Amino acid dipepetide frequency for Kaistia soli DSM 19436

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.001AlaAla: 20.001 ± 0.182
0.887AlaCys: 0.887 ± 0.026
7.498AlaAsp: 7.498 ± 0.074
7.99AlaGlu: 7.99 ± 0.09
4.982AlaPhe: 4.982 ± 0.05
11.763AlaGly: 11.763 ± 0.096
2.167AlaHis: 2.167 ± 0.041
7.539AlaIle: 7.539 ± 0.086
3.863AlaLys: 3.863 ± 0.062
14.313AlaLeu: 14.313 ± 0.13
3.609AlaMet: 3.609 ± 0.045
2.812AlaAsn: 2.812 ± 0.044
5.971AlaPro: 5.971 ± 0.082
3.091AlaGln: 3.091 ± 0.051
9.027AlaArg: 9.027 ± 0.093
7.182AlaSer: 7.182 ± 0.083
6.703AlaThr: 6.703 ± 0.075
9.616AlaVal: 9.616 ± 0.076
1.525AlaTrp: 1.525 ± 0.034
2.551AlaTyr: 2.551 ± 0.041
0.0AlaXaa: 0.0 ± 0.0
Cys
0.747CysAla: 0.747 ± 0.022
0.098CysCys: 0.098 ± 0.008
0.441CysAsp: 0.441 ± 0.015
0.323CysGlu: 0.323 ± 0.014
0.279CysPhe: 0.279 ± 0.014
0.757CysGly: 0.757 ± 0.026
0.223CysHis: 0.223 ± 0.014
0.355CysIle: 0.355 ± 0.015
0.117CysLys: 0.117 ± 0.009
0.686CysLeu: 0.686 ± 0.024
0.117CysMet: 0.117 ± 0.009
0.17CysAsn: 0.17 ± 0.009
0.374CysPro: 0.374 ± 0.017
0.172CysGln: 0.172 ± 0.011
0.551CysArg: 0.551 ± 0.02
0.384CysSer: 0.384 ± 0.016
0.359CysThr: 0.359 ± 0.016
0.493CysVal: 0.493 ± 0.019
0.094CysTrp: 0.094 ± 0.008
0.16CysTyr: 0.16 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
7.414AspAla: 7.414 ± 0.077
0.454AspCys: 0.454 ± 0.017
3.133AspAsp: 3.133 ± 0.051
3.417AspGlu: 3.417 ± 0.043
2.261AspPhe: 2.261 ± 0.041
5.483AspGly: 5.483 ± 0.07
1.278AspHis: 1.278 ± 0.033
3.192AspIle: 3.192 ± 0.043
1.582AspLys: 1.582 ± 0.036
5.813AspLeu: 5.813 ± 0.061
1.226AspMet: 1.226 ± 0.029
1.253AspAsn: 1.253 ± 0.035
3.766AspPro: 3.766 ± 0.049
1.657AspGln: 1.657 ± 0.03
4.464AspArg: 4.464 ± 0.06
2.164AspSer: 2.164 ± 0.039
2.495AspThr: 2.495 ± 0.044
4.192AspVal: 4.192 ± 0.049
0.993AspTrp: 0.993 ± 0.025
1.466AspTyr: 1.466 ± 0.028
0.0AspXaa: 0.0 ± 0.0
Glu
8.157GluAla: 8.157 ± 0.094
0.273GluCys: 0.273 ± 0.014
2.542GluAsp: 2.542 ± 0.044
2.615GluGlu: 2.615 ± 0.053
1.584GluPhe: 1.584 ± 0.037
4.216GluGly: 4.216 ± 0.054
1.046GluHis: 1.046 ± 0.028
3.426GluIle: 3.426 ± 0.054
1.818GluLys: 1.818 ± 0.04
4.835GluLeu: 4.835 ± 0.063
1.351GluMet: 1.351 ± 0.029
1.321GluAsn: 1.321 ± 0.029
2.914GluPro: 2.914 ± 0.05
1.746GluGln: 1.746 ± 0.034
4.716GluArg: 4.716 ± 0.063
2.257GluSer: 2.257 ± 0.037
3.535GluThr: 3.535 ± 0.048
3.501GluVal: 3.501 ± 0.051
0.621GluTrp: 0.621 ± 0.021
0.788GluTyr: 0.788 ± 0.025
0.0GluXaa: 0.0 ± 0.0
Phe
4.939PheAla: 4.939 ± 0.058
0.339PheCys: 0.339 ± 0.014
2.701PheAsp: 2.701 ± 0.046
2.127PheGlu: 2.127 ± 0.038
1.525PhePhe: 1.525 ± 0.035
3.976PheGly: 3.976 ± 0.06
0.744PheHis: 0.744 ± 0.022
1.765PheIle: 1.765 ± 0.036
0.931PheLys: 0.931 ± 0.026
3.593PheLeu: 3.593 ± 0.058
0.806PheMet: 0.806 ± 0.025
1.061PheAsn: 1.061 ± 0.025
1.678PhePro: 1.678 ± 0.032
0.996PheGln: 0.996 ± 0.024
2.298PheArg: 2.298 ± 0.041
2.211PheSer: 2.211 ± 0.037
1.913PheThr: 1.913 ± 0.038
3.133PheVal: 3.133 ± 0.047
0.585PheTrp: 0.585 ± 0.021
0.886PheTyr: 0.886 ± 0.025
0.0PheXaa: 0.0 ± 0.0
Gly
10.136GlyAla: 10.136 ± 0.086
0.72GlyCys: 0.72 ± 0.026
4.579GlyAsp: 4.579 ± 0.074
4.561GlyGlu: 4.561 ± 0.055
3.76GlyPhe: 3.76 ± 0.053
7.86GlyGly: 7.86 ± 0.108
1.904GlyHis: 1.904 ± 0.04
5.084GlyIle: 5.084 ± 0.061
3.07GlyLys: 3.07 ± 0.052
9.375GlyLeu: 9.375 ± 0.096
2.163GlyMet: 2.163 ± 0.039
2.125GlyAsn: 2.125 ± 0.05
3.868GlyPro: 3.868 ± 0.053
2.56GlyGln: 2.56 ± 0.041
6.676GlyArg: 6.676 ± 0.075
5.031GlySer: 5.031 ± 0.075
4.834GlyThr: 4.834 ± 0.077
6.328GlyVal: 6.328 ± 0.096
1.476GlyTrp: 1.476 ± 0.035
2.304GlyTyr: 2.304 ± 0.045
0.0GlyXaa: 0.0 ± 0.0
His
2.355HisAla: 2.355 ± 0.045
0.189HisCys: 0.189 ± 0.012
1.269HisAsp: 1.269 ± 0.035
1.004HisGlu: 1.004 ± 0.022
0.86HisPhe: 0.86 ± 0.026
1.893HisGly: 1.893 ± 0.035
0.559HisHis: 0.559 ± 0.022
0.911HisIle: 0.911 ± 0.025
0.384HisLys: 0.384 ± 0.017
2.031HisLeu: 2.031 ± 0.04
0.426HisMet: 0.426 ± 0.015
0.37HisAsn: 0.37 ± 0.016
1.352HisPro: 1.352 ± 0.033
0.56HisGln: 0.56 ± 0.02
1.423HisArg: 1.423 ± 0.035
0.855HisSer: 0.855 ± 0.025
0.722HisThr: 0.722 ± 0.021
1.526HisVal: 1.526 ± 0.032
0.303HisTrp: 0.303 ± 0.013
0.52HisTyr: 0.52 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
8.548IleAla: 8.548 ± 0.072
0.45IleCys: 0.45 ± 0.019
3.985IleAsp: 3.985 ± 0.052
3.792IleGlu: 3.792 ± 0.055
1.818IlePhe: 1.818 ± 0.037
5.724IleGly: 5.724 ± 0.067
0.919IleHis: 0.919 ± 0.024
2.513IleIle: 2.513 ± 0.045
1.299IleLys: 1.299 ± 0.033
4.73IleLeu: 4.73 ± 0.057
0.973IleMet: 0.973 ± 0.027
1.358IleAsn: 1.358 ± 0.033
2.432IlePro: 2.432 ± 0.04
1.109IleGln: 1.109 ± 0.026
3.51IleArg: 3.51 ± 0.048
2.892IleSer: 2.892 ± 0.051
2.719IleThr: 2.719 ± 0.049
4.813IleVal: 4.813 ± 0.052
0.624IleTrp: 0.624 ± 0.018
1.151IleTyr: 1.151 ± 0.029
0.0IleXaa: 0.0 ± 0.0
Lys
4.184LysAla: 4.184 ± 0.062
0.108LysCys: 0.108 ± 0.009
1.544LysAsp: 1.544 ± 0.035
1.248LysGlu: 1.248 ± 0.032
0.748LysPhe: 0.748 ± 0.023
2.395LysGly: 2.395 ± 0.044
0.488LysHis: 0.488 ± 0.018
1.523LysIle: 1.523 ± 0.034
1.021LysLys: 1.021 ± 0.032
2.905LysLeu: 2.905 ± 0.046
0.585LysMet: 0.585 ± 0.021
0.719LysAsn: 0.719 ± 0.023
1.996LysPro: 1.996 ± 0.04
0.815LysGln: 0.815 ± 0.024
2.198LysArg: 2.198 ± 0.042
1.683LysSer: 1.683 ± 0.033
1.819LysThr: 1.819 ± 0.034
2.19LysVal: 2.19 ± 0.038
0.324LysTrp: 0.324 ± 0.016
0.491LysTyr: 0.491 ± 0.019
0.001LysXaa: 0.001 ± 0.001
Leu
14.936LeuAla: 14.936 ± 0.113
0.747LeuCys: 0.747 ± 0.023
6.262LeuAsp: 6.262 ± 0.067
4.573LeuGlu: 4.573 ± 0.066
3.816LeuPhe: 3.816 ± 0.058
8.774LeuGly: 8.774 ± 0.081
1.79LeuHis: 1.79 ± 0.039
5.451LeuIle: 5.451 ± 0.068
3.235LeuLys: 3.235 ± 0.047
9.294LeuLeu: 9.294 ± 0.112
2.287LeuMet: 2.287 ± 0.04
2.235LeuAsn: 2.235 ± 0.04
5.837LeuPro: 5.837 ± 0.07
2.537LeuGln: 2.537 ± 0.037
6.223LeuArg: 6.223 ± 0.067
6.324LeuSer: 6.324 ± 0.069
5.503LeuThr: 5.503 ± 0.068
8.233LeuVal: 8.233 ± 0.084
1.12LeuTrp: 1.12 ± 0.025
2.085LeuTyr: 2.085 ± 0.039
0.0LeuXaa: 0.0 ± 0.0
Met
3.078MetAla: 3.078 ± 0.047
0.103MetCys: 0.103 ± 0.008
1.026MetAsp: 1.026 ± 0.023
0.929MetGlu: 0.929 ± 0.026
0.662MetPhe: 0.662 ± 0.023
1.555MetGly: 1.555 ± 0.032
0.402MetHis: 0.402 ± 0.016
1.426MetIle: 1.426 ± 0.027
0.842MetLys: 0.842 ± 0.023
2.495MetLeu: 2.495 ± 0.042
0.63MetMet: 0.63 ± 0.022
0.722MetAsn: 0.722 ± 0.022
1.526MetPro: 1.526 ± 0.03
0.744MetGln: 0.744 ± 0.02
1.76MetArg: 1.76 ± 0.033
1.631MetSer: 1.631 ± 0.031
1.946MetThr: 1.946 ± 0.032
1.664MetVal: 1.664 ± 0.036
0.173MetTrp: 0.173 ± 0.01
0.246MetTyr: 0.246 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
3.03AsnAla: 3.03 ± 0.045
0.193AsnCys: 0.193 ± 0.012
1.295AsnAsp: 1.295 ± 0.032
1.131AsnGlu: 1.131 ± 0.027
0.907AsnPhe: 0.907 ± 0.026
2.341AsnGly: 2.341 ± 0.046
0.432AsnHis: 0.432 ± 0.016
1.289AsnIle: 1.289 ± 0.034
0.588AsnLys: 0.588 ± 0.022
2.358AsnLeu: 2.358 ± 0.04
0.513AsnMet: 0.513 ± 0.018
0.657AsnAsn: 0.657 ± 0.026
1.731AsnPro: 1.731 ± 0.033
0.717AsnGln: 0.717 ± 0.022
1.645AsnArg: 1.645 ± 0.032
1.167AsnSer: 1.167 ± 0.038
1.133AsnThr: 1.133 ± 0.032
1.825AsnVal: 1.825 ± 0.04
0.42AsnTrp: 0.42 ± 0.017
0.61AsnTyr: 0.61 ± 0.022
0.0AsnXaa: 0.0 ± 0.0
Pro
6.942ProAla: 6.942 ± 0.089
0.271ProCys: 0.271 ± 0.013
3.747ProAsp: 3.747 ± 0.06
3.402ProGlu: 3.402 ± 0.05
2.137ProPhe: 2.137 ± 0.04
4.803ProGly: 4.803 ± 0.059
1.09ProHis: 1.09 ± 0.026
2.73ProIle: 2.73 ± 0.036
1.602ProLys: 1.602 ± 0.035
5.061ProLeu: 5.061 ± 0.058
1.265ProMet: 1.265 ± 0.026
1.312ProAsn: 1.312 ± 0.035
2.948ProPro: 2.948 ± 0.058
1.419ProGln: 1.419 ± 0.032
3.092ProArg: 3.092 ± 0.045
2.995ProSer: 2.995 ± 0.047
2.76ProThr: 2.76 ± 0.042
4.35ProVal: 4.35 ± 0.053
0.696ProTrp: 0.696 ± 0.02
1.17ProTyr: 1.17 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
3.418GlnAla: 3.418 ± 0.05
0.135GlnCys: 0.135 ± 0.009
1.217GlnAsp: 1.217 ± 0.029
1.088GlnGlu: 1.088 ± 0.028
0.996GlnPhe: 0.996 ± 0.027
2.03GlnGly: 2.03 ± 0.039
0.582GlnHis: 0.582 ± 0.02
1.627GlnIle: 1.627 ± 0.034
0.953GlnLys: 0.953 ± 0.027
2.678GlnLeu: 2.678 ± 0.044
0.748GlnMet: 0.748 ± 0.02
0.717GlnAsn: 0.717 ± 0.022
1.702GlnPro: 1.702 ± 0.04
1.097GlnGln: 1.097 ± 0.03
2.27GlnArg: 2.27 ± 0.039
1.677GlnSer: 1.677 ± 0.03
1.507GlnThr: 1.507 ± 0.035
1.886GlnVal: 1.886 ± 0.038
0.356GlnTrp: 0.356 ± 0.017
0.54GlnTyr: 0.54 ± 0.02
0.0GlnXaa: 0.0 ± 0.0
Arg
8.089ArgAla: 8.089 ± 0.087
0.417ArgCys: 0.417 ± 0.016
3.898ArgAsp: 3.898 ± 0.058
3.652ArgGlu: 3.652 ± 0.049
3.091ArgPhe: 3.091 ± 0.049
4.959ArgGly: 4.959 ± 0.061
1.699ArgHis: 1.699 ± 0.036
4.372ArgIle: 4.372 ± 0.057
1.825ArgLys: 1.825 ± 0.039
8.263ArgLeu: 8.263 ± 0.097
1.786ArgMet: 1.786 ± 0.032
1.614ArgAsn: 1.614 ± 0.034
3.738ArgPro: 3.738 ± 0.057
2.374ArgGln: 2.374 ± 0.045
5.962ArgArg: 5.962 ± 0.075
3.878ArgSer: 3.878 ± 0.056
3.239ArgThr: 3.239 ± 0.048
4.699ArgVal: 4.699 ± 0.052
0.991ArgTrp: 0.991 ± 0.027
1.661ArgTyr: 1.661 ± 0.033
0.0ArgXaa: 0.0 ± 0.0
Ser
6.542SerAla: 6.542 ± 0.074
0.343SerCys: 0.343 ± 0.015
3.063SerAsp: 3.063 ± 0.046
2.844SerGlu: 2.844 ± 0.045
2.387SerPhe: 2.387 ± 0.04
5.878SerGly: 5.878 ± 0.08
1.045SerHis: 1.045 ± 0.028
3.088SerIle: 3.088 ± 0.047
1.435SerLys: 1.435 ± 0.033
5.604SerLeu: 5.604 ± 0.066
1.276SerMet: 1.276 ± 0.025
1.346SerAsn: 1.346 ± 0.029
2.846SerPro: 2.846 ± 0.045
1.399SerGln: 1.399 ± 0.033
3.526SerArg: 3.526 ± 0.046
3.022SerSer: 3.022 ± 0.054
2.715SerThr: 2.715 ± 0.043
4.137SerVal: 4.137 ± 0.054
0.776SerTrp: 0.776 ± 0.022
1.266SerTyr: 1.266 ± 0.03
0.0SerXaa: 0.0 ± 0.0
Thr
6.737ThrAla: 6.737 ± 0.075
0.348ThrCys: 0.348 ± 0.016
2.877ThrAsp: 2.877 ± 0.044
2.601ThrGlu: 2.601 ± 0.041
2.079ThrPhe: 2.079 ± 0.038
5.007ThrGly: 5.007 ± 0.066
0.968ThrHis: 0.968 ± 0.025
3.337ThrIle: 3.337 ± 0.05
1.329ThrLys: 1.329 ± 0.032
5.901ThrLeu: 5.901 ± 0.069
1.252ThrMet: 1.252 ± 0.028
1.217ThrAsn: 1.217 ± 0.029
3.222ThrPro: 3.222 ± 0.05
1.128ThrGln: 1.128 ± 0.026
3.301ThrArg: 3.301 ± 0.049
2.795ThrSer: 2.795 ± 0.044
3.036ThrThr: 3.036 ± 0.058
4.635ThrVal: 4.635 ± 0.065
0.622ThrTrp: 0.622 ± 0.025
1.103ThrTyr: 1.103 ± 0.028
0.0ThrXaa: 0.0 ± 0.0
Val
10.257ValAla: 10.257 ± 0.09
0.496ValCys: 0.496 ± 0.018
4.609ValAsp: 4.609 ± 0.051
4.373ValGlu: 4.373 ± 0.061
2.85ValPhe: 2.85 ± 0.042
6.035ValGly: 6.035 ± 0.093
1.399ValHis: 1.399 ± 0.028
4.205ValIle: 4.205 ± 0.049
2.117ValLys: 2.117 ± 0.044
7.569ValLeu: 7.569 ± 0.077
1.818ValMet: 1.818 ± 0.039
1.91ValAsn: 1.91 ± 0.04
4.029ValPro: 4.029 ± 0.054
1.796ValGln: 1.796 ± 0.039
4.64ValArg: 4.64 ± 0.057
4.413ValSer: 4.413 ± 0.055
4.751ValThr: 4.751 ± 0.064
6.292ValVal: 6.292 ± 0.072
0.884ValTrp: 0.884 ± 0.023
1.507ValTyr: 1.507 ± 0.031
0.0ValXaa: 0.0 ± 0.0
Trp
1.13TrpAla: 1.13 ± 0.029
0.124TrpCys: 0.124 ± 0.009
0.619TrpAsp: 0.619 ± 0.02
0.463TrpGlu: 0.463 ± 0.019
0.556TrpPhe: 0.556 ± 0.021
0.882TrpGly: 0.882 ± 0.024
0.325TrpHis: 0.325 ± 0.012
0.712TrpIle: 0.712 ± 0.023
0.424TrpLys: 0.424 ± 0.018
1.579TrpLeu: 1.579 ± 0.032
0.354TrpMet: 0.354 ± 0.016
0.477TrpAsn: 0.477 ± 0.018
0.756TrpPro: 0.756 ± 0.024
0.603TrpGln: 0.603 ± 0.02
1.188TrpArg: 1.188 ± 0.028
0.851TrpSer: 0.851 ± 0.028
0.839TrpThr: 0.839 ± 0.024
0.761TrpVal: 0.761 ± 0.024
0.239TrpTrp: 0.239 ± 0.015
0.308TrpTyr: 0.308 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.447TyrAla: 2.447 ± 0.047
0.201TyrCys: 0.201 ± 0.011
1.397TyrAsp: 1.397 ± 0.031
1.129TyrGlu: 1.129 ± 0.025
0.911TyrPhe: 0.911 ± 0.024
2.081TyrGly: 2.081 ± 0.042
0.455TyrHis: 0.455 ± 0.018
0.816TyrIle: 0.816 ± 0.027
0.549TyrLys: 0.549 ± 0.022
2.179TyrLeu: 2.179 ± 0.042
0.375TyrMet: 0.375 ± 0.018
0.58TyrAsn: 0.58 ± 0.019
1.107TyrPro: 1.107 ± 0.031
0.704TyrGln: 0.704 ± 0.021
1.741TyrArg: 1.741 ± 0.032
1.127TyrSer: 1.127 ± 0.027
0.968TyrThr: 0.968 ± 0.027
1.676TyrVal: 1.676 ± 0.038
0.369TyrTrp: 0.369 ± 0.016
0.56TyrTyr: 0.56 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.001XaaAsn: 0.001 ± 0.001
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.002XaaXaa: 0.002 ± 0.002
Statistics based on 4866 proteins (1558496 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski