Amino acid dipepetide frequency for Sclerotinia borealis (strain F-4128)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.22AlaAla: 7.22 ± 0.056	0.902AlaCys: 0.902 ± 0.018	3.691AlaAsp: 3.691 ± 0.026	4.677AlaGlu: 4.677 ± 0.044	2.83AlaPhe: 2.83 ± 0.024	5.2AlaGly: 5.2 ± 0.039	1.549AlaHis: 1.549 ± 0.019	4.338AlaIle: 4.338 ± 0.031	4.076AlaLys: 4.076 ± 0.04	6.736AlaLeu: 6.736 ± 0.046	1.822AlaMet: 1.822 ± 0.02	3.008AlaAsn: 3.008 ± 0.029	4.256AlaPro: 4.256 ± 0.042	3.036AlaGln: 3.036 ± 0.026	4.183AlaArg: 4.183 ± 0.032	6.831AlaSer: 6.831 ± 0.05	4.914AlaThr: 4.914 ± 0.034	4.479AlaVal: 4.479 ± 0.034	0.984AlaTrp: 0.984 ± 0.014	2.004AlaTyr: 2.004 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	0.819CysAla: 0.819 ± 0.015	0.219CysCys: 0.219 ± 0.009	0.624CysAsp: 0.624 ± 0.012	0.602CysGlu: 0.602 ± 0.012	0.485CysPhe: 0.485 ± 0.008	0.91CysGly: 0.91 ± 0.016	0.286CysHis: 0.286 ± 0.008	0.701CysIle: 0.701 ± 0.013	0.536CysLys: 0.536 ± 0.011	1.103CysLeu: 1.103 ± 0.016	0.257CysMet: 0.257 ± 0.007	0.432CysAsn: 0.432 ± 0.01	0.598CysPro: 0.598 ± 0.012	0.409CysGln: 0.409 ± 0.009	0.625CysArg: 0.625 ± 0.011	0.858CysSer: 0.858 ± 0.016	0.682CysThr: 0.682 ± 0.014	0.7CysVal: 0.7 ± 0.015	0.182CysTrp: 0.182 ± 0.007	0.332CysTyr: 0.332 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.149AspAla: 4.149 ± 0.031	0.608AspCys: 0.608 ± 0.011	4.292AspAsp: 4.292 ± 0.049	4.744AspGlu: 4.744 ± 0.042	2.254AspPhe: 2.254 ± 0.022	4.023AspGly: 4.023 ± 0.033	1.188AspHis: 1.188 ± 0.016	3.437AspIle: 3.437 ± 0.028	2.428AspLys: 2.428 ± 0.026	4.957AspLeu: 4.957 ± 0.036	1.321AspMet: 1.321 ± 0.017	2.115AspAsn: 2.115 ± 0.022	2.977AspPro: 2.977 ± 0.025	1.787AspGln: 1.787 ± 0.022	2.824AspArg: 2.824 ± 0.03	4.267AspSer: 4.267 ± 0.032	3.076AspThr: 3.076 ± 0.024	3.514AspVal: 3.514 ± 0.027	0.825AspTrp: 0.825 ± 0.013	1.604AspTyr: 1.604 ± 0.019	0.0AspXaa: 0.0 ± 0.0
Glu	4.901GluAla: 4.901 ± 0.041	0.608GluCys: 0.608 ± 0.011	4.594GluAsp: 4.594 ± 0.039	6.288GluGlu: 6.288 ± 0.071	2.071GluPhe: 2.071 ± 0.02	4.245GluGly: 4.245 ± 0.033	1.326GluHis: 1.326 ± 0.016	3.657GluIle: 3.657 ± 0.032	4.403GluLys: 4.403 ± 0.044	5.165GluLeu: 5.165 ± 0.04	1.678GluMet: 1.678 ± 0.021	2.817GluAsn: 2.817 ± 0.027	2.618GluPro: 2.618 ± 0.039	2.344GluGln: 2.344 ± 0.027	4.151GluArg: 4.151 ± 0.043	4.662GluSer: 4.662 ± 0.041	3.502GluThr: 3.502 ± 0.031	3.852GluVal: 3.852 ± 0.032	0.9GluTrp: 0.9 ± 0.014	1.759GluTyr: 1.759 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	2.806PheAla: 2.806 ± 0.026	0.527PheCys: 0.527 ± 0.012	2.286PheAsp: 2.286 ± 0.022	2.323PheGlu: 2.323 ± 0.023	1.485PhePhe: 1.485 ± 0.02	2.879PheGly: 2.879 ± 0.033	0.859PheHis: 0.859 ± 0.014	1.882PheIle: 1.882 ± 0.023	1.664PheLys: 1.664 ± 0.019	3.288PheLeu: 3.288 ± 0.032	0.811PheMet: 0.811 ± 0.011	1.552PheAsn: 1.552 ± 0.018	1.912PhePro: 1.912 ± 0.018	1.393PheGln: 1.393 ± 0.018	1.799PheArg: 1.799 ± 0.021	3.029PheSer: 3.029 ± 0.022	2.241PheThr: 2.241 ± 0.028	2.209PheVal: 2.209 ± 0.024	0.6PheTrp: 0.6 ± 0.013	1.071PheTyr: 1.071 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	4.73GlyAla: 4.73 ± 0.036	0.822GlyCys: 0.822 ± 0.014	3.68GlyAsp: 3.68 ± 0.035	4.127GlyGlu: 4.127 ± 0.036	2.766GlyPhe: 2.766 ± 0.023	6.246GlyGly: 6.246 ± 0.067	1.558GlyHis: 1.558 ± 0.019	3.829GlyIle: 3.829 ± 0.028	3.937GlyLys: 3.937 ± 0.034	5.78GlyLeu: 5.78 ± 0.041	1.771GlyMet: 1.771 ± 0.02	2.995GlyAsn: 2.995 ± 0.028	2.946GlyPro: 2.946 ± 0.029	2.313GlyGln: 2.313 ± 0.025	3.94GlyArg: 3.94 ± 0.036	5.795GlySer: 5.795 ± 0.04	4.039GlyThr: 4.039 ± 0.032	4.337GlyVal: 4.337 ± 0.037	1.129GlyTrp: 1.129 ± 0.016	2.138GlyTyr: 2.138 ± 0.027	0.0GlyXaa: 0.0 ± 0.0
His	1.596HisAla: 1.596 ± 0.02	0.3HisCys: 0.3 ± 0.008	1.301HisAsp: 1.301 ± 0.016	1.34HisGlu: 1.34 ± 0.017	0.872HisPhe: 0.872 ± 0.014	1.549HisGly: 1.549 ± 0.019	0.813HisHis: 0.813 ± 0.016	1.294HisIle: 1.294 ± 0.015	1.02HisLys: 1.02 ± 0.018	2.071HisLeu: 2.071 ± 0.02	0.481HisMet: 0.481 ± 0.011	0.968HisAsn: 0.968 ± 0.014	1.555HisPro: 1.555 ± 0.022	1.005HisGln: 1.005 ± 0.016	1.381HisArg: 1.381 ± 0.018	1.869HisSer: 1.869 ± 0.02	1.373HisThr: 1.373 ± 0.02	1.261HisVal: 1.261 ± 0.017	0.299HisTrp: 0.299 ± 0.008	0.678HisTyr: 0.678 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.285IleAla: 4.285 ± 0.027	0.785IleCys: 0.785 ± 0.015	3.196IleAsp: 3.196 ± 0.023	3.405IleGlu: 3.405 ± 0.031	2.18IlePhe: 2.18 ± 0.023	3.458IleGly: 3.458 ± 0.033	1.304IleHis: 1.304 ± 0.017	3.085IleIle: 3.085 ± 0.031	2.708IleLys: 2.708 ± 0.028	4.935IleLeu: 4.935 ± 0.035	1.151IleMet: 1.151 ± 0.017	2.201IleAsn: 2.201 ± 0.023	3.573IlePro: 3.573 ± 0.031	2.102IleGln: 2.102 ± 0.021	2.863IleArg: 2.863 ± 0.025	4.744IleSer: 4.744 ± 0.034	3.351IleThr: 3.351 ± 0.03	3.266IleVal: 3.266 ± 0.029	0.773IleTrp: 0.773 ± 0.011	1.578IleTyr: 1.578 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	4.252LysAla: 4.252 ± 0.037	0.534LysCys: 0.534 ± 0.012	3.152LysAsp: 3.152 ± 0.026	4.063LysGlu: 4.063 ± 0.043	1.695LysPhe: 1.695 ± 0.02	3.391LysGly: 3.391 ± 0.032	1.171LysHis: 1.171 ± 0.017	2.871LysIle: 2.871 ± 0.027	4.049LysLys: 4.049 ± 0.046	4.367LysLeu: 4.367 ± 0.033	1.195LysMet: 1.195 ± 0.017	2.18LysAsn: 2.18 ± 0.022	2.786LysPro: 2.786 ± 0.03	1.899LysGln: 1.899 ± 0.022	3.604LysArg: 3.604 ± 0.03	4.25LysSer: 4.25 ± 0.033	3.121LysThr: 3.121 ± 0.027	3.098LysVal: 3.098 ± 0.029	0.72LysTrp: 0.72 ± 0.013	1.531LysTyr: 1.531 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	6.817LeuAla: 6.817 ± 0.041	1.058LeuCys: 1.058 ± 0.016	4.849LeuAsp: 4.849 ± 0.036	5.585LeuGlu: 5.585 ± 0.044	3.085LeuPhe: 3.085 ± 0.026	5.625LeuGly: 5.625 ± 0.035	2.05LeuHis: 2.05 ± 0.023	4.173LeuIle: 4.173 ± 0.037	4.578LeuLys: 4.578 ± 0.033	7.611LeuLeu: 7.611 ± 0.063	1.777LeuMet: 1.777 ± 0.02	3.403LeuAsn: 3.403 ± 0.027	5.279LeuPro: 5.279 ± 0.041	3.664LeuGln: 3.664 ± 0.028	5.129LeuArg: 5.129 ± 0.037	7.248LeuSer: 7.248 ± 0.044	4.82LeuThr: 4.82 ± 0.037	4.823LeuVal: 4.823 ± 0.04	1.071LeuTrp: 1.071 ± 0.017	2.25LeuTyr: 2.25 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	2.058MetAla: 2.058 ± 0.024	0.234MetCys: 0.234 ± 0.007	1.337MetAsp: 1.337 ± 0.017	1.491MetGlu: 1.491 ± 0.018	0.768MetPhe: 0.768 ± 0.011	1.65MetGly: 1.65 ± 0.018	0.477MetHis: 0.477 ± 0.011	1.134MetIle: 1.134 ± 0.017	1.203MetLys: 1.203 ± 0.017	1.723MetLeu: 1.723 ± 0.02	0.63MetMet: 0.63 ± 0.012	0.962MetAsn: 0.962 ± 0.014	1.188MetPro: 1.188 ± 0.016	0.87MetGln: 0.87 ± 0.015	1.269MetArg: 1.269 ± 0.017	2.013MetSer: 2.013 ± 0.02	1.329MetThr: 1.329 ± 0.019	1.299MetVal: 1.299 ± 0.017	0.251MetTrp: 0.251 ± 0.007	0.525MetTyr: 0.525 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.173AsnAla: 3.173 ± 0.03	0.46AsnCys: 0.46 ± 0.01	2.234AsnAsp: 2.234 ± 0.025	2.432AsnGlu: 2.432 ± 0.024	1.586AsnPhe: 1.586 ± 0.017	3.438AsnGly: 3.438 ± 0.03	1.014AsnHis: 1.014 ± 0.013	2.527AsnIle: 2.527 ± 0.021	1.868AsnLys: 1.868 ± 0.022	3.558AsnLeu: 3.558 ± 0.03	0.948AsnMet: 0.948 ± 0.014	1.951AsnAsn: 1.951 ± 0.032	2.621AsnPro: 2.621 ± 0.028	1.517AsnGln: 1.517 ± 0.022	2.115AsnArg: 2.115 ± 0.022	3.472AsnSer: 3.472 ± 0.031	2.74AsnThr: 2.74 ± 0.023	2.442AsnVal: 2.442 ± 0.023	0.584AsnTrp: 0.584 ± 0.012	1.208AsnTyr: 1.208 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	4.365ProAla: 4.365 ± 0.043	0.451ProCys: 0.451 ± 0.01	2.807ProAsp: 2.807 ± 0.027	3.521ProGlu: 3.521 ± 0.033	1.962ProPhe: 1.962 ± 0.021	3.431ProGly: 3.431 ± 0.029	1.292ProHis: 1.292 ± 0.018	3.086ProIle: 3.086 ± 0.03	2.943ProLys: 2.943 ± 0.029	4.585ProLeu: 4.585 ± 0.033	1.087ProMet: 1.087 ± 0.017	2.445ProAsn: 2.445 ± 0.026	4.878ProPro: 4.878 ± 0.076	2.495ProGln: 2.495 ± 0.036	3.185ProArg: 3.185 ± 0.031	6.183ProSer: 6.183 ± 0.048	4.248ProThr: 4.248 ± 0.037	3.185ProVal: 3.185 ± 0.034	0.631ProTrp: 0.631 ± 0.011	1.52ProTyr: 1.52 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	3.068GlnAla: 3.068 ± 0.03	0.404GlnCys: 0.404 ± 0.01	1.986GlnAsp: 1.986 ± 0.022	2.422GlnGlu: 2.422 ± 0.024	1.281GlnPhe: 1.281 ± 0.015	2.249GlnGly: 2.249 ± 0.026	1.019GlnHis: 1.019 ± 0.016	2.145GlnIle: 2.145 ± 0.021	2.188GlnLys: 2.188 ± 0.026	3.183GlnLeu: 3.183 ± 0.025	0.88GlnMet: 0.88 ± 0.016	1.808GlnAsn: 1.808 ± 0.021	2.25GlnPro: 2.25 ± 0.032	2.367GlnGln: 2.367 ± 0.06	2.412GlnArg: 2.412 ± 0.025	3.31GlnSer: 3.31 ± 0.034	2.366GlnThr: 2.366 ± 0.024	2.018GlnVal: 2.018 ± 0.021	0.519GlnTrp: 0.519 ± 0.01	1.232GlnTyr: 1.232 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	4.013ArgAla: 4.013 ± 0.034	0.608ArgCys: 0.608 ± 0.012	3.194ArgAsp: 3.194 ± 0.029	4.052ArgGlu: 4.052 ± 0.043	1.94ArgPhe: 1.94 ± 0.02	3.752ArgGly: 3.752 ± 0.039	1.376ArgHis: 1.376 ± 0.019	2.97ArgIle: 2.97 ± 0.023	3.697ArgLys: 3.697 ± 0.034	4.772ArgLeu: 4.772 ± 0.041	1.264ArgMet: 1.264 ± 0.016	2.477ArgAsn: 2.477 ± 0.023	3.088ArgPro: 3.088 ± 0.03	2.345ArgGln: 2.345 ± 0.024	4.611ArgArg: 4.611 ± 0.045	4.713ArgSer: 4.713 ± 0.036	3.124ArgThr: 3.124 ± 0.028	3.038ArgVal: 3.038 ± 0.028	0.797ArgTrp: 0.797 ± 0.013	1.548ArgTyr: 1.548 ± 0.016	0.0ArgXaa: 0.0 ± 0.0
Ser	6.227SerAla: 6.227 ± 0.044	0.831SerCys: 0.831 ± 0.015	4.321SerAsp: 4.321 ± 0.035	4.524SerGlu: 4.524 ± 0.039	3.122SerPhe: 3.122 ± 0.03	5.672SerGly: 5.672 ± 0.04	2.062SerHis: 2.062 ± 0.023	4.887SerIle: 4.887 ± 0.038	4.412SerLys: 4.412 ± 0.035	7.086SerLeu: 7.086 ± 0.045	1.844SerMet: 1.844 ± 0.02	3.815SerAsn: 3.815 ± 0.031	5.847SerPro: 5.847 ± 0.052	3.473SerGln: 3.473 ± 0.031	4.896SerArg: 4.896 ± 0.037	10.107SerSer: 10.107 ± 0.097	6.564SerThr: 6.564 ± 0.057	4.41SerVal: 4.41 ± 0.031	1.041SerTrp: 1.041 ± 0.014	2.228SerTyr: 2.228 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	4.749ThrAla: 4.749 ± 0.03	0.723ThrCys: 0.723 ± 0.012	2.813ThrAsp: 2.813 ± 0.024	3.284ThrGlu: 3.284 ± 0.026	2.35ThrPhe: 2.35 ± 0.021	4.16ThrGly: 4.16 ± 0.033	1.384ThrHis: 1.384 ± 0.017	3.657ThrIle: 3.657 ± 0.029	3.023ThrLys: 3.023 ± 0.03	5.286ThrLeu: 5.286 ± 0.037	1.207ThrMet: 1.207 ± 0.014	2.614ThrAsn: 2.614 ± 0.024	4.626ThrPro: 4.626 ± 0.043	2.248ThrGln: 2.248 ± 0.021	3.052ThrArg: 3.052 ± 0.029	6.412ThrSer: 6.412 ± 0.065	4.85ThrThr: 4.85 ± 0.052	3.367ThrVal: 3.367 ± 0.032	0.784ThrTrp: 0.784 ± 0.013	1.706ThrTyr: 1.706 ± 0.024	0.0ThrXaa: 0.0 ± 0.0
Val	4.532ValAla: 4.532 ± 0.031	0.697ValCys: 0.697 ± 0.012	3.521ValAsp: 3.521 ± 0.025	4.147ValGlu: 4.147 ± 0.035	2.219ValPhe: 2.219 ± 0.023	4.013ValGly: 4.013 ± 0.028	1.243ValHis: 1.243 ± 0.016	2.996ValIle: 2.996 ± 0.028	3.101ValLys: 3.101 ± 0.029	4.981ValLeu: 4.981 ± 0.041	1.302ValMet: 1.302 ± 0.017	2.227ValAsn: 2.227 ± 0.024	3.264ValPro: 3.264 ± 0.031	2.17ValGln: 2.17 ± 0.022	3.007ValArg: 3.007 ± 0.029	4.462ValSer: 4.462 ± 0.036	3.349ValThr: 3.349 ± 0.029	3.937ValVal: 3.937 ± 0.033	0.784ValTrp: 0.784 ± 0.014	1.601ValTyr: 1.601 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	0.958TrpAla: 0.958 ± 0.014	0.181TrpCys: 0.181 ± 0.006	0.849TrpAsp: 0.849 ± 0.014	0.869TrpGlu: 0.869 ± 0.016	0.489TrpPhe: 0.489 ± 0.01	0.941TrpGly: 0.941 ± 0.016	0.317TrpHis: 0.317 ± 0.007	0.756TrpIle: 0.756 ± 0.013	0.838TrpLys: 0.838 ± 0.013	1.183TrpLeu: 1.183 ± 0.018	0.37TrpMet: 0.37 ± 0.009	0.658TrpAsn: 0.658 ± 0.01	0.517TrpPro: 0.517 ± 0.012	0.503TrpGln: 0.503 ± 0.01	0.833TrpArg: 0.833 ± 0.013	0.989TrpSer: 0.989 ± 0.015	0.842TrpThr: 0.842 ± 0.012	0.8TrpVal: 0.8 ± 0.014	0.25TrpTrp: 0.25 ± 0.008	0.397TrpTyr: 0.397 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.018TyrAla: 2.018 ± 0.022	0.406TyrCys: 0.406 ± 0.009	1.664TyrAsp: 1.664 ± 0.02	1.645TyrGlu: 1.645 ± 0.017	1.175TyrPhe: 1.175 ± 0.017	2.044TyrGly: 2.044 ± 0.027	0.738TyrHis: 0.738 ± 0.014	1.519TyrIle: 1.519 ± 0.02	1.258TyrLys: 1.258 ± 0.016	2.529TyrLeu: 2.529 ± 0.028	0.618TyrMet: 0.618 ± 0.011	1.259TyrAsn: 1.259 ± 0.017	1.521TyrPro: 1.521 ± 0.021	1.169TyrGln: 1.169 ± 0.018	1.501TyrArg: 1.501 ± 0.017	2.154TyrSer: 2.154 ± 0.023	1.759TyrThr: 1.759 ± 0.019	1.518TyrVal: 1.518 ± 0.018	0.417TyrTrp: 0.417 ± 0.009	0.931TyrTyr: 0.931 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 10165 proteins (5168600 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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