Amino acid dipepetide frequency for Arcicella aurantiaca

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.894AlaAla: 3.894 ± 0.058	0.638AlaCys: 0.638 ± 0.023	3.684AlaAsp: 3.684 ± 0.069	4.115AlaGlu: 4.115 ± 0.054	3.276AlaPhe: 3.276 ± 0.053	4.858AlaGly: 4.858 ± 0.083	0.988AlaHis: 0.988 ± 0.028	5.0AlaIle: 5.0 ± 0.06	4.942AlaLys: 4.942 ± 0.053	6.009AlaLeu: 6.009 ± 0.057	1.587AlaMet: 1.587 ± 0.035	4.122AlaAsn: 4.122 ± 0.055	1.993AlaPro: 1.993 ± 0.041	2.83AlaGln: 2.83 ± 0.048	2.072AlaArg: 2.072 ± 0.037	4.329AlaSer: 4.329 ± 0.073	4.35AlaThr: 4.35 ± 0.104	4.025AlaVal: 4.025 ± 0.054	0.746AlaTrp: 0.746 ± 0.022	2.51AlaTyr: 2.51 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.446CysAla: 0.446 ± 0.018	0.116CysCys: 0.116 ± 0.008	0.441CysAsp: 0.441 ± 0.021	0.517CysGlu: 0.517 ± 0.016	0.465CysPhe: 0.465 ± 0.016	0.635CysGly: 0.635 ± 0.022	0.195CysHis: 0.195 ± 0.011	0.576CysIle: 0.576 ± 0.018	0.541CysLys: 0.541 ± 0.02	0.816CysLeu: 0.816 ± 0.024	0.173CysMet: 0.173 ± 0.011	0.459CysAsn: 0.459 ± 0.021	0.365CysPro: 0.365 ± 0.017	0.322CysGln: 0.322 ± 0.014	0.269CysArg: 0.269 ± 0.013	0.654CysSer: 0.654 ± 0.025	0.559CysThr: 0.559 ± 0.025	0.563CysVal: 0.563 ± 0.021	0.092CysTrp: 0.092 ± 0.007	0.328CysTyr: 0.328 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.64AspAla: 3.64 ± 0.059	0.462AspCys: 0.462 ± 0.018	2.532AspAsp: 2.532 ± 0.043	3.368AspGlu: 3.368 ± 0.055	3.618AspPhe: 3.618 ± 0.056	3.924AspGly: 3.924 ± 0.111	0.654AspHis: 0.654 ± 0.025	4.018AspIle: 4.018 ± 0.047	4.148AspLys: 4.148 ± 0.054	5.092AspLeu: 5.092 ± 0.06	1.032AspMet: 1.032 ± 0.026	3.145AspAsn: 3.145 ± 0.054	1.532AspPro: 1.532 ± 0.037	1.168AspGln: 1.168 ± 0.037	1.796AspArg: 1.796 ± 0.037	3.154AspSer: 3.154 ± 0.066	2.542AspThr: 2.542 ± 0.056	3.225AspVal: 3.225 ± 0.056	0.783AspTrp: 0.783 ± 0.023	2.481AspTyr: 2.481 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	4.067GluAla: 4.067 ± 0.062	0.364GluCys: 0.364 ± 0.014	2.938GluAsp: 2.938 ± 0.047	4.049GluGlu: 4.049 ± 0.106	2.727GluPhe: 2.727 ± 0.044	3.568GluGly: 3.568 ± 0.046	0.979GluHis: 0.979 ± 0.025	5.295GluIle: 5.295 ± 0.07	5.56GluLys: 5.56 ± 0.084	5.439GluLeu: 5.439 ± 0.074	1.603GluMet: 1.603 ± 0.034	4.313GluAsn: 4.313 ± 0.066	1.564GluPro: 1.564 ± 0.032	2.403GluGln: 2.403 ± 0.048	2.422GluArg: 2.422 ± 0.051	3.257GluSer: 3.257 ± 0.048	3.25GluThr: 3.25 ± 0.048	4.02GluVal: 4.02 ± 0.051	0.67GluTrp: 0.67 ± 0.019	2.325GluTyr: 2.325 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.255PheAla: 3.255 ± 0.047	0.533PheCys: 0.533 ± 0.018	3.177PheAsp: 3.177 ± 0.046	3.327PheGlu: 3.327 ± 0.049	2.659PhePhe: 2.659 ± 0.056	3.655PheGly: 3.655 ± 0.048	0.821PheHis: 0.821 ± 0.027	3.508PheIle: 3.508 ± 0.049	3.499PheLys: 3.499 ± 0.051	4.803PheLeu: 4.803 ± 0.062	1.193PheMet: 1.193 ± 0.029	2.932PheAsn: 2.932 ± 0.041	1.805PhePro: 1.805 ± 0.034	1.886PheGln: 1.886 ± 0.037	1.842PheArg: 1.842 ± 0.032	3.938PheSer: 3.938 ± 0.05	3.212PheThr: 3.212 ± 0.053	3.268PheVal: 3.268 ± 0.047	0.698PheTrp: 0.698 ± 0.022	2.127PheTyr: 2.127 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	4.121GlyAla: 4.121 ± 0.071	0.661GlyCys: 0.661 ± 0.028	3.24GlyAsp: 3.24 ± 0.054	3.517GlyGlu: 3.517 ± 0.051	3.719GlyPhe: 3.719 ± 0.055	5.059GlyGly: 5.059 ± 0.085	0.982GlyHis: 0.982 ± 0.028	5.39GlyIle: 5.39 ± 0.067	5.336GlyLys: 5.336 ± 0.067	5.971GlyLeu: 5.971 ± 0.061	1.639GlyMet: 1.639 ± 0.034	3.839GlyAsn: 3.839 ± 0.06	1.082GlyPro: 1.082 ± 0.032	2.294GlyGln: 2.294 ± 0.045	2.299GlyArg: 2.299 ± 0.046	4.249GlySer: 4.249 ± 0.071	4.621GlyThr: 4.621 ± 0.146	4.551GlyVal: 4.551 ± 0.063	0.822GlyTrp: 0.822 ± 0.023	2.816GlyTyr: 2.816 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	0.928HisAla: 0.928 ± 0.024	0.179HisCys: 0.179 ± 0.011	0.782HisAsp: 0.782 ± 0.021	0.952HisGlu: 0.952 ± 0.026	1.164HisPhe: 1.164 ± 0.032	0.991HisGly: 0.991 ± 0.026	0.448HisHis: 0.448 ± 0.019	1.226HisIle: 1.226 ± 0.027	1.022HisLys: 1.022 ± 0.031	1.717HisLeu: 1.717 ± 0.037	0.184HisMet: 0.184 ± 0.01	0.838HisAsn: 0.838 ± 0.021	0.809HisPro: 0.809 ± 0.021	0.709HisGln: 0.709 ± 0.021	0.695HisArg: 0.695 ± 0.022	0.981HisSer: 0.981 ± 0.028	0.865HisThr: 0.865 ± 0.023	0.723HisVal: 0.723 ± 0.022	0.265HisTrp: 0.265 ± 0.012	0.777HisTyr: 0.777 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.229IleAla: 5.229 ± 0.061	0.786IleCys: 0.786 ± 0.026	4.468IleAsp: 4.468 ± 0.054	5.043IleGlu: 5.043 ± 0.071	3.835IlePhe: 3.835 ± 0.062	4.906IleGly: 4.906 ± 0.058	1.276IleHis: 1.276 ± 0.031	5.433IleIle: 5.433 ± 0.076	5.188IleLys: 5.188 ± 0.068	6.963IleLeu: 6.963 ± 0.082	1.376IleMet: 1.376 ± 0.033	4.402IleAsn: 4.402 ± 0.064	3.171IlePro: 3.171 ± 0.047	2.771IleGln: 2.771 ± 0.045	2.701IleArg: 2.701 ± 0.045	5.675IleSer: 5.675 ± 0.063	4.675IleThr: 4.675 ± 0.08	4.431IleVal: 4.431 ± 0.056	0.754IleTrp: 0.754 ± 0.022	2.68IleTyr: 2.68 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	5.151LysAla: 5.151 ± 0.059	0.409LysCys: 0.409 ± 0.015	4.201LysAsp: 4.201 ± 0.064	4.805LysGlu: 4.805 ± 0.074	3.023LysPhe: 3.023 ± 0.043	4.651LysGly: 4.651 ± 0.06	1.233LysHis: 1.233 ± 0.028	6.305LysIle: 6.305 ± 0.082	5.887LysLys: 5.887 ± 0.078	6.153LysLeu: 6.153 ± 0.068	2.126LysMet: 2.126 ± 0.037	5.045LysAsn: 5.045 ± 0.062	2.669LysPro: 2.669 ± 0.049	2.701LysGln: 2.701 ± 0.041	2.611LysArg: 2.611 ± 0.044	4.56LysSer: 4.56 ± 0.056	4.773LysThr: 4.773 ± 0.06	4.879LysVal: 4.879 ± 0.062	0.764LysTrp: 0.764 ± 0.021	3.172LysTyr: 3.172 ± 0.054	0.0LysXaa: 0.0 ± 0.0
Leu	6.217LeuAla: 6.217 ± 0.065	0.799LeuCys: 0.799 ± 0.026	4.51LeuAsp: 4.51 ± 0.057	5.32LeuGlu: 5.32 ± 0.08	4.594LeuPhe: 4.594 ± 0.061	5.91LeuGly: 5.91 ± 0.057	1.476LeuHis: 1.476 ± 0.029	6.505LeuIle: 6.505 ± 0.067	7.501LeuLys: 7.501 ± 0.085	8.426LeuLeu: 8.426 ± 0.091	2.235LeuMet: 2.235 ± 0.038	5.401LeuAsn: 5.401 ± 0.069	3.895LeuPro: 3.895 ± 0.055	3.518LeuGln: 3.518 ± 0.052	3.387LeuArg: 3.387 ± 0.056	7.008LeuSer: 7.008 ± 0.069	5.803LeuThr: 5.803 ± 0.085	5.129LeuVal: 5.129 ± 0.063	0.915LeuTrp: 0.915 ± 0.025	3.027LeuTyr: 3.027 ± 0.052	0.001LeuXaa: 0.001 ± 0.001
Met	1.693MetAla: 1.693 ± 0.03	0.14MetCys: 0.14 ± 0.009	1.015MetAsp: 1.015 ± 0.025	1.235MetGlu: 1.235 ± 0.033	0.866MetPhe: 0.866 ± 0.026	1.51MetGly: 1.51 ± 0.032	0.274MetHis: 0.274 ± 0.013	1.592MetIle: 1.592 ± 0.031	2.254MetLys: 2.254 ± 0.038	2.021MetLeu: 2.021 ± 0.038	0.662MetMet: 0.662 ± 0.021	1.444MetAsn: 1.444 ± 0.03	0.988MetPro: 0.988 ± 0.023	0.869MetGln: 0.869 ± 0.022	0.838MetArg: 0.838 ± 0.021	1.415MetSer: 1.415 ± 0.031	1.389MetThr: 1.389 ± 0.029	1.337MetVal: 1.337 ± 0.03	0.176MetTrp: 0.176 ± 0.011	0.706MetTyr: 0.706 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	4.022AsnAla: 4.022 ± 0.066	0.49AsnCys: 0.49 ± 0.022	2.968AsnAsp: 2.968 ± 0.049	3.319AsnGlu: 3.319 ± 0.052	3.219AsnPhe: 3.219 ± 0.044	4.19AsnGly: 4.19 ± 0.074	1.123AsnHis: 1.123 ± 0.028	4.758AsnIle: 4.758 ± 0.056	3.722AsnLys: 3.722 ± 0.052	5.776AsnLeu: 5.776 ± 0.07	1.117AsnMet: 1.117 ± 0.031	3.767AsnAsn: 3.767 ± 0.066	3.095AsnPro: 3.095 ± 0.055	2.724AsnGln: 2.724 ± 0.047	2.331AsnArg: 2.331 ± 0.044	3.875AsnSer: 3.875 ± 0.068	3.814AsnThr: 3.814 ± 0.07	3.729AsnVal: 3.729 ± 0.069	0.777AsnTrp: 0.777 ± 0.022	2.851AsnTyr: 2.851 ± 0.055	0.0AsnXaa: 0.0 ± 0.0
Pro	2.453ProAla: 2.453 ± 0.05	0.252ProCys: 0.252 ± 0.015	2.262ProAsp: 2.262 ± 0.042	2.527ProGlu: 2.527 ± 0.04	1.907ProPhe: 1.907 ± 0.038	1.19ProGly: 1.19 ± 0.03	0.646ProHis: 0.646 ± 0.02	2.781ProIle: 2.781 ± 0.043	2.515ProLys: 2.515 ± 0.043	2.984ProLeu: 2.984 ± 0.042	0.786ProMet: 0.786 ± 0.02	2.558ProAsn: 2.558 ± 0.05	0.969ProPro: 0.969 ± 0.026	1.429ProGln: 1.429 ± 0.031	0.984ProArg: 0.984 ± 0.023	2.528ProSer: 2.528 ± 0.045	2.643ProThr: 2.643 ± 0.067	2.424ProVal: 2.424 ± 0.042	0.315ProTrp: 0.315 ± 0.015	1.419ProTyr: 1.419 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	2.494GlnAla: 2.494 ± 0.043	0.202GlnCys: 0.202 ± 0.011	1.767GlnAsp: 1.767 ± 0.037	2.397GlnGlu: 2.397 ± 0.049	1.829GlnPhe: 1.829 ± 0.039	2.085GlnGly: 2.085 ± 0.037	0.6GlnHis: 0.6 ± 0.019	3.112GlnIle: 3.112 ± 0.047	3.413GlnLys: 3.413 ± 0.053	3.342GlnLeu: 3.342 ± 0.05	0.93GlnMet: 0.93 ± 0.025	2.776GlnAsn: 2.776 ± 0.043	1.209GlnPro: 1.209 ± 0.031	1.651GlnGln: 1.651 ± 0.033	1.422GlnArg: 1.422 ± 0.034	2.359GlnSer: 2.359 ± 0.04	2.464GlnThr: 2.464 ± 0.042	2.208GlnVal: 2.208 ± 0.04	0.378GlnTrp: 0.378 ± 0.017	1.461GlnTyr: 1.461 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	2.073ArgAla: 2.073 ± 0.041	0.249ArgCys: 0.249 ± 0.013	1.742ArgAsp: 1.742 ± 0.033	2.297ArgGlu: 2.297 ± 0.042	1.993ArgPhe: 1.993 ± 0.042	2.039ArgGly: 2.039 ± 0.041	0.567ArgHis: 0.567 ± 0.021	2.815ArgIle: 2.815 ± 0.046	2.813ArgLys: 2.813 ± 0.044	3.456ArgLeu: 3.456 ± 0.052	0.953ArgMet: 0.953 ± 0.027	2.245ArgAsn: 2.245 ± 0.034	1.201ArgPro: 1.201 ± 0.032	1.434ArgGln: 1.434 ± 0.032	1.43ArgArg: 1.43 ± 0.032	1.838ArgSer: 1.838 ± 0.043	2.009ArgThr: 2.009 ± 0.036	2.18ArgVal: 2.18 ± 0.038	0.475ArgTrp: 0.475 ± 0.017	1.511ArgTyr: 1.511 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	4.326SerAla: 4.326 ± 0.065	0.63SerCys: 0.63 ± 0.023	3.31SerAsp: 3.31 ± 0.047	3.861SerGlu: 3.861 ± 0.049	3.78SerPhe: 3.78 ± 0.045	4.868SerGly: 4.868 ± 0.087	1.032SerHis: 1.032 ± 0.025	5.047SerIle: 5.047 ± 0.06	4.527SerLys: 4.527 ± 0.058	6.401SerLeu: 6.401 ± 0.069	1.33SerMet: 1.33 ± 0.03	3.791SerAsn: 3.791 ± 0.068	2.61SerPro: 2.61 ± 0.042	2.542SerGln: 2.542 ± 0.043	2.163SerArg: 2.163 ± 0.042	4.511SerSer: 4.511 ± 0.078	4.036SerThr: 4.036 ± 0.086	4.406SerVal: 4.406 ± 0.057	0.753SerTrp: 0.753 ± 0.024	2.558SerTyr: 2.558 ± 0.046	0.001SerXaa: 0.001 ± 0.001
Thr	4.34ThrAla: 4.34 ± 0.108	0.494ThrCys: 0.494 ± 0.027	3.438ThrAsp: 3.438 ± 0.073	3.365ThrGlu: 3.365 ± 0.039	3.324ThrPhe: 3.324 ± 0.052	4.478ThrGly: 4.478 ± 0.105	1.009ThrHis: 1.009 ± 0.023	4.793ThrIle: 4.793 ± 0.071	3.915ThrLys: 3.915 ± 0.048	5.679ThrLeu: 5.679 ± 0.068	1.099ThrMet: 1.099 ± 0.024	3.794ThrAsn: 3.794 ± 0.092	2.861ThrPro: 2.861 ± 0.063	2.328ThrGln: 2.328 ± 0.038	1.718ThrArg: 1.718 ± 0.039	3.901ThrSer: 3.901 ± 0.086	4.196ThrThr: 4.196 ± 0.119	4.201ThrVal: 4.201 ± 0.117	0.708ThrTrp: 0.708 ± 0.023	2.479ThrTyr: 2.479 ± 0.059	0.0ThrXaa: 0.0 ± 0.0
Val	4.328ValAla: 4.328 ± 0.065	0.637ValCys: 0.637 ± 0.028	3.078ValAsp: 3.078 ± 0.051	3.846ValGlu: 3.846 ± 0.045	3.112ValPhe: 3.112 ± 0.044	4.304ValGly: 4.304 ± 0.06	0.942ValHis: 0.942 ± 0.027	4.529ValIle: 4.529 ± 0.06	4.783ValLys: 4.783 ± 0.067	5.477ValLeu: 5.477 ± 0.056	1.41ValMet: 1.41 ± 0.029	3.739ValAsn: 3.739 ± 0.068	2.133ValPro: 2.133 ± 0.036	2.005ValGln: 2.005 ± 0.036	2.204ValArg: 2.204 ± 0.04	4.806ValSer: 4.806 ± 0.067	3.895ValThr: 3.895 ± 0.1	4.241ValVal: 4.241 ± 0.058	0.685ValTrp: 0.685 ± 0.02	2.295ValTyr: 2.295 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	0.775TrpAla: 0.775 ± 0.02	0.097TrpCys: 0.097 ± 0.007	0.598TrpAsp: 0.598 ± 0.021	0.686TrpGlu: 0.686 ± 0.019	0.578TrpPhe: 0.578 ± 0.018	0.837TrpGly: 0.837 ± 0.025	0.23TrpHis: 0.23 ± 0.011	0.742TrpIle: 0.742 ± 0.024	0.877TrpLys: 0.877 ± 0.023	1.08TrpLeu: 1.08 ± 0.027	0.283TrpMet: 0.283 ± 0.014	0.719TrpAsn: 0.719 ± 0.022	0.133TrpPro: 0.133 ± 0.009	0.577TrpGln: 0.577 ± 0.02	0.474TrpArg: 0.474 ± 0.017	0.698TrpSer: 0.698 ± 0.024	0.674TrpThr: 0.674 ± 0.023	0.732TrpVal: 0.732 ± 0.023	0.179TrpTrp: 0.179 ± 0.011	0.455TrpTyr: 0.455 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.515TyrAla: 2.515 ± 0.037	0.395TyrCys: 0.395 ± 0.015	2.161TyrAsp: 2.161 ± 0.04	2.269TyrGlu: 2.269 ± 0.044	2.449TyrPhe: 2.449 ± 0.042	2.545TyrGly: 2.545 ± 0.042	0.782TyrHis: 0.782 ± 0.02	2.34TyrIle: 2.34 ± 0.035	2.675TyrLys: 2.675 ± 0.042	3.974TyrLeu: 3.974 ± 0.051	0.705TyrMet: 0.705 ± 0.019	2.338TyrAsn: 2.338 ± 0.041	1.49TyrPro: 1.49 ± 0.035	1.939TyrGln: 1.939 ± 0.037	1.66TyrArg: 1.66 ± 0.035	2.744TyrSer: 2.744 ± 0.045	2.346TyrThr: 2.346 ± 0.052	2.179TyrVal: 2.179 ± 0.039	0.469TyrTrp: 0.469 ± 0.017	1.777TyrTyr: 1.777 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.001	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.004XaaXaa: 0.004 ± 0.002

Statistics based on 4947 proteins (1708684 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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