Amino acid dipepetide frequency for Dactylococcopsis salina PCC 8305

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.532AlaAla: 5.532 ± 0.088
0.631AlaCys: 0.631 ± 0.033
3.716AlaAsp: 3.716 ± 0.095
5.205AlaGlu: 5.205 ± 0.081
2.894AlaPhe: 2.894 ± 0.062
5.205AlaGly: 5.205 ± 0.153
1.108AlaHis: 1.108 ± 0.042
6.315AlaIle: 6.315 ± 0.086
3.709AlaLys: 3.709 ± 0.083
7.779AlaLeu: 7.779 ± 0.101
1.539AlaMet: 1.539 ± 0.047
3.093AlaAsn: 3.093 ± 0.096
2.547AlaPro: 2.547 ± 0.054
3.753AlaGln: 3.753 ± 0.071
3.404AlaArg: 3.404 ± 0.061
4.517AlaSer: 4.517 ± 0.086
4.693AlaThr: 4.693 ± 0.112
5.339AlaVal: 5.339 ± 0.092
0.889AlaTrp: 0.889 ± 0.034
2.164AlaTyr: 2.164 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
0.545CysAla: 0.545 ± 0.027
0.156CysCys: 0.156 ± 0.013
0.497CysAsp: 0.497 ± 0.026
0.572CysGlu: 0.572 ± 0.023
0.422CysPhe: 0.422 ± 0.023
0.713CysGly: 0.713 ± 0.031
0.275CysHis: 0.275 ± 0.021
0.446CysIle: 0.446 ± 0.022
0.255CysLys: 0.255 ± 0.018
1.135CysLeu: 1.135 ± 0.047
0.119CysMet: 0.119 ± 0.012
0.315CysAsn: 0.315 ± 0.021
0.519CysPro: 0.519 ± 0.028
0.544CysGln: 0.544 ± 0.026
0.461CysArg: 0.461 ± 0.025
0.579CysSer: 0.579 ± 0.023
0.391CysThr: 0.391 ± 0.021
0.515CysVal: 0.515 ± 0.028
0.14CysTrp: 0.14 ± 0.014
0.348CysTyr: 0.348 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
3.457AspAla: 3.457 ± 0.09
0.465AspCys: 0.465 ± 0.027
2.742AspAsp: 2.742 ± 0.136
3.422AspGlu: 3.422 ± 0.081
2.524AspPhe: 2.524 ± 0.07
3.817AspGly: 3.817 ± 0.193
0.973AspHis: 0.973 ± 0.036
3.0AspIle: 3.0 ± 0.064
1.667AspLys: 1.667 ± 0.054
6.043AspLeu: 6.043 ± 0.095
0.654AspMet: 0.654 ± 0.029
2.183AspAsn: 2.183 ± 0.108
2.717AspPro: 2.717 ± 0.077
2.919AspGln: 2.919 ± 0.059
3.751AspArg: 3.751 ± 0.063
3.028AspSer: 3.028 ± 0.08
2.682AspThr: 2.682 ± 0.113
3.273AspVal: 3.273 ± 0.076
0.812AspTrp: 0.812 ± 0.033
2.022AspTyr: 2.022 ± 0.041
0.0AspXaa: 0.0 ± 0.0
Glu
6.345GluAla: 6.345 ± 0.088
0.391GluCys: 0.391 ± 0.022
3.714GluAsp: 3.714 ± 0.087
6.387GluGlu: 6.387 ± 0.116
2.527GluPhe: 2.527 ± 0.055
4.429GluGly: 4.429 ± 0.101
0.927GluHis: 0.927 ± 0.036
5.593GluIle: 5.593 ± 0.09
4.823GluLys: 4.823 ± 0.114
7.139GluLeu: 7.139 ± 0.113
1.621GluMet: 1.621 ± 0.049
3.956GluAsn: 3.956 ± 0.087
2.238GluPro: 2.238 ± 0.059
4.042GluGln: 4.042 ± 0.075
3.231GluArg: 3.231 ± 0.088
3.813GluSer: 3.813 ± 0.062
5.783GluThr: 5.783 ± 0.09
4.87GluVal: 4.87 ± 0.079
0.78GluTrp: 0.78 ± 0.031
1.712GluTyr: 1.712 ± 0.042
0.0GluXaa: 0.0 ± 0.0
Phe
2.974PheAla: 2.974 ± 0.061
0.487PheCys: 0.487 ± 0.023
2.423PheAsp: 2.423 ± 0.067
2.176PheGlu: 2.176 ± 0.052
1.869PhePhe: 1.869 ± 0.056
3.065PheGly: 3.065 ± 0.074
0.72PheHis: 0.72 ± 0.029
2.236PheIle: 2.236 ± 0.05
1.343PheLys: 1.343 ± 0.044
4.421PheLeu: 4.421 ± 0.1
0.588PheMet: 0.588 ± 0.028
1.971PheAsn: 1.971 ± 0.055
2.18PhePro: 2.18 ± 0.058
1.934PheGln: 1.934 ± 0.047
1.899PheArg: 1.899 ± 0.04
3.333PheSer: 3.333 ± 0.071
2.448PheThr: 2.448 ± 0.061
2.323PheVal: 2.323 ± 0.056
0.704PheTrp: 0.704 ± 0.031
1.367PheTyr: 1.367 ± 0.042
0.0PheXaa: 0.0 ± 0.0
Gly
4.632GlyAla: 4.632 ± 0.147
0.682GlyCys: 0.682 ± 0.028
3.964GlyAsp: 3.964 ± 0.157
5.963GlyGlu: 5.963 ± 0.143
3.24GlyPhe: 3.24 ± 0.065
5.701GlyGly: 5.701 ± 0.181
1.049GlyHis: 1.049 ± 0.036
5.145GlyIle: 5.145 ± 0.091
4.473GlyLys: 4.473 ± 0.092
6.993GlyLeu: 6.993 ± 0.096
1.515GlyMet: 1.515 ± 0.047
3.539GlyAsn: 3.539 ± 0.148
1.124GlyPro: 1.124 ± 0.043
2.396GlyGln: 2.396 ± 0.056
2.985GlyArg: 2.985 ± 0.059
4.026GlySer: 4.026 ± 0.112
3.981GlyThr: 3.981 ± 0.102
4.954GlyVal: 4.954 ± 0.085
1.11GlyTrp: 1.11 ± 0.035
2.255GlyTyr: 2.255 ± 0.057
0.0GlyXaa: 0.0 ± 0.0
His
0.829HisAla: 0.829 ± 0.039
0.266HisCys: 0.266 ± 0.017
0.694HisAsp: 0.694 ± 0.036
0.772HisGlu: 0.772 ± 0.029
0.784HisPhe: 0.784 ± 0.031
1.006HisGly: 1.006 ± 0.032
0.594HisHis: 0.594 ± 0.032
0.883HisIle: 0.883 ± 0.034
0.59HisLys: 0.59 ± 0.029
2.272HisLeu: 2.272 ± 0.06
0.205HisMet: 0.205 ± 0.017
0.632HisAsn: 0.632 ± 0.024
1.348HisPro: 1.348 ± 0.046
1.182HisGln: 1.182 ± 0.041
1.037HisArg: 1.037 ± 0.041
1.062HisSer: 1.062 ± 0.036
0.719HisThr: 0.719 ± 0.025
0.671HisVal: 0.671 ± 0.025
0.391HisTrp: 0.391 ± 0.02
0.748HisTyr: 0.748 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
6.319IleAla: 6.319 ± 0.1
0.667IleCys: 0.667 ± 0.031
3.814IleAsp: 3.814 ± 0.094
4.922IleGlu: 4.922 ± 0.086
2.594IlePhe: 2.594 ± 0.06
4.536IleGly: 4.536 ± 0.082
0.979IleHis: 0.979 ± 0.035
4.274IleIle: 4.274 ± 0.08
2.961IleLys: 2.961 ± 0.072
6.496IleLeu: 6.496 ± 0.12
0.86IleMet: 0.86 ± 0.032
3.23IleAsn: 3.23 ± 0.083
3.66IlePro: 3.66 ± 0.071
2.695IleGln: 2.695 ± 0.058
2.969IleArg: 2.969 ± 0.057
4.364IleSer: 4.364 ± 0.078
4.237IleThr: 4.237 ± 0.111
3.918IleVal: 3.918 ± 0.065
0.728IleTrp: 0.728 ± 0.033
1.863IleTyr: 1.863 ± 0.053
0.0IleXaa: 0.0 ± 0.0
Lys
3.812LysAla: 3.812 ± 0.086
0.32LysCys: 0.32 ± 0.022
2.011LysAsp: 2.011 ± 0.052
3.473LysGlu: 3.473 ± 0.09
1.364LysPhe: 1.364 ± 0.045
3.014LysGly: 3.014 ± 0.069
0.747LysHis: 0.747 ± 0.029
3.302LysIle: 3.302 ± 0.075
2.66LysLys: 2.66 ± 0.077
4.713LysLeu: 4.713 ± 0.105
1.047LysMet: 1.047 ± 0.045
2.085LysAsn: 2.085 ± 0.058
2.269LysPro: 2.269 ± 0.055
3.127LysGln: 3.127 ± 0.076
2.709LysArg: 2.709 ± 0.085
2.73LysSer: 2.73 ± 0.07
3.412LysThr: 3.412 ± 0.081
2.936LysVal: 2.936 ± 0.062
0.503LysTrp: 0.503 ± 0.027
1.173LysTyr: 1.173 ± 0.045
0.0LysXaa: 0.0 ± 0.0
Leu
8.361LeuAla: 8.361 ± 0.104
0.835LeuCys: 0.835 ± 0.034
5.699LeuAsp: 5.699 ± 0.095
8.334LeuGlu: 8.334 ± 0.111
4.03LeuPhe: 4.03 ± 0.082
7.733LeuGly: 7.733 ± 0.114
1.654LeuHis: 1.654 ± 0.054
6.857LeuIle: 6.857 ± 0.112
5.524LeuLys: 5.524 ± 0.104
10.508LeuLeu: 10.508 ± 0.189
2.043LeuMet: 2.043 ± 0.065
4.842LeuAsn: 4.842 ± 0.084
5.542LeuPro: 5.542 ± 0.108
5.152LeuGln: 5.152 ± 0.082
5.082LeuArg: 5.082 ± 0.095
7.747LeuSer: 7.747 ± 0.115
6.74LeuThr: 6.74 ± 0.109
6.545LeuVal: 6.545 ± 0.109
1.247LeuTrp: 1.247 ± 0.046
2.635LeuTyr: 2.635 ± 0.059
0.0LeuXaa: 0.0 ± 0.0
Met
1.543MetAla: 1.543 ± 0.053
0.084MetCys: 0.084 ± 0.008
0.717MetAsp: 0.717 ± 0.033
1.175MetGlu: 1.175 ± 0.039
0.568MetPhe: 0.568 ± 0.022
1.573MetGly: 1.573 ± 0.057
0.192MetHis: 0.192 ± 0.016
1.245MetIle: 1.245 ± 0.045
1.018MetLys: 1.018 ± 0.034
1.708MetLeu: 1.708 ± 0.055
0.46MetMet: 0.46 ± 0.024
0.81MetAsn: 0.81 ± 0.035
0.664MetPro: 0.664 ± 0.029
0.727MetGln: 0.727 ± 0.028
0.92MetArg: 0.92 ± 0.033
1.361MetSer: 1.361 ± 0.037
1.36MetThr: 1.36 ± 0.049
1.26MetVal: 1.26 ± 0.039
0.138MetTrp: 0.138 ± 0.01
0.352MetTyr: 0.352 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
3.075AsnAla: 3.075 ± 0.104
0.499AsnCys: 0.499 ± 0.023
2.297AsnAsp: 2.297 ± 0.126
2.343AsnGlu: 2.343 ± 0.064
1.943AsnPhe: 1.943 ± 0.06
2.854AsnGly: 2.854 ± 0.113
0.877AsnHis: 0.877 ± 0.035
2.471AsnIle: 2.471 ± 0.065
1.407AsnLys: 1.407 ± 0.044
5.63AsnLeu: 5.63 ± 0.091
0.646AsnMet: 0.646 ± 0.025
2.189AsnAsn: 2.189 ± 0.102
3.108AsnPro: 3.108 ± 0.073
3.077AsnGln: 3.077 ± 0.069
2.481AsnArg: 2.481 ± 0.052
3.132AsnSer: 3.132 ± 0.125
2.355AsnThr: 2.355 ± 0.081
2.43AsnVal: 2.43 ± 0.079
0.861AsnTrp: 0.861 ± 0.033
1.621AsnTyr: 1.621 ± 0.044
0.0AsnXaa: 0.0 ± 0.0
Pro
2.432ProAla: 2.432 ± 0.047
0.426ProCys: 0.426 ± 0.036
3.044ProAsp: 3.044 ± 0.07
4.503ProGlu: 4.503 ± 0.077
1.823ProPhe: 1.823 ± 0.044
2.35ProGly: 2.35 ± 0.055
0.968ProHis: 0.968 ± 0.038
3.007ProIle: 3.007 ± 0.064
2.241ProLys: 2.241 ± 0.065
4.767ProLeu: 4.767 ± 0.087
0.756ProMet: 0.756 ± 0.03
2.327ProAsn: 2.327 ± 0.053
2.425ProPro: 2.425 ± 0.072
2.684ProGln: 2.684 ± 0.061
1.745ProArg: 1.745 ± 0.053
2.988ProSer: 2.988 ± 0.06
2.787ProThr: 2.787 ± 0.054
2.889ProVal: 2.889 ± 0.055
0.547ProTrp: 0.547 ± 0.026
1.412ProTyr: 1.412 ± 0.04
0.0ProXaa: 0.0 ± 0.0
Gln
3.956GlnAla: 3.956 ± 0.076
0.323GlnCys: 0.323 ± 0.018
2.203GlnAsp: 2.203 ± 0.058
4.275GlnGlu: 4.275 ± 0.089
1.983GlnPhe: 1.983 ± 0.053
3.666GlnGly: 3.666 ± 0.062
0.731GlnHis: 0.731 ± 0.031
3.137GlnIle: 3.137 ± 0.06
2.91GlnLys: 2.91 ± 0.081
5.839GlnLeu: 5.839 ± 0.097
1.035GlnMet: 1.035 ± 0.036
2.083GlnAsn: 2.083 ± 0.054
2.34GlnPro: 2.34 ± 0.054
3.57GlnGln: 3.57 ± 0.105
2.899GlnArg: 2.899 ± 0.072
2.787GlnSer: 2.787 ± 0.058
2.997GlnThr: 2.997 ± 0.063
3.676GlnVal: 3.676 ± 0.07
0.865GlnTrp: 0.865 ± 0.031
1.251GlnTyr: 1.251 ± 0.037
0.0GlnXaa: 0.0 ± 0.0
Arg
3.173ArgAla: 3.173 ± 0.069
0.496ArgCys: 0.496 ± 0.025
2.613ArgAsp: 2.613 ± 0.053
3.885ArgGlu: 3.885 ± 0.077
2.275ArgPhe: 2.275 ± 0.054
3.028ArgGly: 3.028 ± 0.068
0.952ArgHis: 0.952 ± 0.037
3.156ArgIle: 3.156 ± 0.061
2.411ArgLys: 2.411 ± 0.065
5.79ArgLeu: 5.79 ± 0.101
0.92ArgMet: 0.92 ± 0.036
2.186ArgAsn: 2.186 ± 0.045
1.914ArgPro: 1.914 ± 0.049
2.867ArgGln: 2.867 ± 0.068
3.069ArgArg: 3.069 ± 0.081
3.28ArgSer: 3.28 ± 0.062
2.188ArgThr: 2.188 ± 0.052
3.345ArgVal: 3.345 ± 0.063
0.775ArgTrp: 0.775 ± 0.033
1.866ArgTyr: 1.866 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
4.373SerAla: 4.373 ± 0.081
0.619SerCys: 0.619 ± 0.026
3.408SerAsp: 3.408 ± 0.093
4.465SerGlu: 4.465 ± 0.067
2.68SerPhe: 2.68 ± 0.057
4.747SerGly: 4.747 ± 0.132
1.152SerHis: 1.152 ± 0.037
3.854SerIle: 3.854 ± 0.074
2.367SerLys: 2.367 ± 0.064
7.453SerLeu: 7.453 ± 0.102
1.08SerMet: 1.08 ± 0.037
2.867SerAsn: 2.867 ± 0.088
3.729SerPro: 3.729 ± 0.072
3.689SerGln: 3.689 ± 0.072
3.162SerArg: 3.162 ± 0.07
4.403SerSer: 4.403 ± 0.081
3.065SerThr: 3.065 ± 0.082
3.956SerVal: 3.956 ± 0.077
0.889SerTrp: 0.889 ± 0.032
1.83SerTyr: 1.83 ± 0.046
0.0SerXaa: 0.0 ± 0.0
Thr
5.078ThrAla: 5.078 ± 0.131
0.465ThrCys: 0.465 ± 0.025
3.07ThrAsp: 3.07 ± 0.093
4.338ThrGlu: 4.338 ± 0.08
2.336ThrPhe: 2.336 ± 0.049
4.331ThrGly: 4.331 ± 0.104
0.917ThrHis: 0.917 ± 0.031
4.341ThrIle: 4.341 ± 0.108
2.06ThrLys: 2.06 ± 0.053
6.839ThrLeu: 6.839 ± 0.107
0.806ThrMet: 0.806 ± 0.027
2.257ThrAsn: 2.257 ± 0.076
3.577ThrPro: 3.577 ± 0.074
2.637ThrGln: 2.637 ± 0.055
2.556ThrArg: 2.556 ± 0.054
3.266ThrSer: 3.266 ± 0.067
3.325ThrThr: 3.325 ± 0.062
4.951ThrVal: 4.951 ± 0.15
0.694ThrTrp: 0.694 ± 0.027
1.651ThrTyr: 1.651 ± 0.05
0.0ThrXaa: 0.0 ± 0.0
Val
5.236ValAla: 5.236 ± 0.098
0.624ValCys: 0.624 ± 0.029
3.395ValAsp: 3.395 ± 0.096
4.933ValGlu: 4.933 ± 0.087
2.627ValPhe: 2.627 ± 0.058
4.777ValGly: 4.777 ± 0.084
0.897ValHis: 0.897 ± 0.035
4.601ValIle: 4.601 ± 0.071
3.268ValLys: 3.268 ± 0.072
6.116ValLeu: 6.116 ± 0.103
1.316ValMet: 1.316 ± 0.044
2.992ValAsn: 2.992 ± 0.088
2.471ValPro: 2.471 ± 0.065
2.347ValGln: 2.347 ± 0.049
3.131ValArg: 3.131 ± 0.06
4.687ValSer: 4.687 ± 0.084
4.293ValThr: 4.293 ± 0.125
4.373ValVal: 4.373 ± 0.079
0.769ValTrp: 0.769 ± 0.03
1.809ValTyr: 1.809 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
0.585TrpAla: 0.585 ± 0.029
0.163TrpCys: 0.163 ± 0.017
0.567TrpAsp: 0.567 ± 0.023
1.311TrpGlu: 1.311 ± 0.04
0.594TrpPhe: 0.594 ± 0.028
1.059TrpGly: 1.059 ± 0.042
0.275TrpHis: 0.275 ± 0.017
0.729TrpIle: 0.729 ± 0.027
0.641TrpLys: 0.641 ± 0.031
1.987TrpLeu: 1.987 ± 0.059
0.276TrpMet: 0.276 ± 0.018
0.491TrpAsn: 0.491 ± 0.022
0.175TrpPro: 0.175 ± 0.014
1.01TrpGln: 1.01 ± 0.036
0.841TrpArg: 0.841 ± 0.033
0.832TrpSer: 0.832 ± 0.032
0.588TrpThr: 0.588 ± 0.025
0.863TrpVal: 0.863 ± 0.03
0.231TrpTrp: 0.231 ± 0.016
0.372TrpTyr: 0.372 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.775TyrAla: 1.775 ± 0.043
0.347TyrCys: 0.347 ± 0.021
1.564TyrAsp: 1.564 ± 0.048
1.864TyrGlu: 1.864 ± 0.058
1.386TyrPhe: 1.386 ± 0.039
2.125TyrGly: 2.125 ± 0.049
0.7TyrHis: 0.7 ± 0.029
1.494TyrIle: 1.494 ± 0.048
1.079TyrLys: 1.079 ± 0.037
3.482TyrLeu: 3.482 ± 0.07
0.384TyrMet: 0.384 ± 0.021
1.248TyrAsn: 1.248 ± 0.04
1.573TyrPro: 1.573 ± 0.047
2.175TyrGln: 2.175 ± 0.06
1.856TyrArg: 1.856 ± 0.053
1.852TyrSer: 1.852 ± 0.046
1.451TyrThr: 1.451 ± 0.04
1.575TyrVal: 1.575 ± 0.041
0.52TyrTrp: 0.52 ± 0.024
1.069TyrTyr: 1.069 ± 0.038
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3305 proteins (1004375 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski