Amino acid dipepetide frequency for Prauserella marina

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.918AlaAla: 18.918 ± 0.124	0.98AlaCys: 0.98 ± 0.027	8.404AlaAsp: 8.404 ± 0.072	9.798AlaGlu: 9.798 ± 0.104	3.573AlaPhe: 3.573 ± 0.045	12.66AlaGly: 12.66 ± 0.078	2.511AlaHis: 2.511 ± 0.038	4.752AlaIle: 4.752 ± 0.054	3.177AlaLys: 3.177 ± 0.056	13.753AlaLeu: 13.753 ± 0.099	2.755AlaMet: 2.755 ± 0.033	2.271AlaAsn: 2.271 ± 0.033	5.739AlaPro: 5.739 ± 0.061	3.18AlaGln: 3.18 ± 0.045	9.537AlaArg: 9.537 ± 0.08	6.234AlaSer: 6.234 ± 0.052	7.313AlaThr: 7.313 ± 0.059	11.62AlaVal: 11.62 ± 0.091	1.677AlaTrp: 1.677 ± 0.026	2.166AlaTyr: 2.166 ± 0.033	0.0AlaXaa: 0.0 ± 0.0
Cys	1.054CysAla: 1.054 ± 0.025	0.096CysCys: 0.096 ± 0.007	0.421CysAsp: 0.421 ± 0.015	0.416CysGlu: 0.416 ± 0.017	0.231CysPhe: 0.231 ± 0.01	0.901CysGly: 0.901 ± 0.029	0.182CysHis: 0.182 ± 0.009	0.165CysIle: 0.165 ± 0.008	0.11CysLys: 0.11 ± 0.008	0.696CysLeu: 0.696 ± 0.02	0.093CysMet: 0.093 ± 0.006	0.114CysAsn: 0.114 ± 0.008	0.443CysPro: 0.443 ± 0.016	0.154CysGln: 0.154 ± 0.009	0.485CysArg: 0.485 ± 0.017	0.423CysSer: 0.423 ± 0.016	0.447CysThr: 0.447 ± 0.018	0.677CysVal: 0.677 ± 0.021	0.128CysTrp: 0.128 ± 0.008	0.177CysTyr: 0.177 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	6.761AspAla: 6.761 ± 0.076	0.369AspCys: 0.369 ± 0.013	3.719AspAsp: 3.719 ± 0.053	4.372AspGlu: 4.372 ± 0.048	1.612AspPhe: 1.612 ± 0.032	5.582AspGly: 5.582 ± 0.06	1.242AspHis: 1.242 ± 0.03	2.362AspIle: 2.362 ± 0.038	1.248AspLys: 1.248 ± 0.027	6.12AspLeu: 6.12 ± 0.059	0.866AspMet: 0.866 ± 0.02	1.229AspAsn: 1.229 ± 0.025	4.199AspPro: 4.199 ± 0.05	1.558AspGln: 1.558 ± 0.032	4.384AspArg: 4.384 ± 0.046	2.752AspSer: 2.752 ± 0.043	3.192AspThr: 3.192 ± 0.044	5.4AspVal: 5.4 ± 0.055	0.875AspTrp: 0.875 ± 0.021	1.3AspTyr: 1.3 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	7.211GluAla: 7.211 ± 0.068	0.362GluCys: 0.362 ± 0.015	2.687GluAsp: 2.687 ± 0.038	3.291GluGlu: 3.291 ± 0.045	1.818GluPhe: 1.818 ± 0.032	4.842GluGly: 4.842 ± 0.053	1.826GluHis: 1.826 ± 0.033	2.445GluIle: 2.445 ± 0.037	1.393GluLys: 1.393 ± 0.029	7.89GluLeu: 7.89 ± 0.086	0.848GluMet: 0.848 ± 0.021	1.268GluAsn: 1.268 ± 0.027	3.748GluPro: 3.748 ± 0.048	2.651GluGln: 2.651 ± 0.047	5.935GluArg: 5.935 ± 0.068	2.921GluSer: 2.921 ± 0.046	3.13GluThr: 3.13 ± 0.034	4.863GluVal: 4.863 ± 0.051	0.946GluTrp: 0.946 ± 0.022	1.142GluTyr: 1.142 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	4.271PheAla: 4.271 ± 0.05	0.263PheCys: 0.263 ± 0.011	2.13PheAsp: 2.13 ± 0.035	1.531PheGlu: 1.531 ± 0.027	0.912PhePhe: 0.912 ± 0.023	3.511PheGly: 3.511 ± 0.05	0.589PheHis: 0.589 ± 0.018	0.797PheIle: 0.797 ± 0.023	0.392PheLys: 0.392 ± 0.014	2.633PheLeu: 2.633 ± 0.043	0.367PheMet: 0.367 ± 0.014	0.565PheAsn: 0.565 ± 0.017	1.424PhePro: 1.424 ± 0.026	0.597PheGln: 0.597 ± 0.017	1.8PheArg: 1.8 ± 0.026	1.588PheSer: 1.588 ± 0.029	2.035PheThr: 2.035 ± 0.031	2.65PheVal: 2.65 ± 0.034	0.401PheTrp: 0.401 ± 0.017	0.581PheTyr: 0.581 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	10.57GlyAla: 10.57 ± 0.077	0.759GlyCys: 0.759 ± 0.021	5.225GlyAsp: 5.225 ± 0.054	6.123GlyGlu: 6.123 ± 0.053	3.158GlyPhe: 3.158 ± 0.048	8.523GlyGly: 8.523 ± 0.09	2.053GlyHis: 2.053 ± 0.03	4.157GlyIle: 4.157 ± 0.045	2.885GlyLys: 2.885 ± 0.046	9.384GlyLeu: 9.384 ± 0.08	2.144GlyMet: 2.144 ± 0.038	2.131GlyAsn: 2.131 ± 0.038	4.308GlyPro: 4.308 ± 0.044	2.749GlyGln: 2.749 ± 0.041	6.537GlyArg: 6.537 ± 0.06	5.419GlySer: 5.419 ± 0.058	6.025GlyThr: 6.025 ± 0.058	7.811GlyVal: 7.811 ± 0.062	1.632GlyTrp: 1.632 ± 0.028	2.419GlyTyr: 2.419 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	2.557HisAla: 2.557 ± 0.041	0.21HisCys: 0.21 ± 0.01	1.373HisAsp: 1.373 ± 0.026	1.293HisGlu: 1.293 ± 0.029	0.607HisPhe: 0.607 ± 0.017	2.299HisGly: 2.299 ± 0.033	0.579HisHis: 0.579 ± 0.02	0.692HisIle: 0.692 ± 0.019	0.337HisLys: 0.337 ± 0.014	2.109HisLeu: 2.109 ± 0.031	0.307HisMet: 0.307 ± 0.012	0.438HisAsn: 0.438 ± 0.013	1.526HisPro: 1.526 ± 0.028	0.605HisGln: 0.605 ± 0.017	1.862HisArg: 1.862 ± 0.03	0.981HisSer: 0.981 ± 0.024	1.177HisThr: 1.177 ± 0.026	1.717HisVal: 1.717 ± 0.032	0.334HisTrp: 0.334 ± 0.015	0.48HisTyr: 0.48 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	5.764IleAla: 5.764 ± 0.063	0.278IleCys: 0.278 ± 0.013	2.615IleAsp: 2.615 ± 0.04	2.498IleGlu: 2.498 ± 0.036	0.806IlePhe: 0.806 ± 0.023	4.243IleGly: 4.243 ± 0.055	0.625IleHis: 0.625 ± 0.016	1.135IleIle: 1.135 ± 0.03	0.684IleLys: 0.684 ± 0.018	2.569IleLeu: 2.569 ± 0.039	0.523IleMet: 0.523 ± 0.017	0.774IleAsn: 0.774 ± 0.019	2.025IlePro: 2.025 ± 0.033	0.742IleGln: 0.742 ± 0.018	2.373IleArg: 2.373 ± 0.038	1.958IleSer: 1.958 ± 0.036	2.518IleThr: 2.518 ± 0.035	3.593IleVal: 3.593 ± 0.053	0.358IleTrp: 0.358 ± 0.015	0.613IleTyr: 0.613 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	2.95LysAla: 2.95 ± 0.044	0.085LysCys: 0.085 ± 0.007	1.161LysAsp: 1.161 ± 0.023	1.19LysGlu: 1.19 ± 0.029	0.443LysPhe: 0.443 ± 0.013	1.727LysGly: 1.727 ± 0.03	0.497LysHis: 0.497 ± 0.018	0.889LysIle: 0.889 ± 0.02	0.58LysLys: 0.58 ± 0.023	2.227LysLeu: 2.227 ± 0.037	0.333LysMet: 0.333 ± 0.013	0.448LysAsn: 0.448 ± 0.016	1.488LysPro: 1.488 ± 0.026	0.721LysGln: 0.721 ± 0.023	1.68LysArg: 1.68 ± 0.031	1.011LysSer: 1.011 ± 0.025	1.252LysThr: 1.252 ± 0.029	2.035LysVal: 2.035 ± 0.032	0.25LysTrp: 0.25 ± 0.011	0.413LysTyr: 0.413 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	15.795LeuAla: 15.795 ± 0.108	0.825LeuCys: 0.825 ± 0.024	6.827LeuAsp: 6.827 ± 0.066	4.453LeuGlu: 4.453 ± 0.054	2.786LeuPhe: 2.786 ± 0.04	9.891LeuGly: 9.891 ± 0.087	2.145LeuHis: 2.145 ± 0.035	3.545LeuIle: 3.545 ± 0.049	1.561LeuLys: 1.561 ± 0.033	11.378LeuLeu: 11.378 ± 0.108	1.482LeuMet: 1.482 ± 0.027	1.778LeuAsn: 1.778 ± 0.03	6.336LeuPro: 6.336 ± 0.06	1.715LeuGln: 1.715 ± 0.033	9.047LeuArg: 9.047 ± 0.079	5.953LeuSer: 5.953 ± 0.057	6.643LeuThr: 6.643 ± 0.056	9.41LeuVal: 9.41 ± 0.08	1.247LeuTrp: 1.247 ± 0.026	1.6LeuTyr: 1.6 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.251MetAla: 2.251 ± 0.032	0.128MetCys: 0.128 ± 0.009	0.811MetAsp: 0.811 ± 0.02	0.695MetGlu: 0.695 ± 0.017	0.515MetPhe: 0.515 ± 0.016	1.291MetGly: 1.291 ± 0.025	0.327MetHis: 0.327 ± 0.014	0.765MetIle: 0.765 ± 0.022	0.376MetLys: 0.376 ± 0.013	1.893MetLeu: 1.893 ± 0.031	0.287MetMet: 0.287 ± 0.013	0.473MetAsn: 0.473 ± 0.015	1.093MetPro: 1.093 ± 0.025	0.393MetGln: 0.393 ± 0.013	1.566MetArg: 1.566 ± 0.027	1.425MetSer: 1.425 ± 0.028	1.593MetThr: 1.593 ± 0.031	1.375MetVal: 1.375 ± 0.024	0.213MetTrp: 0.213 ± 0.01	0.264MetTyr: 0.264 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.478AsnAla: 2.478 ± 0.039	0.152AsnCys: 0.152 ± 0.009	1.046AsnAsp: 1.046 ± 0.025	0.998AsnGlu: 0.998 ± 0.026	0.49AsnPhe: 0.49 ± 0.016	1.975AsnGly: 1.975 ± 0.037	0.397AsnHis: 0.397 ± 0.013	0.738AsnIle: 0.738 ± 0.017	0.395AsnLys: 0.395 ± 0.015	1.891AsnLeu: 1.891 ± 0.033	0.354AsnMet: 0.354 ± 0.014	0.455AsnAsn: 0.455 ± 0.017	1.523AsnPro: 1.523 ± 0.027	0.551AsnGln: 0.551 ± 0.02	1.42AsnArg: 1.42 ± 0.027	0.974AsnSer: 0.974 ± 0.025	1.231AsnThr: 1.231 ± 0.025	1.584AsnVal: 1.584 ± 0.029	0.325AsnTrp: 0.325 ± 0.011	0.442AsnTyr: 0.442 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	7.166ProAla: 7.166 ± 0.071	0.327ProCys: 0.327 ± 0.012	3.871ProAsp: 3.871 ± 0.048	4.427ProGlu: 4.427 ± 0.053	1.615ProPhe: 1.615 ± 0.029	6.051ProGly: 6.051 ± 0.064	1.225ProHis: 1.225 ± 0.027	1.615ProIle: 1.615 ± 0.027	1.201ProLys: 1.201 ± 0.024	5.031ProLeu: 5.031 ± 0.053	1.052ProMet: 1.052 ± 0.021	0.97ProAsn: 0.97 ± 0.025	3.339ProPro: 3.339 ± 0.076	1.39ProGln: 1.39 ± 0.032	3.844ProArg: 3.844 ± 0.048	3.618ProSer: 3.618 ± 0.049	2.794ProThr: 2.794 ± 0.042	5.368ProVal: 5.368 ± 0.06	0.801ProTrp: 0.801 ± 0.022	1.056ProTyr: 1.056 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.315GlnAla: 3.315 ± 0.048	0.157GlnCys: 0.157 ± 0.008	1.191GlnAsp: 1.191 ± 0.025	1.233GlnGlu: 1.233 ± 0.027	0.708GlnPhe: 0.708 ± 0.018	2.089GlnGly: 2.089 ± 0.036	0.672GlnHis: 0.672 ± 0.015	1.031GlnIle: 1.031 ± 0.023	0.405GlnLys: 0.405 ± 0.016	3.103GlnLeu: 3.103 ± 0.047	0.374GlnMet: 0.374 ± 0.015	0.504GlnAsn: 0.504 ± 0.015	1.791GlnPro: 1.791 ± 0.041	1.274GlnGln: 1.274 ± 0.046	2.728GlnArg: 2.728 ± 0.042	1.211GlnSer: 1.211 ± 0.029	1.189GlnThr: 1.189 ± 0.027	2.236GlnVal: 2.236 ± 0.037	0.455GlnTrp: 0.455 ± 0.016	0.513GlnTyr: 0.513 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	9.118ArgAla: 9.118 ± 0.087	0.565ArgCys: 0.565 ± 0.019	4.308ArgAsp: 4.308 ± 0.046	5.05ArgGlu: 5.05 ± 0.059	2.613ArgPhe: 2.613 ± 0.042	5.831ArgGly: 5.831 ± 0.058	1.923ArgHis: 1.923 ± 0.029	3.274ArgIle: 3.274 ± 0.036	2.158ArgLys: 2.158 ± 0.035	8.276ArgLeu: 8.276 ± 0.082	1.88ArgMet: 1.88 ± 0.03	1.553ArgAsn: 1.553 ± 0.026	4.183ArgPro: 4.183 ± 0.052	2.453ArgGln: 2.453 ± 0.036	7.026ArgArg: 7.026 ± 0.076	4.05ArgSer: 4.05 ± 0.049	4.594ArgThr: 4.594 ± 0.048	5.846ArgVal: 5.846 ± 0.055	1.372ArgTrp: 1.372 ± 0.026	1.915ArgTyr: 1.915 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	7.397SerAla: 7.397 ± 0.061	0.412SerCys: 0.412 ± 0.016	2.774SerAsp: 2.774 ± 0.041	3.008SerGlu: 3.008 ± 0.042	1.659SerPhe: 1.659 ± 0.029	6.222SerGly: 6.222 ± 0.053	0.918SerHis: 0.918 ± 0.019	1.787SerIle: 1.787 ± 0.031	1.058SerLys: 1.058 ± 0.023	4.965SerLeu: 4.965 ± 0.046	1.197SerMet: 1.197 ± 0.024	0.883SerAsn: 0.883 ± 0.022	3.156SerPro: 3.156 ± 0.044	1.266SerGln: 1.266 ± 0.025	3.865SerArg: 3.865 ± 0.048	2.965SerSer: 2.965 ± 0.041	3.427SerThr: 3.427 ± 0.04	4.619SerVal: 4.619 ± 0.046	0.92SerTrp: 0.92 ± 0.019	1.128SerTyr: 1.128 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	7.868ThrAla: 7.868 ± 0.064	0.417ThrCys: 0.417 ± 0.016	3.335ThrAsp: 3.335 ± 0.042	3.898ThrGlu: 3.898 ± 0.042	1.67ThrPhe: 1.67 ± 0.035	6.574ThrGly: 6.574 ± 0.063	1.057ThrHis: 1.057 ± 0.025	2.246ThrIle: 2.246 ± 0.038	1.234ThrLys: 1.234 ± 0.027	5.655ThrLeu: 5.655 ± 0.055	1.136ThrMet: 1.136 ± 0.022	1.057ThrAsn: 1.057 ± 0.023	3.555ThrPro: 3.555 ± 0.045	1.243ThrGln: 1.243 ± 0.027	3.891ThrArg: 3.891 ± 0.047	3.384ThrSer: 3.384 ± 0.044	3.917ThrThr: 3.917 ± 0.054	6.071ThrVal: 6.071 ± 0.059	0.844ThrTrp: 0.844 ± 0.024	1.116ThrTyr: 1.116 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	11.775ValAla: 11.775 ± 0.076	0.72ValCys: 0.72 ± 0.021	5.309ValAsp: 5.309 ± 0.05	5.168ValGlu: 5.168 ± 0.061	2.663ValPhe: 2.663 ± 0.041	6.918ValGly: 6.918 ± 0.066	1.896ValHis: 1.896 ± 0.029	3.219ValIle: 3.219 ± 0.041	1.588ValLys: 1.588 ± 0.031	10.543ValLeu: 10.543 ± 0.1	1.292ValMet: 1.292 ± 0.031	1.786ValAsn: 1.786 ± 0.032	5.0ValPro: 5.0 ± 0.049	1.761ValGln: 1.761 ± 0.028	6.835ValArg: 6.835 ± 0.075	4.848ValSer: 4.848 ± 0.051	5.735ValThr: 5.735 ± 0.059	8.818ValVal: 8.818 ± 0.083	1.037ValTrp: 1.037 ± 0.023	1.424ValTyr: 1.424 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	1.487TrpAla: 1.487 ± 0.028	0.143TrpCys: 0.143 ± 0.009	0.68TrpAsp: 0.68 ± 0.02	0.693TrpGlu: 0.693 ± 0.019	0.529TrpPhe: 0.529 ± 0.018	0.939TrpGly: 0.939 ± 0.021	0.374TrpHis: 0.374 ± 0.013	0.611TrpIle: 0.611 ± 0.015	0.311TrpLys: 0.311 ± 0.012	2.01TrpLeu: 2.01 ± 0.036	0.268TrpMet: 0.268 ± 0.012	0.365TrpAsn: 0.365 ± 0.014	0.783TrpPro: 0.783 ± 0.02	0.571TrpGln: 0.571 ± 0.015	1.362TrpArg: 1.362 ± 0.028	0.868TrpSer: 0.868 ± 0.023	0.849TrpThr: 0.849 ± 0.02	0.973TrpVal: 0.973 ± 0.024	0.355TrpTrp: 0.355 ± 0.014	0.298TrpTyr: 0.298 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.313TyrAla: 2.313 ± 0.033	0.165TyrCys: 0.165 ± 0.009	1.255TyrAsp: 1.255 ± 0.024	1.085TyrGlu: 1.085 ± 0.025	0.631TyrPhe: 0.631 ± 0.019	1.944TyrGly: 1.944 ± 0.036	0.446TyrHis: 0.446 ± 0.016	0.471TyrIle: 0.471 ± 0.017	0.287TyrLys: 0.287 ± 0.012	2.292TyrLeu: 2.292 ± 0.036	0.177TyrMet: 0.177 ± 0.01	0.358TyrAsn: 0.358 ± 0.014	1.103TyrPro: 1.103 ± 0.023	0.603TyrGln: 0.603 ± 0.018	1.809TyrArg: 1.809 ± 0.032	1.039TyrSer: 1.039 ± 0.024	1.105TyrThr: 1.105 ± 0.021	1.666TyrVal: 1.666 ± 0.031	0.3TyrTrp: 0.3 ± 0.013	0.456TyrTyr: 0.456 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6551 proteins (2104163 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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