Amino acid dipepetide frequency for Enhydra lutris kenyoni

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.321AlaAla: 7.321 ± 0.046	1.428AlaCys: 1.428 ± 0.011	2.98AlaAsp: 2.98 ± 0.014	4.907AlaGlu: 4.907 ± 0.021	2.653AlaPhe: 2.653 ± 0.016	4.999AlaGly: 4.999 ± 0.024	1.591AlaHis: 1.591 ± 0.01	2.684AlaIle: 2.684 ± 0.013	3.342AlaLys: 3.342 ± 0.016	7.4AlaLeu: 7.4 ± 0.028	1.477AlaMet: 1.477 ± 0.011	1.982AlaAsn: 1.982 ± 0.01	4.55AlaPro: 4.55 ± 0.026	3.331AlaGln: 3.331 ± 0.018	3.902AlaArg: 3.902 ± 0.02	5.941AlaSer: 5.941 ± 0.023	3.527AlaThr: 3.527 ± 0.016	4.81AlaVal: 4.81 ± 0.018	0.799AlaTrp: 0.799 ± 0.007	1.528AlaTyr: 1.528 ± 0.011	0.005AlaXaa: 0.005 ± 0.0
Cys	1.29CysAla: 1.29 ± 0.011	0.628CysCys: 0.628 ± 0.01	1.013CysAsp: 1.013 ± 0.01	1.257CysGlu: 1.257 ± 0.013	0.817CysPhe: 0.817 ± 0.008	1.812CysGly: 1.812 ± 0.02	0.652CysHis: 0.652 ± 0.007	0.891CysIle: 0.891 ± 0.009	1.087CysLys: 1.087 ± 0.013	2.13CysLeu: 2.13 ± 0.013	0.401CysMet: 0.401 ± 0.005	0.753CysAsn: 0.753 ± 0.008	1.383CysPro: 1.383 ± 0.014	1.054CysGln: 1.054 ± 0.01	1.317CysArg: 1.317 ± 0.011	1.962CysSer: 1.962 ± 0.013	1.058CysThr: 1.058 ± 0.008	1.297CysVal: 1.297 ± 0.011	0.277CysTrp: 0.277 ± 0.004	0.566CysTyr: 0.566 ± 0.006	0.002CysXaa: 0.002 ± 0.0
Asp	2.881AspAla: 2.881 ± 0.014	1.035AspCys: 1.035 ± 0.01	2.656AspAsp: 2.656 ± 0.016	3.459AspGlu: 3.459 ± 0.018	2.097AspPhe: 2.097 ± 0.011	3.349AspGly: 3.349 ± 0.018	1.125AspHis: 1.125 ± 0.008	2.484AspIle: 2.484 ± 0.013	2.473AspLys: 2.473 ± 0.013	5.017AspLeu: 5.017 ± 0.017	1.12AspMet: 1.12 ± 0.007	1.633AspAsn: 1.633 ± 0.011	3.034AspPro: 3.034 ± 0.014	1.811AspGln: 1.811 ± 0.011	2.524AspArg: 2.524 ± 0.014	4.207AspSer: 4.207 ± 0.019	2.429AspThr: 2.429 ± 0.012	3.047AspVal: 3.047 ± 0.016	0.62AspTrp: 0.62 ± 0.007	1.44AspTyr: 1.44 ± 0.008	0.002AspXaa: 0.002 ± 0.0
Glu	5.381GluAla: 5.381 ± 0.023	1.436GluCys: 1.436 ± 0.023	4.5GluAsp: 4.5 ± 0.017	8.065GluGlu: 8.065 ± 0.042	2.008GluPhe: 2.008 ± 0.012	4.257GluGly: 4.257 ± 0.018	1.5GluHis: 1.5 ± 0.01	3.018GluIle: 3.018 ± 0.017	5.308GluLys: 5.308 ± 0.028	6.47GluLeu: 6.47 ± 0.029	1.658GluMet: 1.658 ± 0.009	3.032GluAsn: 3.032 ± 0.015	3.399GluPro: 3.399 ± 0.02	3.177GluGln: 3.177 ± 0.019	4.152GluArg: 4.152 ± 0.021	4.467GluSer: 4.467 ± 0.02	3.334GluThr: 3.334 ± 0.017	4.127GluVal: 4.127 ± 0.017	0.676GluTrp: 0.676 ± 0.006	1.533GluTyr: 1.533 ± 0.011	0.003GluXaa: 0.003 ± 0.0
Phe	1.973PheAla: 1.973 ± 0.011	0.937PheCys: 0.937 ± 0.009	1.652PheAsp: 1.652 ± 0.01	1.979PheGlu: 1.979 ± 0.011	1.577PhePhe: 1.577 ± 0.011	2.236PheGly: 2.236 ± 0.017	1.026PheHis: 1.026 ± 0.007	1.773PheIle: 1.773 ± 0.012	1.678PheLys: 1.678 ± 0.01	4.073PheLeu: 4.073 ± 0.021	0.76PheMet: 0.76 ± 0.006	1.276PheAsn: 1.276 ± 0.009	2.027PhePro: 2.027 ± 0.011	1.763PheGln: 1.763 ± 0.01	1.982PheArg: 1.982 ± 0.014	3.397PheSer: 3.397 ± 0.017	1.957PheThr: 1.957 ± 0.012	2.135PheVal: 2.135 ± 0.012	0.471PheTrp: 0.471 ± 0.005	1.171PheTyr: 1.171 ± 0.009	0.003PheXaa: 0.003 ± 0.0
Gly	4.82GlyAla: 4.82 ± 0.026	1.278GlyCys: 1.278 ± 0.009	3.202GlyAsp: 3.202 ± 0.016	4.185GlyGlu: 4.185 ± 0.023	2.394GlyPhe: 2.394 ± 0.015	5.416GlyGly: 5.416 ± 0.038	1.719GlyHis: 1.719 ± 0.01	2.607GlyIle: 2.607 ± 0.012	3.715GlyLys: 3.715 ± 0.021	6.005GlyLeu: 6.005 ± 0.023	1.302GlyMet: 1.302 ± 0.01	2.339GlyAsn: 2.339 ± 0.011	4.59GlyPro: 4.59 ± 0.036	2.824GlyGln: 2.824 ± 0.015	4.03GlyArg: 4.03 ± 0.021	6.018GlySer: 6.018 ± 0.025	3.572GlyThr: 3.572 ± 0.014	3.57GlyVal: 3.57 ± 0.015	0.783GlyTrp: 0.783 ± 0.008	1.667GlyTyr: 1.667 ± 0.011	0.006GlyXaa: 0.006 ± 0.001
His	1.347HisAla: 1.347 ± 0.008	0.701HisCys: 0.701 ± 0.006	0.885HisAsp: 0.885 ± 0.006	1.308HisGlu: 1.308 ± 0.009	1.061HisPhe: 1.061 ± 0.008	1.569HisGly: 1.569 ± 0.011	0.902HisHis: 0.902 ± 0.01	1.209HisIle: 1.209 ± 0.008	1.226HisLys: 1.226 ± 0.01	2.938HisLeu: 2.938 ± 0.014	0.582HisMet: 0.582 ± 0.005	0.821HisAsn: 0.821 ± 0.007	1.692HisPro: 1.692 ± 0.011	1.36HisGln: 1.36 ± 0.013	1.665HisArg: 1.665 ± 0.01	2.344HisSer: 2.344 ± 0.013	1.515HisThr: 1.515 ± 0.015	1.521HisVal: 1.521 ± 0.009	0.354HisTrp: 0.354 ± 0.005	0.802HisTyr: 0.802 ± 0.006	0.002HisXaa: 0.002 ± 0.0
Ile	2.485IleAla: 2.485 ± 0.013	1.038IleCys: 1.038 ± 0.008	1.91IleAsp: 1.91 ± 0.011	2.467IleGlu: 2.467 ± 0.014	1.831IlePhe: 1.831 ± 0.015	2.11IleGly: 2.11 ± 0.012	1.306IleHis: 1.306 ± 0.012	2.262IleIle: 2.262 ± 0.014	2.476IleLys: 2.476 ± 0.013	4.419IleLeu: 4.419 ± 0.019	0.962IleMet: 0.962 ± 0.008	1.691IleAsn: 1.691 ± 0.011	2.55IlePro: 2.55 ± 0.012	2.225IleGln: 2.225 ± 0.011	2.311IleArg: 2.311 ± 0.011	3.584IleSer: 3.584 ± 0.013	2.406IleThr: 2.406 ± 0.014	2.397IleVal: 2.397 ± 0.015	0.492IleTrp: 0.492 ± 0.005	1.316IleTyr: 1.316 ± 0.009	0.003IleXaa: 0.003 ± 0.0
Lys	3.914LysAla: 3.914 ± 0.018	1.084LysCys: 1.084 ± 0.011	3.063LysAsp: 3.063 ± 0.017	4.983LysGlu: 4.983 ± 0.029	1.661LysPhe: 1.661 ± 0.01	3.146LysGly: 3.146 ± 0.018	1.359LysHis: 1.359 ± 0.01	2.649LysIle: 2.649 ± 0.014	4.62LysLys: 4.62 ± 0.027	5.053LysLeu: 5.053 ± 0.021	1.42LysMet: 1.42 ± 0.01	2.277LysAsn: 2.277 ± 0.013	3.159LysPro: 3.159 ± 0.022	2.566LysGln: 2.566 ± 0.014	3.299LysArg: 3.299 ± 0.017	3.853LysSer: 3.853 ± 0.018	3.034LysThr: 3.034 ± 0.016	3.37LysVal: 3.37 ± 0.018	0.566LysTrp: 0.566 ± 0.007	1.492LysTyr: 1.492 ± 0.011	0.003LysXaa: 0.003 ± 0.0
Leu	6.968LeuAla: 6.968 ± 0.029	2.16LeuCys: 2.16 ± 0.012	4.739LeuAsp: 4.739 ± 0.018	7.236LeuGlu: 7.236 ± 0.035	3.369LeuPhe: 3.369 ± 0.018	6.049LeuGly: 6.049 ± 0.024	2.735LeuHis: 2.735 ± 0.014	3.766LeuIle: 3.766 ± 0.016	5.673LeuLys: 5.673 ± 0.025	10.927LeuLeu: 10.927 ± 0.042	1.989LeuMet: 1.989 ± 0.012	3.412LeuAsn: 3.412 ± 0.017	6.183LeuPro: 6.183 ± 0.026	5.767LeuGln: 5.767 ± 0.03	6.194LeuArg: 6.194 ± 0.026	8.054LeuSer: 8.054 ± 0.027	5.017LeuThr: 5.017 ± 0.021	5.529LeuVal: 5.529 ± 0.021	1.124LeuTrp: 1.124 ± 0.009	2.458LeuTyr: 2.458 ± 0.012	0.008LeuXaa: 0.008 ± 0.001
Met	1.945MetAla: 1.945 ± 0.01	0.38MetCys: 0.38 ± 0.004	1.244MetAsp: 1.244 ± 0.008	1.834MetGlu: 1.834 ± 0.011	0.731MetPhe: 0.731 ± 0.007	1.286MetGly: 1.286 ± 0.009	0.456MetHis: 0.456 ± 0.005	0.798MetIle: 0.798 ± 0.007	1.385MetLys: 1.385 ± 0.009	1.956MetLeu: 1.956 ± 0.011	0.554MetMet: 0.554 ± 0.006	0.878MetAsn: 0.878 ± 0.007	1.068MetPro: 1.068 ± 0.009	0.91MetGln: 0.91 ± 0.007	1.051MetArg: 1.051 ± 0.009	1.554MetSer: 1.554 ± 0.011	1.087MetThr: 1.087 ± 0.008	1.37MetVal: 1.37 ± 0.009	0.232MetTrp: 0.232 ± 0.003	0.583MetTyr: 0.583 ± 0.006	0.001MetXaa: 0.001 ± 0.0
Asn	1.996AsnAla: 1.996 ± 0.011	0.796AsnCys: 0.796 ± 0.008	1.442AsnAsp: 1.442 ± 0.009	2.116AsnGlu: 2.116 ± 0.012	1.419AsnPhe: 1.419 ± 0.009	2.364AsnGly: 2.364 ± 0.014	0.936AsnHis: 0.936 ± 0.007	1.987AsnIle: 1.987 ± 0.01	2.105AsnLys: 2.105 ± 0.012	3.582AsnLeu: 3.582 ± 0.014	0.88AsnMet: 0.88 ± 0.006	1.441AsnAsn: 1.441 ± 0.01	2.167AsnPro: 2.167 ± 0.012	1.62AsnGln: 1.62 ± 0.01	1.793AsnArg: 1.793 ± 0.011	3.047AsnSer: 3.047 ± 0.017	1.895AsnThr: 1.895 ± 0.011	2.129AsnVal: 2.129 ± 0.012	0.429AsnTrp: 0.429 ± 0.005	1.047AsnTyr: 1.047 ± 0.008	0.002AsnXaa: 0.002 ± 0.0
Pro	5.32ProAla: 5.32 ± 0.031	1.16ProCys: 1.16 ± 0.012	2.859ProAsp: 2.859 ± 0.016	4.608ProGlu: 4.608 ± 0.019	1.969ProPhe: 1.969 ± 0.012	5.585ProGly: 5.585 ± 0.042	1.528ProHis: 1.528 ± 0.011	1.808ProIle: 1.808 ± 0.012	2.798ProLys: 2.798 ± 0.018	5.434ProLeu: 5.434 ± 0.022	1.093ProMet: 1.093 ± 0.009	1.774ProAsn: 1.774 ± 0.011	6.649ProPro: 6.649 ± 0.051	2.993ProGln: 2.993 ± 0.019	3.647ProArg: 3.647 ± 0.021	5.956ProSer: 5.956 ± 0.032	3.127ProThr: 3.127 ± 0.018	3.936ProVal: 3.936 ± 0.02	0.691ProTrp: 0.691 ± 0.007	1.532ProTyr: 1.532 ± 0.014	0.007ProXaa: 0.007 ± 0.001
Gln	3.61GlnAla: 3.61 ± 0.022	0.913GlnCys: 0.913 ± 0.01	2.332GlnAsp: 2.332 ± 0.011	3.924GlnGlu: 3.924 ± 0.024	1.328GlnPhe: 1.328 ± 0.009	2.86GlnGly: 2.86 ± 0.015	1.334GlnHis: 1.334 ± 0.009	1.937GlnIle: 1.937 ± 0.012	2.901GlnLys: 2.901 ± 0.015	4.805GlnLeu: 4.805 ± 0.025	1.107GlnMet: 1.107 ± 0.008	1.782GlnAsn: 1.782 ± 0.011	2.924GlnPro: 2.924 ± 0.02	3.099GlnGln: 3.099 ± 0.026	3.086GlnArg: 3.086 ± 0.017	3.153GlnSer: 3.153 ± 0.016	2.294GlnThr: 2.294 ± 0.012	2.795GlnVal: 2.795 ± 0.014	0.528GlnTrp: 0.528 ± 0.005	1.125GlnTyr: 1.125 ± 0.008	0.002GlnXaa: 0.002 ± 0.0
Arg	4.17ArgAla: 4.17 ± 0.02	1.216ArgCys: 1.216 ± 0.012	2.846ArgAsp: 2.846 ± 0.016	4.198ArgGlu: 4.198 ± 0.022	1.858ArgPhe: 1.858 ± 0.011	3.824ArgGly: 3.824 ± 0.024	1.592ArgHis: 1.592 ± 0.01	2.391ArgIle: 2.391 ± 0.012	3.727ArgLys: 3.727 ± 0.016	5.608ArgLeu: 5.608 ± 0.023	1.189ArgMet: 1.189 ± 0.009	2.095ArgAsn: 2.095 ± 0.01	3.52ArgPro: 3.52 ± 0.02	2.723ArgGln: 2.723 ± 0.017	4.721ArgArg: 4.721 ± 0.03	4.537ArgSer: 4.537 ± 0.029	2.901ArgThr: 2.901 ± 0.014	3.204ArgVal: 3.204 ± 0.016	0.691ArgTrp: 0.691 ± 0.007	1.437ArgTyr: 1.437 ± 0.01	0.004ArgXaa: 0.004 ± 0.0
Ser	5.495SerAla: 5.495 ± 0.02	1.846SerCys: 1.846 ± 0.013	3.915SerAsp: 3.915 ± 0.018	5.236SerGlu: 5.236 ± 0.022	3.011SerPhe: 3.011 ± 0.015	5.803SerGly: 5.803 ± 0.027	2.114SerHis: 2.114 ± 0.011	3.071SerIle: 3.071 ± 0.014	4.031SerLys: 4.031 ± 0.017	8.284SerLeu: 8.284 ± 0.026	1.56SerMet: 1.56 ± 0.011	2.595SerAsn: 2.595 ± 0.014	6.354SerPro: 6.354 ± 0.038	3.932SerGln: 3.932 ± 0.019	4.803SerArg: 4.803 ± 0.027	9.668SerSer: 9.668 ± 0.054	4.412SerThr: 4.412 ± 0.021	4.925SerVal: 4.925 ± 0.017	1.066SerTrp: 1.066 ± 0.008	2.031SerTyr: 2.031 ± 0.012	0.005SerXaa: 0.005 ± 0.001
Thr	3.764ThrAla: 3.764 ± 0.016	1.263ThrCys: 1.263 ± 0.013	2.409ThrAsp: 2.409 ± 0.012	3.479ThrGlu: 3.479 ± 0.016	2.058ThrPhe: 2.058 ± 0.012	3.536ThrGly: 3.536 ± 0.019	1.292ThrHis: 1.292 ± 0.01	2.258ThrIle: 2.258 ± 0.014	2.537ThrLys: 2.537 ± 0.013	5.193ThrLeu: 5.193 ± 0.017	1.065ThrMet: 1.065 ± 0.009	1.649ThrAsn: 1.649 ± 0.01	3.656ThrPro: 3.656 ± 0.021	2.257ThrGln: 2.257 ± 0.012	2.526ThrArg: 2.526 ± 0.012	4.549ThrSer: 4.549 ± 0.02	2.845ThrThr: 2.845 ± 0.021	3.784ThrVal: 3.784 ± 0.019	0.659ThrTrp: 0.659 ± 0.007	1.372ThrTyr: 1.372 ± 0.011	0.004ThrXaa: 0.004 ± 0.0
Val	4.277ValAla: 4.277 ± 0.015	1.44ValCys: 1.44 ± 0.01	2.887ValAsp: 2.887 ± 0.013	3.797ValGlu: 3.797 ± 0.019	2.38ValPhe: 2.38 ± 0.013	3.425ValGly: 3.425 ± 0.014	1.591ValHis: 1.591 ± 0.012	2.834ValIle: 2.834 ± 0.015	3.319ValLys: 3.319 ± 0.018	6.301ValLeu: 6.301 ± 0.022	1.303ValMet: 1.303 ± 0.008	2.188ValAsn: 2.188 ± 0.012	3.761ValPro: 3.761 ± 0.02	2.677ValGln: 2.677 ± 0.012	3.153ValArg: 3.153 ± 0.016	4.87ValSer: 4.87 ± 0.017	3.678ValThr: 3.678 ± 0.024	3.969ValVal: 3.969 ± 0.016	0.703ValTrp: 0.703 ± 0.006	1.584ValTyr: 1.584 ± 0.009	0.003ValXaa: 0.003 ± 0.0
Trp	0.807TrpAla: 0.807 ± 0.007	0.246TrpCys: 0.246 ± 0.004	0.653TrpAsp: 0.653 ± 0.006	0.787TrpGlu: 0.787 ± 0.008	0.436TrpPhe: 0.436 ± 0.005	0.731TrpGly: 0.731 ± 0.008	0.295TrpHis: 0.295 ± 0.004	0.504TrpIle: 0.504 ± 0.006	0.767TrpLys: 0.767 ± 0.007	1.184TrpLeu: 1.184 ± 0.009	0.295TrpMet: 0.295 ± 0.004	0.533TrpAsn: 0.533 ± 0.005	0.524TrpPro: 0.524 ± 0.006	0.522TrpGln: 0.522 ± 0.006	0.731TrpArg: 0.731 ± 0.007	0.844TrpSer: 0.844 ± 0.007	0.644TrpThr: 0.644 ± 0.007	0.672TrpVal: 0.672 ± 0.006	0.191TrpTrp: 0.191 ± 0.003	0.325TrpTyr: 0.325 ± 0.004	0.001TrpXaa: 0.001 ± 0.0
Tyr	1.39TyrAla: 1.39 ± 0.009	0.659TyrCys: 0.659 ± 0.006	1.253TyrAsp: 1.253 ± 0.009	1.674TyrGlu: 1.674 ± 0.013	1.183TyrPhe: 1.183 ± 0.009	1.677TyrGly: 1.677 ± 0.013	0.747TyrHis: 0.747 ± 0.006	1.308TyrIle: 1.308 ± 0.01	1.399TyrLys: 1.399 ± 0.012	2.574TyrLeu: 2.574 ± 0.014	0.584TyrMet: 0.584 ± 0.006	1.04TyrAsn: 1.04 ± 0.008	1.279TyrPro: 1.279 ± 0.009	1.225TyrGln: 1.225 ± 0.009	1.562TyrArg: 1.562 ± 0.011	2.146TyrSer: 2.146 ± 0.012	1.417TyrThr: 1.417 ± 0.01	1.55TyrVal: 1.55 ± 0.01	0.34TyrTrp: 0.34 ± 0.005	0.903TyrTyr: 0.903 ± 0.008	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.005XaaAla: 0.005 ± 0.001	0.001XaaCys: 0.001 ± 0.0	0.003XaaAsp: 0.003 ± 0.0	0.004XaaGlu: 0.004 ± 0.0	0.002XaaPhe: 0.002 ± 0.0	0.006XaaGly: 0.006 ± 0.001	0.001XaaHis: 0.001 ± 0.0	0.002XaaIle: 0.002 ± 0.0	0.004XaaLys: 0.004 ± 0.0	0.005XaaLeu: 0.005 ± 0.001	0.002XaaMet: 0.002 ± 0.0	0.002XaaAsn: 0.002 ± 0.0	0.006XaaPro: 0.006 ± 0.001	0.002XaaGln: 0.002 ± 0.0	0.004XaaArg: 0.004 ± 0.001	0.006XaaSer: 0.006 ± 0.001	0.003XaaThr: 0.003 ± 0.0	0.004XaaVal: 0.004 ± 0.001	0.001XaaTrp: 0.001 ± 0.0	0.002XaaTyr: 0.002 ± 0.0	0.018XaaXaa: 0.018 ± 0.004

Statistics based on 32891 proteins (20466548 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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