Amino acid dipepetide frequency for Corynebacterium lowii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.626AlaAla: 16.626 ± 0.22
0.971AlaCys: 0.971 ± 0.035
5.778AlaAsp: 5.778 ± 0.093
8.594AlaGlu: 8.594 ± 0.138
3.363AlaPhe: 3.363 ± 0.075
10.078AlaGly: 10.078 ± 0.124
2.498AlaHis: 2.498 ± 0.059
5.047AlaIle: 5.047 ± 0.085
2.955AlaLys: 2.955 ± 0.081
13.62AlaLeu: 13.62 ± 0.176
2.82AlaMet: 2.82 ± 0.061
2.25AlaAsn: 2.25 ± 0.061
5.834AlaPro: 5.834 ± 0.108
5.266AlaGln: 5.266 ± 0.104
7.671AlaArg: 7.671 ± 0.122
6.258AlaSer: 6.258 ± 0.098
7.043AlaThr: 7.043 ± 0.105
9.953AlaVal: 9.953 ± 0.14
1.65AlaTrp: 1.65 ± 0.054
2.392AlaTyr: 2.392 ± 0.062
0.0AlaXaa: 0.0 ± 0.0
Cys
1.015CysAla: 1.015 ± 0.037
0.089CysCys: 0.089 ± 0.011
0.397CysAsp: 0.397 ± 0.021
0.394CysGlu: 0.394 ± 0.025
0.227CysPhe: 0.227 ± 0.021
0.783CysGly: 0.783 ± 0.037
0.161CysHis: 0.161 ± 0.014
0.278CysIle: 0.278 ± 0.021
0.126CysLys: 0.126 ± 0.014
0.695CysLeu: 0.695 ± 0.032
0.14CysMet: 0.14 ± 0.014
0.146CysAsn: 0.146 ± 0.014
0.387CysPro: 0.387 ± 0.025
0.211CysGln: 0.211 ± 0.02
0.404CysArg: 0.404 ± 0.027
0.521CysSer: 0.521 ± 0.026
0.459CysThr: 0.459 ± 0.024
0.586CysVal: 0.586 ± 0.029
0.114CysTrp: 0.114 ± 0.013
0.167CysTyr: 0.167 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
6.09AspAla: 6.09 ± 0.103
0.304AspCys: 0.304 ± 0.022
2.549AspAsp: 2.549 ± 0.071
3.644AspGlu: 3.644 ± 0.091
1.858AspPhe: 1.858 ± 0.051
3.904AspGly: 3.904 ± 0.09
1.111AspHis: 1.111 ± 0.043
2.423AspIle: 2.423 ± 0.053
1.546AspLys: 1.546 ± 0.052
5.497AspLeu: 5.497 ± 0.096
1.067AspMet: 1.067 ± 0.039
1.361AspAsn: 1.361 ± 0.049
3.391AspPro: 3.391 ± 0.065
1.434AspGln: 1.434 ± 0.043
3.079AspArg: 3.079 ± 0.069
3.347AspSer: 3.347 ± 0.066
3.078AspThr: 3.078 ± 0.065
4.204AspVal: 4.204 ± 0.09
0.769AspTrp: 0.769 ± 0.035
1.512AspTyr: 1.512 ± 0.045
0.0AspXaa: 0.0 ± 0.0
Glu
8.148GluAla: 8.148 ± 0.135
0.336GluCys: 0.336 ± 0.019
3.472GluAsp: 3.472 ± 0.073
6.23GluGlu: 6.23 ± 0.12
1.793GluPhe: 1.793 ± 0.052
5.637GluGly: 5.637 ± 0.109
1.766GluHis: 1.766 ± 0.052
3.179GluIle: 3.179 ± 0.082
2.449GluLys: 2.449 ± 0.07
6.441GluLeu: 6.441 ± 0.104
1.354GluMet: 1.354 ± 0.041
1.999GluAsn: 1.999 ± 0.065
3.063GluPro: 3.063 ± 0.093
3.1GluGln: 3.1 ± 0.084
4.837GluArg: 4.837 ± 0.086
3.226GluSer: 3.226 ± 0.072
2.939GluThr: 2.939 ± 0.069
5.943GluVal: 5.943 ± 0.1
0.786GluTrp: 0.786 ± 0.038
1.641GluTyr: 1.641 ± 0.048
0.0GluXaa: 0.0 ± 0.0
Phe
3.442PheAla: 3.442 ± 0.08
0.266PheCys: 0.266 ± 0.02
1.943PheAsp: 1.943 ± 0.051
1.778PheGlu: 1.778 ± 0.051
1.265PhePhe: 1.265 ± 0.048
3.179PheGly: 3.179 ± 0.073
0.725PheHis: 0.725 ± 0.033
1.488PheIle: 1.488 ± 0.051
0.591PheLys: 0.591 ± 0.032
3.267PheLeu: 3.267 ± 0.085
0.613PheMet: 0.613 ± 0.029
0.779PheAsn: 0.779 ± 0.037
1.388PhePro: 1.388 ± 0.044
0.861PheGln: 0.861 ± 0.033
1.667PheArg: 1.667 ± 0.054
2.279PheSer: 2.279 ± 0.065
1.838PheThr: 1.838 ± 0.055
2.241PheVal: 2.241 ± 0.061
0.424PheTrp: 0.424 ± 0.028
0.808PheTyr: 0.808 ± 0.035
0.0PheXaa: 0.0 ± 0.0
Gly
9.416GlyAla: 9.416 ± 0.126
0.668GlyCys: 0.668 ± 0.032
4.153GlyAsp: 4.153 ± 0.088
5.751GlyGlu: 5.751 ± 0.108
2.901GlyPhe: 2.901 ± 0.07
7.115GlyGly: 7.115 ± 0.138
1.878GlyHis: 1.878 ± 0.05
4.601GlyIle: 4.601 ± 0.077
2.76GlyLys: 2.76 ± 0.075
8.841GlyLeu: 8.841 ± 0.119
2.436GlyMet: 2.436 ± 0.065
2.21GlyAsn: 2.21 ± 0.06
3.336GlyPro: 3.336 ± 0.072
2.808GlyGln: 2.808 ± 0.059
5.134GlyArg: 5.134 ± 0.094
5.28GlySer: 5.28 ± 0.089
5.425GlyThr: 5.425 ± 0.105
7.449GlyVal: 7.449 ± 0.109
1.46GlyTrp: 1.46 ± 0.048
2.283GlyTyr: 2.283 ± 0.059
0.0GlyXaa: 0.0 ± 0.0
His
2.281HisAla: 2.281 ± 0.056
0.212HisCys: 0.212 ± 0.018
1.142HisAsp: 1.142 ± 0.038
1.276HisGlu: 1.276 ± 0.04
0.64HisPhe: 0.64 ± 0.028
2.012HisGly: 2.012 ± 0.06
0.636HisHis: 0.636 ± 0.03
0.94HisIle: 0.94 ± 0.035
0.495HisLys: 0.495 ± 0.027
2.363HisLeu: 2.363 ± 0.06
0.428HisMet: 0.428 ± 0.024
0.61HisAsn: 0.61 ± 0.031
1.578HisPro: 1.578 ± 0.05
0.728HisGln: 0.728 ± 0.031
1.758HisArg: 1.758 ± 0.053
1.266HisSer: 1.266 ± 0.041
1.234HisThr: 1.234 ± 0.036
1.471HisVal: 1.471 ± 0.055
0.287HisTrp: 0.287 ± 0.018
0.567HisTyr: 0.567 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
6.336IleAla: 6.336 ± 0.103
0.363IleCys: 0.363 ± 0.024
3.12IleAsp: 3.12 ± 0.064
2.977IleGlu: 2.977 ± 0.068
1.588IlePhe: 1.588 ± 0.058
3.94IleGly: 3.94 ± 0.077
0.883IleHis: 0.883 ± 0.039
2.234IleIle: 2.234 ± 0.067
1.232IleLys: 1.232 ± 0.042
3.978IleLeu: 3.978 ± 0.085
0.979IleMet: 0.979 ± 0.037
1.34IleAsn: 1.34 ± 0.045
2.74IlePro: 2.74 ± 0.065
1.116IleGln: 1.116 ± 0.038
2.38IleArg: 2.38 ± 0.062
2.795IleSer: 2.795 ± 0.075
3.145IleThr: 3.145 ± 0.078
3.966IleVal: 3.966 ± 0.088
0.455IleTrp: 0.455 ± 0.028
0.931IleTyr: 0.931 ± 0.035
0.0IleXaa: 0.0 ± 0.0
Lys
3.266LysAla: 3.266 ± 0.086
0.106LysCys: 0.106 ± 0.013
1.577LysAsp: 1.577 ± 0.058
2.112LysGlu: 2.112 ± 0.068
0.601LysPhe: 0.601 ± 0.03
2.055LysGly: 2.055 ± 0.061
0.562LysHis: 0.562 ± 0.028
1.468LysIle: 1.468 ± 0.051
1.56LysLys: 1.56 ± 0.057
2.172LysLeu: 2.172 ± 0.057
0.636LysMet: 0.636 ± 0.031
1.012LysAsn: 1.012 ± 0.039
1.547LysPro: 1.547 ± 0.065
1.087LysGln: 1.087 ± 0.045
1.792LysArg: 1.792 ± 0.051
1.33LysSer: 1.33 ± 0.046
1.437LysThr: 1.437 ± 0.045
2.286LysVal: 2.286 ± 0.065
0.311LysTrp: 0.311 ± 0.02
0.639LysTyr: 0.639 ± 0.033
0.0LysXaa: 0.0 ± 0.0
Leu
12.471LeuAla: 12.471 ± 0.15
0.957LeuCys: 0.957 ± 0.038
5.817LeuAsp: 5.817 ± 0.102
5.033LeuGlu: 5.033 ± 0.084
3.035LeuPhe: 3.035 ± 0.085
9.407LeuGly: 9.407 ± 0.141
2.348LeuHis: 2.348 ± 0.064
4.933LeuIle: 4.933 ± 0.097
2.261LeuLys: 2.261 ± 0.063
10.332LeuLeu: 10.332 ± 0.17
2.098LeuMet: 2.098 ± 0.059
2.675LeuAsn: 2.675 ± 0.063
5.604LeuPro: 5.604 ± 0.099
2.19LeuGln: 2.19 ± 0.065
7.714LeuArg: 7.714 ± 0.117
7.226LeuSer: 7.226 ± 0.096
5.7LeuThr: 5.7 ± 0.094
8.118LeuVal: 8.118 ± 0.12
1.371LeuTrp: 1.371 ± 0.051
1.95LeuTyr: 1.95 ± 0.055
0.0LeuXaa: 0.0 ± 0.0
Met
2.686MetAla: 2.686 ± 0.072
0.136MetCys: 0.136 ± 0.014
1.02MetAsp: 1.02 ± 0.041
1.332MetGlu: 1.332 ± 0.042
0.66MetPhe: 0.66 ± 0.032
1.874MetGly: 1.874 ± 0.054
0.4MetHis: 0.4 ± 0.023
1.129MetIle: 1.129 ± 0.044
0.749MetLys: 0.749 ± 0.034
2.101MetLeu: 2.101 ± 0.062
0.574MetMet: 0.574 ± 0.029
0.766MetAsn: 0.766 ± 0.035
1.212MetPro: 1.212 ± 0.04
0.63MetGln: 0.63 ± 0.028
1.54MetArg: 1.54 ± 0.044
1.758MetSer: 1.758 ± 0.047
1.431MetThr: 1.431 ± 0.041
1.787MetVal: 1.787 ± 0.053
0.254MetTrp: 0.254 ± 0.02
0.376MetTyr: 0.376 ± 0.024
0.0MetXaa: 0.0 ± 0.0
Asn
2.63AsnAla: 2.63 ± 0.058
0.161AsnCys: 0.161 ± 0.015
1.234AsnAsp: 1.234 ± 0.048
1.403AsnGlu: 1.403 ± 0.046
0.846AsnPhe: 0.846 ± 0.039
1.852AsnGly: 1.852 ± 0.057
0.541AsnHis: 0.541 ± 0.027
1.307AsnIle: 1.307 ± 0.045
0.839AsnLys: 0.839 ± 0.031
2.621AsnLeu: 2.621 ± 0.061
0.579AsnMet: 0.579 ± 0.03
0.812AsnAsn: 0.812 ± 0.035
2.118AsnPro: 2.118 ± 0.059
0.863AsnGln: 0.863 ± 0.035
1.547AsnArg: 1.547 ± 0.05
1.471AsnSer: 1.471 ± 0.05
1.6AsnThr: 1.6 ± 0.049
1.697AsnVal: 1.697 ± 0.055
0.362AsnTrp: 0.362 ± 0.022
0.634AsnTyr: 0.634 ± 0.03
0.0AsnXaa: 0.0 ± 0.0
Pro
6.24ProAla: 6.24 ± 0.134
0.28ProCys: 0.28 ± 0.022
2.786ProAsp: 2.786 ± 0.07
5.039ProGlu: 5.039 ± 0.099
1.496ProPhe: 1.496 ± 0.043
4.817ProGly: 4.817 ± 0.102
1.296ProHis: 1.296 ± 0.044
1.949ProIle: 1.949 ± 0.052
1.373ProLys: 1.373 ± 0.052
4.972ProLeu: 4.972 ± 0.091
1.046ProMet: 1.046 ± 0.034
1.142ProAsn: 1.142 ± 0.043
1.949ProPro: 1.949 ± 0.06
2.259ProGln: 2.259 ± 0.063
3.13ProArg: 3.13 ± 0.076
3.049ProSer: 3.049 ± 0.066
3.326ProThr: 3.326 ± 0.065
4.399ProVal: 4.399 ± 0.079
0.78ProTrp: 0.78 ± 0.034
1.102ProTyr: 1.102 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
4.509GlnAla: 4.509 ± 0.087
0.201GlnCys: 0.201 ± 0.016
1.513GlnAsp: 1.513 ± 0.054
2.553GlnGlu: 2.553 ± 0.057
0.865GlnPhe: 0.865 ± 0.037
2.911GlnGly: 2.911 ± 0.062
0.752GlnHis: 0.752 ± 0.031
1.679GlnIle: 1.679 ± 0.051
0.88GlnLys: 0.88 ± 0.035
2.825GlnLeu: 2.825 ± 0.07
0.804GlnMet: 0.804 ± 0.029
0.722GlnAsn: 0.722 ± 0.029
1.78GlnPro: 1.78 ± 0.053
1.594GlnGln: 1.594 ± 0.053
3.196GlnArg: 3.196 ± 0.076
1.546GlnSer: 1.546 ± 0.046
1.323GlnThr: 1.323 ± 0.042
2.95GlnVal: 2.95 ± 0.063
0.733GlnTrp: 0.733 ± 0.035
0.678GlnTyr: 0.678 ± 0.033
0.0GlnXaa: 0.0 ± 0.0
Arg
7.418ArgAla: 7.418 ± 0.121
0.449ArgCys: 0.449 ± 0.024
3.585ArgAsp: 3.585 ± 0.069
4.862ArgGlu: 4.862 ± 0.095
2.083ArgPhe: 2.083 ± 0.059
5.251ArgGly: 5.251 ± 0.089
1.532ArgHis: 1.532 ± 0.044
3.022ArgIle: 3.022 ± 0.068
1.939ArgLys: 1.939 ± 0.053
6.418ArgLeu: 6.418 ± 0.11
1.741ArgMet: 1.741 ± 0.05
1.652ArgAsn: 1.652 ± 0.054
3.138ArgPro: 3.138 ± 0.067
2.223ArgGln: 2.223 ± 0.06
5.81ArgArg: 5.81 ± 0.122
3.907ArgSer: 3.907 ± 0.082
3.76ArgThr: 3.76 ± 0.072
4.782ArgVal: 4.782 ± 0.106
1.108ArgTrp: 1.108 ± 0.042
1.778ArgTyr: 1.778 ± 0.049
0.0ArgXaa: 0.0 ± 0.0
Ser
7.061SerAla: 7.061 ± 0.101
0.349SerCys: 0.349 ± 0.022
2.802SerAsp: 2.802 ± 0.064
3.702SerGlu: 3.702 ± 0.094
2.002SerPhe: 2.002 ± 0.049
5.762SerGly: 5.762 ± 0.106
1.195SerHis: 1.195 ± 0.042
2.504SerIle: 2.504 ± 0.062
1.444SerLys: 1.444 ± 0.043
6.082SerLeu: 6.082 ± 0.104
1.453SerMet: 1.453 ± 0.054
1.375SerAsn: 1.375 ± 0.043
3.332SerPro: 3.332 ± 0.071
2.069SerGln: 2.069 ± 0.051
3.617SerArg: 3.617 ± 0.071
3.732SerSer: 3.732 ± 0.098
4.242SerThr: 4.242 ± 0.085
4.635SerVal: 4.635 ± 0.091
0.897SerTrp: 0.897 ± 0.036
1.351SerTyr: 1.351 ± 0.049
0.0SerXaa: 0.0 ± 0.0
Thr
6.928ThrAla: 6.928 ± 0.1
0.408ThrCys: 0.408 ± 0.026
2.736ThrAsp: 2.736 ± 0.064
3.465ThrGlu: 3.465 ± 0.076
1.778ThrPhe: 1.778 ± 0.043
5.329ThrGly: 5.329 ± 0.087
1.248ThrHis: 1.248 ± 0.041
2.682ThrIle: 2.682 ± 0.072
1.549ThrLys: 1.549 ± 0.048
5.974ThrLeu: 5.974 ± 0.089
1.188ThrMet: 1.188 ± 0.04
1.265ThrAsn: 1.265 ± 0.042
3.882ThrPro: 3.882 ± 0.079
2.086ThrGln: 2.086 ± 0.052
3.257ThrArg: 3.257 ± 0.077
3.49ThrSer: 3.49 ± 0.082
3.537ThrThr: 3.537 ± 0.069
5.409ThrVal: 5.409 ± 0.094
0.883ThrTrp: 0.883 ± 0.038
1.279ThrTyr: 1.279 ± 0.041
0.0ThrXaa: 0.0 ± 0.0
Val
10.072ValAla: 10.072 ± 0.127
0.701ValCys: 0.701 ± 0.035
4.71ValAsp: 4.71 ± 0.094
5.822ValGlu: 5.822 ± 0.101
2.483ValPhe: 2.483 ± 0.06
6.853ValGly: 6.853 ± 0.117
1.601ValHis: 1.601 ± 0.05
4.019ValIle: 4.019 ± 0.094
1.91ValLys: 1.91 ± 0.059
8.83ValLeu: 8.83 ± 0.128
1.795ValMet: 1.795 ± 0.048
2.063ValAsn: 2.063 ± 0.065
4.173ValPro: 4.173 ± 0.076
2.111ValGln: 2.111 ± 0.056
5.15ValArg: 5.15 ± 0.086
4.922ValSer: 4.922 ± 0.086
4.886ValThr: 4.886 ± 0.079
7.563ValVal: 7.563 ± 0.129
0.978ValTrp: 0.978 ± 0.04
1.604ValTyr: 1.604 ± 0.044
0.0ValXaa: 0.0 ± 0.0
Trp
1.639TrpAla: 1.639 ± 0.049
0.143TrpCys: 0.143 ± 0.015
0.65TrpAsp: 0.65 ± 0.031
0.927TrpGlu: 0.927 ± 0.036
0.55TrpPhe: 0.55 ± 0.034
1.088TrpGly: 1.088 ± 0.04
0.302TrpHis: 0.302 ± 0.02
0.725TrpIle: 0.725 ± 0.036
0.407TrpLys: 0.407 ± 0.022
1.67TrpLeu: 1.67 ± 0.06
0.3TrpMet: 0.3 ± 0.021
0.38TrpAsn: 0.38 ± 0.023
0.667TrpPro: 0.667 ± 0.031
0.555TrpGln: 0.555 ± 0.028
1.067TrpArg: 1.067 ± 0.041
0.76TrpSer: 0.76 ± 0.035
0.649TrpThr: 0.649 ± 0.029
1.176TrpVal: 1.176 ± 0.046
0.415TrpTrp: 0.415 ± 0.025
0.307TrpTyr: 0.307 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.395TyrAla: 2.395 ± 0.058
0.202TyrCys: 0.202 ± 0.017
1.184TyrAsp: 1.184 ± 0.039
1.443TyrGlu: 1.443 ± 0.042
0.807TyrPhe: 0.807 ± 0.032
2.06TyrGly: 2.06 ± 0.056
0.486TyrHis: 0.486 ± 0.026
0.892TyrIle: 0.892 ± 0.038
0.492TyrLys: 0.492 ± 0.024
2.542TyrLeu: 2.542 ± 0.06
0.365TyrMet: 0.365 ± 0.023
0.562TyrAsn: 0.562 ± 0.028
1.31TyrPro: 1.31 ± 0.044
0.824TyrGln: 0.824 ± 0.034
1.707TyrArg: 1.707 ± 0.056
1.441TyrSer: 1.441 ± 0.04
1.32TyrThr: 1.32 ± 0.047
1.628TyrVal: 1.628 ± 0.047
0.339TyrTrp: 0.339 ± 0.023
0.533TyrTyr: 0.533 ± 0.031
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2252 proteins (707702 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski