Amino acid dipepetide frequency for Aspergillus lentulus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.151AlaAla: 9.151 ± 0.061	1.095AlaCys: 1.095 ± 0.016	4.36AlaAsp: 4.36 ± 0.034	5.31AlaGlu: 5.31 ± 0.042	3.191AlaPhe: 3.191 ± 0.029	5.931AlaGly: 5.931 ± 0.043	1.799AlaHis: 1.799 ± 0.017	4.319AlaIle: 4.319 ± 0.034	3.924AlaLys: 3.924 ± 0.036	8.001AlaLeu: 8.001 ± 0.044	1.977AlaMet: 1.977 ± 0.02	2.997AlaAsn: 2.997 ± 0.024	4.71AlaPro: 4.71 ± 0.049	3.459AlaGln: 3.459 ± 0.029	5.212AlaArg: 5.212 ± 0.044	7.399AlaSer: 7.399 ± 0.045	5.256AlaThr: 5.256 ± 0.037	5.65AlaVal: 5.65 ± 0.039	1.167AlaTrp: 1.167 ± 0.017	2.242AlaTyr: 2.242 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	0.957CysAla: 0.957 ± 0.014	0.237CysCys: 0.237 ± 0.009	0.67CysAsp: 0.67 ± 0.013	0.599CysGlu: 0.599 ± 0.013	0.527CysPhe: 0.527 ± 0.012	0.918CysGly: 0.918 ± 0.016	0.326CysHis: 0.326 ± 0.008	0.662CysIle: 0.662 ± 0.015	0.48CysLys: 0.48 ± 0.01	1.341CysLeu: 1.341 ± 0.019	0.279CysMet: 0.279 ± 0.008	0.426CysAsn: 0.426 ± 0.009	0.682CysPro: 0.682 ± 0.015	0.448CysGln: 0.448 ± 0.01	0.795CysArg: 0.795 ± 0.014	0.919CysSer: 0.919 ± 0.018	0.669CysThr: 0.669 ± 0.013	0.815CysVal: 0.815 ± 0.014	0.204CysTrp: 0.204 ± 0.007	0.357CysTyr: 0.357 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.733AspAla: 4.733 ± 0.033	0.626AspCys: 0.626 ± 0.013	3.85AspAsp: 3.85 ± 0.038	4.34AspGlu: 4.34 ± 0.039	2.173AspPhe: 2.173 ± 0.022	3.936AspGly: 3.936 ± 0.032	1.282AspHis: 1.282 ± 0.016	3.065AspIle: 3.065 ± 0.029	2.234AspLys: 2.234 ± 0.025	5.125AspLeu: 5.125 ± 0.035	1.225AspMet: 1.225 ± 0.017	1.829AspAsn: 1.829 ± 0.018	3.448AspPro: 3.448 ± 0.027	1.927AspGln: 1.927 ± 0.019	3.169AspArg: 3.169 ± 0.031	4.116AspSer: 4.116 ± 0.035	2.877AspThr: 2.877 ± 0.025	3.658AspVal: 3.658 ± 0.027	0.876AspTrp: 0.876 ± 0.012	1.685AspTyr: 1.685 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	5.346GluAla: 5.346 ± 0.043	0.622GluCys: 0.622 ± 0.012	4.132GluAsp: 4.132 ± 0.039	5.441GluGlu: 5.441 ± 0.054	1.953GluPhe: 1.953 ± 0.025	3.689GluGly: 3.689 ± 0.029	1.385GluHis: 1.385 ± 0.018	3.091GluIle: 3.091 ± 0.029	3.579GluLys: 3.579 ± 0.032	5.284GluLeu: 5.284 ± 0.042	1.455GluMet: 1.455 ± 0.019	2.305GluAsn: 2.305 ± 0.024	2.801GluPro: 2.801 ± 0.039	2.55GluGln: 2.55 ± 0.026	4.023GluArg: 4.023 ± 0.032	4.398GluSer: 4.398 ± 0.036	3.526GluThr: 3.526 ± 0.034	3.555GluVal: 3.555 ± 0.029	0.884GluTrp: 0.884 ± 0.014	1.718GluTyr: 1.718 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.085PheAla: 3.085 ± 0.028	0.554PheCys: 0.554 ± 0.011	2.274PheAsp: 2.274 ± 0.023	2.135PheGlu: 2.135 ± 0.021	1.64PhePhe: 1.64 ± 0.022	2.782PheGly: 2.782 ± 0.029	0.915PheHis: 0.915 ± 0.014	1.814PheIle: 1.814 ± 0.018	1.413PheLys: 1.413 ± 0.019	3.603PheLeu: 3.603 ± 0.033	0.778PheMet: 0.778 ± 0.014	1.404PheAsn: 1.404 ± 0.015	1.991PhePro: 1.991 ± 0.023	1.417PheGln: 1.417 ± 0.018	2.043PheArg: 2.043 ± 0.021	2.999PheSer: 2.999 ± 0.028	2.107PheThr: 2.107 ± 0.024	2.436PheVal: 2.436 ± 0.022	0.66PheTrp: 0.66 ± 0.014	1.144PheTyr: 1.144 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	5.397GlyAla: 5.397 ± 0.042	0.878GlyCys: 0.878 ± 0.013	3.569GlyAsp: 3.569 ± 0.026	3.588GlyGlu: 3.588 ± 0.03	2.784GlyPhe: 2.784 ± 0.027	5.361GlyGly: 5.361 ± 0.057	1.696GlyHis: 1.696 ± 0.02	3.486GlyIle: 3.486 ± 0.031	3.327GlyLys: 3.327 ± 0.029	6.146GlyLeu: 6.146 ± 0.037	1.519GlyMet: 1.519 ± 0.02	2.475GlyAsn: 2.475 ± 0.023	3.429GlyPro: 3.429 ± 0.034	2.649GlyGln: 2.649 ± 0.026	4.122GlyArg: 4.122 ± 0.031	5.645GlySer: 5.645 ± 0.041	3.961GlyThr: 3.961 ± 0.033	4.433GlyVal: 4.433 ± 0.033	1.175GlyTrp: 1.175 ± 0.017	2.181GlyTyr: 2.181 ± 0.024	0.0GlyXaa: 0.0 ± 0.0
His	1.895HisAla: 1.895 ± 0.02	0.327HisCys: 0.327 ± 0.009	1.312HisAsp: 1.312 ± 0.016	1.328HisGlu: 1.328 ± 0.017	0.931HisPhe: 0.931 ± 0.014	1.726HisGly: 1.726 ± 0.018	0.839HisHis: 0.839 ± 0.017	1.227HisIle: 1.227 ± 0.016	0.838HisLys: 0.838 ± 0.014	2.262HisLeu: 2.262 ± 0.024	0.478HisMet: 0.478 ± 0.009	0.84HisAsn: 0.84 ± 0.014	1.707HisPro: 1.707 ± 0.023	0.968HisGln: 0.968 ± 0.016	1.613HisArg: 1.613 ± 0.02	1.864HisSer: 1.864 ± 0.022	1.25HisThr: 1.25 ± 0.015	1.401HisVal: 1.401 ± 0.018	0.355HisTrp: 0.355 ± 0.009	0.715HisTyr: 0.715 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.272IleAla: 4.272 ± 0.034	0.774IleCys: 0.774 ± 0.013	2.801IleAsp: 2.801 ± 0.026	2.852IleGlu: 2.852 ± 0.025	2.01IlePhe: 2.01 ± 0.026	3.137IleGly: 3.137 ± 0.031	1.212IleHis: 1.212 ± 0.015	2.491IleIle: 2.491 ± 0.029	2.05IleLys: 2.05 ± 0.025	4.758IleLeu: 4.758 ± 0.033	0.971IleMet: 0.971 ± 0.017	1.77IleAsn: 1.77 ± 0.021	3.118IlePro: 3.118 ± 0.026	1.934IleGln: 1.934 ± 0.019	2.875IleArg: 2.875 ± 0.024	3.827IleSer: 3.827 ± 0.03	2.753IleThr: 2.753 ± 0.028	3.248IleVal: 3.248 ± 0.026	0.72IleTrp: 0.72 ± 0.011	1.463IleTyr: 1.463 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	4.041LysAla: 4.041 ± 0.032	0.484LysCys: 0.484 ± 0.01	2.687LysAsp: 2.687 ± 0.02	3.322LysGlu: 3.322 ± 0.032	1.382LysPhe: 1.382 ± 0.017	2.849LysGly: 2.849 ± 0.027	1.079LysHis: 1.079 ± 0.015	2.166LysIle: 2.166 ± 0.02	3.025LysLys: 3.025 ± 0.041	3.917LysLeu: 3.917 ± 0.03	0.931LysMet: 0.931 ± 0.013	1.662LysAsn: 1.662 ± 0.02	2.62LysPro: 2.62 ± 0.03	1.818LysGln: 1.818 ± 0.025	3.307LysArg: 3.307 ± 0.031	3.295LysSer: 3.295 ± 0.029	2.637LysThr: 2.637 ± 0.022	2.744LysVal: 2.744 ± 0.024	0.65LysTrp: 0.65 ± 0.012	1.375LysTyr: 1.375 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	8.1LeuAla: 8.1 ± 0.049	1.266LeuCys: 1.266 ± 0.018	5.24LeuAsp: 5.24 ± 0.036	5.621LeuGlu: 5.621 ± 0.046	3.382LeuPhe: 3.382 ± 0.034	5.997LeuGly: 5.997 ± 0.039	2.323LeuHis: 2.323 ± 0.023	4.073LeuIle: 4.073 ± 0.031	4.083LeuLys: 4.083 ± 0.032	8.764LeuLeu: 8.764 ± 0.063	1.793LeuMet: 1.793 ± 0.018	3.231LeuAsn: 3.231 ± 0.023	5.574LeuPro: 5.574 ± 0.034	3.926LeuGln: 3.926 ± 0.033	6.02LeuArg: 6.02 ± 0.037	7.657LeuSer: 7.657 ± 0.041	4.881LeuThr: 4.881 ± 0.035	5.605LeuVal: 5.605 ± 0.042	1.223LeuTrp: 1.223 ± 0.017	2.479LeuTyr: 2.479 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.159MetAla: 2.159 ± 0.021	0.237MetCys: 0.237 ± 0.007	1.208MetAsp: 1.208 ± 0.017	1.268MetGlu: 1.268 ± 0.017	0.743MetPhe: 0.743 ± 0.013	1.424MetGly: 1.424 ± 0.018	0.464MetHis: 0.464 ± 0.01	0.998MetIle: 0.998 ± 0.015	0.97MetLys: 0.97 ± 0.015	1.831MetLeu: 1.831 ± 0.023	0.548MetMet: 0.548 ± 0.01	0.797MetAsn: 0.797 ± 0.015	1.171MetPro: 1.171 ± 0.018	0.86MetGln: 0.86 ± 0.012	1.241MetArg: 1.241 ± 0.016	1.788MetSer: 1.788 ± 0.02	1.303MetThr: 1.303 ± 0.017	1.341MetVal: 1.341 ± 0.015	0.261MetTrp: 0.261 ± 0.008	0.531MetTyr: 0.531 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.175AsnAla: 3.175 ± 0.027	0.449AsnCys: 0.449 ± 0.01	1.901AsnAsp: 1.901 ± 0.018	2.029AsnGlu: 2.029 ± 0.019	1.315AsnPhe: 1.315 ± 0.017	2.987AsnGly: 2.987 ± 0.031	0.841AsnHis: 0.841 ± 0.012	1.994AsnIle: 1.994 ± 0.022	1.452AsnLys: 1.452 ± 0.015	3.288AsnLeu: 3.288 ± 0.026	0.791AsnMet: 0.791 ± 0.014	1.396AsnAsn: 1.396 ± 0.02	2.447AsnPro: 2.447 ± 0.026	1.325AsnGln: 1.325 ± 0.02	1.977AsnArg: 1.977 ± 0.018	2.64AsnSer: 2.64 ± 0.025	2.068AsnThr: 2.068 ± 0.021	2.347AsnVal: 2.347 ± 0.023	0.579AsnTrp: 0.579 ± 0.01	1.067AsnTyr: 1.067 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	5.382ProAla: 5.382 ± 0.055	0.547ProCys: 0.547 ± 0.013	3.242ProAsp: 3.242 ± 0.029	3.861ProGlu: 3.861 ± 0.033	2.11ProPhe: 2.11 ± 0.024	3.962ProGly: 3.962 ± 0.035	1.323ProHis: 1.323 ± 0.017	2.443ProIle: 2.443 ± 0.022	2.493ProLys: 2.493 ± 0.025	4.855ProLeu: 4.855 ± 0.038	1.012ProMet: 1.012 ± 0.014	2.119ProAsn: 2.119 ± 0.02	4.893ProPro: 4.893 ± 0.066	2.42ProGln: 2.42 ± 0.032	3.478ProArg: 3.478 ± 0.042	6.219ProSer: 6.219 ± 0.046	3.856ProThr: 3.856 ± 0.036	3.739ProVal: 3.739 ± 0.032	0.777ProTrp: 0.777 ± 0.013	1.547ProTyr: 1.547 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	3.462GlnAla: 3.462 ± 0.034	0.45GlnCys: 0.45 ± 0.011	2.004GlnAsp: 2.004 ± 0.022	2.449GlnGlu: 2.449 ± 0.026	1.322GlnPhe: 1.322 ± 0.015	2.477GlnGly: 2.477 ± 0.026	1.038GlnHis: 1.038 ± 0.017	1.954GlnIle: 1.954 ± 0.022	1.956GlnLys: 1.956 ± 0.021	3.582GlnLeu: 3.582 ± 0.03	0.887GlnMet: 0.887 ± 0.015	1.534GlnAsn: 1.534 ± 0.02	2.504GlnPro: 2.504 ± 0.032	2.327GlnGln: 2.327 ± 0.044	2.705GlnArg: 2.705 ± 0.025	3.314GlnSer: 3.314 ± 0.036	2.374GlnThr: 2.374 ± 0.021	2.228GlnVal: 2.228 ± 0.021	0.594GlnTrp: 0.594 ± 0.012	1.151GlnTyr: 1.151 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	4.973ArgAla: 4.973 ± 0.048	0.707ArgCys: 0.707 ± 0.013	3.355ArgAsp: 3.355 ± 0.03	3.938ArgGlu: 3.938 ± 0.033	2.257ArgPhe: 2.257 ± 0.022	3.692ArgGly: 3.692 ± 0.035	1.564ArgHis: 1.564 ± 0.019	2.948ArgIle: 2.948 ± 0.026	3.416ArgLys: 3.416 ± 0.031	5.802ArgLeu: 5.802 ± 0.041	1.323ArgMet: 1.323 ± 0.018	2.285ArgAsn: 2.285 ± 0.02	3.585ArgPro: 3.585 ± 0.034	2.666ArgGln: 2.666 ± 0.026	5.248ArgArg: 5.248 ± 0.048	4.895ArgSer: 4.895 ± 0.042	3.352ArgThr: 3.352 ± 0.029	3.557ArgVal: 3.557 ± 0.027	0.968ArgTrp: 0.968 ± 0.015	1.739ArgTyr: 1.739 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	6.932SerAla: 6.932 ± 0.046	0.862SerCys: 0.862 ± 0.015	4.281SerAsp: 4.281 ± 0.038	4.226SerGlu: 4.226 ± 0.027	3.016SerPhe: 3.016 ± 0.024	5.591SerGly: 5.591 ± 0.044	1.981SerHis: 1.981 ± 0.021	3.974SerIle: 3.974 ± 0.032	3.601SerLys: 3.601 ± 0.028	7.488SerLeu: 7.488 ± 0.046	1.697SerMet: 1.697 ± 0.019	2.96SerAsn: 2.96 ± 0.026	5.484SerPro: 5.484 ± 0.05	3.39SerGln: 3.39 ± 0.033	5.102SerArg: 5.102 ± 0.038	8.871SerSer: 8.871 ± 0.083	5.538SerThr: 5.538 ± 0.041	4.809SerVal: 4.809 ± 0.038	1.142SerTrp: 1.142 ± 0.017	2.09SerTyr: 2.09 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	5.353ThrAla: 5.353 ± 0.04	0.732ThrCys: 0.732 ± 0.014	2.922ThrAsp: 2.922 ± 0.025	3.132ThrGlu: 3.132 ± 0.029	2.19ThrPhe: 2.19 ± 0.02	4.3ThrGly: 4.3 ± 0.035	1.247ThrHis: 1.247 ± 0.015	3.04ThrIle: 3.04 ± 0.026	2.448ThrLys: 2.448 ± 0.024	5.258ThrLeu: 5.258 ± 0.035	1.161ThrMet: 1.161 ± 0.016	2.007ThrAsn: 2.007 ± 0.021	4.188ThrPro: 4.188 ± 0.038	2.062ThrGln: 2.062 ± 0.024	3.04ThrArg: 3.04 ± 0.027	5.168ThrSer: 5.168 ± 0.034	4.126ThrThr: 4.126 ± 0.044	3.949ThrVal: 3.949 ± 0.032	0.862ThrTrp: 0.862 ± 0.014	1.617ThrTyr: 1.617 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	5.351ValAla: 5.351 ± 0.037	0.861ValCys: 0.861 ± 0.014	3.822ValAsp: 3.822 ± 0.028	3.861ValGlu: 3.861 ± 0.034	2.519ValPhe: 2.519 ± 0.021	4.007ValGly: 4.007 ± 0.029	1.448ValHis: 1.448 ± 0.016	3.056ValIle: 3.056 ± 0.03	2.806ValLys: 2.806 ± 0.026	5.775ValLeu: 5.775 ± 0.048	1.308ValMet: 1.308 ± 0.016	2.272ValAsn: 2.272 ± 0.021	3.721ValPro: 3.721 ± 0.029	2.479ValGln: 2.479 ± 0.023	3.595ValArg: 3.595 ± 0.025	4.88ValSer: 4.88 ± 0.032	3.646ValThr: 3.646 ± 0.028	4.339ValVal: 4.339 ± 0.037	0.89ValTrp: 0.89 ± 0.014	1.836ValTyr: 1.836 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	1.134TrpAla: 1.134 ± 0.016	0.185TrpCys: 0.185 ± 0.006	0.919TrpAsp: 0.919 ± 0.014	0.85TrpGlu: 0.85 ± 0.013	0.541TrpPhe: 0.541 ± 0.01	0.941TrpGly: 0.941 ± 0.015	0.349TrpHis: 0.349 ± 0.008	0.77TrpIle: 0.77 ± 0.012	0.807TrpLys: 0.807 ± 0.014	1.376TrpLeu: 1.376 ± 0.017	0.373TrpMet: 0.373 ± 0.009	0.627TrpAsn: 0.627 ± 0.011	0.629TrpPro: 0.629 ± 0.013	0.573TrpGln: 0.573 ± 0.011	0.996TrpArg: 0.996 ± 0.012	1.067TrpSer: 1.067 ± 0.016	0.953TrpThr: 0.953 ± 0.012	0.9TrpVal: 0.9 ± 0.014	0.275TrpTrp: 0.275 ± 0.008	0.452TrpTyr: 0.452 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.248TyrAla: 2.248 ± 0.021	0.416TyrCys: 0.416 ± 0.008	1.625TyrAsp: 1.625 ± 0.018	1.586TyrGlu: 1.586 ± 0.018	1.207TyrPhe: 1.207 ± 0.015	2.115TyrGly: 2.115 ± 0.023	0.765TyrHis: 0.765 ± 0.013	1.466TyrIle: 1.466 ± 0.019	1.089TyrLys: 1.089 ± 0.015	2.785TyrLeu: 2.785 ± 0.028	0.633TyrMet: 0.633 ± 0.013	1.133TyrAsn: 1.133 ± 0.015	1.581TyrPro: 1.581 ± 0.02	1.113TyrGln: 1.113 ± 0.014	1.712TyrArg: 1.712 ± 0.02	2.073TyrSer: 2.073 ± 0.019	1.667TyrThr: 1.667 ± 0.02	1.718TyrVal: 1.718 ± 0.018	0.457TyrTrp: 0.457 ± 0.01	0.977TyrTyr: 0.977 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9664 proteins (5093457 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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