Amino acid dipepetide frequency for Intrasporangium oryzae NRRL B-24470

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.306AlaAla: 20.306 ± 0.204	0.918AlaCys: 0.918 ± 0.027	8.03AlaAsp: 8.03 ± 0.1	7.473AlaGlu: 7.473 ± 0.1	3.58AlaPhe: 3.58 ± 0.06	12.293AlaGly: 12.293 ± 0.11	2.8AlaHis: 2.8 ± 0.045	4.775AlaIle: 4.775 ± 0.066	2.632AlaLys: 2.632 ± 0.062	14.02AlaLeu: 14.02 ± 0.142	2.725AlaMet: 2.725 ± 0.044	2.122AlaAsn: 2.122 ± 0.039	6.55AlaPro: 6.55 ± 0.086	3.508AlaGln: 3.508 ± 0.064	10.157AlaArg: 10.157 ± 0.11	7.065AlaSer: 7.065 ± 0.088	8.111AlaThr: 8.111 ± 0.087	12.022AlaVal: 12.022 ± 0.121	2.062AlaTrp: 2.062 ± 0.041	2.664AlaTyr: 2.664 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.822CysAla: 0.822 ± 0.025	0.076CysCys: 0.076 ± 0.008	0.435CysAsp: 0.435 ± 0.017	0.333CysGlu: 0.333 ± 0.016	0.232CysPhe: 0.232 ± 0.013	0.752CysGly: 0.752 ± 0.024	0.175CysHis: 0.175 ± 0.013	0.246CysIle: 0.246 ± 0.013	0.088CysLys: 0.088 ± 0.009	0.593CysLeu: 0.593 ± 0.02	0.104CysMet: 0.104 ± 0.009	0.114CysAsn: 0.114 ± 0.01	0.434CysPro: 0.434 ± 0.02	0.146CysGln: 0.146 ± 0.01	0.503CysArg: 0.503 ± 0.019	0.4CysSer: 0.4 ± 0.02	0.477CysThr: 0.477 ± 0.025	0.572CysVal: 0.572 ± 0.023	0.089CysTrp: 0.089 ± 0.008	0.134CysTyr: 0.134 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.939AspAla: 7.939 ± 0.091	0.342AspCys: 0.342 ± 0.018	4.022AspAsp: 4.022 ± 0.062	4.332AspGlu: 4.332 ± 0.069	1.565AspPhe: 1.565 ± 0.038	6.078AspGly: 6.078 ± 0.079	1.51AspHis: 1.51 ± 0.032	2.054AspIle: 2.054 ± 0.042	0.997AspLys: 0.997 ± 0.031	6.94AspLeu: 6.94 ± 0.079	0.767AspMet: 0.767 ± 0.027	0.927AspAsn: 0.927 ± 0.03	4.584AspPro: 4.584 ± 0.06	1.552AspGln: 1.552 ± 0.034	4.986AspArg: 4.986 ± 0.074	2.44AspSer: 2.44 ± 0.039	2.955AspThr: 2.955 ± 0.056	5.901AspVal: 5.901 ± 0.075	0.976AspTrp: 0.976 ± 0.029	1.171AspTyr: 1.171 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	7.43GluAla: 7.43 ± 0.1	0.339GluCys: 0.339 ± 0.016	2.719GluAsp: 2.719 ± 0.048	2.974GluGlu: 2.974 ± 0.052	1.29GluPhe: 1.29 ± 0.035	4.373GluGly: 4.373 ± 0.06	1.62GluHis: 1.62 ± 0.036	2.233GluIle: 2.233 ± 0.045	1.149GluLys: 1.149 ± 0.037	6.086GluLeu: 6.086 ± 0.079	0.904GluMet: 0.904 ± 0.027	0.789GluAsn: 0.789 ± 0.024	3.224GluPro: 3.224 ± 0.061	2.018GluGln: 2.018 ± 0.042	5.333GluArg: 5.333 ± 0.083	2.757GluSer: 2.757 ± 0.046	2.892GluThr: 2.892 ± 0.044	5.054GluVal: 5.054 ± 0.079	0.832GluTrp: 0.832 ± 0.026	0.853GluTyr: 0.853 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	3.567PheAla: 3.567 ± 0.059	0.238PheCys: 0.238 ± 0.013	2.047PheAsp: 2.047 ± 0.039	1.597PheGlu: 1.597 ± 0.038	0.954PhePhe: 0.954 ± 0.031	3.029PheGly: 3.029 ± 0.058	0.57PheHis: 0.57 ± 0.022	0.913PheIle: 0.913 ± 0.033	0.425PheLys: 0.425 ± 0.019	2.474PheLeu: 2.474 ± 0.048	0.42PheMet: 0.42 ± 0.018	0.595PheAsn: 0.595 ± 0.021	1.304PhePro: 1.304 ± 0.034	0.591PheGln: 0.591 ± 0.021	1.659PheArg: 1.659 ± 0.037	1.519PheSer: 1.519 ± 0.035	1.951PheThr: 1.951 ± 0.042	2.762PheVal: 2.762 ± 0.051	0.445PheTrp: 0.445 ± 0.018	0.617PheTyr: 0.617 ± 0.021	0.0PheXaa: 0.0 ± 0.0
Gly	10.944GlyAla: 10.944 ± 0.104	0.685GlyCys: 0.685 ± 0.027	5.248GlyAsp: 5.248 ± 0.076	4.674GlyGlu: 4.674 ± 0.061	2.892GlyPhe: 2.892 ± 0.051	8.125GlyGly: 8.125 ± 0.119	2.307GlyHis: 2.307 ± 0.041	3.938GlyIle: 3.938 ± 0.053	1.991GlyLys: 1.991 ± 0.047	9.712GlyLeu: 9.712 ± 0.103	1.937GlyMet: 1.937 ± 0.04	1.647GlyAsn: 1.647 ± 0.04	4.911GlyPro: 4.911 ± 0.07	2.642GlyGln: 2.642 ± 0.051	7.369GlyArg: 7.369 ± 0.079	5.88GlySer: 5.88 ± 0.079	5.955GlyThr: 5.955 ± 0.082	7.976GlyVal: 7.976 ± 0.096	1.798GlyTrp: 1.798 ± 0.035	2.091GlyTyr: 2.091 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.719HisAla: 2.719 ± 0.045	0.166HisCys: 0.166 ± 0.011	1.554HisAsp: 1.554 ± 0.033	1.356HisGlu: 1.356 ± 0.033	0.613HisPhe: 0.613 ± 0.023	2.226HisGly: 2.226 ± 0.044	0.671HisHis: 0.671 ± 0.026	0.645HisIle: 0.645 ± 0.023	0.273HisLys: 0.273 ± 0.014	2.454HisLeu: 2.454 ± 0.043	0.267HisMet: 0.267 ± 0.016	0.348HisAsn: 0.348 ± 0.016	1.736HisPro: 1.736 ± 0.037	0.556HisGln: 0.556 ± 0.023	1.819HisArg: 1.819 ± 0.038	0.913HisSer: 0.913 ± 0.027	1.188HisThr: 1.188 ± 0.024	2.197HisVal: 2.197 ± 0.041	0.337HisTrp: 0.337 ± 0.016	0.44HisTyr: 0.44 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	5.333IleAla: 5.333 ± 0.066	0.269IleCys: 0.269 ± 0.013	2.679IleAsp: 2.679 ± 0.05	2.439IleGlu: 2.439 ± 0.044	0.841IlePhe: 0.841 ± 0.028	3.853IleGly: 3.853 ± 0.055	0.732IleHis: 0.732 ± 0.024	1.206IleIle: 1.206 ± 0.034	0.705IleLys: 0.705 ± 0.027	2.858IleLeu: 2.858 ± 0.057	0.518IleMet: 0.518 ± 0.02	0.743IleAsn: 0.743 ± 0.024	1.965IlePro: 1.965 ± 0.042	0.772IleGln: 0.772 ± 0.024	2.424IleArg: 2.424 ± 0.045	1.844IleSer: 1.844 ± 0.041	2.323IleThr: 2.323 ± 0.05	3.619IleVal: 3.619 ± 0.06	0.441IleTrp: 0.441 ± 0.02	0.622IleTyr: 0.622 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	2.663LysAla: 2.663 ± 0.068	0.075LysCys: 0.075 ± 0.008	1.25LysAsp: 1.25 ± 0.041	0.982LysGlu: 0.982 ± 0.033	0.394LysPhe: 0.394 ± 0.015	1.681LysGly: 1.681 ± 0.045	0.376LysHis: 0.376 ± 0.017	0.776LysIle: 0.776 ± 0.027	0.63LysLys: 0.63 ± 0.028	1.467LysLeu: 1.467 ± 0.04	0.297LysMet: 0.297 ± 0.015	0.424LysAsn: 0.424 ± 0.018	1.093LysPro: 1.093 ± 0.033	0.646LysGln: 0.646 ± 0.025	1.322LysArg: 1.322 ± 0.035	1.001LysSer: 1.001 ± 0.031	1.139LysThr: 1.139 ± 0.039	1.83LysVal: 1.83 ± 0.044	0.222LysTrp: 0.222 ± 0.011	0.4LysTyr: 0.4 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	14.842LeuAla: 14.842 ± 0.134	0.66LeuCys: 0.66 ± 0.021	6.93LeuAsp: 6.93 ± 0.081	5.145LeuGlu: 5.145 ± 0.069	2.483LeuPhe: 2.483 ± 0.043	9.926LeuGly: 9.926 ± 0.117	2.044LeuHis: 2.044 ± 0.04	3.113LeuIle: 3.113 ± 0.052	1.698LeuLys: 1.698 ± 0.043	10.33LeuLeu: 10.33 ± 0.116	1.611LeuMet: 1.611 ± 0.031	1.472LeuAsn: 1.472 ± 0.034	5.595LeuPro: 5.595 ± 0.068	2.257LeuGln: 2.257 ± 0.041	7.785LeuArg: 7.785 ± 0.093	5.44LeuSer: 5.44 ± 0.065	6.61LeuThr: 6.61 ± 0.068	10.453LeuVal: 10.453 ± 0.107	1.354LeuTrp: 1.354 ± 0.033	1.523LeuTyr: 1.523 ± 0.036	0.0LeuXaa: 0.0 ± 0.0
Met	2.278MetAla: 2.278 ± 0.038	0.113MetCys: 0.113 ± 0.009	0.842MetAsp: 0.842 ± 0.025	0.718MetGlu: 0.718 ± 0.024	0.475MetPhe: 0.475 ± 0.019	1.408MetGly: 1.408 ± 0.033	0.358MetHis: 0.358 ± 0.015	0.658MetIle: 0.658 ± 0.024	0.428MetLys: 0.428 ± 0.02	1.669MetLeu: 1.669 ± 0.035	0.29MetMet: 0.29 ± 0.016	0.401MetAsn: 0.401 ± 0.019	1.159MetPro: 1.159 ± 0.031	0.463MetGln: 0.463 ± 0.021	1.46MetArg: 1.46 ± 0.035	1.502MetSer: 1.502 ± 0.037	1.741MetThr: 1.741 ± 0.033	1.486MetVal: 1.486 ± 0.036	0.212MetTrp: 0.212 ± 0.011	0.259MetTyr: 0.259 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.172AsnAla: 2.172 ± 0.038	0.116AsnCys: 0.116 ± 0.009	0.997AsnAsp: 0.997 ± 0.033	0.868AsnGlu: 0.868 ± 0.027	0.471AsnPhe: 0.471 ± 0.02	1.724AsnGly: 1.724 ± 0.045	0.411AsnHis: 0.411 ± 0.017	0.62AsnIle: 0.62 ± 0.021	0.336AsnLys: 0.336 ± 0.018	1.735AsnLeu: 1.735 ± 0.041	0.249AsnMet: 0.249 ± 0.014	0.402AsnAsn: 0.402 ± 0.025	1.463AsnPro: 1.463 ± 0.033	0.483AsnGln: 0.483 ± 0.019	1.221AsnArg: 1.221 ± 0.029	0.78AsnSer: 0.78 ± 0.024	0.996AsnThr: 0.996 ± 0.026	1.529AsnVal: 1.529 ± 0.036	0.249AsnTrp: 0.249 ± 0.013	0.394AsnTyr: 0.394 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	7.543ProAla: 7.543 ± 0.089	0.273ProCys: 0.273 ± 0.015	4.373ProAsp: 4.373 ± 0.059	3.925ProGlu: 3.925 ± 0.068	1.566ProPhe: 1.566 ± 0.034	6.097ProGly: 6.097 ± 0.08	1.222ProHis: 1.222 ± 0.028	1.773ProIle: 1.773 ± 0.04	1.066ProLys: 1.066 ± 0.031	4.801ProLeu: 4.801 ± 0.058	1.086ProMet: 1.086 ± 0.028	0.967ProAsn: 0.967 ± 0.03	2.881ProPro: 2.881 ± 0.059	1.479ProGln: 1.479 ± 0.038	3.673ProArg: 3.673 ± 0.054	3.53ProSer: 3.53 ± 0.051	3.954ProThr: 3.954 ± 0.066	5.431ProVal: 5.431 ± 0.068	0.976ProTrp: 0.976 ± 0.028	1.061ProTyr: 1.061 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	3.434GlnAla: 3.434 ± 0.065	0.173GlnCys: 0.173 ± 0.012	1.187GlnAsp: 1.187 ± 0.028	1.118GlnGlu: 1.118 ± 0.033	0.682GlnPhe: 0.682 ± 0.022	2.102GlnGly: 2.102 ± 0.041	0.629GlnHis: 0.629 ± 0.023	1.045GlnIle: 1.045 ± 0.028	0.503GlnLys: 0.503 ± 0.021	2.84GlnLeu: 2.84 ± 0.051	0.483GlnMet: 0.483 ± 0.02	0.434GlnAsn: 0.434 ± 0.018	1.657GlnPro: 1.657 ± 0.036	1.039GlnGln: 1.039 ± 0.036	2.283GlnArg: 2.283 ± 0.045	1.391GlnSer: 1.391 ± 0.034	1.49GlnThr: 1.49 ± 0.033	2.634GlnVal: 2.634 ± 0.048	0.48GlnTrp: 0.48 ± 0.023	0.477GlnTyr: 0.477 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	9.67ArgAla: 9.67 ± 0.112	0.475ArgCys: 0.475 ± 0.02	4.519ArgAsp: 4.519 ± 0.066	4.388ArgGlu: 4.388 ± 0.061	2.333ArgPhe: 2.333 ± 0.04	5.751ArgGly: 5.751 ± 0.067	1.923ArgHis: 1.923 ± 0.042	3.108ArgIle: 3.108 ± 0.05	1.265ArgLys: 1.265 ± 0.036	8.489ArgLeu: 8.489 ± 0.1	1.715ArgMet: 1.715 ± 0.036	1.187ArgAsn: 1.187 ± 0.033	4.608ArgPro: 4.608 ± 0.071	2.104ArgGln: 2.104 ± 0.043	7.306ArgArg: 7.306 ± 0.096	4.413ArgSer: 4.413 ± 0.062	4.656ArgThr: 4.656 ± 0.063	6.373ArgVal: 6.373 ± 0.074	1.441ArgTrp: 1.441 ± 0.038	1.569ArgTyr: 1.569 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	6.922SerAla: 6.922 ± 0.091	0.362SerCys: 0.362 ± 0.016	3.18SerAsp: 3.18 ± 0.05	2.569SerGlu: 2.569 ± 0.048	1.666SerPhe: 1.666 ± 0.039	6.086SerGly: 6.086 ± 0.089	1.143SerHis: 1.143 ± 0.031	1.997SerIle: 1.997 ± 0.047	0.962SerLys: 0.962 ± 0.029	5.322SerLeu: 5.322 ± 0.072	1.286SerMet: 1.286 ± 0.028	0.959SerAsn: 0.959 ± 0.03	3.266SerPro: 3.266 ± 0.059	1.362SerGln: 1.362 ± 0.037	4.064SerArg: 4.064 ± 0.06	3.446SerSer: 3.446 ± 0.058	3.775SerThr: 3.775 ± 0.065	4.638SerVal: 4.638 ± 0.061	0.97SerTrp: 0.97 ± 0.03	1.108SerTyr: 1.108 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	7.955ThrAla: 7.955 ± 0.089	0.476ThrCys: 0.476 ± 0.023	3.688ThrAsp: 3.688 ± 0.051	2.898ThrGlu: 2.898 ± 0.047	1.978ThrPhe: 1.978 ± 0.04	6.152ThrGly: 6.152 ± 0.087	1.271ThrHis: 1.271 ± 0.033	2.488ThrIle: 2.488 ± 0.041	1.26ThrLys: 1.26 ± 0.036	5.844ThrLeu: 5.844 ± 0.065	1.167ThrMet: 1.167 ± 0.027	1.223ThrAsn: 1.223 ± 0.032	4.231ThrPro: 4.231 ± 0.062	1.438ThrGln: 1.438 ± 0.035	4.165ThrArg: 4.165 ± 0.056	3.862ThrSer: 3.862 ± 0.061	4.626ThrThr: 4.626 ± 0.09	6.094ThrVal: 6.094 ± 0.073	1.07ThrTrp: 1.07 ± 0.03	1.397ThrTyr: 1.397 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	12.722ValAla: 12.722 ± 0.11	0.694ValCys: 0.694 ± 0.023	6.123ValAsp: 6.123 ± 0.068	5.357ValGlu: 5.357 ± 0.074	2.495ValPhe: 2.495 ± 0.053	8.049ValGly: 8.049 ± 0.086	1.984ValHis: 1.984 ± 0.037	3.572ValIle: 3.572 ± 0.053	1.634ValLys: 1.634 ± 0.044	9.778ValLeu: 9.778 ± 0.099	1.585ValMet: 1.585 ± 0.036	1.724ValAsn: 1.724 ± 0.041	5.209ValPro: 5.209 ± 0.07	1.979ValGln: 1.979 ± 0.038	6.861ValArg: 6.861 ± 0.081	4.92ValSer: 4.92 ± 0.064	6.37ValThr: 6.37 ± 0.077	10.469ValVal: 10.469 ± 0.115	1.228ValTrp: 1.228 ± 0.032	1.426ValTyr: 1.426 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.735TrpAla: 1.735 ± 0.039	0.138TrpCys: 0.138 ± 0.011	0.858TrpAsp: 0.858 ± 0.029	0.677TrpGlu: 0.677 ± 0.022	0.566TrpPhe: 0.566 ± 0.025	1.163TrpGly: 1.163 ± 0.034	0.373TrpHis: 0.373 ± 0.019	0.532TrpIle: 0.532 ± 0.022	0.307TrpLys: 0.307 ± 0.018	1.859TrpLeu: 1.859 ± 0.043	0.304TrpMet: 0.304 ± 0.014	0.354TrpAsn: 0.354 ± 0.016	0.834TrpPro: 0.834 ± 0.026	0.517TrpGln: 0.517 ± 0.017	1.366TrpArg: 1.366 ± 0.034	1.106TrpSer: 1.106 ± 0.03	1.063TrpThr: 1.063 ± 0.028	1.422TrpVal: 1.422 ± 0.033	0.416TrpTrp: 0.416 ± 0.02	0.306TrpTyr: 0.306 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.818TyrAla: 2.818 ± 0.045	0.137TyrCys: 0.137 ± 0.011	1.357TyrAsp: 1.357 ± 0.04	1.046TyrGlu: 1.046 ± 0.031	0.599TyrPhe: 0.599 ± 0.022	1.853TyrGly: 1.853 ± 0.042	0.362TyrHis: 0.362 ± 0.016	0.496TyrIle: 0.496 ± 0.019	0.317TyrLys: 0.317 ± 0.018	2.001TyrLeu: 2.001 ± 0.041	0.205TyrMet: 0.205 ± 0.013	0.383TyrAsn: 0.383 ± 0.018	0.971TyrPro: 0.971 ± 0.029	0.529TyrGln: 0.529 ± 0.021	1.537TyrArg: 1.537 ± 0.035	0.875TyrSer: 0.875 ± 0.026	1.01TyrThr: 1.01 ± 0.035	1.718TyrVal: 1.718 ± 0.031	0.299TyrTrp: 0.299 ± 0.016	0.42TyrTyr: 0.42 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4086 proteins (1346621 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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