Amino acid dipepetide frequency for Apis mellifera associated microvirus 45

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.529AlaAla: 7.529 ± 3.235
0.0AlaCys: 0.0 ± 0.0
2.738AlaAsp: 2.738 ± 1.243
5.476AlaGlu: 5.476 ± 3.163
0.0AlaPhe: 0.0 ± 0.0
6.845AlaGly: 6.845 ± 1.686
0.0AlaHis: 0.0 ± 0.0
1.369AlaIle: 1.369 ± 0.642
4.791AlaLys: 4.791 ± 1.288
6.845AlaLeu: 6.845 ± 1.756
3.422AlaMet: 3.422 ± 1.045
2.053AlaAsn: 2.053 ± 0.824
6.845AlaPro: 6.845 ± 1.521
0.684AlaGln: 0.684 ± 0.657
9.582AlaArg: 9.582 ± 2.562
8.214AlaSer: 8.214 ± 1.421
4.107AlaThr: 4.107 ± 0.954
4.791AlaVal: 4.791 ± 0.8
1.369AlaTrp: 1.369 ± 0.573
2.053AlaTyr: 2.053 ± 0.824
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.684CysGly: 0.684 ± 0.577
0.0CysHis: 0.0 ± 0.0
0.684CysIle: 0.684 ± 0.577
0.0CysLys: 0.0 ± 0.0
1.369CysLeu: 1.369 ± 1.228
0.0CysMet: 0.0 ± 0.548
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
1.369CysArg: 1.369 ± 0.778
1.369CysSer: 1.369 ± 0.573
0.0CysThr: 0.0 ± 0.0
0.684CysVal: 0.684 ± 0.647
0.684CysTrp: 0.684 ± 0.577
0.684CysTyr: 0.684 ± 0.577
0.0CysXaa: 0.0 ± 0.0
Asp
3.422AspAla: 3.422 ± 1.045
0.0AspCys: 0.0 ± 0.0
6.845AspAsp: 6.845 ± 4.452
2.738AspGlu: 2.738 ± 1.142
4.107AspPhe: 4.107 ± 1.522
4.791AspGly: 4.791 ± 2.193
0.0AspHis: 0.0 ± 0.0
0.684AspIle: 0.684 ± 0.577
1.369AspLys: 1.369 ± 0.573
4.791AspLeu: 4.791 ± 1.119
0.684AspMet: 0.684 ± 0.42
0.0AspAsn: 0.0 ± 0.0
2.738AspPro: 2.738 ± 2.344
0.684AspGln: 0.684 ± 0.42
2.053AspArg: 2.053 ± 0.802
2.738AspSer: 2.738 ± 1.173
2.738AspThr: 2.738 ± 1.207
4.107AspVal: 4.107 ± 1.703
0.0AspTrp: 0.0 ± 0.0
2.738AspTyr: 2.738 ± 1.219
0.0AspXaa: 0.0 ± 0.0
Glu
4.791GluAla: 4.791 ± 0.795
0.0GluCys: 0.0 ± 0.0
2.053GluAsp: 2.053 ± 0.871
7.529GluGlu: 7.529 ± 2.23
3.422GluPhe: 3.422 ± 0.865
2.053GluGly: 2.053 ± 0.887
3.422GluHis: 3.422 ± 1.348
2.053GluIle: 2.053 ± 1.425
4.107GluLys: 4.107 ± 1.427
3.422GluLeu: 3.422 ± 2.29
1.369GluMet: 1.369 ± 0.939
2.053GluAsn: 2.053 ± 1.106
2.053GluPro: 2.053 ± 1.17
2.738GluGln: 2.738 ± 1.503
2.738GluArg: 2.738 ± 1.03
2.053GluSer: 2.053 ± 0.785
2.738GluThr: 2.738 ± 1.582
5.476GluVal: 5.476 ± 1.699
2.053GluTrp: 2.053 ± 0.929
4.107GluTyr: 4.107 ± 1.214
0.0GluXaa: 0.0 ± 0.0
Phe
3.422PheAla: 3.422 ± 1.096
0.0PheCys: 0.0 ± 0.0
2.738PheAsp: 2.738 ± 2.443
2.738PheGlu: 2.738 ± 0.88
2.738PhePhe: 2.738 ± 1.042
3.422PheGly: 3.422 ± 0.865
0.0PheHis: 0.0 ± 0.0
2.053PheIle: 2.053 ± 0.512
2.053PheLys: 2.053 ± 0.785
2.053PheLeu: 2.053 ± 1.207
2.738PheMet: 2.738 ± 1.042
2.053PheAsn: 2.053 ± 0.645
2.053PhePro: 2.053 ± 0.906
1.369PheGln: 1.369 ± 0.653
2.738PheArg: 2.738 ± 0.762
4.107PheSer: 4.107 ± 1.426
1.369PheThr: 1.369 ± 0.642
1.369PheVal: 1.369 ± 0.84
0.684PheTrp: 0.684 ± 0.42
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
4.107GlyAla: 4.107 ± 0.677
0.684GlyCys: 0.684 ± 0.577
2.738GlyAsp: 2.738 ± 1.173
2.738GlyGlu: 2.738 ± 0.672
2.738GlyPhe: 2.738 ± 0.971
6.845GlyGly: 6.845 ± 2.59
2.738GlyHis: 2.738 ± 0.861
3.422GlyIle: 3.422 ± 1.096
4.107GlyLys: 4.107 ± 1.173
6.845GlyLeu: 6.845 ± 1.436
2.053GlyMet: 2.053 ± 0.822
2.053GlyAsn: 2.053 ± 0.512
5.476GlyPro: 5.476 ± 2.509
2.053GlyGln: 2.053 ± 0.512
6.16GlyArg: 6.16 ± 2.152
5.476GlySer: 5.476 ± 2.243
4.791GlyThr: 4.791 ± 1.908
4.791GlyVal: 4.791 ± 1.756
2.053GlyTrp: 2.053 ± 0.512
3.422GlyTyr: 3.422 ± 1.151
0.0GlyXaa: 0.0 ± 0.0
His
2.053HisAla: 2.053 ± 0.824
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
1.369HisGlu: 1.369 ± 1.154
0.684HisPhe: 0.684 ± 0.577
2.738HisGly: 2.738 ± 0.911
0.684HisHis: 0.684 ± 0.42
2.053HisIle: 2.053 ± 0.645
0.684HisLys: 0.684 ± 0.657
2.053HisLeu: 2.053 ± 1.323
0.684HisMet: 0.684 ± 0.42
0.0HisAsn: 0.0 ± 0.0
2.738HisPro: 2.738 ± 0.861
0.0HisGln: 0.0 ± 0.0
2.053HisArg: 2.053 ± 1.219
0.684HisSer: 0.684 ± 0.42
0.0HisThr: 0.0 ± 0.0
1.369HisVal: 1.369 ± 0.671
2.738HisTrp: 2.738 ± 0.602
2.053HisTyr: 2.053 ± 0.512
0.0HisXaa: 0.0 ± 0.0
Ile
2.738IleAla: 2.738 ± 0.861
0.684IleCys: 0.684 ± 0.647
0.0IleAsp: 0.0 ± 0.0
1.369IleGlu: 1.369 ± 0.653
1.369IlePhe: 1.369 ± 0.642
3.422IleGly: 3.422 ± 1.909
0.684IleHis: 0.684 ± 0.657
0.684IleIle: 0.684 ± 0.42
4.107IleLys: 4.107 ± 1.363
0.0IleLeu: 0.0 ± 0.271
1.369IleMet: 1.369 ± 0.474
4.107IleAsn: 4.107 ± 1.718
2.053IlePro: 2.053 ± 0.512
1.369IleGln: 1.369 ± 0.84
2.053IleArg: 2.053 ± 1.58
2.738IleSer: 2.738 ± 0.672
2.738IleThr: 2.738 ± 1.03
1.369IleVal: 1.369 ± 0.771
0.684IleTrp: 0.684 ± 0.577
0.684IleTyr: 0.684 ± 0.657
0.0IleXaa: 0.0 ± 0.0
Lys
2.053LysAla: 2.053 ± 1.26
0.0LysCys: 0.0 ± 0.0
3.422LysAsp: 3.422 ± 1.617
4.791LysGlu: 4.791 ± 1.695
2.053LysPhe: 2.053 ± 0.645
3.422LysGly: 3.422 ± 1.034
1.369LysHis: 1.369 ± 1.08
2.053LysIle: 2.053 ± 1.07
2.053LysLys: 2.053 ± 1.043
6.16LysLeu: 6.16 ± 1.492
0.0LysMet: 0.0 ± 0.0
1.369LysAsn: 1.369 ± 0.671
2.738LysPro: 2.738 ± 0.602
3.422LysGln: 3.422 ± 1.348
5.476LysArg: 5.476 ± 2.613
2.738LysSer: 2.738 ± 1.56
2.738LysThr: 2.738 ± 1.042
3.422LysVal: 3.422 ± 1.532
0.684LysTrp: 0.684 ± 0.657
0.684LysTyr: 0.684 ± 0.823
0.0LysXaa: 0.0 ± 0.0
Leu
5.476LeuAla: 5.476 ± 1.399
1.369LeuCys: 1.369 ± 1.154
1.369LeuAsp: 1.369 ± 0.84
4.107LeuGlu: 4.107 ± 1.773
2.738LeuPhe: 2.738 ± 1.725
6.845LeuGly: 6.845 ± 1.696
0.684LeuHis: 0.684 ± 0.577
0.684LeuIle: 0.684 ± 0.823
3.422LeuLys: 3.422 ± 1.034
6.845LeuLeu: 6.845 ± 1.037
0.684LeuMet: 0.684 ± 0.422
2.738LeuAsn: 2.738 ± 0.672
8.898LeuPro: 8.898 ± 1.463
7.529LeuGln: 7.529 ± 1.706
4.791LeuArg: 4.791 ± 0.747
6.845LeuSer: 6.845 ± 1.73
3.422LeuThr: 3.422 ± 1.147
7.529LeuVal: 7.529 ± 1.747
0.684LeuTrp: 0.684 ± 0.42
0.684LeuTyr: 0.684 ± 0.657
0.0LeuXaa: 0.0 ± 0.0
Met
3.422MetAla: 3.422 ± 1.194
0.0MetCys: 0.0 ± 0.0
1.369MetAsp: 1.369 ± 0.671
1.369MetGlu: 1.369 ± 0.573
0.0MetPhe: 0.0 ± 0.0
4.107MetGly: 4.107 ± 1.271
0.684MetHis: 0.684 ± 0.42
0.0MetIle: 0.0 ± 0.0
1.369MetLys: 1.369 ± 0.84
2.053MetLeu: 2.053 ± 1.07
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
0.0MetPro: 0.0 ± 0.0
1.369MetGln: 1.369 ± 0.96
1.369MetArg: 1.369 ± 0.573
2.053MetSer: 2.053 ± 1.043
0.684MetThr: 0.684 ± 0.577
1.369MetVal: 1.369 ± 0.84
0.0MetTrp: 0.0 ± 0.0
1.369MetTyr: 1.369 ± 0.671
0.0MetXaa: 0.0 ± 0.0
Asn
4.791AsnAla: 4.791 ± 0.756
0.0AsnCys: 0.0 ± 0.0
3.422AsnAsp: 3.422 ± 1.454
2.053AsnGlu: 2.053 ± 0.512
1.369AsnPhe: 1.369 ± 1.295
2.053AsnGly: 2.053 ± 1.436
1.369AsnHis: 1.369 ± 0.671
0.684AsnIle: 0.684 ± 0.823
2.738AsnLys: 2.738 ± 0.88
2.738AsnLeu: 2.738 ± 0.672
0.684AsnMet: 0.684 ± 0.657
1.369AsnAsn: 1.369 ± 0.653
2.053AsnPro: 2.053 ± 0.645
1.369AsnGln: 1.369 ± 1.315
3.422AsnArg: 3.422 ± 0.997
1.369AsnSer: 1.369 ± 0.653
1.369AsnThr: 1.369 ± 0.573
2.053AsnVal: 2.053 ± 0.802
0.0AsnTrp: 0.0 ± 0.0
0.684AsnTyr: 0.684 ± 0.657
0.0AsnXaa: 0.0 ± 0.0
Pro
5.476ProAla: 5.476 ± 2.929
0.684ProCys: 0.684 ± 0.577
2.738ProAsp: 2.738 ± 1.243
6.845ProGlu: 6.845 ± 2.831
5.476ProPhe: 5.476 ± 1.415
3.422ProGly: 3.422 ± 0.997
2.738ProHis: 2.738 ± 0.555
3.422ProIle: 3.422 ± 1.471
2.053ProLys: 2.053 ± 1.436
4.791ProLeu: 4.791 ± 1.375
0.684ProMet: 0.684 ± 0.823
3.422ProAsn: 3.422 ± 1.756
3.422ProPro: 3.422 ± 1.855
2.738ProGln: 2.738 ± 0.993
4.791ProArg: 4.791 ± 1.718
6.845ProSer: 6.845 ± 2.308
6.16ProThr: 6.16 ± 1.117
3.422ProVal: 3.422 ± 0.997
1.369ProTrp: 1.369 ± 0.671
1.369ProTyr: 1.369 ± 1.154
0.0ProXaa: 0.0 ± 0.0
Gln
3.422GlnAla: 3.422 ± 0.824
0.684GlnCys: 0.684 ± 0.577
4.791GlnAsp: 4.791 ± 0.756
2.053GlnGlu: 2.053 ± 0.824
2.053GlnPhe: 2.053 ± 0.512
2.053GlnGly: 2.053 ± 1.26
1.369GlnHis: 1.369 ± 0.84
2.053GlnIle: 2.053 ± 1.177
2.053GlnLys: 2.053 ± 0.929
2.738GlnLeu: 2.738 ± 1.395
1.369GlnMet: 1.369 ± 0.671
0.684GlnAsn: 0.684 ± 0.657
0.684GlnPro: 0.684 ± 0.42
2.053GlnGln: 2.053 ± 0.785
3.422GlnArg: 3.422 ± 1.045
1.369GlnSer: 1.369 ± 0.899
2.738GlnThr: 2.738 ± 1.219
1.369GlnVal: 1.369 ± 0.771
2.053GlnTrp: 2.053 ± 1.043
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
3.422ArgAla: 3.422 ± 1.909
1.369ArgCys: 1.369 ± 1.295
2.738ArgAsp: 2.738 ± 0.555
3.422ArgGlu: 3.422 ± 1.612
2.053ArgPhe: 2.053 ± 1.07
2.738ArgGly: 2.738 ± 1.042
2.053ArgHis: 2.053 ± 1.31
2.738ArgIle: 2.738 ± 1.253
6.845ArgLys: 6.845 ± 1.575
6.16ArgLeu: 6.16 ± 1.514
1.369ArgMet: 1.369 ± 0.84
2.053ArgAsn: 2.053 ± 1.17
5.476ArgPro: 5.476 ± 1.412
3.422ArgGln: 3.422 ± 1.826
10.267ArgArg: 10.267 ± 4.609
7.529ArgSer: 7.529 ± 2.111
6.845ArgThr: 6.845 ± 1.341
4.791ArgVal: 4.791 ± 0.8
0.684ArgTrp: 0.684 ± 0.647
6.845ArgTyr: 6.845 ± 1.956
0.0ArgXaa: 0.0 ± 0.0
Ser
6.16SerAla: 6.16 ± 1.723
2.053SerCys: 2.053 ± 1.07
1.369SerAsp: 1.369 ± 0.573
2.738SerGlu: 2.738 ± 0.672
3.422SerPhe: 3.422 ± 1.619
7.529SerGly: 7.529 ± 1.416
1.369SerHis: 1.369 ± 0.573
4.107SerIle: 4.107 ± 2.012
2.053SerLys: 2.053 ± 0.785
6.16SerLeu: 6.16 ± 1.605
1.369SerMet: 1.369 ± 0.573
3.422SerAsn: 3.422 ± 1.295
8.214SerPro: 8.214 ± 2.261
1.369SerGln: 1.369 ± 1.315
4.791SerArg: 4.791 ± 1.008
9.582SerSer: 9.582 ± 3.725
3.422SerThr: 3.422 ± 0.932
4.107SerVal: 4.107 ± 0.82
2.053SerTrp: 2.053 ± 0.887
3.422SerTyr: 3.422 ± 1.651
0.0SerXaa: 0.0 ± 0.0
Thr
6.16ThrAla: 6.16 ± 1.305
0.684ThrCys: 0.684 ± 0.577
4.107ThrAsp: 4.107 ± 1.185
1.369ThrGlu: 1.369 ± 0.939
1.369ThrPhe: 1.369 ± 1.154
4.107ThrGly: 4.107 ± 1.504
2.053ThrHis: 2.053 ± 1.043
0.684ThrIle: 0.684 ± 0.42
1.369ThrLys: 1.369 ± 0.671
2.738ThrLeu: 2.738 ± 1.365
1.369ThrMet: 1.369 ± 0.717
2.738ThrAsn: 2.738 ± 1.341
6.16ThrPro: 6.16 ± 1.811
2.738ThrGln: 2.738 ± 0.672
2.738ThrArg: 2.738 ± 1.914
4.107ThrSer: 4.107 ± 1.214
6.16ThrThr: 6.16 ± 2.326
4.791ThrVal: 4.791 ± 1.737
0.684ThrTrp: 0.684 ± 0.42
0.684ThrTyr: 0.684 ± 0.577
0.0ThrXaa: 0.0 ± 0.0
Val
6.845ValAla: 6.845 ± 1.107
0.0ValCys: 0.0 ± 0.0
3.422ValAsp: 3.422 ± 2.29
2.053ValGlu: 2.053 ± 0.929
2.053ValPhe: 2.053 ± 0.949
5.476ValGly: 5.476 ± 2.164
1.369ValHis: 1.369 ± 0.84
4.107ValIle: 4.107 ± 1.308
1.369ValLys: 1.369 ± 1.154
4.107ValLeu: 4.107 ± 1.504
1.369ValMet: 1.369 ± 0.573
2.053ValAsn: 2.053 ± 1.26
8.898ValPro: 8.898 ± 2.889
2.053ValGln: 2.053 ± 0.512
7.529ValArg: 7.529 ± 2.559
4.791ValSer: 4.791 ± 0.747
2.053ValThr: 2.053 ± 0.871
0.684ValVal: 0.684 ± 0.647
1.369ValTrp: 1.369 ± 0.573
1.369ValTyr: 1.369 ± 0.84
0.0ValXaa: 0.0 ± 0.0
Trp
0.684TrpAla: 0.684 ± 0.577
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
4.107TrpGlu: 4.107 ± 1.438
0.684TrpPhe: 0.684 ± 0.42
1.369TrpGly: 1.369 ± 1.154
1.369TrpHis: 1.369 ± 0.671
0.684TrpIle: 0.684 ± 0.42
1.369TrpLys: 1.369 ± 0.671
1.369TrpLeu: 1.369 ± 0.96
0.684TrpMet: 0.684 ± 0.657
1.369TrpAsn: 1.369 ± 0.573
0.684TrpPro: 0.684 ± 0.823
0.684TrpGln: 0.684 ± 0.42
1.369TrpArg: 1.369 ± 0.653
2.738TrpSer: 2.738 ± 1.725
0.684TrpThr: 0.684 ± 0.577
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.684TrpTyr: 0.684 ± 0.42
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.738TyrAla: 2.738 ± 1.318
0.0TyrCys: 0.0 ± 0.0
1.369TyrAsp: 1.369 ± 0.671
1.369TyrGlu: 1.369 ± 0.573
1.369TyrPhe: 1.369 ± 0.84
1.369TyrGly: 1.369 ± 0.573
0.684TyrHis: 0.684 ± 0.577
0.0TyrIle: 0.0 ± 0.0
2.738TyrLys: 2.738 ± 1.503
4.107TyrLeu: 4.107 ± 1.576
0.0TyrMet: 0.0 ± 0.531
2.053TyrAsn: 2.053 ± 1.436
0.684TyrPro: 0.684 ± 0.657
1.369TyrGln: 1.369 ± 0.671
4.107TyrArg: 4.107 ± 0.757
1.369TyrSer: 1.369 ± 0.573
2.053TyrThr: 2.053 ± 1.177
5.476TyrVal: 5.476 ± 1.082
0.684TyrTrp: 0.684 ± 0.42
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (1462 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski