Human papillomavirus type 6

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Alphapapillomavirus; Alphapapillomavirus 10

Average proteome isoelectric point is 6.4

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 9 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>tr|E7BBT8|E7BBT8_9PAPI Regulatory protein E2 OS=Human papillomavirus type 6 OX=31552 GN=E2 PE=3 SV=1
MM1 pKa = 7.52HH2 pKa = 7.07GRR4 pKa = 11.84HH5 pKa = 5.21VTLKK9 pKa = 10.88DD10 pKa = 3.13IVLDD14 pKa = 4.05LQPPDD19 pKa = 3.7PVGLHH24 pKa = 6.82CYY26 pKa = 8.05EE27 pKa = 4.11QLVDD31 pKa = 3.79SSEE34 pKa = 4.72DD35 pKa = 3.49EE36 pKa = 4.01VDD38 pKa = 3.8EE39 pKa = 5.48VDD41 pKa = 4.53GQDD44 pKa = 3.62SQPLKK49 pKa = 10.18QHH51 pKa = 5.65FQIVTCCCGCDD62 pKa = 3.33SNVRR66 pKa = 11.84LVVQCTEE73 pKa = 3.39TDD75 pKa = 3.0IRR77 pKa = 11.84EE78 pKa = 4.21VQQLLLGTLNIVCPICAPKK97 pKa = 9.43TT98 pKa = 3.6

Molecular weight: 10.89 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>tr|Q71U66|Q71U66_9PAPI Protein E6 OS=Human papillomavirus type 6 OX=31552 GN=E6 PE=3 SV=1
MM1 pKa = 7.54GAPNIGKK8 pKa = 9.38YY9 pKa = 10.38VMAAQLYY16 pKa = 8.94VLLHH20 pKa = 6.77LYY22 pKa = 10.09LALHH26 pKa = 6.53KK27 pKa = 10.3KK28 pKa = 10.52YY29 pKa = 10.45PFLNLLHH36 pKa = 6.49TPPHH40 pKa = 6.73RR41 pKa = 11.84PPPLCPQAPRR51 pKa = 11.84KK52 pKa = 6.0TQCKK56 pKa = 8.73RR57 pKa = 11.84RR58 pKa = 11.84LGNEE62 pKa = 3.91HH63 pKa = 6.9EE64 pKa = 4.67EE65 pKa = 4.6SNSPLATPCVWPTLDD80 pKa = 3.13PWTVEE85 pKa = 4.11TTTSSLTITTSTKK98 pKa = 10.67DD99 pKa = 3.22GTTVTVQLRR108 pKa = 11.84LL109 pKa = 3.44

Molecular weight: 12.21 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

9

0

9

2496

72

649

277.3

31.06

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

5.929 ± 0.552

2.764 ± 0.802

5.088 ± 0.568

5.128 ± 0.782

3.886 ± 0.449

5.889 ± 0.661

3.365 ± 0.544

5.288 ± 0.841

5.168 ± 0.933

8.413 ± 0.991

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

2.244 ± 0.327

3.966 ± 0.506

6.33 ± 1.347

4.327 ± 0.396

4.287 ± 0.366

7.212 ± 0.767

8.253 ± 0.726

7.171 ± 0.704

1.563 ± 0.269

3.726 ± 0.459
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski