Amino acid dipepetide frequency for Flavobacterium terrae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.776AlaAla: 3.776 ± 0.099	0.567AlaCys: 0.567 ± 0.025	2.963AlaAsp: 2.963 ± 0.063	3.77AlaGlu: 3.77 ± 0.095	3.138AlaPhe: 3.138 ± 0.064	3.912AlaGly: 3.912 ± 0.084	1.013AlaHis: 1.013 ± 0.037	5.073AlaIle: 5.073 ± 0.076	4.986AlaLys: 4.986 ± 0.097	5.743AlaLeu: 5.743 ± 0.098	1.399AlaMet: 1.399 ± 0.041	3.753AlaAsn: 3.753 ± 0.07	1.799AlaPro: 1.799 ± 0.048	2.48AlaGln: 2.48 ± 0.062	1.783AlaArg: 1.783 ± 0.055	4.239AlaSer: 4.239 ± 0.084	3.791AlaThr: 3.791 ± 0.095	3.752AlaVal: 3.752 ± 0.072	0.542AlaTrp: 0.542 ± 0.024	2.173AlaTyr: 2.173 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.473CysAla: 0.473 ± 0.024	0.12CysCys: 0.12 ± 0.014	0.439CysAsp: 0.439 ± 0.023	0.469CysGlu: 0.469 ± 0.021	0.462CysPhe: 0.462 ± 0.022	0.657CysGly: 0.657 ± 0.029	0.174CysHis: 0.174 ± 0.015	0.641CysIle: 0.641 ± 0.023	0.542CysLys: 0.542 ± 0.026	0.689CysLeu: 0.689 ± 0.027	0.147CysMet: 0.147 ± 0.013	0.469CysAsn: 0.469 ± 0.025	0.367CysPro: 0.367 ± 0.024	0.279CysGln: 0.279 ± 0.019	0.204CysArg: 0.204 ± 0.015	0.634CysSer: 0.634 ± 0.036	0.464CysThr: 0.464 ± 0.038	0.504CysVal: 0.504 ± 0.026	0.065CysTrp: 0.065 ± 0.009	0.311CysTyr: 0.311 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	3.37AspAla: 3.37 ± 0.066	0.46AspCys: 0.46 ± 0.021	2.608AspAsp: 2.608 ± 0.063	3.701AspGlu: 3.701 ± 0.073	3.696AspPhe: 3.696 ± 0.069	3.342AspGly: 3.342 ± 0.068	0.703AspHis: 0.703 ± 0.026	4.074AspIle: 4.074 ± 0.068	4.492AspLys: 4.492 ± 0.077	4.956AspLeu: 4.956 ± 0.076	0.991AspMet: 0.991 ± 0.033	3.31AspAsn: 3.31 ± 0.058	1.428AspPro: 1.428 ± 0.044	1.365AspGln: 1.365 ± 0.04	1.647AspArg: 1.647 ± 0.047	3.209AspSer: 3.209 ± 0.056	2.497AspThr: 2.497 ± 0.048	3.458AspVal: 3.458 ± 0.068	0.65AspTrp: 0.65 ± 0.029	2.863AspTyr: 2.863 ± 0.063	0.0AspXaa: 0.0 ± 0.0
Glu	4.064GluAla: 4.064 ± 0.09	0.365GluCys: 0.365 ± 0.022	3.2GluAsp: 3.2 ± 0.074	4.825GluGlu: 4.825 ± 0.082	3.207GluPhe: 3.207 ± 0.063	3.457GluGly: 3.457 ± 0.061	1.013GluHis: 1.013 ± 0.036	5.956GluIle: 5.956 ± 0.101	6.687GluLys: 6.687 ± 0.116	5.835GluLeu: 5.835 ± 0.095	1.645GluMet: 1.645 ± 0.038	5.182GluAsn: 5.182 ± 0.087	1.472GluPro: 1.472 ± 0.044	2.147GluGln: 2.147 ± 0.055	2.209GluArg: 2.209 ± 0.055	3.423GluSer: 3.423 ± 0.058	3.582GluThr: 3.582 ± 0.063	4.331GluVal: 4.331 ± 0.075	0.602GluTrp: 0.602 ± 0.023	2.516GluTyr: 2.516 ± 0.057	0.0GluXaa: 0.0 ± 0.0
Phe	3.06PheAla: 3.06 ± 0.061	0.524PheCys: 0.524 ± 0.025	3.399PheAsp: 3.399 ± 0.066	3.736PheGlu: 3.736 ± 0.068	3.04PhePhe: 3.04 ± 0.065	3.765PheGly: 3.765 ± 0.063	0.774PheHis: 0.774 ± 0.028	4.061PheIle: 4.061 ± 0.081	3.936PheLys: 3.936 ± 0.09	4.92PheLeu: 4.92 ± 0.084	1.123PheMet: 1.123 ± 0.032	3.522PheAsn: 3.522 ± 0.068	1.784PhePro: 1.784 ± 0.045	1.717PheGln: 1.717 ± 0.046	1.493PheArg: 1.493 ± 0.041	4.274PheSer: 4.274 ± 0.078	3.272PheThr: 3.272 ± 0.077	3.34PheVal: 3.34 ± 0.066	0.579PheTrp: 0.579 ± 0.028	2.288PheTyr: 2.288 ± 0.053	0.0PheXaa: 0.0 ± 0.0
Gly	3.955GlyAla: 3.955 ± 0.095	0.632GlyCys: 0.632 ± 0.034	3.012GlyAsp: 3.012 ± 0.057	3.354GlyGlu: 3.354 ± 0.063	3.672GlyPhe: 3.672 ± 0.064	4.378GlyGly: 4.378 ± 0.104	1.085GlyHis: 1.085 ± 0.035	5.23GlyIle: 5.23 ± 0.077	5.061GlyLys: 5.061 ± 0.079	5.425GlyLeu: 5.425 ± 0.072	1.555GlyMet: 1.555 ± 0.043	3.935GlyAsn: 3.935 ± 0.084	1.263GlyPro: 1.263 ± 0.044	1.902GlyGln: 1.902 ± 0.048	1.802GlyArg: 1.802 ± 0.049	4.014GlySer: 4.014 ± 0.082	4.019GlyThr: 4.019 ± 0.104	4.121GlyVal: 4.121 ± 0.068	0.661GlyTrp: 0.661 ± 0.029	2.764GlyTyr: 2.764 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	0.868HisAla: 0.868 ± 0.034	0.185HisCys: 0.185 ± 0.015	0.804HisAsp: 0.804 ± 0.032	0.97HisGlu: 0.97 ± 0.034	1.146HisPhe: 1.146 ± 0.039	0.987HisGly: 0.987 ± 0.032	0.443HisHis: 0.443 ± 0.024	1.266HisIle: 1.266 ± 0.04	1.228HisLys: 1.228 ± 0.035	1.622HisLeu: 1.622 ± 0.045	0.312HisMet: 0.312 ± 0.018	0.969HisAsn: 0.969 ± 0.033	0.73HisPro: 0.73 ± 0.031	0.682HisGln: 0.682 ± 0.029	0.569HisArg: 0.569 ± 0.025	1.008HisSer: 1.008 ± 0.028	0.803HisThr: 0.803 ± 0.029	0.827HisVal: 0.827 ± 0.028	0.184HisTrp: 0.184 ± 0.016	0.831HisTyr: 0.831 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.398IleAla: 5.398 ± 0.082	0.7IleCys: 0.7 ± 0.03	4.866IleAsp: 4.866 ± 0.065	5.865IleGlu: 5.865 ± 0.097	3.816IlePhe: 3.816 ± 0.07	4.992IleGly: 4.992 ± 0.079	1.346IleHis: 1.346 ± 0.04	6.281IleIle: 6.281 ± 0.103	6.428IleLys: 6.428 ± 0.074	7.127IleLeu: 7.127 ± 0.116	1.444IleMet: 1.444 ± 0.041	5.241IleAsn: 5.241 ± 0.086	3.158IlePro: 3.158 ± 0.066	2.727IleGln: 2.727 ± 0.061	2.275IleArg: 2.275 ± 0.055	5.767IleSer: 5.767 ± 0.095	5.022IleThr: 5.022 ± 0.089	5.062IleVal: 5.062 ± 0.079	0.665IleTrp: 0.665 ± 0.03	2.956IleTyr: 2.956 ± 0.058	0.0IleXaa: 0.0 ± 0.0
Lys	4.995LysAla: 4.995 ± 0.111	0.406LysCys: 0.406 ± 0.021	4.427LysAsp: 4.427 ± 0.076	6.538LysGlu: 6.538 ± 0.118	3.349LysPhe: 3.349 ± 0.063	4.564LysGly: 4.564 ± 0.076	1.289LysHis: 1.289 ± 0.039	7.354LysIle: 7.354 ± 0.102	7.81LysLys: 7.81 ± 0.137	6.894LysLeu: 6.894 ± 0.108	2.344LysMet: 2.344 ± 0.052	6.08LysAsn: 6.08 ± 0.094	2.601LysPro: 2.601 ± 0.049	2.888LysGln: 2.888 ± 0.06	2.653LysArg: 2.653 ± 0.06	5.046LysSer: 5.046 ± 0.08	4.853LysThr: 4.853 ± 0.076	5.136LysVal: 5.136 ± 0.088	0.725LysTrp: 0.725 ± 0.028	3.347LysTyr: 3.347 ± 0.068	0.0LysXaa: 0.0 ± 0.0
Leu	5.558LeuAla: 5.558 ± 0.084	0.697LeuCys: 0.697 ± 0.026	4.777LeuAsp: 4.777 ± 0.077	5.873LeuGlu: 5.873 ± 0.091	5.012LeuPhe: 5.012 ± 0.09	5.461LeuGly: 5.461 ± 0.074	1.52LeuHis: 1.52 ± 0.042	6.846LeuIle: 6.846 ± 0.117	7.905LeuLys: 7.905 ± 0.113	8.477LeuLeu: 8.477 ± 0.13	1.98LeuMet: 1.98 ± 0.048	5.825LeuAsn: 5.825 ± 0.086	3.357LeuPro: 3.357 ± 0.066	3.149LeuGln: 3.149 ± 0.058	2.791LeuArg: 2.791 ± 0.05	6.607LeuSer: 6.607 ± 0.092	4.929LeuThr: 4.929 ± 0.083	5.297LeuVal: 5.297 ± 0.07	0.746LeuTrp: 0.746 ± 0.031	3.157LeuTyr: 3.157 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	1.429MetAla: 1.429 ± 0.042	0.152MetCys: 0.152 ± 0.015	1.009MetAsp: 1.009 ± 0.038	1.331MetGlu: 1.331 ± 0.044	0.938MetPhe: 0.938 ± 0.033	1.284MetGly: 1.284 ± 0.04	0.409MetHis: 0.409 ± 0.021	1.661MetIle: 1.661 ± 0.042	2.324MetLys: 2.324 ± 0.051	1.822MetLeu: 1.822 ± 0.048	0.643MetMet: 0.643 ± 0.029	1.427MetAsn: 1.427 ± 0.045	0.841MetPro: 0.841 ± 0.031	0.834MetGln: 0.834 ± 0.027	0.863MetArg: 0.863 ± 0.03	1.504MetSer: 1.504 ± 0.044	1.18MetThr: 1.18 ± 0.034	1.27MetVal: 1.27 ± 0.041	0.166MetTrp: 0.166 ± 0.014	0.78MetTyr: 0.78 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	3.86AsnAla: 3.86 ± 0.071	0.562AsnCys: 0.562 ± 0.029	3.604AsnAsp: 3.604 ± 0.056	4.214AsnGlu: 4.214 ± 0.067	3.556AsnPhe: 3.556 ± 0.067	4.435AsnGly: 4.435 ± 0.089	1.204AsnHis: 1.204 ± 0.038	5.096AsnIle: 5.096 ± 0.082	5.003AsnLys: 5.003 ± 0.089	5.865AsnLeu: 5.865 ± 0.082	1.319AsnMet: 1.319 ± 0.037	4.553AsnAsn: 4.553 ± 0.099	3.052AsnPro: 3.052 ± 0.057	2.616AsnGln: 2.616 ± 0.056	1.992AsnArg: 1.992 ± 0.047	4.585AsnSer: 4.585 ± 0.086	3.731AsnThr: 3.731 ± 0.079	3.927AsnVal: 3.927 ± 0.069	0.829AsnTrp: 0.829 ± 0.031	3.258AsnTyr: 3.258 ± 0.064	0.0AsnXaa: 0.0 ± 0.0
Pro	1.82ProAla: 1.82 ± 0.051	0.226ProCys: 0.226 ± 0.016	1.798ProAsp: 1.798 ± 0.045	2.618ProGlu: 2.618 ± 0.055	1.905ProPhe: 1.905 ± 0.043	1.788ProGly: 1.788 ± 0.053	0.532ProHis: 0.532 ± 0.023	2.749ProIle: 2.749 ± 0.05	2.603ProLys: 2.603 ± 0.062	2.695ProLeu: 2.695 ± 0.056	0.694ProMet: 0.694 ± 0.033	2.413ProAsn: 2.413 ± 0.061	0.716ProPro: 0.716 ± 0.032	1.127ProGln: 1.127 ± 0.035	0.831ProArg: 0.831 ± 0.038	2.319ProSer: 2.319 ± 0.057	2.111ProThr: 2.111 ± 0.064	2.301ProVal: 2.301 ± 0.057	0.291ProTrp: 0.291 ± 0.017	1.281ProTyr: 1.281 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	1.96GlnAla: 1.96 ± 0.05	0.216GlnCys: 0.216 ± 0.018	1.618GlnAsp: 1.618 ± 0.048	2.336GlnGlu: 2.336 ± 0.063	1.825GlnPhe: 1.825 ± 0.042	1.785GlnGly: 1.785 ± 0.043	0.539GlnHis: 0.539 ± 0.023	2.937GlnIle: 2.937 ± 0.057	3.284GlnLys: 3.284 ± 0.063	3.284GlnLeu: 3.284 ± 0.069	0.82GlnMet: 0.82 ± 0.032	2.638GlnAsn: 2.638 ± 0.057	1.021GlnPro: 1.021 ± 0.035	1.311GlnGln: 1.311 ± 0.042	1.07GlnArg: 1.07 ± 0.04	1.999GlnSer: 1.999 ± 0.045	1.891GlnThr: 1.891 ± 0.049	1.99GlnVal: 1.99 ± 0.054	0.359GlnTrp: 0.359 ± 0.019	1.347GlnTyr: 1.347 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	1.765ArgAla: 1.765 ± 0.05	0.192ArgCys: 0.192 ± 0.015	1.574ArgAsp: 1.574 ± 0.041	1.943ArgGlu: 1.943 ± 0.052	1.736ArgPhe: 1.736 ± 0.046	1.68ArgGly: 1.68 ± 0.045	0.52ArgHis: 0.52 ± 0.024	2.746ArgIle: 2.746 ± 0.054	2.581ArgLys: 2.581 ± 0.053	2.859ArgLeu: 2.859 ± 0.061	0.854ArgMet: 0.854 ± 0.032	1.979ArgAsn: 1.979 ± 0.047	0.97ArgPro: 0.97 ± 0.033	0.897ArgGln: 0.897 ± 0.03	1.096ArgArg: 1.096 ± 0.038	1.582ArgSer: 1.582 ± 0.044	1.609ArgThr: 1.609 ± 0.045	1.959ArgVal: 1.959 ± 0.048	0.308ArgTrp: 0.308 ± 0.018	1.352ArgTyr: 1.352 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	3.73SerAla: 3.73 ± 0.09	0.698SerCys: 0.698 ± 0.03	3.426SerAsp: 3.426 ± 0.06	4.016SerGlu: 4.016 ± 0.066	4.169SerPhe: 4.169 ± 0.075	4.713SerGly: 4.713 ± 0.1	1.104SerHis: 1.104 ± 0.035	5.497SerIle: 5.497 ± 0.088	5.5SerLys: 5.5 ± 0.088	5.898SerLeu: 5.898 ± 0.084	1.323SerMet: 1.323 ± 0.036	4.431SerAsn: 4.431 ± 0.089	2.085SerPro: 2.085 ± 0.052	2.398SerGln: 2.398 ± 0.054	1.873SerArg: 1.873 ± 0.043	4.626SerSer: 4.626 ± 0.1	3.858SerThr: 3.858 ± 0.086	4.197SerVal: 4.197 ± 0.078	0.677SerTrp: 0.677 ± 0.026	2.84SerTyr: 2.84 ± 0.059	0.0SerXaa: 0.0 ± 0.0
Thr	3.606ThrAla: 3.606 ± 0.112	0.43ThrCys: 0.43 ± 0.031	2.995ThrAsp: 2.995 ± 0.058	3.338ThrGlu: 3.338 ± 0.066	3.202ThrPhe: 3.202 ± 0.072	3.92ThrGly: 3.92 ± 0.096	0.898ThrHis: 0.898 ± 0.033	5.147ThrIle: 5.147 ± 0.098	4.165ThrLys: 4.165 ± 0.077	5.151ThrLeu: 5.151 ± 0.082	0.924ThrMet: 0.924 ± 0.03	3.873ThrAsn: 3.873 ± 0.084	2.466ThrPro: 2.466 ± 0.065	1.873ThrGln: 1.873 ± 0.044	1.492ThrArg: 1.492 ± 0.038	4.148ThrSer: 4.148 ± 0.091	3.756ThrThr: 3.756 ± 0.109	3.821ThrVal: 3.821 ± 0.094	0.55ThrTrp: 0.55 ± 0.029	2.414ThrTyr: 2.414 ± 0.072	0.0ThrXaa: 0.0 ± 0.0
Val	4.03ValAla: 4.03 ± 0.072	0.517ValCys: 0.517 ± 0.024	3.433ValAsp: 3.433 ± 0.07	3.84ValGlu: 3.84 ± 0.066	3.477ValPhe: 3.477 ± 0.066	3.665ValGly: 3.665 ± 0.069	0.903ValHis: 0.903 ± 0.028	4.91ValIle: 4.91 ± 0.073	4.826ValLys: 4.826 ± 0.077	5.975ValLeu: 5.975 ± 0.084	1.318ValMet: 1.318 ± 0.04	3.977ValAsn: 3.977 ± 0.063	2.101ValPro: 2.101 ± 0.05	1.85ValGln: 1.85 ± 0.048	1.798ValArg: 1.798 ± 0.043	4.657ValSer: 4.657 ± 0.075	3.779ValThr: 3.779 ± 0.111	4.374ValVal: 4.374 ± 0.086	0.592ValTrp: 0.592 ± 0.024	2.547ValTyr: 2.547 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	0.601TrpAla: 0.601 ± 0.025	0.109TrpCys: 0.109 ± 0.01	0.53TrpAsp: 0.53 ± 0.025	0.611TrpGlu: 0.611 ± 0.028	0.551TrpPhe: 0.551 ± 0.025	0.599TrpGly: 0.599 ± 0.027	0.19TrpHis: 0.19 ± 0.015	0.711TrpIle: 0.711 ± 0.026	0.804TrpLys: 0.804 ± 0.03	0.9TrpLeu: 0.9 ± 0.034	0.274TrpMet: 0.274 ± 0.017	0.751TrpAsn: 0.751 ± 0.029	0.157TrpPro: 0.157 ± 0.015	0.388TrpGln: 0.388 ± 0.019	0.336TrpArg: 0.336 ± 0.02	0.568TrpSer: 0.568 ± 0.024	0.584TrpThr: 0.584 ± 0.029	0.549TrpVal: 0.549 ± 0.026	0.129TrpTrp: 0.129 ± 0.012	0.428TrpTyr: 0.428 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.336TyrAla: 2.336 ± 0.053	0.357TyrCys: 0.357 ± 0.02	2.337TyrAsp: 2.337 ± 0.054	2.369TyrGlu: 2.369 ± 0.052	2.71TyrPhe: 2.71 ± 0.058	2.459TyrGly: 2.459 ± 0.057	0.775TyrHis: 0.775 ± 0.029	2.901TyrIle: 2.901 ± 0.054	3.135TyrLys: 3.135 ± 0.063	3.827TyrLeu: 3.827 ± 0.061	0.76TyrMet: 0.76 ± 0.027	2.934TyrAsn: 2.934 ± 0.07	1.447TyrPro: 1.447 ± 0.041	1.598TyrGln: 1.598 ± 0.04	1.423TyrArg: 1.423 ± 0.042	2.848TyrSer: 2.848 ± 0.061	2.439TyrThr: 2.439 ± 0.069	2.351TyrVal: 2.351 ± 0.051	0.451TyrTrp: 0.451 ± 0.02	2.02TyrTyr: 2.02 ± 0.059	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2883 proteins (969809 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---