Amino acid dipepetide frequency for Paenibacillus nanensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.021AlaAla: 11.021 ± 0.138	0.744AlaCys: 0.744 ± 0.022	4.879AlaAsp: 4.879 ± 0.061	6.63AlaGlu: 6.63 ± 0.071	3.755AlaPhe: 3.755 ± 0.053	7.672AlaGly: 7.672 ± 0.075	1.462AlaHis: 1.462 ± 0.031	5.592AlaIle: 5.592 ± 0.065	4.46AlaLys: 4.46 ± 0.056	8.853AlaLeu: 8.853 ± 0.084	2.509AlaMet: 2.509 ± 0.045	2.838AlaAsn: 2.838 ± 0.049	3.012AlaPro: 3.012 ± 0.053	2.672AlaGln: 2.672 ± 0.046	3.838AlaArg: 3.838 ± 0.058	5.948AlaSer: 5.948 ± 0.064	3.651AlaThr: 3.651 ± 0.052	7.259AlaVal: 7.259 ± 0.08	1.049AlaTrp: 1.049 ± 0.028	2.911AlaTyr: 2.911 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.531CysAla: 0.531 ± 0.019	0.102CysCys: 0.102 ± 0.007	0.332CysAsp: 0.332 ± 0.014	0.453CysGlu: 0.453 ± 0.018	0.268CysPhe: 0.268 ± 0.014	0.741CysGly: 0.741 ± 0.024	0.163CysHis: 0.163 ± 0.009	0.409CysIle: 0.409 ± 0.016	0.313CysLys: 0.313 ± 0.013	0.67CysLeu: 0.67 ± 0.019	0.211CysMet: 0.211 ± 0.011	0.229CysAsn: 0.229 ± 0.014	0.309CysPro: 0.309 ± 0.016	0.183CysGln: 0.183 ± 0.011	0.423CysArg: 0.423 ± 0.019	0.545CysSer: 0.545 ± 0.016	0.329CysThr: 0.329 ± 0.014	0.436CysVal: 0.436 ± 0.016	0.09CysTrp: 0.09 ± 0.007	0.239CysTyr: 0.239 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	4.534AspAla: 4.534 ± 0.061	0.342AspCys: 0.342 ± 0.013	2.469AspAsp: 2.469 ± 0.041	3.864AspGlu: 3.864 ± 0.045	2.057AspPhe: 2.057 ± 0.035	4.561AspGly: 4.561 ± 0.068	1.014AspHis: 1.014 ± 0.025	3.397AspIle: 3.397 ± 0.05	2.504AspLys: 2.504 ± 0.034	4.523AspLeu: 4.523 ± 0.047	1.375AspMet: 1.375 ± 0.028	1.846AspAsn: 1.846 ± 0.034	2.481AspPro: 2.481 ± 0.045	1.655AspGln: 1.655 ± 0.033	3.084AspArg: 3.084 ± 0.049	2.815AspSer: 2.815 ± 0.043	2.491AspThr: 2.491 ± 0.04	3.511AspVal: 3.511 ± 0.052	0.896AspTrp: 0.896 ± 0.025	2.174AspTyr: 2.174 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	6.996GluAla: 6.996 ± 0.078	0.36GluCys: 0.36 ± 0.016	3.229GluAsp: 3.229 ± 0.042	5.719GluGlu: 5.719 ± 0.067	1.998GluPhe: 1.998 ± 0.035	4.841GluGly: 4.841 ± 0.06	1.502GluHis: 1.502 ± 0.028	3.958GluIle: 3.958 ± 0.05	3.827GluLys: 3.827 ± 0.052	7.867GluLeu: 7.867 ± 0.087	1.994GluMet: 1.994 ± 0.032	2.374GluAsn: 2.374 ± 0.039	2.616GluPro: 2.616 ± 0.042	3.671GluGln: 3.671 ± 0.05	4.535GluArg: 4.535 ± 0.068	3.76GluSer: 3.76 ± 0.046	3.595GluThr: 3.595 ± 0.051	4.192GluVal: 4.192 ± 0.051	1.116GluTrp: 1.116 ± 0.026	1.884GluTyr: 1.884 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	3.541PheAla: 3.541 ± 0.043	0.317PheCys: 0.317 ± 0.017	2.312PheAsp: 2.312 ± 0.039	2.536PheGlu: 2.536 ± 0.039	1.747PhePhe: 1.747 ± 0.041	3.313PheGly: 3.313 ± 0.048	0.877PheHis: 0.877 ± 0.026	2.744PheIle: 2.744 ± 0.042	1.934PheLys: 1.934 ± 0.041	3.798PheLeu: 3.798 ± 0.06	1.146PheMet: 1.146 ± 0.023	1.469PheAsn: 1.469 ± 0.031	1.572PhePro: 1.572 ± 0.03	1.372PheGln: 1.372 ± 0.031	2.206PheArg: 2.206 ± 0.032	2.664PheSer: 2.664 ± 0.041	2.363PheThr: 2.363 ± 0.043	2.944PheVal: 2.944 ± 0.045	0.562PheTrp: 0.562 ± 0.019	1.486PheTyr: 1.486 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	6.449GlyAla: 6.449 ± 0.077	0.656GlyCys: 0.656 ± 0.023	3.725GlyAsp: 3.725 ± 0.055	5.088GlyGlu: 5.088 ± 0.055	3.339GlyPhe: 3.339 ± 0.045	6.181GlyGly: 6.181 ± 0.079	1.5GlyHis: 1.5 ± 0.03	5.438GlyIle: 5.438 ± 0.061	4.459GlyLys: 4.459 ± 0.056	7.389GlyLeu: 7.389 ± 0.072	2.482GlyMet: 2.482 ± 0.041	2.818GlyAsn: 2.818 ± 0.055	2.012GlyPro: 2.012 ± 0.048	2.553GlyGln: 2.553 ± 0.036	3.795GlyArg: 3.795 ± 0.046	4.99GlySer: 4.99 ± 0.058	4.373GlyThr: 4.373 ± 0.064	5.298GlyVal: 5.298 ± 0.054	1.169GlyTrp: 1.169 ± 0.032	3.032GlyTyr: 3.032 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.727HisAla: 1.727 ± 0.033	0.186HisCys: 0.186 ± 0.013	0.989HisAsp: 0.989 ± 0.024	1.225HisGlu: 1.225 ± 0.026	0.997HisPhe: 0.997 ± 0.023	1.481HisGly: 1.481 ± 0.029	0.579HisHis: 0.579 ± 0.02	1.28HisIle: 1.28 ± 0.028	0.767HisLys: 0.767 ± 0.022	1.899HisLeu: 1.899 ± 0.042	0.546HisMet: 0.546 ± 0.018	0.674HisAsn: 0.674 ± 0.019	1.168HisPro: 1.168 ± 0.026	0.686HisGln: 0.686 ± 0.02	1.056HisArg: 1.056 ± 0.029	1.114HisSer: 1.114 ± 0.026	1.024HisThr: 1.024 ± 0.023	1.36HisVal: 1.36 ± 0.024	0.304HisTrp: 0.304 ± 0.014	0.925HisTyr: 0.925 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.334IleAla: 6.334 ± 0.065	0.526IleCys: 0.526 ± 0.018	3.706IleAsp: 3.706 ± 0.048	4.358IleGlu: 4.358 ± 0.054	2.16IlePhe: 2.16 ± 0.038	5.378IleGly: 5.378 ± 0.065	1.306IleHis: 1.306 ± 0.029	3.799IleIle: 3.799 ± 0.061	2.629IleLys: 2.629 ± 0.041	5.219IleLeu: 5.219 ± 0.069	1.577IleMet: 1.577 ± 0.034	2.133IleAsn: 2.133 ± 0.035	2.951IlePro: 2.951 ± 0.038	2.182IleGln: 2.182 ± 0.041	3.857IleArg: 3.857 ± 0.051	4.073IleSer: 4.073 ± 0.054	3.607IleThr: 3.607 ± 0.05	5.202IleVal: 5.202 ± 0.065	0.737IleTrp: 0.737 ± 0.022	1.988IleTyr: 1.988 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	4.588LysAla: 4.588 ± 0.063	0.217LysCys: 0.217 ± 0.012	2.713LysAsp: 2.713 ± 0.038	4.219LysGlu: 4.219 ± 0.059	1.437LysPhe: 1.437 ± 0.029	3.528LysGly: 3.528 ± 0.046	1.078LysHis: 1.078 ± 0.024	2.638LysIle: 2.638 ± 0.045	2.824LysLys: 2.824 ± 0.055	5.74LysLeu: 5.74 ± 0.058	1.419LysMet: 1.419 ± 0.032	1.739LysAsn: 1.739 ± 0.032	2.324LysPro: 2.324 ± 0.043	2.205LysGln: 2.205 ± 0.04	2.987LysArg: 2.987 ± 0.04	2.76LysSer: 2.76 ± 0.043	2.655LysThr: 2.655 ± 0.041	3.295LysVal: 3.295 ± 0.044	0.76LysTrp: 0.76 ± 0.022	1.549LysTyr: 1.549 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	8.841LeuAla: 8.841 ± 0.088	0.728LeuCys: 0.728 ± 0.019	4.994LeuAsp: 4.994 ± 0.064	6.378LeuGlu: 6.378 ± 0.073	4.569LeuPhe: 4.569 ± 0.06	6.604LeuGly: 6.604 ± 0.069	2.121LeuHis: 2.121 ± 0.038	6.285LeuIle: 6.285 ± 0.074	5.092LeuLys: 5.092 ± 0.051	11.187LeuLeu: 11.187 ± 0.117	2.677LeuMet: 2.677 ± 0.043	3.549LeuAsn: 3.549 ± 0.045	4.549LeuPro: 4.549 ± 0.054	3.972LeuGln: 3.972 ± 0.06	5.32LeuArg: 5.32 ± 0.062	7.048LeuSer: 7.048 ± 0.072	5.822LeuThr: 5.822 ± 0.059	6.117LeuVal: 6.117 ± 0.067	1.075LeuTrp: 1.075 ± 0.024	3.315LeuTyr: 3.315 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	2.375MetAla: 2.375 ± 0.042	0.139MetCys: 0.139 ± 0.01	1.45MetAsp: 1.45 ± 0.027	1.93MetGlu: 1.93 ± 0.036	0.992MetPhe: 0.992 ± 0.026	1.71MetGly: 1.71 ± 0.029	0.487MetHis: 0.487 ± 0.016	1.784MetIle: 1.784 ± 0.036	1.988MetLys: 1.988 ± 0.035	3.07MetLeu: 3.07 ± 0.043	0.853MetMet: 0.853 ± 0.021	1.458MetAsn: 1.458 ± 0.028	1.216MetPro: 1.216 ± 0.026	0.937MetGln: 0.937 ± 0.023	1.477MetArg: 1.477 ± 0.031	1.828MetSer: 1.828 ± 0.029	1.775MetThr: 1.775 ± 0.033	1.698MetVal: 1.698 ± 0.036	0.253MetTrp: 0.253 ± 0.013	0.761MetTyr: 0.761 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.244AsnAla: 3.244 ± 0.057	0.227AsnCys: 0.227 ± 0.011	1.894AsnAsp: 1.894 ± 0.031	2.63AsnGlu: 2.63 ± 0.038	1.163AsnPhe: 1.163 ± 0.027	3.619AsnGly: 3.619 ± 0.054	0.751AsnHis: 0.751 ± 0.021	2.075AsnIle: 2.075 ± 0.032	1.852AsnLys: 1.852 ± 0.038	2.911AsnLeu: 2.911 ± 0.045	0.938AsnMet: 0.938 ± 0.025	1.551AsnAsn: 1.551 ± 0.038	1.95AsnPro: 1.95 ± 0.035	1.307AsnGln: 1.307 ± 0.026	2.194AsnArg: 2.194 ± 0.038	1.886AsnSer: 1.886 ± 0.038	1.809AsnThr: 1.809 ± 0.038	2.576AsnVal: 2.576 ± 0.038	0.567AsnTrp: 0.567 ± 0.015	1.279AsnTyr: 1.279 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	3.739ProAla: 3.739 ± 0.053	0.239ProCys: 0.239 ± 0.014	2.732ProAsp: 2.732 ± 0.039	3.435ProGlu: 3.435 ± 0.057	1.909ProPhe: 1.909 ± 0.038	3.04ProGly: 3.04 ± 0.049	0.874ProHis: 0.874 ± 0.022	2.531ProIle: 2.531 ± 0.035	1.76ProLys: 1.76 ± 0.031	3.995ProLeu: 3.995 ± 0.05	0.959ProMet: 0.959 ± 0.024	1.611ProAsn: 1.611 ± 0.033	1.389ProPro: 1.389 ± 0.035	1.302ProGln: 1.302 ± 0.03	1.452ProArg: 1.452 ± 0.029	2.699ProSer: 2.699 ± 0.043	1.897ProThr: 1.897 ± 0.061	3.263ProVal: 3.263 ± 0.048	0.521ProTrp: 0.521 ± 0.019	1.582ProTyr: 1.582 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	3.358GlnAla: 3.358 ± 0.05	0.166GlnCys: 0.166 ± 0.01	1.549GlnAsp: 1.549 ± 0.029	2.483GlnGlu: 2.483 ± 0.044	1.535GlnPhe: 1.535 ± 0.033	2.439GlnGly: 2.439 ± 0.042	0.747GlnHis: 0.747 ± 0.02	2.206GlnIle: 2.206 ± 0.039	1.738GlnLys: 1.738 ± 0.031	4.087GlnLeu: 4.087 ± 0.058	1.076GlnMet: 1.076 ± 0.023	1.205GlnAsn: 1.205 ± 0.026	1.502GlnPro: 1.502 ± 0.027	1.571GlnGln: 1.571 ± 0.035	1.741GlnArg: 1.741 ± 0.033	2.3GlnSer: 2.3 ± 0.032	1.908GlnThr: 1.908 ± 0.036	2.218GlnVal: 2.218 ± 0.033	0.509GlnTrp: 0.509 ± 0.02	1.32GlnTyr: 1.32 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	3.763ArgAla: 3.763 ± 0.057	0.329ArgCys: 0.329 ± 0.013	2.546ArgAsp: 2.546 ± 0.041	3.919ArgGlu: 3.919 ± 0.055	2.437ArgPhe: 2.437 ± 0.041	3.273ArgGly: 3.273 ± 0.05	1.091ArgHis: 1.091 ± 0.026	3.855ArgIle: 3.855 ± 0.053	3.104ArgLys: 3.104 ± 0.047	5.818ArgLeu: 5.818 ± 0.073	1.861ArgMet: 1.861 ± 0.033	2.037ArgAsn: 2.037 ± 0.036	1.804ArgPro: 1.804 ± 0.031	2.036ArgGln: 2.036 ± 0.036	2.91ArgArg: 2.91 ± 0.045	3.324ArgSer: 3.324 ± 0.046	2.703ArgThr: 2.703 ± 0.042	3.206ArgVal: 3.206 ± 0.044	0.704ArgTrp: 0.704 ± 0.02	2.085ArgTyr: 2.085 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	5.589SerAla: 5.589 ± 0.067	0.427SerCys: 0.427 ± 0.018	3.095SerAsp: 3.095 ± 0.047	4.104SerGlu: 4.104 ± 0.059	3.056SerPhe: 3.056 ± 0.045	5.758SerGly: 5.758 ± 0.067	1.156SerHis: 1.156 ± 0.024	4.213SerIle: 4.213 ± 0.052	2.957SerLys: 2.957 ± 0.047	6.234SerLeu: 6.234 ± 0.068	1.766SerMet: 1.766 ± 0.034	2.138SerAsn: 2.138 ± 0.036	2.58SerPro: 2.58 ± 0.041	1.868SerGln: 1.868 ± 0.034	3.163SerArg: 3.163 ± 0.045	4.154SerSer: 4.154 ± 0.056	2.866SerThr: 2.866 ± 0.047	4.543SerVal: 4.543 ± 0.054	0.841SerTrp: 0.841 ± 0.022	2.351SerTyr: 2.351 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	4.993ThrAla: 4.993 ± 0.063	0.299ThrCys: 0.299 ± 0.013	2.86ThrAsp: 2.86 ± 0.051	3.364ThrGlu: 3.364 ± 0.045	2.382ThrPhe: 2.382 ± 0.042	4.528ThrGly: 4.528 ± 0.06	0.922ThrHis: 0.922 ± 0.025	3.72ThrIle: 3.72 ± 0.048	2.319ThrLys: 2.319 ± 0.036	5.264ThrLeu: 5.264 ± 0.06	1.341ThrMet: 1.341 ± 0.029	1.907ThrAsn: 1.907 ± 0.035	2.524ThrPro: 2.524 ± 0.064	1.385ThrGln: 1.385 ± 0.029	2.161ThrArg: 2.161 ± 0.041	3.111ThrSer: 3.111 ± 0.05	2.757ThrThr: 2.757 ± 0.056	4.638ThrVal: 4.638 ± 0.071	0.647ThrTrp: 0.647 ± 0.023	1.959ThrTyr: 1.959 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	5.251ValAla: 5.251 ± 0.063	0.591ValCys: 0.591 ± 0.02	3.49ValAsp: 3.49 ± 0.052	4.391ValGlu: 4.391 ± 0.058	2.905ValPhe: 2.905 ± 0.041	4.38ValGly: 4.38 ± 0.051	1.398ValHis: 1.398 ± 0.031	4.929ValIle: 4.929 ± 0.061	3.759ValLys: 3.759 ± 0.052	6.856ValLeu: 6.856 ± 0.071	2.071ValMet: 2.071 ± 0.041	2.791ValAsn: 2.791 ± 0.041	3.015ValPro: 3.015 ± 0.038	2.472ValGln: 2.472 ± 0.036	3.667ValArg: 3.667 ± 0.047	4.837ValSer: 4.837 ± 0.057	4.759ValThr: 4.759 ± 0.064	4.889ValVal: 4.889 ± 0.057	0.89ValTrp: 0.89 ± 0.027	2.481ValTyr: 2.481 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.909TrpAla: 0.909 ± 0.028	0.097TrpCys: 0.097 ± 0.008	0.693TrpAsp: 0.693 ± 0.022	0.844TrpGlu: 0.844 ± 0.025	0.587TrpPhe: 0.587 ± 0.021	0.891TrpGly: 0.891 ± 0.026	0.269TrpHis: 0.269 ± 0.014	0.831TrpIle: 0.831 ± 0.023	0.736TrpLys: 0.736 ± 0.02	1.566TrpLeu: 1.566 ± 0.037	0.464TrpMet: 0.464 ± 0.016	0.682TrpAsn: 0.682 ± 0.021	0.415TrpPro: 0.415 ± 0.015	0.503TrpGln: 0.503 ± 0.018	0.744TrpArg: 0.744 ± 0.022	0.908TrpSer: 0.908 ± 0.024	0.787TrpThr: 0.787 ± 0.03	0.803TrpVal: 0.803 ± 0.023	0.192TrpTrp: 0.192 ± 0.01	0.457TrpTyr: 0.457 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.974TyrAla: 2.974 ± 0.044	0.284TyrCys: 0.284 ± 0.013	1.939TyrAsp: 1.939 ± 0.038	2.463TyrGlu: 2.463 ± 0.03	1.609TyrPhe: 1.609 ± 0.031	2.808TyrGly: 2.808 ± 0.046	0.688TyrHis: 0.688 ± 0.018	2.037TyrIle: 2.037 ± 0.031	1.651TyrLys: 1.651 ± 0.032	3.296TyrLeu: 3.296 ± 0.041	0.914TyrMet: 0.914 ± 0.021	1.375TyrAsn: 1.375 ± 0.033	1.538TyrPro: 1.538 ± 0.03	1.129TyrGln: 1.129 ± 0.031	2.196TyrArg: 2.196 ± 0.032	2.1TyrSer: 2.1 ± 0.039	1.908TyrThr: 1.908 ± 0.041	2.375TyrVal: 2.375 ± 0.031	0.493TyrTrp: 0.493 ± 0.016	1.45TyrTyr: 1.45 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5258 proteins (1792965 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---