Amino acid dipepetide frequency for Cyanobacterium stanieri (strain ATCC 29140 / PCC 7202)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.537AlaAla: 3.537 ± 0.086	0.666AlaCys: 0.666 ± 0.026	3.497AlaAsp: 3.497 ± 0.074	4.515AlaGlu: 4.515 ± 0.083	2.553AlaPhe: 2.553 ± 0.055	4.607AlaGly: 4.607 ± 0.092	1.359AlaHis: 1.359 ± 0.039	6.382AlaIle: 6.382 ± 0.099	3.874AlaLys: 3.874 ± 0.072	7.507AlaLeu: 7.507 ± 0.109	1.729AlaMet: 1.729 ± 0.043	3.02AlaAsn: 3.02 ± 0.087	2.409AlaPro: 2.409 ± 0.055	3.872AlaGln: 3.872 ± 0.073	2.948AlaArg: 2.948 ± 0.058	4.116AlaSer: 4.116 ± 0.067	3.734AlaThr: 3.734 ± 0.068	4.39AlaVal: 4.39 ± 0.072	0.834AlaTrp: 0.834 ± 0.038	2.058AlaTyr: 2.058 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	0.576CysAla: 0.576 ± 0.028	0.155CysCys: 0.155 ± 0.015	0.677CysAsp: 0.677 ± 0.027	0.589CysGlu: 0.589 ± 0.029	0.463CysPhe: 0.463 ± 0.025	0.852CysGly: 0.852 ± 0.034	0.288CysHis: 0.288 ± 0.019	0.556CysIle: 0.556 ± 0.027	0.35CysLys: 0.35 ± 0.019	1.175CysLeu: 1.175 ± 0.041	0.144CysMet: 0.144 ± 0.014	0.383CysAsn: 0.383 ± 0.02	0.545CysPro: 0.545 ± 0.028	0.555CysGln: 0.555 ± 0.024	0.475CysArg: 0.475 ± 0.025	0.58CysSer: 0.58 ± 0.029	0.449CysThr: 0.449 ± 0.024	0.569CysVal: 0.569 ± 0.029	0.157CysTrp: 0.157 ± 0.019	0.432CysTyr: 0.432 ± 0.028	0.0CysXaa: 0.0 ± 0.0
Asp	3.002AspAla: 3.002 ± 0.065	0.57AspCys: 0.57 ± 0.028	2.945AspAsp: 2.945 ± 0.066	3.296AspGlu: 3.296 ± 0.059	2.731AspPhe: 2.731 ± 0.06	3.39AspGly: 3.39 ± 0.063	0.964AspHis: 0.964 ± 0.04	4.227AspIle: 4.227 ± 0.072	2.796AspLys: 2.796 ± 0.062	6.303AspLeu: 6.303 ± 0.091	0.964AspMet: 0.964 ± 0.038	3.227AspAsn: 3.227 ± 0.053	1.97AspPro: 1.97 ± 0.047	2.046AspGln: 2.046 ± 0.053	2.64AspArg: 2.64 ± 0.06	3.112AspSer: 3.112 ± 0.062	2.557AspThr: 2.557 ± 0.049	3.112AspVal: 3.112 ± 0.062	0.812AspTrp: 0.812 ± 0.031	2.242AspTyr: 2.242 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	4.613GluAla: 4.613 ± 0.083	0.5GluCys: 0.5 ± 0.027	3.414GluAsp: 3.414 ± 0.067	5.443GluGlu: 5.443 ± 0.109	2.414GluPhe: 2.414 ± 0.048	3.898GluGly: 3.898 ± 0.077	0.944GluHis: 0.944 ± 0.035	5.736GluIle: 5.736 ± 0.084	5.272GluLys: 5.272 ± 0.1	6.666GluLeu: 6.666 ± 0.094	1.489GluMet: 1.489 ± 0.043	4.114GluAsn: 4.114 ± 0.08	1.943GluPro: 1.943 ± 0.051	3.27GluGln: 3.27 ± 0.068	2.832GluArg: 2.832 ± 0.063	3.53GluSer: 3.53 ± 0.069	3.497GluThr: 3.497 ± 0.063	4.254GluVal: 4.254 ± 0.061	0.72GluTrp: 0.72 ± 0.029	2.177GluTyr: 2.177 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	3.084PheAla: 3.084 ± 0.066	0.574PheCys: 0.574 ± 0.029	2.503PheAsp: 2.503 ± 0.05	2.326PheGlu: 2.326 ± 0.057	2.062PhePhe: 2.062 ± 0.061	2.95PheGly: 2.95 ± 0.065	0.72PheHis: 0.72 ± 0.029	3.06PheIle: 3.06 ± 0.067	1.778PheLys: 1.778 ± 0.044	4.564PheLeu: 4.564 ± 0.087	0.796PheMet: 0.796 ± 0.034	2.247PheAsn: 2.247 ± 0.057	1.874PhePro: 1.874 ± 0.046	1.515PheGln: 1.515 ± 0.044	1.755PheArg: 1.755 ± 0.047	3.215PheSer: 3.215 ± 0.065	2.322PheThr: 2.322 ± 0.053	2.593PheVal: 2.593 ± 0.067	0.644PheTrp: 0.644 ± 0.029	1.585PheTyr: 1.585 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	4.645GlyAla: 4.645 ± 0.097	0.808GlyCys: 0.808 ± 0.03	3.734GlyAsp: 3.734 ± 0.073	4.445GlyGlu: 4.445 ± 0.072	3.184GlyPhe: 3.184 ± 0.064	4.844GlyGly: 4.844 ± 0.088	1.162GlyHis: 1.162 ± 0.045	5.657GlyIle: 5.657 ± 0.098	4.321GlyLys: 4.321 ± 0.085	6.511GlyLeu: 6.511 ± 0.099	1.555GlyMet: 1.555 ± 0.045	3.324GlyAsn: 3.324 ± 0.069	1.081GlyPro: 1.081 ± 0.037	2.439GlyGln: 2.439 ± 0.06	2.814GlyArg: 2.814 ± 0.062	3.719GlySer: 3.719 ± 0.063	3.215GlyThr: 3.215 ± 0.062	4.91GlyVal: 4.91 ± 0.088	1.059GlyTrp: 1.059 ± 0.036	2.54GlyTyr: 2.54 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	0.809HisAla: 0.809 ± 0.035	0.288HisCys: 0.288 ± 0.017	0.874HisAsp: 0.874 ± 0.039	0.862HisGlu: 0.862 ± 0.031	0.847HisPhe: 0.847 ± 0.029	1.324HisGly: 1.324 ± 0.039	0.777HisHis: 0.777 ± 0.044	1.289HisIle: 1.289 ± 0.038	0.874HisLys: 0.874 ± 0.032	2.161HisLeu: 2.161 ± 0.055	0.189HisMet: 0.189 ± 0.014	0.952HisAsn: 0.952 ± 0.034	1.186HisPro: 1.186 ± 0.045	1.269HisGln: 1.269 ± 0.032	1.034HisArg: 1.034 ± 0.035	1.178HisSer: 1.178 ± 0.037	0.886HisThr: 0.886 ± 0.03	0.755HisVal: 0.755 ± 0.031	0.346HisTrp: 0.346 ± 0.023	0.702HisTyr: 0.702 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	6.951IleAla: 6.951 ± 0.099	0.835IleCys: 0.835 ± 0.032	4.49IleAsp: 4.49 ± 0.075	4.987IleGlu: 4.987 ± 0.081	3.364IlePhe: 3.364 ± 0.075	4.806IleGly: 4.806 ± 0.083	1.356IleHis: 1.356 ± 0.039	6.109IleIle: 6.109 ± 0.088	4.565IleLys: 4.565 ± 0.078	7.814IleLeu: 7.814 ± 0.116	1.17IleMet: 1.17 ± 0.04	4.728IleAsn: 4.728 ± 0.083	4.06IlePro: 4.06 ± 0.063	2.693IleGln: 2.693 ± 0.06	3.245IleArg: 3.245 ± 0.065	5.095IleSer: 5.095 ± 0.085	4.737IleThr: 4.737 ± 0.086	4.706IleVal: 4.706 ± 0.079	0.873IleTrp: 0.873 ± 0.035	2.404IleTyr: 2.404 ± 0.057	0.0IleXaa: 0.0 ± 0.0
Lys	3.915LysAla: 3.915 ± 0.076	0.409LysCys: 0.409 ± 0.021	2.786LysAsp: 2.786 ± 0.061	4.181LysGlu: 4.181 ± 0.084	1.923LysPhe: 1.923 ± 0.046	3.155LysGly: 3.155 ± 0.067	0.792LysHis: 0.792 ± 0.032	5.117LysIle: 5.117 ± 0.098	4.174LysLys: 4.174 ± 0.091	5.667LysLeu: 5.667 ± 0.099	1.324LysMet: 1.324 ± 0.04	3.255LysAsn: 3.255 ± 0.077	2.439LysPro: 2.439 ± 0.056	2.739LysGln: 2.739 ± 0.065	2.343LysArg: 2.343 ± 0.056	3.236LysSer: 3.236 ± 0.062	3.33LysThr: 3.33 ± 0.066	3.541LysVal: 3.541 ± 0.073	0.592LysTrp: 0.592 ± 0.032	1.956LysTyr: 1.956 ± 0.051	0.0LysXaa: 0.0 ± 0.0
Leu	7.816LeuAla: 7.816 ± 0.105	0.96LeuCys: 0.96 ± 0.032	5.718LeuAsp: 5.718 ± 0.084	7.517LeuGlu: 7.517 ± 0.118	4.093LeuPhe: 4.093 ± 0.08	7.427LeuGly: 7.427 ± 0.108	1.757LeuHis: 1.757 ± 0.047	8.057LeuIle: 8.057 ± 0.117	6.301LeuLys: 6.301 ± 0.1	10.222LeuLeu: 10.222 ± 0.149	2.219LeuMet: 2.219 ± 0.054	5.261LeuAsn: 5.261 ± 0.087	5.054LeuPro: 5.054 ± 0.075	4.747LeuGln: 4.747 ± 0.073	4.623LeuArg: 4.623 ± 0.075	7.41LeuSer: 7.41 ± 0.09	6.26LeuThr: 6.26 ± 0.084	6.748LeuVal: 6.748 ± 0.104	1.269LeuTrp: 1.269 ± 0.037	2.675LeuTyr: 2.675 ± 0.068	0.0LeuXaa: 0.0 ± 0.0
Met	1.844MetAla: 1.844 ± 0.056	0.138MetCys: 0.138 ± 0.013	1.066MetAsp: 1.066 ± 0.034	1.345MetGlu: 1.345 ± 0.043	0.585MetPhe: 0.585 ± 0.023	1.724MetGly: 1.724 ± 0.05	0.216MetHis: 0.216 ± 0.018	1.625MetIle: 1.625 ± 0.047	1.142MetLys: 1.142 ± 0.04	1.855MetLeu: 1.855 ± 0.041	0.563MetMet: 0.563 ± 0.028	1.06MetAsn: 1.06 ± 0.034	0.836MetPro: 0.836 ± 0.033	0.606MetGln: 0.606 ± 0.029	0.884MetArg: 0.884 ± 0.037	1.325MetSer: 1.325 ± 0.039	1.35MetThr: 1.35 ± 0.043	1.627MetVal: 1.627 ± 0.05	0.185MetTrp: 0.185 ± 0.013	0.404MetTyr: 0.404 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.9AsnAla: 2.9 ± 0.057	0.528AsnCys: 0.528 ± 0.023	2.222AsnAsp: 2.222 ± 0.051	2.217AsnGlu: 2.217 ± 0.048	2.419AsnPhe: 2.419 ± 0.063	2.85AsnGly: 2.85 ± 0.071	1.275AsnHis: 1.275 ± 0.039	4.38AsnIle: 4.38 ± 0.087	2.665AsnLys: 2.665 ± 0.056	6.668AsnLeu: 6.668 ± 0.13	0.948AsnMet: 0.948 ± 0.033	3.554AsnAsn: 3.554 ± 0.09	3.452AsnPro: 3.452 ± 0.068	3.342AsnGln: 3.342 ± 0.065	2.477AsnArg: 2.477 ± 0.053	3.416AsnSer: 3.416 ± 0.071	2.521AsnThr: 2.521 ± 0.061	2.609AsnVal: 2.609 ± 0.055	0.781AsnTrp: 0.781 ± 0.029	2.201AsnTyr: 2.201 ± 0.054	0.0AsnXaa: 0.0 ± 0.0
Pro	2.262ProAla: 2.262 ± 0.05	0.371ProCys: 0.371 ± 0.018	2.823ProAsp: 2.823 ± 0.063	3.812ProGlu: 3.812 ± 0.071	1.896ProPhe: 1.896 ± 0.049	1.927ProGly: 1.927 ± 0.052	1.061ProHis: 1.061 ± 0.033	3.091ProIle: 3.091 ± 0.055	1.932ProLys: 1.932 ± 0.052	4.63ProLeu: 4.63 ± 0.076	0.852ProMet: 0.852 ± 0.035	2.183ProAsn: 2.183 ± 0.053	2.09ProPro: 2.09 ± 0.063	2.367ProGln: 2.367 ± 0.044	1.714ProArg: 1.714 ± 0.042	2.922ProSer: 2.922 ± 0.063	2.375ProThr: 2.375 ± 0.053	2.767ProVal: 2.767 ± 0.054	0.589ProTrp: 0.589 ± 0.026	1.402ProTyr: 1.402 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	3.218GlnAla: 3.218 ± 0.052	0.331GlnCys: 0.331 ± 0.023	2.214GlnAsp: 2.214 ± 0.055	4.12GlnGlu: 4.12 ± 0.084	1.649GlnPhe: 1.649 ± 0.049	3.391GlnGly: 3.391 ± 0.065	0.604GlnHis: 0.604 ± 0.028	3.65GlnIle: 3.65 ± 0.062	3.447GlnLys: 3.447 ± 0.079	4.73GlnLeu: 4.73 ± 0.091	0.959GlnMet: 0.959 ± 0.035	2.513GlnAsn: 2.513 ± 0.053	2.025GlnPro: 2.025 ± 0.051	2.657GlnGln: 2.657 ± 0.07	2.248GlnArg: 2.248 ± 0.054	2.7GlnSer: 2.7 ± 0.069	2.414GlnThr: 2.414 ± 0.056	2.959GlnVal: 2.959 ± 0.065	0.74GlnTrp: 0.74 ± 0.025	1.293GlnTyr: 1.293 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	2.897ArgAla: 2.897 ± 0.067	0.446ArgCys: 0.446 ± 0.022	2.429ArgAsp: 2.429 ± 0.055	3.193ArgGlu: 3.193 ± 0.065	1.961ArgPhe: 1.961 ± 0.046	2.893ArgGly: 2.893 ± 0.065	0.888ArgHis: 0.888 ± 0.033	3.165ArgIle: 3.165 ± 0.058	2.438ArgLys: 2.438 ± 0.053	5.014ArgLeu: 5.014 ± 0.078	0.922ArgMet: 0.922 ± 0.036	2.196ArgAsn: 2.196 ± 0.049	1.658ArgPro: 1.658 ± 0.05	2.54ArgGln: 2.54 ± 0.058	2.334ArgArg: 2.334 ± 0.063	2.388ArgSer: 2.388 ± 0.056	2.221ArgThr: 2.221 ± 0.053	2.948ArgVal: 2.948 ± 0.06	0.655ArgTrp: 0.655 ± 0.027	1.657ArgTyr: 1.657 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	4.306SerAla: 4.306 ± 0.066	0.674SerCys: 0.674 ± 0.026	2.861SerAsp: 2.861 ± 0.059	3.57SerGlu: 3.57 ± 0.07	2.909SerPhe: 2.909 ± 0.064	4.15SerGly: 4.15 ± 0.07	1.395SerHis: 1.395 ± 0.037	4.459SerIle: 4.459 ± 0.074	2.796SerLys: 2.796 ± 0.058	7.456SerLeu: 7.456 ± 0.094	1.312SerMet: 1.312 ± 0.036	3.054SerAsn: 3.054 ± 0.063	3.237SerPro: 3.237 ± 0.067	3.193SerGln: 3.193 ± 0.07	3.005SerArg: 3.005 ± 0.055	4.332SerSer: 4.332 ± 0.071	3.011SerThr: 3.011 ± 0.056	3.627SerVal: 3.627 ± 0.064	0.885SerTrp: 0.885 ± 0.032	1.986SerTyr: 1.986 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	3.609ThrAla: 3.609 ± 0.077	0.482ThrCys: 0.482 ± 0.025	2.618ThrAsp: 2.618 ± 0.051	3.378ThrGlu: 3.378 ± 0.066	2.23ThrPhe: 2.23 ± 0.053	3.906ThrGly: 3.906 ± 0.074	0.954ThrHis: 0.954 ± 0.033	4.719ThrIle: 4.719 ± 0.072	2.691ThrLys: 2.691 ± 0.055	5.777ThrLeu: 5.777 ± 0.073	1.067ThrMet: 1.067 ± 0.036	2.62ThrAsn: 2.62 ± 0.05	3.179ThrPro: 3.179 ± 0.064	2.336ThrGln: 2.336 ± 0.049	2.167ThrArg: 2.167 ± 0.049	3.049ThrSer: 3.049 ± 0.065	2.971ThrThr: 2.971 ± 0.066	3.708ThrVal: 3.708 ± 0.067	0.573ThrTrp: 0.573 ± 0.025	1.485ThrTyr: 1.485 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	4.9ValAla: 4.9 ± 0.091	0.661ValCys: 0.661 ± 0.028	3.529ValAsp: 3.529 ± 0.072	4.22ValGlu: 4.22 ± 0.081	2.618ValPhe: 2.618 ± 0.055	4.554ValGly: 4.554 ± 0.083	0.891ValHis: 0.891 ± 0.036	4.903ValIle: 4.903 ± 0.074	3.642ValLys: 3.642 ± 0.061	5.682ValLeu: 5.682 ± 0.078	1.439ValMet: 1.439 ± 0.042	3.529ValAsn: 3.529 ± 0.064	2.171ValPro: 2.171 ± 0.06	2.115ValGln: 2.115 ± 0.048	2.8ValArg: 2.8 ± 0.062	4.188ValSer: 4.188 ± 0.074	3.747ValThr: 3.747 ± 0.063	4.476ValVal: 4.476 ± 0.086	0.731ValTrp: 0.731 ± 0.03	1.925ValTyr: 1.925 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.808TrpAla: 0.808 ± 0.029	0.142TrpCys: 0.142 ± 0.013	0.665TrpAsp: 0.665 ± 0.028	0.884TrpGlu: 0.884 ± 0.04	0.607TrpPhe: 0.607 ± 0.027	1.039TrpGly: 1.039 ± 0.04	0.348TrpHis: 0.348 ± 0.021	0.768TrpIle: 0.768 ± 0.03	0.511TrpLys: 0.511 ± 0.022	1.83TrpLeu: 1.83 ± 0.048	0.286TrpMet: 0.286 ± 0.02	0.585TrpAsn: 0.585 ± 0.026	0.146TrpPro: 0.146 ± 0.013	1.234TrpGln: 1.234 ± 0.049	0.708TrpArg: 0.708 ± 0.031	0.754TrpSer: 0.754 ± 0.034	0.503TrpThr: 0.503 ± 0.026	0.711TrpVal: 0.711 ± 0.03	0.22TrpTrp: 0.22 ± 0.018	0.422TrpTyr: 0.422 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.918TyrAla: 1.918 ± 0.044	0.433TyrCys: 0.433 ± 0.023	1.838TyrAsp: 1.838 ± 0.047	1.827TyrGlu: 1.827 ± 0.049	1.658TyrPhe: 1.658 ± 0.046	2.281TyrGly: 2.281 ± 0.058	0.853TyrHis: 0.853 ± 0.034	2.038TyrIle: 2.038 ± 0.044	1.304TyrLys: 1.304 ± 0.039	3.9TyrLeu: 3.9 ± 0.065	0.454TyrMet: 0.454 ± 0.024	1.622TyrAsn: 1.622 ± 0.039	1.711TyrPro: 1.711 ± 0.042	2.326TyrGln: 2.326 ± 0.054	1.799TyrArg: 1.799 ± 0.051	1.952TyrSer: 1.952 ± 0.051	1.417TyrThr: 1.417 ± 0.043	1.713TyrVal: 1.713 ± 0.046	0.505TyrTrp: 0.505 ± 0.025	1.309TyrTyr: 1.309 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2831 proteins (902738 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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