Amino acid dipepetide frequency for Sinomicrobium sp. N-1-3-6

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.462AlaAla: 5.462 ± 0.081	0.635AlaCys: 0.635 ± 0.022	4.074AlaAsp: 4.074 ± 0.082	4.658AlaGlu: 4.658 ± 0.071	3.359AlaPhe: 3.359 ± 0.056	6.14AlaGly: 6.14 ± 0.076	1.272AlaHis: 1.272 ± 0.034	4.6AlaIle: 4.6 ± 0.065	2.95AlaLys: 2.95 ± 0.056	6.967AlaLeu: 6.967 ± 0.088	1.662AlaMet: 1.662 ± 0.042	2.725AlaAsn: 2.725 ± 0.055	2.586AlaPro: 2.586 ± 0.048	2.215AlaGln: 2.215 ± 0.04	3.797AlaArg: 3.797 ± 0.054	4.43AlaSer: 4.43 ± 0.067	3.634AlaThr: 3.634 ± 0.059	5.275AlaVal: 5.275 ± 0.077	0.781AlaTrp: 0.781 ± 0.025	2.946AlaTyr: 2.946 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.442CysAla: 0.442 ± 0.02	0.104CysCys: 0.104 ± 0.008	0.346CysAsp: 0.346 ± 0.016	0.442CysGlu: 0.442 ± 0.022	0.414CysPhe: 0.414 ± 0.017	0.59CysGly: 0.59 ± 0.024	0.176CysHis: 0.176 ± 0.013	0.505CysIle: 0.505 ± 0.022	0.374CysLys: 0.374 ± 0.017	0.615CysLeu: 0.615 ± 0.023	0.18CysMet: 0.18 ± 0.012	0.343CysAsn: 0.343 ± 0.017	0.323CysPro: 0.323 ± 0.018	0.176CysGln: 0.176 ± 0.012	0.379CysArg: 0.379 ± 0.016	0.539CysSer: 0.539 ± 0.021	0.43CysThr: 0.43 ± 0.021	0.409CysVal: 0.409 ± 0.017	0.068CysTrp: 0.068 ± 0.007	0.318CysTyr: 0.318 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.783AspAla: 3.783 ± 0.062	0.356AspCys: 0.356 ± 0.017	3.07AspAsp: 3.07 ± 0.053	3.787AspGlu: 3.787 ± 0.058	3.401AspPhe: 3.401 ± 0.061	4.351AspGly: 4.351 ± 0.079	1.349AspHis: 1.349 ± 0.034	4.638AspIle: 4.638 ± 0.065	3.481AspLys: 3.481 ± 0.057	5.098AspLeu: 5.098 ± 0.072	1.409AspMet: 1.409 ± 0.031	2.849AspAsn: 2.849 ± 0.057	2.453AspPro: 2.453 ± 0.046	1.609AspGln: 1.609 ± 0.038	3.35AspArg: 3.35 ± 0.049	2.833AspSer: 2.833 ± 0.045	3.22AspThr: 3.22 ± 0.052	3.346AspVal: 3.346 ± 0.053	0.846AspTrp: 0.846 ± 0.028	2.782AspTyr: 2.782 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	5.187GluAla: 5.187 ± 0.069	0.349GluCys: 0.349 ± 0.019	3.979GluAsp: 3.979 ± 0.056	5.776GluGlu: 5.776 ± 0.083	2.52GluPhe: 2.52 ± 0.051	4.718GluGly: 4.718 ± 0.069	1.505GluHis: 1.505 ± 0.033	4.817GluIle: 4.817 ± 0.063	5.63GluLys: 5.63 ± 0.091	6.026GluLeu: 6.026 ± 0.061	1.712GluMet: 1.712 ± 0.035	4.056GluAsn: 4.056 ± 0.055	1.747GluPro: 1.747 ± 0.032	2.637GluGln: 2.637 ± 0.053	3.192GluArg: 3.192 ± 0.055	3.075GluSer: 3.075 ± 0.047	3.741GluThr: 3.741 ± 0.053	4.863GluVal: 4.863 ± 0.072	0.773GluTrp: 0.773 ± 0.026	2.59GluTyr: 2.59 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	2.915PheAla: 2.915 ± 0.053	0.427PheCys: 0.427 ± 0.02	3.135PheAsp: 3.135 ± 0.053	3.003PheGlu: 3.003 ± 0.051	2.438PhePhe: 2.438 ± 0.049	3.728PheGly: 3.728 ± 0.058	0.859PheHis: 0.859 ± 0.025	3.154PheIle: 3.154 ± 0.055	2.273PheLys: 2.273 ± 0.047	4.272PheLeu: 4.272 ± 0.06	1.143PheMet: 1.143 ± 0.033	2.403PheAsn: 2.403 ± 0.049	1.881PhePro: 1.881 ± 0.045	1.257PheGln: 1.257 ± 0.032	2.8PheArg: 2.8 ± 0.049	3.709PheSer: 3.709 ± 0.059	2.917PheThr: 2.917 ± 0.051	2.77PheVal: 2.77 ± 0.048	0.552PheTrp: 0.552 ± 0.021	2.081PheTyr: 2.081 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	4.994GlyAla: 4.994 ± 0.075	0.584GlyCys: 0.584 ± 0.027	4.106GlyAsp: 4.106 ± 0.064	4.916GlyGlu: 4.916 ± 0.071	3.787GlyPhe: 3.787 ± 0.056	5.412GlyGly: 5.412 ± 0.082	1.408GlyHis: 1.408 ± 0.038	5.767GlyIle: 5.767 ± 0.065	5.652GlyLys: 5.652 ± 0.078	6.327GlyLeu: 6.327 ± 0.088	2.078GlyMet: 2.078 ± 0.038	4.132GlyAsn: 4.132 ± 0.063	1.726GlyPro: 1.726 ± 0.038	2.346GlyGln: 2.346 ± 0.043	3.309GlyArg: 3.309 ± 0.059	4.605GlySer: 4.605 ± 0.072	4.736GlyThr: 4.736 ± 0.068	4.919GlyVal: 4.919 ± 0.076	1.008GlyTrp: 1.008 ± 0.032	3.548GlyTyr: 3.548 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	1.207HisAla: 1.207 ± 0.032	0.199HisCys: 0.199 ± 0.013	0.951HisAsp: 0.951 ± 0.027	0.976HisGlu: 0.976 ± 0.03	1.175HisPhe: 1.175 ± 0.029	1.301HisGly: 1.301 ± 0.033	0.573HisHis: 0.573 ± 0.02	1.612HisIle: 1.612 ± 0.039	1.07HisLys: 1.07 ± 0.029	1.845HisLeu: 1.845 ± 0.045	0.404HisMet: 0.404 ± 0.018	0.987HisAsn: 0.987 ± 0.028	1.112HisPro: 1.112 ± 0.035	0.694HisGln: 0.694 ± 0.023	1.165HisArg: 1.165 ± 0.029	1.059HisSer: 1.059 ± 0.026	1.241HisThr: 1.241 ± 0.029	0.972HisVal: 0.972 ± 0.031	0.306HisTrp: 0.306 ± 0.017	1.047HisTyr: 1.047 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	5.363IleAla: 5.363 ± 0.073	0.531IleCys: 0.531 ± 0.022	4.019IleAsp: 4.019 ± 0.054	3.97IleGlu: 3.97 ± 0.06	2.726IlePhe: 2.726 ± 0.047	4.708IleGly: 4.708 ± 0.068	1.296IleHis: 1.296 ± 0.03	4.078IleIle: 4.078 ± 0.064	3.525IleLys: 3.525 ± 0.059	5.869IleLeu: 5.869 ± 0.082	1.237IleMet: 1.237 ± 0.032	3.163IleAsn: 3.163 ± 0.049	3.283IlePro: 3.283 ± 0.049	1.953IleGln: 1.953 ± 0.04	4.127IleArg: 4.127 ± 0.052	4.95IleSer: 4.95 ± 0.065	4.384IleThr: 4.384 ± 0.066	4.034IleVal: 4.034 ± 0.056	0.704IleTrp: 0.704 ± 0.025	2.439IleTyr: 2.439 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	4.384LysAla: 4.384 ± 0.075	0.249LysCys: 0.249 ± 0.016	3.639LysAsp: 3.639 ± 0.059	4.77LysGlu: 4.77 ± 0.076	2.021LysPhe: 2.021 ± 0.034	4.22LysGly: 4.22 ± 0.063	1.175LysHis: 1.175 ± 0.031	4.094LysIle: 4.094 ± 0.064	4.944LysLys: 4.944 ± 0.08	5.025LysLeu: 5.025 ± 0.076	1.524LysMet: 1.524 ± 0.038	3.455LysAsn: 3.455 ± 0.063	2.173LysPro: 2.173 ± 0.043	2.077LysGln: 2.077 ± 0.043	2.886LysArg: 2.886 ± 0.049	3.127LysSer: 3.127 ± 0.052	3.658LysThr: 3.658 ± 0.053	3.82LysVal: 3.82 ± 0.056	0.708LysTrp: 0.708 ± 0.025	2.498LysTyr: 2.498 ± 0.048	0.0LysXaa: 0.0 ± 0.0
Leu	6.041LeuAla: 6.041 ± 0.082	0.74LeuCys: 0.74 ± 0.026	5.071LeuAsp: 5.071 ± 0.067	6.329LeuGlu: 6.329 ± 0.074	4.525LeuPhe: 4.525 ± 0.066	6.171LeuGly: 6.171 ± 0.061	1.888LeuHis: 1.888 ± 0.043	5.267LeuIle: 5.267 ± 0.078	6.182LeuLys: 6.182 ± 0.074	8.872LeuLeu: 8.872 ± 0.106	2.103LeuMet: 2.103 ± 0.037	4.475LeuAsn: 4.475 ± 0.065	3.999LeuPro: 3.999 ± 0.056	3.281LeuGln: 3.281 ± 0.053	4.652LeuArg: 4.652 ± 0.055	6.591LeuSer: 6.591 ± 0.077	4.814LeuThr: 4.814 ± 0.08	5.594LeuVal: 5.594 ± 0.074	1.048LeuTrp: 1.048 ± 0.032	3.536LeuTyr: 3.536 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	1.953MetAla: 1.953 ± 0.036	0.147MetCys: 0.147 ± 0.012	1.328MetAsp: 1.328 ± 0.032	1.77MetGlu: 1.77 ± 0.039	0.823MetPhe: 0.823 ± 0.026	1.595MetGly: 1.595 ± 0.035	0.401MetHis: 0.401 ± 0.018	1.391MetIle: 1.391 ± 0.034	1.971MetLys: 1.971 ± 0.035	1.971MetLeu: 1.971 ± 0.038	0.566MetMet: 0.566 ± 0.022	1.166MetAsn: 1.166 ± 0.028	0.918MetPro: 0.918 ± 0.028	0.798MetGln: 0.798 ± 0.026	1.034MetArg: 1.034 ± 0.029	1.359MetSer: 1.359 ± 0.031	1.229MetThr: 1.229 ± 0.032	1.509MetVal: 1.509 ± 0.037	0.213MetTrp: 0.213 ± 0.013	0.788MetTyr: 0.788 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.422AsnAla: 3.422 ± 0.057	0.276AsnCys: 0.276 ± 0.016	2.604AsnAsp: 2.604 ± 0.046	2.791AsnGlu: 2.791 ± 0.047	2.256AsnPhe: 2.256 ± 0.05	3.858AsnGly: 3.858 ± 0.058	0.926AsnHis: 0.926 ± 0.027	3.8AsnIle: 3.8 ± 0.064	2.603AsnLys: 2.603 ± 0.046	4.175AsnLeu: 4.175 ± 0.066	1.096AsnMet: 1.096 ± 0.026	2.695AsnAsn: 2.695 ± 0.059	2.591AsnPro: 2.591 ± 0.047	1.454AsnGln: 1.454 ± 0.035	2.883AsnArg: 2.883 ± 0.045	2.971AsnSer: 2.971 ± 0.054	3.5AsnThr: 3.5 ± 0.062	2.803AsnVal: 2.803 ± 0.053	0.625AsnTrp: 0.625 ± 0.023	2.28AsnTyr: 2.28 ± 0.047	0.0AsnXaa: 0.0 ± 0.0
Pro	2.771ProAla: 2.771 ± 0.048	0.216ProCys: 0.216 ± 0.013	3.048ProAsp: 3.048 ± 0.051	4.269ProGlu: 4.269 ± 0.061	1.94ProPhe: 1.94 ± 0.038	3.775ProGly: 3.775 ± 0.057	0.716ProHis: 0.716 ± 0.025	1.704ProIle: 1.704 ± 0.034	1.565ProLys: 1.565 ± 0.036	3.505ProLeu: 3.505 ± 0.055	0.759ProMet: 0.759 ± 0.027	1.452ProAsn: 1.452 ± 0.039	1.176ProPro: 1.176 ± 0.035	1.19ProGln: 1.19 ± 0.029	1.568ProArg: 1.568 ± 0.034	2.208ProSer: 2.208 ± 0.04	1.532ProThr: 1.532 ± 0.036	3.677ProVal: 3.677 ± 0.05	0.44ProTrp: 0.44 ± 0.019	1.692ProTyr: 1.692 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	2.226GlnAla: 2.226 ± 0.043	0.172GlnCys: 0.172 ± 0.012	1.634GlnAsp: 1.634 ± 0.035	2.361GlnGlu: 2.361 ± 0.043	1.326GlnPhe: 1.326 ± 0.031	2.251GlnGly: 2.251 ± 0.047	0.683GlnHis: 0.683 ± 0.022	1.838GlnIle: 1.838 ± 0.036	2.188GlnLys: 2.188 ± 0.04	3.292GlnLeu: 3.292 ± 0.055	0.744GlnMet: 0.744 ± 0.025	1.538GlnAsn: 1.538 ± 0.04	1.218GlnPro: 1.218 ± 0.032	1.608GlnGln: 1.608 ± 0.04	1.579GlnArg: 1.579 ± 0.038	1.702GlnSer: 1.702 ± 0.036	1.663GlnThr: 1.663 ± 0.034	2.204GlnVal: 2.204 ± 0.043	0.474GlnTrp: 0.474 ± 0.018	1.394GlnTyr: 1.394 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	3.27ArgAla: 3.27 ± 0.054	0.255ArgCys: 0.255 ± 0.016	2.822ArgAsp: 2.822 ± 0.048	4.324ArgGlu: 4.324 ± 0.066	2.679ArgPhe: 2.679 ± 0.047	3.044ArgGly: 3.044 ± 0.052	1.05ArgHis: 1.05 ± 0.03	3.858ArgIle: 3.858 ± 0.055	3.999ArgLys: 3.999 ± 0.065	4.643ArgLeu: 4.643 ± 0.064	1.334ArgMet: 1.334 ± 0.031	2.941ArgAsn: 2.941 ± 0.052	1.648ArgPro: 1.648 ± 0.035	1.916ArgGln: 1.916 ± 0.041	2.312ArgArg: 2.312 ± 0.045	2.739ArgSer: 2.739 ± 0.049	2.629ArgThr: 2.629 ± 0.043	3.092ArgVal: 3.092 ± 0.05	0.689ArgTrp: 0.689 ± 0.021	2.521ArgTyr: 2.521 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	4.133SerAla: 4.133 ± 0.057	0.627SerCys: 0.627 ± 0.023	3.601SerAsp: 3.601 ± 0.055	3.925SerGlu: 3.925 ± 0.048	3.34SerPhe: 3.34 ± 0.057	5.963SerGly: 5.963 ± 0.078	1.114SerHis: 1.114 ± 0.029	3.697SerIle: 3.697 ± 0.052	2.664SerLys: 2.664 ± 0.048	5.8SerLeu: 5.8 ± 0.075	1.299SerMet: 1.299 ± 0.035	2.581SerAsn: 2.581 ± 0.049	2.542SerPro: 2.542 ± 0.047	1.631SerGln: 1.631 ± 0.034	3.389SerArg: 3.389 ± 0.062	3.823SerSer: 3.823 ± 0.07	2.974SerThr: 2.974 ± 0.056	4.439SerVal: 4.439 ± 0.065	0.777SerTrp: 0.777 ± 0.026	2.961SerTyr: 2.961 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	4.505ThrAla: 4.505 ± 0.067	0.331ThrCys: 0.331 ± 0.017	3.765ThrAsp: 3.765 ± 0.058	3.518ThrGlu: 3.518 ± 0.055	2.59ThrPhe: 2.59 ± 0.042	5.667ThrGly: 5.667 ± 0.073	1.044ThrHis: 1.044 ± 0.026	3.561ThrIle: 3.561 ± 0.061	2.148ThrLys: 2.148 ± 0.044	5.265ThrLeu: 5.265 ± 0.062	0.904ThrMet: 0.904 ± 0.027	2.209ThrAsn: 2.209 ± 0.047	2.775ThrPro: 2.775 ± 0.048	1.471ThrGln: 1.471 ± 0.037	2.809ThrArg: 2.809 ± 0.046	3.506ThrSer: 3.506 ± 0.053	3.193ThrThr: 3.193 ± 0.061	4.511ThrVal: 4.511 ± 0.075	0.655ThrTrp: 0.655 ± 0.028	2.379ThrTyr: 2.379 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	4.447ValAla: 4.447 ± 0.072	0.526ValCys: 0.526 ± 0.022	3.389ValAsp: 3.389 ± 0.061	3.947ValGlu: 3.947 ± 0.054	3.562ValPhe: 3.562 ± 0.058	3.703ValGly: 3.703 ± 0.064	1.185ValHis: 1.185 ± 0.026	4.651ValIle: 4.651 ± 0.06	3.972ValLys: 3.972 ± 0.063	6.668ValLeu: 6.668 ± 0.087	1.565ValMet: 1.565 ± 0.028	3.414ValAsn: 3.414 ± 0.058	2.829ValPro: 2.829 ± 0.045	1.854ValGln: 1.854 ± 0.039	3.265ValArg: 3.265 ± 0.049	4.812ValSer: 4.812 ± 0.072	3.886ValThr: 3.886 ± 0.065	4.617ValVal: 4.617 ± 0.075	0.678ValTrp: 0.678 ± 0.024	2.836ValTyr: 2.836 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.732TrpAla: 0.732 ± 0.027	0.115TrpCys: 0.115 ± 0.009	0.747TrpAsp: 0.747 ± 0.024	0.873TrpGlu: 0.873 ± 0.031	0.562TrpPhe: 0.562 ± 0.022	0.837TrpGly: 0.837 ± 0.03	0.274TrpHis: 0.274 ± 0.014	0.759TrpIle: 0.759 ± 0.025	0.938TrpLys: 0.938 ± 0.032	1.062TrpLeu: 1.062 ± 0.032	0.36TrpMet: 0.36 ± 0.016	0.702TrpAsn: 0.702 ± 0.026	0.373TrpPro: 0.373 ± 0.018	0.499TrpGln: 0.499 ± 0.02	0.519TrpArg: 0.519 ± 0.019	0.671TrpSer: 0.671 ± 0.025	0.664TrpThr: 0.664 ± 0.023	0.675TrpVal: 0.675 ± 0.024	0.215TrpTrp: 0.215 ± 0.014	0.526TrpTyr: 0.526 ± 0.028	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.927TyrAla: 2.927 ± 0.044	0.333TyrCys: 0.333 ± 0.017	2.683TyrAsp: 2.683 ± 0.052	2.489TyrGlu: 2.489 ± 0.047	2.274TyrPhe: 2.274 ± 0.043	3.328TyrGly: 3.328 ± 0.049	1.001TyrHis: 1.001 ± 0.024	2.567TyrIle: 2.567 ± 0.047	2.319TyrLys: 2.319 ± 0.044	3.881TyrLeu: 3.881 ± 0.06	0.854TyrMet: 0.854 ± 0.026	2.326TyrAsn: 2.326 ± 0.049	1.85TyrPro: 1.85 ± 0.038	1.427TyrGln: 1.427 ± 0.033	2.75TyrArg: 2.75 ± 0.052	2.57TyrSer: 2.57 ± 0.048	2.762TyrThr: 2.762 ± 0.049	2.277TyrVal: 2.277 ± 0.042	0.546TyrTrp: 0.546 ± 0.025	2.037TyrTyr: 2.037 ± 0.046	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3695 proteins (1360127 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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