Amino acid dipepetide frequency for Asticcacaulis excentricus (strain ATCC 15261 / DSM 4724 / VKM B-1370 / CB 48)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.68AlaAla: 14.68 ± 0.146	1.097AlaCys: 1.097 ± 0.029	6.278AlaAsp: 6.278 ± 0.083	6.929AlaGlu: 6.929 ± 0.09	4.619AlaPhe: 4.619 ± 0.065	8.989AlaGly: 8.989 ± 0.089	2.305AlaHis: 2.305 ± 0.045	5.234AlaIle: 5.234 ± 0.074	4.48AlaLys: 4.48 ± 0.075	13.449AlaLeu: 13.449 ± 0.144	2.772AlaMet: 2.772 ± 0.05	2.937AlaAsn: 2.937 ± 0.051	5.511AlaPro: 5.511 ± 0.078	4.905AlaGln: 4.905 ± 0.079	7.759AlaArg: 7.759 ± 0.091	6.367AlaSer: 6.367 ± 0.081	6.046AlaThr: 6.046 ± 0.083	7.927AlaVal: 7.927 ± 0.099	1.343AlaTrp: 1.343 ± 0.035	3.183AlaTyr: 3.183 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	1.006CysAla: 1.006 ± 0.028	0.097CysCys: 0.097 ± 0.01	0.498CysAsp: 0.498 ± 0.019	0.423CysGlu: 0.423 ± 0.018	0.282CysPhe: 0.282 ± 0.014	0.815CysGly: 0.815 ± 0.028	0.202CysHis: 0.202 ± 0.013	0.305CysIle: 0.305 ± 0.016	0.23CysLys: 0.23 ± 0.015	0.894CysLeu: 0.894 ± 0.033	0.113CysMet: 0.113 ± 0.01	0.201CysAsn: 0.201 ± 0.013	0.406CysPro: 0.406 ± 0.018	0.258CysGln: 0.258 ± 0.015	0.486CysArg: 0.486 ± 0.023	0.376CysSer: 0.376 ± 0.016	0.391CysThr: 0.391 ± 0.018	0.634CysVal: 0.634 ± 0.022	0.094CysTrp: 0.094 ± 0.008	0.186CysTyr: 0.186 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.523AspAla: 6.523 ± 0.076	0.436AspCys: 0.436 ± 0.021	2.985AspAsp: 2.985 ± 0.056	3.207AspGlu: 3.207 ± 0.056	2.366AspPhe: 2.366 ± 0.054	4.98AspGly: 4.98 ± 0.073	1.243AspHis: 1.243 ± 0.03	3.094AspIle: 3.094 ± 0.048	2.251AspLys: 2.251 ± 0.049	6.167AspLeu: 6.167 ± 0.075	1.406AspMet: 1.406 ± 0.035	1.486AspAsn: 1.486 ± 0.034	3.297AspPro: 3.297 ± 0.054	1.887AspGln: 1.887 ± 0.038	3.632AspArg: 3.632 ± 0.06	2.437AspSer: 2.437 ± 0.046	3.09AspThr: 3.09 ± 0.052	4.004AspVal: 4.004 ± 0.059	1.021AspTrp: 1.021 ± 0.029	1.937AspTyr: 1.937 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	8.218GluAla: 8.218 ± 0.106	0.301GluCys: 0.301 ± 0.019	2.913GluAsp: 2.913 ± 0.053	2.651GluGlu: 2.651 ± 0.061	1.565GluPhe: 1.565 ± 0.041	4.512GluGly: 4.512 ± 0.059	0.986GluHis: 0.986 ± 0.03	2.971GluIle: 2.971 ± 0.053	2.411GluLys: 2.411 ± 0.055	4.682GluLeu: 4.682 ± 0.073	1.297GluMet: 1.297 ± 0.031	1.62GluAsn: 1.62 ± 0.038	2.387GluPro: 2.387 ± 0.05	1.803GluGln: 1.803 ± 0.042	4.198GluArg: 4.198 ± 0.071	2.323GluSer: 2.323 ± 0.046	3.782GluThr: 3.782 ± 0.051	4.135GluVal: 4.135 ± 0.062	0.732GluTrp: 0.732 ± 0.024	1.087GluTyr: 1.087 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.278PheAla: 4.278 ± 0.065	0.363PheCys: 0.363 ± 0.017	2.945PheAsp: 2.945 ± 0.057	2.324PheGlu: 2.324 ± 0.043	1.39PhePhe: 1.39 ± 0.036	3.597PheGly: 3.597 ± 0.059	0.717PheHis: 0.717 ± 0.023	1.809PheIle: 1.809 ± 0.049	1.425PheLys: 1.425 ± 0.039	3.234PheLeu: 3.234 ± 0.056	0.89PheMet: 0.89 ± 0.03	1.398PheAsn: 1.398 ± 0.038	1.493PhePro: 1.493 ± 0.033	1.026PheGln: 1.026 ± 0.028	2.064PheArg: 2.064 ± 0.04	2.394PheSer: 2.394 ± 0.049	2.169PheThr: 2.169 ± 0.046	2.812PheVal: 2.812 ± 0.05	0.572PheTrp: 0.572 ± 0.023	1.07PheTyr: 1.07 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	8.26GlyAla: 8.26 ± 0.091	0.671GlyCys: 0.671 ± 0.024	4.329GlyAsp: 4.329 ± 0.07	4.532GlyGlu: 4.532 ± 0.057	3.812GlyPhe: 3.812 ± 0.057	6.836GlyGly: 6.836 ± 0.11	1.807GlyHis: 1.807 ± 0.041	3.913GlyIle: 3.913 ± 0.063	3.548GlyLys: 3.548 ± 0.065	9.378GlyLeu: 9.378 ± 0.109	1.985GlyMet: 1.985 ± 0.044	2.212GlyAsn: 2.212 ± 0.05	3.263GlyPro: 3.263 ± 0.054	3.314GlyGln: 3.314 ± 0.051	5.204GlyArg: 5.204 ± 0.075	4.198GlySer: 4.198 ± 0.071	4.308GlyThr: 4.308 ± 0.066	6.438GlyVal: 6.438 ± 0.081	1.426GlyTrp: 1.426 ± 0.04	2.617GlyTyr: 2.617 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.052HisAla: 2.052 ± 0.048	0.194HisCys: 0.194 ± 0.013	1.19HisAsp: 1.19 ± 0.035	1.02HisGlu: 1.02 ± 0.03	0.822HisPhe: 0.822 ± 0.03	1.61HisGly: 1.61 ± 0.039	0.555HisHis: 0.555 ± 0.026	1.049HisIle: 1.049 ± 0.026	0.736HisLys: 0.736 ± 0.021	2.169HisLeu: 2.169 ± 0.048	0.504HisMet: 0.504 ± 0.019	0.598HisAsn: 0.598 ± 0.022	1.263HisPro: 1.263 ± 0.035	0.644HisGln: 0.644 ± 0.019	1.257HisArg: 1.257 ± 0.035	1.009HisSer: 1.009 ± 0.031	0.945HisThr: 0.945 ± 0.03	1.323HisVal: 1.323 ± 0.03	0.321HisTrp: 0.321 ± 0.017	0.656HisTyr: 0.656 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.944IleAla: 5.944 ± 0.083	0.455IleCys: 0.455 ± 0.02	3.659IleAsp: 3.659 ± 0.063	3.498IleGlu: 3.498 ± 0.064	1.545IlePhe: 1.545 ± 0.034	4.522IleGly: 4.522 ± 0.063	0.9IleHis: 0.9 ± 0.028	2.211IleIle: 2.211 ± 0.05	1.799IleLys: 1.799 ± 0.043	4.182IleLeu: 4.182 ± 0.069	0.976IleMet: 0.976 ± 0.027	1.613IleAsn: 1.613 ± 0.039	2.081IlePro: 2.081 ± 0.043	1.301IleGln: 1.301 ± 0.034	3.06IleArg: 3.06 ± 0.051	3.007IleSer: 3.007 ± 0.054	2.726IleThr: 2.726 ± 0.047	3.574IleVal: 3.574 ± 0.064	0.604IleTrp: 0.604 ± 0.025	1.211IleTyr: 1.211 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	5.728LysAla: 5.728 ± 0.082	0.181LysCys: 0.181 ± 0.01	2.332LysAsp: 2.332 ± 0.04	1.62LysGlu: 1.62 ± 0.046	1.081LysPhe: 1.081 ± 0.031	3.598LysGly: 3.598 ± 0.058	0.661LysHis: 0.661 ± 0.023	1.877LysIle: 1.877 ± 0.039	1.629LysLys: 1.629 ± 0.04	3.639LysLeu: 3.639 ± 0.056	0.923LysMet: 0.923 ± 0.028	1.136LysAsn: 1.136 ± 0.032	2.695LysPro: 2.695 ± 0.056	1.046LysGln: 1.046 ± 0.031	2.58LysArg: 2.58 ± 0.051	2.421LysSer: 2.421 ± 0.041	2.907LysThr: 2.907 ± 0.048	3.028LysVal: 3.028 ± 0.059	0.505LysTrp: 0.505 ± 0.019	0.838LysTyr: 0.838 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	10.551LeuAla: 10.551 ± 0.114	0.93LeuCys: 0.93 ± 0.029	5.573LeuAsp: 5.573 ± 0.078	4.982LeuGlu: 4.982 ± 0.073	3.774LeuPhe: 3.774 ± 0.063	7.544LeuGly: 7.544 ± 0.088	1.773LeuHis: 1.773 ± 0.038	5.844LeuIle: 5.844 ± 0.08	5.436LeuLys: 5.436 ± 0.073	8.697LeuLeu: 8.697 ± 0.123	2.705LeuMet: 2.705 ± 0.057	3.688LeuAsn: 3.688 ± 0.051	5.336LeuPro: 5.336 ± 0.078	2.715LeuGln: 2.715 ± 0.046	6.425LeuArg: 6.425 ± 0.085	8.723LeuSer: 8.723 ± 0.121	6.677LeuThr: 6.677 ± 0.113	6.002LeuVal: 6.002 ± 0.078	1.425LeuTrp: 1.425 ± 0.038	2.578LeuTyr: 2.578 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	3.002MetAla: 3.002 ± 0.057	0.15MetCys: 0.15 ± 0.011	1.196MetAsp: 1.196 ± 0.03	0.941MetGlu: 0.941 ± 0.027	0.637MetPhe: 0.637 ± 0.026	1.904MetGly: 1.904 ± 0.039	0.419MetHis: 0.419 ± 0.019	1.172MetIle: 1.172 ± 0.033	1.031MetLys: 1.031 ± 0.028	1.837MetLeu: 1.837 ± 0.041	0.569MetMet: 0.569 ± 0.023	0.742MetAsn: 0.742 ± 0.024	1.283MetPro: 1.283 ± 0.033	0.824MetGln: 0.824 ± 0.027	1.577MetArg: 1.577 ± 0.036	1.737MetSer: 1.737 ± 0.035	1.898MetThr: 1.898 ± 0.038	1.462MetVal: 1.462 ± 0.038	0.232MetTrp: 0.232 ± 0.013	0.339MetTyr: 0.339 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.51AsnAla: 3.51 ± 0.056	0.24AsnCys: 0.24 ± 0.014	1.658AsnAsp: 1.658 ± 0.038	1.414AsnGlu: 1.414 ± 0.033	1.061AsnPhe: 1.061 ± 0.034	2.934AsnGly: 2.934 ± 0.055	0.572AsnHis: 0.572 ± 0.023	1.544AsnIle: 1.544 ± 0.043	0.875AsnLys: 0.875 ± 0.024	3.131AsnLeu: 3.131 ± 0.055	0.597AsnMet: 0.597 ± 0.023	0.884AsnAsn: 0.884 ± 0.029	2.003AsnPro: 2.003 ± 0.042	0.855AsnGln: 0.855 ± 0.03	1.988AsnArg: 1.988 ± 0.041	1.533AsnSer: 1.533 ± 0.036	1.598AsnThr: 1.598 ± 0.042	2.009AsnVal: 2.009 ± 0.045	0.516AsnTrp: 0.516 ± 0.022	0.888AsnTyr: 0.888 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	5.658ProAla: 5.658 ± 0.064	0.323ProCys: 0.323 ± 0.017	3.671ProAsp: 3.671 ± 0.054	3.621ProGlu: 3.621 ± 0.057	1.983ProPhe: 1.983 ± 0.043	3.662ProGly: 3.662 ± 0.061	1.02ProHis: 1.02 ± 0.028	2.048ProIle: 2.048 ± 0.046	2.244ProLys: 2.244 ± 0.046	4.892ProLeu: 4.892 ± 0.071	1.019ProMet: 1.019 ± 0.033	1.503ProAsn: 1.503 ± 0.034	2.429ProPro: 2.429 ± 0.066	2.133ProGln: 2.133 ± 0.044	2.552ProArg: 2.552 ± 0.054	2.873ProSer: 2.873 ± 0.049	2.586ProThr: 2.586 ± 0.053	4.448ProVal: 4.448 ± 0.062	0.719ProTrp: 0.719 ± 0.025	1.368ProTyr: 1.368 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.635GlnAla: 4.635 ± 0.065	0.212GlnCys: 0.212 ± 0.014	1.472GlnAsp: 1.472 ± 0.033	1.352GlnGlu: 1.352 ± 0.037	1.097GlnPhe: 1.097 ± 0.035	2.631GlnGly: 2.631 ± 0.054	0.595GlnHis: 0.595 ± 0.021	1.953GlnIle: 1.953 ± 0.07	1.585GlnLys: 1.585 ± 0.037	2.897GlnLeu: 2.897 ± 0.074	0.962GlnMet: 0.962 ± 0.034	1.046GlnAsn: 1.046 ± 0.029	1.75GlnPro: 1.75 ± 0.039	1.113GlnGln: 1.113 ± 0.032	2.315GlnArg: 2.315 ± 0.044	2.211GlnSer: 2.211 ± 0.042	2.567GlnThr: 2.567 ± 0.045	2.642GlnVal: 2.642 ± 0.053	0.609GlnTrp: 0.609 ± 0.025	0.819GlnTyr: 0.819 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	6.837ArgAla: 6.837 ± 0.084	0.425ArgCys: 0.425 ± 0.019	3.732ArgAsp: 3.732 ± 0.058	3.503ArgGlu: 3.503 ± 0.065	2.952ArgPhe: 2.952 ± 0.049	4.211ArgGly: 4.211 ± 0.075	1.552ArgHis: 1.552 ± 0.043	3.318ArgIle: 3.318 ± 0.052	2.495ArgLys: 2.495 ± 0.049	7.983ArgLeu: 7.983 ± 0.093	1.472ArgMet: 1.472 ± 0.037	1.872ArgAsn: 1.872 ± 0.042	3.221ArgPro: 3.221 ± 0.057	2.621ArgGln: 2.621 ± 0.043	4.562ArgArg: 4.562 ± 0.071	3.246ArgSer: 3.246 ± 0.052	3.361ArgThr: 3.361 ± 0.053	4.395ArgVal: 4.395 ± 0.057	0.899ArgTrp: 0.899 ± 0.029	1.944ArgTyr: 1.944 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.841SerAla: 6.841 ± 0.089	0.379SerCys: 0.379 ± 0.018	3.642SerAsp: 3.642 ± 0.053	3.423SerGlu: 3.423 ± 0.048	2.211SerPhe: 2.211 ± 0.044	5.739SerGly: 5.739 ± 0.08	1.202SerHis: 1.202 ± 0.031	2.408SerIle: 2.408 ± 0.047	2.09SerLys: 2.09 ± 0.041	6.245SerLeu: 6.245 ± 0.076	1.128SerMet: 1.128 ± 0.03	1.616SerAsn: 1.616 ± 0.042	3.032SerPro: 3.032 ± 0.056	2.05SerGln: 2.05 ± 0.041	3.5SerArg: 3.5 ± 0.049	3.048SerSer: 3.048 ± 0.066	2.925SerThr: 2.925 ± 0.076	4.441SerVal: 4.441 ± 0.059	0.759SerTrp: 0.759 ± 0.025	1.59SerTyr: 1.59 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	6.682ThrAla: 6.682 ± 0.085	0.438ThrCys: 0.438 ± 0.022	3.054ThrAsp: 3.054 ± 0.054	2.763ThrGlu: 2.763 ± 0.043	2.252ThrPhe: 2.252 ± 0.045	5.33ThrGly: 5.33 ± 0.065	1.224ThrHis: 1.224 ± 0.032	2.497ThrIle: 2.497 ± 0.044	1.776ThrLys: 1.776 ± 0.038	6.782ThrLeu: 6.782 ± 0.077	0.822ThrMet: 0.822 ± 0.027	1.58ThrAsn: 1.58 ± 0.043	4.091ThrPro: 4.091 ± 0.067	2.253ThrGln: 2.253 ± 0.12	3.606ThrArg: 3.606 ± 0.056	3.115ThrSer: 3.115 ± 0.065	3.378ThrThr: 3.378 ± 0.096	4.339ThrVal: 4.339 ± 0.062	0.692ThrTrp: 0.692 ± 0.023	1.722ThrTyr: 1.722 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	7.998ValAla: 7.998 ± 0.089	0.641ValCys: 0.641 ± 0.02	3.746ValAsp: 3.746 ± 0.056	4.22ValGlu: 4.22 ± 0.06	2.901ValPhe: 2.901 ± 0.05	5.115ValGly: 5.115 ± 0.072	1.299ValHis: 1.299 ± 0.036	3.897ValIle: 3.897 ± 0.063	2.843ValLys: 2.843 ± 0.058	6.995ValLeu: 6.995 ± 0.1	1.871ValMet: 1.871 ± 0.042	2.276ValAsn: 2.276 ± 0.05	3.326ValPro: 3.326 ± 0.055	2.225ValGln: 2.225 ± 0.039	4.754ValArg: 4.754 ± 0.066	4.862ValSer: 4.862 ± 0.069	4.712ValThr: 4.712 ± 0.065	5.504ValVal: 5.504 ± 0.082	1.115ValTrp: 1.115 ± 0.034	1.783ValTyr: 1.783 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.375TrpAla: 1.375 ± 0.035	0.121TrpCys: 0.121 ± 0.009	0.727TrpAsp: 0.727 ± 0.026	0.605TrpGlu: 0.605 ± 0.021	0.571TrpPhe: 0.571 ± 0.021	1.085TrpGly: 1.085 ± 0.034	0.327TrpHis: 0.327 ± 0.015	0.597TrpIle: 0.597 ± 0.024	0.534TrpLys: 0.534 ± 0.022	1.681TrpLeu: 1.681 ± 0.042	0.348TrpMet: 0.348 ± 0.017	0.453TrpAsn: 0.453 ± 0.019	0.705TrpPro: 0.705 ± 0.024	0.577TrpGln: 0.577 ± 0.022	1.173TrpArg: 1.173 ± 0.035	0.941TrpSer: 0.941 ± 0.03	0.811TrpThr: 0.811 ± 0.025	0.967TrpVal: 0.967 ± 0.03	0.268TrpTrp: 0.268 ± 0.017	0.375TrpTyr: 0.375 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.03TyrAla: 3.03 ± 0.049	0.244TyrCys: 0.244 ± 0.013	1.852TyrAsp: 1.852 ± 0.04	1.548TyrGlu: 1.548 ± 0.034	1.047TyrPhe: 1.047 ± 0.029	2.436TyrGly: 2.436 ± 0.052	0.555TyrHis: 0.555 ± 0.02	1.128TyrIle: 1.128 ± 0.033	1.009TyrLys: 1.009 ± 0.034	2.445TyrLeu: 2.445 ± 0.043	0.591TyrMet: 0.591 ± 0.022	0.949TyrAsn: 0.949 ± 0.034	1.179TyrPro: 1.179 ± 0.029	0.911TyrGln: 0.911 ± 0.031	1.911TyrArg: 1.911 ± 0.05	1.446TyrSer: 1.446 ± 0.04	1.518TyrThr: 1.518 ± 0.041	2.0TyrVal: 2.0 ± 0.043	0.393TyrTrp: 0.393 ± 0.019	0.894TyrTyr: 0.894 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3743 proteins (1252122 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---