArg: 1.512 ± 0.277
0.807TrpSer: 0.807 ± 0.165
0.857TrpThr: 0.857 ± 0.175
0.756TrpVal: 0.756 ± 0.252
0.101TrpTrp: 0.101 ± 0.056
0.302TrpTyr: 0.302 ± 0.107
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.268TyrAla: 2.268 ± 0.345
0.202TyrCys: 0.202 ± 0.107
1.865TyrAsp: 1.865 ± 0.308
1.361TyrGlu: 1.361 ± 0.227
0.807TyrPhe: 0.807 ± 0.16
1.916TyrGly: 1.916 ± 0.291
0.353TyrHis: 0.353 ± 0.133
0.706TyrIle: 0.706 ± 0.188
0.706TyrLys: 0.706 ± 0.188
2.016TyrLeu: 2.016 ± 0.283
0.706TyrMet: 0.706 ± 0.208
1.109TyrAsn: 1.109 ± 0.215
1.411TyrPro: 1.411 ± 0.295
0.706TyrGln: 0.706 ± 0.188
2.067TyrArg: 2.067 ± 0.296
1.008TyrSer: 1.008 ± 0.193
1.663TyrThr: 1.663 ± 0.33
1.663TyrVal: 1.663 ± 0.288
0.403TyrTrp: 0.403 ± 0.186
0.706TyrTyr: 0.706 ± 0.183
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 76 proteins (19839 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski