Amino acid dipepetide frequency for Streptococcus satellite phage Javan608

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.0AlaCys: 0.0 ± 0.0
2.975AlaAsp: 2.975 ± 1.091
2.975AlaGlu: 2.975 ± 1.04
2.975AlaPhe: 2.975 ± 1.152
1.983AlaGly: 1.983 ± 0.821
0.0AlaHis: 0.0 ± 0.0
3.966AlaIle: 3.966 ± 1.248
5.454AlaLys: 5.454 ± 1.342
5.454AlaLeu: 5.454 ± 1.763
1.487AlaMet: 1.487 ± 1.046
6.445AlaAsn: 6.445 ± 1.568
0.992AlaPro: 0.992 ± 0.922
2.479AlaGln: 2.479 ± 1.332
1.983AlaArg: 1.983 ± 0.777
2.479AlaSer: 2.479 ± 0.984
2.975AlaThr: 2.975 ± 1.263
2.479AlaVal: 2.479 ± 0.934
0.496AlaTrp: 0.496 ± 0.381
3.471AlaTyr: 3.471 ± 0.971
0.0AlaXaa: 0.0 ± 0.0
Cys
0.496CysAla: 0.496 ± 0.445
0.0CysCys: 0.0 ± 0.0
0.992CysAsp: 0.992 ± 0.731
0.0CysGlu: 0.0 ± 0.0
0.496CysPhe: 0.496 ± 0.614
0.496CysGly: 0.496 ± 0.445
0.0CysHis: 0.0 ± 0.0
0.496CysIle: 0.496 ± 0.461
0.0CysLys: 0.0 ± 0.0
0.496CysLeu: 0.496 ± 0.485
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.496CysArg: 0.496 ± 0.381
0.496CysSer: 0.496 ± 0.515
0.0CysThr: 0.0 ± 0.0
0.496CysVal: 0.496 ± 0.445
0.0CysTrp: 0.0 ± 0.0
0.496CysTyr: 0.496 ± 0.539
0.0CysXaa: 0.0 ± 0.0
Asp
0.496AspAla: 0.496 ± 0.485
0.496AspCys: 0.496 ± 0.539
1.983AspAsp: 1.983 ± 0.828
4.958AspGlu: 4.958 ± 2.043
3.471AspPhe: 3.471 ± 0.829
2.975AspGly: 2.975 ± 1.336
0.496AspHis: 0.496 ± 0.515
7.933AspIle: 7.933 ± 1.727
8.428AspLys: 8.428 ± 1.616
2.975AspLeu: 2.975 ± 0.933
1.983AspMet: 1.983 ± 1.085
5.454AspAsn: 5.454 ± 1.636
0.992AspPro: 0.992 ± 0.593
0.0AspGln: 0.0 ± 0.0
1.487AspArg: 1.487 ± 0.865
6.941AspSer: 6.941 ± 2.565
3.471AspThr: 3.471 ± 1.415
3.471AspVal: 3.471 ± 1.235
0.0AspTrp: 0.0 ± 0.0
4.958AspTyr: 4.958 ± 1.753
0.0AspXaa: 0.0 ± 0.0
Glu
4.462GluAla: 4.462 ± 1.49
0.992GluCys: 0.992 ± 0.585
2.975GluAsp: 2.975 ± 1.058
3.966GluGlu: 3.966 ± 1.395
3.471GluPhe: 3.471 ± 1.047
2.479GluGly: 2.479 ± 0.874
0.0GluHis: 0.0 ± 0.0
5.949GluIle: 5.949 ± 1.381
4.462GluLys: 4.462 ± 1.331
11.403GluLeu: 11.403 ± 1.422
1.983GluMet: 1.983 ± 1.114
2.975GluAsn: 2.975 ± 0.807
3.966GluPro: 3.966 ± 1.218
3.966GluGln: 3.966 ± 1.593
5.949GluArg: 5.949 ± 2.117
2.479GluSer: 2.479 ± 0.843
3.966GluThr: 3.966 ± 1.405
1.983GluVal: 1.983 ± 1.069
0.496GluTrp: 0.496 ± 0.445
1.983GluTyr: 1.983 ± 0.922
0.0GluXaa: 0.0 ± 0.0
Phe
0.0PheAla: 0.0 ± 0.0
0.0PheCys: 0.0 ± 0.0
3.471PheAsp: 3.471 ± 1.336
3.471PheGlu: 3.471 ± 1.391
0.496PhePhe: 0.496 ± 0.445
2.975PheGly: 2.975 ± 0.906
0.496PheHis: 0.496 ± 0.381
3.966PheIle: 3.966 ± 1.295
4.462PheLys: 4.462 ± 1.099
5.454PheLeu: 5.454 ± 0.884
0.496PheMet: 0.496 ± 0.543
2.479PheAsn: 2.479 ± 0.876
0.992PhePro: 0.992 ± 0.593
0.992PheGln: 0.992 ± 0.82
1.983PheArg: 1.983 ± 0.929
1.983PheSer: 1.983 ± 1.217
1.487PheThr: 1.487 ± 0.84
0.992PheVal: 0.992 ± 0.648
0.0PheTrp: 0.0 ± 0.0
0.992PheTyr: 0.992 ± 0.677
0.0PheXaa: 0.0 ± 0.0
Gly
1.983GlyAla: 1.983 ± 0.999
1.487GlyCys: 1.487 ± 0.641
1.983GlyAsp: 1.983 ± 1.206
4.958GlyGlu: 4.958 ± 1.511
3.966GlyPhe: 3.966 ± 1.253
2.479GlyGly: 2.479 ± 1.44
0.496GlyHis: 0.496 ± 0.381
1.487GlyIle: 1.487 ± 0.68
3.471GlyLys: 3.471 ± 1.629
6.941GlyLeu: 6.941 ± 2.136
1.487GlyMet: 1.487 ± 0.729
0.992GlyAsn: 0.992 ± 0.922
0.0GlyPro: 0.0 ± 0.0
0.992GlyGln: 0.992 ± 0.789
1.983GlyArg: 1.983 ± 0.911
0.992GlySer: 0.992 ± 0.761
5.454GlyThr: 5.454 ± 2.079
5.949GlyVal: 5.949 ± 1.322
0.992GlyTrp: 0.992 ± 0.89
4.958GlyTyr: 4.958 ± 1.64
0.0GlyXaa: 0.0 ± 0.0
His
1.983HisAla: 1.983 ± 1.071
0.496HisCys: 0.496 ± 0.445
0.0HisAsp: 0.0 ± 0.0
1.487HisGlu: 1.487 ± 0.74
0.992HisPhe: 0.992 ± 0.761
1.487HisGly: 1.487 ± 0.878
0.0HisHis: 0.0 ± 0.0
0.992HisIle: 0.992 ± 0.473
0.496HisLys: 0.496 ± 0.381
0.496HisLeu: 0.496 ± 0.381
0.0HisMet: 0.0 ± 0.0
1.983HisAsn: 1.983 ± 1.277
1.983HisPro: 1.983 ± 1.404
0.992HisGln: 0.992 ± 0.793
0.496HisArg: 0.496 ± 0.381
0.496HisSer: 0.496 ± 0.381
1.983HisThr: 1.983 ± 0.617
0.496HisVal: 0.496 ± 0.381
0.0HisTrp: 0.0 ± 0.0
1.487HisTyr: 1.487 ± 0.622
0.0HisXaa: 0.0 ± 0.0
Ile
5.454IleAla: 5.454 ± 1.906
0.496IleCys: 0.496 ± 0.614
5.949IleAsp: 5.949 ± 1.144
5.454IleGlu: 5.454 ± 1.887
0.496IlePhe: 0.496 ± 0.461
2.479IleGly: 2.479 ± 0.805
1.983IleHis: 1.983 ± 0.953
5.454IleIle: 5.454 ± 1.768
5.949IleLys: 5.949 ± 2.168
5.454IleLeu: 5.454 ± 1.432
1.487IleMet: 1.487 ± 0.665
2.479IleAsn: 2.479 ± 1.249
1.983IlePro: 1.983 ± 0.814
2.975IleGln: 2.975 ± 1.653
0.496IleArg: 0.496 ± 0.445
3.471IleSer: 3.471 ± 1.288
4.958IleThr: 4.958 ± 1.07
1.983IleVal: 1.983 ± 0.867
0.992IleTrp: 0.992 ± 1.228
3.966IleTyr: 3.966 ± 1.563
0.0IleXaa: 0.0 ± 0.0
Lys
5.454LysAla: 5.454 ± 1.433
0.0LysCys: 0.0 ± 0.0
2.975LysAsp: 2.975 ± 0.993
7.437LysGlu: 7.437 ± 1.607
3.471LysPhe: 3.471 ± 1.087
6.445LysGly: 6.445 ± 1.677
2.975LysHis: 2.975 ± 1.061
5.454LysIle: 5.454 ± 1.117
13.386LysLys: 13.386 ± 3.638
5.949LysLeu: 5.949 ± 2.812
0.992LysMet: 0.992 ± 0.637
5.454LysAsn: 5.454 ± 1.442
3.471LysPro: 3.471 ± 1.755
7.437LysGln: 7.437 ± 2.001
9.42LysArg: 9.42 ± 1.468
5.454LysSer: 5.454 ± 1.054
2.975LysThr: 2.975 ± 0.773
6.445LysVal: 6.445 ± 1.705
0.0LysTrp: 0.0 ± 0.0
1.983LysTyr: 1.983 ± 0.767
0.0LysXaa: 0.0 ± 0.0
Leu
8.428LeuAla: 8.428 ± 2.204
0.496LeuCys: 0.496 ± 0.485
6.941LeuAsp: 6.941 ± 1.037
7.933LeuGlu: 7.933 ± 2.871
2.975LeuPhe: 2.975 ± 0.895
8.428LeuGly: 8.428 ± 1.947
1.983LeuHis: 1.983 ± 0.939
5.949LeuIle: 5.949 ± 1.313
8.428LeuLys: 8.428 ± 1.933
8.428LeuLeu: 8.428 ± 1.694
2.479LeuMet: 2.479 ± 1.079
4.958LeuAsn: 4.958 ± 1.569
2.975LeuPro: 2.975 ± 0.938
3.966LeuGln: 3.966 ± 1.406
3.471LeuArg: 3.471 ± 2.027
6.941LeuSer: 6.941 ± 1.456
5.949LeuThr: 5.949 ± 1.701
2.479LeuVal: 2.479 ± 1.371
0.496LeuTrp: 0.496 ± 0.529
0.992LeuTyr: 0.992 ± 0.628
0.0LeuXaa: 0.0 ± 0.0
Met
1.487MetAla: 1.487 ± 1.048
0.0MetCys: 0.0 ± 0.0
3.471MetAsp: 3.471 ± 0.972
0.0MetGlu: 0.0 ± 0.0
0.0MetPhe: 0.0 ± 0.0
0.0MetGly: 0.0 ± 0.0
0.0MetHis: 0.0 ± 0.0
1.487MetIle: 1.487 ± 0.761
2.479MetLys: 2.479 ± 1.248
1.487MetLeu: 1.487 ± 1.014
0.496MetMet: 0.496 ± 0.381
1.983MetAsn: 1.983 ± 0.742
0.496MetPro: 0.496 ± 0.461
0.496MetGln: 0.496 ± 0.518
0.992MetArg: 0.992 ± 0.922
1.983MetSer: 1.983 ± 1.337
2.975MetThr: 2.975 ± 1.335
2.479MetVal: 2.479 ± 1.397
0.496MetTrp: 0.496 ± 0.539
0.496MetTyr: 0.496 ± 0.614
0.0MetXaa: 0.0 ± 0.0
Asn
3.471AsnAla: 3.471 ± 1.147
0.0AsnCys: 0.0 ± 0.0
2.975AsnAsp: 2.975 ± 0.758
4.462AsnGlu: 4.462 ± 1.011
0.496AsnPhe: 0.496 ± 0.517
3.471AsnGly: 3.471 ± 1.043
1.983AsnHis: 1.983 ± 0.668
0.992AsnIle: 0.992 ± 0.761
5.949AsnLys: 5.949 ± 1.841
3.966AsnLeu: 3.966 ± 1.166
1.487AsnMet: 1.487 ± 1.162
3.966AsnAsn: 3.966 ± 1.385
1.487AsnPro: 1.487 ± 0.644
1.983AsnGln: 1.983 ± 1.03
2.479AsnArg: 2.479 ± 0.969
6.445AsnSer: 6.445 ± 2.426
6.445AsnThr: 6.445 ± 1.645
2.975AsnVal: 2.975 ± 1.119
0.0AsnTrp: 0.0 ± 0.0
3.471AsnTyr: 3.471 ± 0.863
0.0AsnXaa: 0.0 ± 0.0
Pro
1.487ProAla: 1.487 ± 0.637
0.0ProCys: 0.0 ± 0.0
1.983ProAsp: 1.983 ± 1.285
1.487ProGlu: 1.487 ± 0.883
1.487ProPhe: 1.487 ± 0.986
0.0ProGly: 0.0 ± 0.0
0.992ProHis: 0.992 ± 0.593
2.975ProIle: 2.975 ± 1.566
1.487ProLys: 1.487 ± 0.515
2.479ProLeu: 2.479 ± 0.874
0.992ProMet: 0.992 ± 0.575
1.983ProAsn: 1.983 ± 0.825
0.992ProPro: 0.992 ± 0.736
0.496ProGln: 0.496 ± 0.539
2.975ProArg: 2.975 ± 1.098
1.983ProSer: 1.983 ± 0.945
2.479ProThr: 2.479 ± 0.951
2.479ProVal: 2.479 ± 1.062
0.0ProTrp: 0.0 ± 0.0
1.487ProTyr: 1.487 ± 0.515
0.0ProXaa: 0.0 ± 0.0
Gln
2.479GlnAla: 2.479 ± 0.852
0.0GlnCys: 0.0 ± 0.0
0.992GlnAsp: 0.992 ± 0.669
2.975GlnGlu: 2.975 ± 0.72
1.983GlnPhe: 1.983 ± 0.822
2.975GlnGly: 2.975 ± 0.981
1.487GlnHis: 1.487 ± 0.734
2.975GlnIle: 2.975 ± 1.872
4.462GlnLys: 4.462 ± 1.255
2.975GlnLeu: 2.975 ± 1.321
0.496GlnMet: 0.496 ± 0.614
0.496GlnAsn: 0.496 ± 0.445
0.992GlnPro: 0.992 ± 0.704
1.487GlnGln: 1.487 ± 0.768
0.992GlnArg: 0.992 ± 0.89
2.975GlnSer: 2.975 ± 1.301
2.479GlnThr: 2.479 ± 0.907
2.975GlnVal: 2.975 ± 0.972
0.0GlnTrp: 0.0 ± 0.0
2.975GlnTyr: 2.975 ± 1.347
0.0GlnXaa: 0.0 ± 0.0
Arg
3.966ArgAla: 3.966 ± 1.795
0.0ArgCys: 0.0 ± 0.0
2.975ArgAsp: 2.975 ± 1.241
2.479ArgGlu: 2.479 ± 1.223
0.496ArgPhe: 0.496 ± 0.445
2.479ArgGly: 2.479 ± 1.028
1.487ArgHis: 1.487 ± 0.641
2.975ArgIle: 2.975 ± 0.892
3.471ArgLys: 3.471 ± 1.366
4.462ArgLeu: 4.462 ± 1.176
0.0ArgMet: 0.0 ± 0.0
3.471ArgAsn: 3.471 ± 1.32
0.992ArgPro: 0.992 ± 0.593
2.479ArgGln: 2.479 ± 1.175
0.992ArgArg: 0.992 ± 0.612
0.992ArgSer: 0.992 ± 0.922
3.471ArgThr: 3.471 ± 1.237
4.462ArgVal: 4.462 ± 1.241
0.496ArgTrp: 0.496 ± 0.518
3.966ArgTyr: 3.966 ± 0.86
0.0ArgXaa: 0.0 ± 0.0
Ser
1.983SerAla: 1.983 ± 1.033
0.0SerCys: 0.0 ± 0.0
6.941SerAsp: 6.941 ± 1.634
2.975SerGlu: 2.975 ± 1.625
3.471SerPhe: 3.471 ± 1.18
1.487SerGly: 1.487 ± 0.734
0.992SerHis: 0.992 ± 0.584
2.479SerIle: 2.479 ± 0.867
7.437SerLys: 7.437 ± 1.099
6.941SerLeu: 6.941 ± 1.243
0.992SerMet: 0.992 ± 0.584
4.462SerAsn: 4.462 ± 1.555
0.992SerPro: 0.992 ± 0.473
3.471SerGln: 3.471 ± 1.322
0.992SerArg: 0.992 ± 0.761
3.966SerSer: 3.966 ± 1.821
3.471SerThr: 3.471 ± 1.33
2.975SerVal: 2.975 ± 1.301
1.983SerTrp: 1.983 ± 1.369
3.966SerTyr: 3.966 ± 1.376
0.0SerXaa: 0.0 ± 0.0
Thr
3.966ThrAla: 3.966 ± 1.169
0.0ThrCys: 0.0 ± 0.0
6.445ThrAsp: 6.445 ± 1.572
1.983ThrGlu: 1.983 ± 0.778
1.487ThrPhe: 1.487 ± 0.705
5.454ThrGly: 5.454 ± 1.23
1.487ThrHis: 1.487 ± 0.898
2.975ThrIle: 2.975 ± 1.31
5.949ThrLys: 5.949 ± 1.524
4.462ThrLeu: 4.462 ± 1.38
3.966ThrMet: 3.966 ± 1.331
2.479ThrAsn: 2.479 ± 1.282
2.479ThrPro: 2.479 ± 1.222
1.487ThrGln: 1.487 ± 0.858
3.966ThrArg: 3.966 ± 2.016
2.479ThrSer: 2.479 ± 1.298
3.471ThrThr: 3.471 ± 1.341
7.437ThrVal: 7.437 ± 1.66
0.496ThrTrp: 0.496 ± 0.461
4.958ThrTyr: 4.958 ± 1.142
0.0ThrXaa: 0.0 ± 0.0
Val
3.471ValAla: 3.471 ± 1.245
0.496ValCys: 0.496 ± 0.515
2.479ValAsp: 2.479 ± 0.782
2.479ValGlu: 2.479 ± 1.033
1.983ValPhe: 1.983 ± 0.796
3.471ValGly: 3.471 ± 1.151
0.496ValHis: 0.496 ± 0.381
2.479ValIle: 2.479 ± 1.045
5.949ValLys: 5.949 ± 2.003
8.428ValLeu: 8.428 ± 1.71
0.496ValMet: 0.496 ± 0.608
2.479ValAsn: 2.479 ± 1.074
1.983ValPro: 1.983 ± 0.821
1.487ValGln: 1.487 ± 0.927
0.496ValArg: 0.496 ± 0.652
4.958ValSer: 4.958 ± 1.72
7.933ValThr: 7.933 ± 1.883
4.462ValVal: 4.462 ± 1.319
0.992ValTrp: 0.992 ± 0.89
1.983ValTyr: 1.983 ± 0.955
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
1.487TrpAsp: 1.487 ± 0.836
0.992TrpGlu: 0.992 ± 0.765
0.496TrpPhe: 0.496 ± 0.445
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.992TrpLys: 0.992 ± 0.685
1.983TrpLeu: 1.983 ± 1.417
0.496TrpMet: 0.496 ± 0.539
0.496TrpAsn: 0.496 ± 0.614
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.496TrpArg: 0.496 ± 0.445
0.992TrpSer: 0.992 ± 0.495
0.0TrpThr: 0.0 ± 0.0
0.0TrpVal: 0.0 ± 0.0
0.496TrpTrp: 0.496 ± 0.381
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.0TyrAla: 0.0 ± 0.0
0.496TyrCys: 0.496 ± 0.461
2.975TyrAsp: 2.975 ± 1.074
7.437TyrGlu: 7.437 ± 1.328
2.479TyrPhe: 2.479 ± 1.081
1.487TyrGly: 1.487 ± 0.827
0.992TyrHis: 0.992 ± 0.89
2.975TyrIle: 2.975 ± 1.293
4.462TyrLys: 4.462 ± 1.612
4.462TyrLeu: 4.462 ± 1.216
0.992TyrMet: 0.992 ± 0.804
3.966TyrAsn: 3.966 ± 1.509
2.479TyrPro: 2.479 ± 0.895
1.983TyrGln: 1.983 ± 0.955
3.966TyrArg: 3.966 ± 1.253
3.471TyrSer: 3.471 ± 0.762
1.487TyrThr: 1.487 ± 1.021
1.983TyrVal: 1.983 ± 0.703
0.496TyrTrp: 0.496 ± 0.485
2.975TyrTyr: 2.975 ± 1.086
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 14 proteins (2018 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski