Amino acid dipepetide frequency for Sphingomonas guangdongensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
23.794AlaAla: 23.794 ± 0.274
1.046AlaCys: 1.046 ± 0.036
8.497AlaAsp: 8.497 ± 0.108
7.913AlaGlu: 7.913 ± 0.115
4.309AlaPhe: 4.309 ± 0.069
12.898AlaGly: 12.898 ± 0.12
2.31AlaHis: 2.31 ± 0.051
6.572AlaIle: 6.572 ± 0.084
3.433AlaLys: 3.433 ± 0.069
15.379AlaLeu: 15.379 ± 0.178
3.567AlaMet: 3.567 ± 0.073
3.1AlaAsn: 3.1 ± 0.061
7.183AlaPro: 7.183 ± 0.1
4.414AlaGln: 4.414 ± 0.07
11.581AlaArg: 11.581 ± 0.132
6.762AlaSer: 6.762 ± 0.081
7.868AlaThr: 7.868 ± 0.098
10.288AlaVal: 10.288 ± 0.117
1.882AlaTrp: 1.882 ± 0.048
2.53AlaTyr: 2.53 ± 0.05
0.0AlaXaa: 0.0 ± 0.0
Cys
0.945CysAla: 0.945 ± 0.033
0.069CysCys: 0.069 ± 0.009
0.475CysAsp: 0.475 ± 0.021
0.31CysGlu: 0.31 ± 0.02
0.275CysPhe: 0.275 ± 0.016
0.796CysGly: 0.796 ± 0.028
0.171CysHis: 0.171 ± 0.014
0.253CysIle: 0.253 ± 0.015
0.1CysLys: 0.1 ± 0.01
0.641CysLeu: 0.641 ± 0.026
0.104CysMet: 0.104 ± 0.011
0.174CysAsn: 0.174 ± 0.014
0.422CysPro: 0.422 ± 0.02
0.157CysGln: 0.157 ± 0.013
0.555CysArg: 0.555 ± 0.026
0.383CysSer: 0.383 ± 0.02
0.379CysThr: 0.379 ± 0.025
0.551CysVal: 0.551 ± 0.019
0.092CysTrp: 0.092 ± 0.009
0.137CysTyr: 0.137 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
8.61AspAla: 8.61 ± 0.104
0.385AspCys: 0.385 ± 0.02
3.457AspAsp: 3.457 ± 0.079
3.253AspGlu: 3.253 ± 0.059
1.923AspPhe: 1.923 ± 0.047
5.786AspGly: 5.786 ± 0.085
1.266AspHis: 1.266 ± 0.033
2.236AspIle: 2.236 ± 0.041
1.286AspLys: 1.286 ± 0.039
5.794AspLeu: 5.794 ± 0.083
1.108AspMet: 1.108 ± 0.029
1.141AspAsn: 1.141 ± 0.042
3.933AspPro: 3.933 ± 0.068
1.766AspGln: 1.766 ± 0.045
5.381AspArg: 5.381 ± 0.071
1.988AspSer: 1.988 ± 0.046
2.898AspThr: 2.898 ± 0.063
4.531AspVal: 4.531 ± 0.064
1.11AspTrp: 1.11 ± 0.035
1.486AspTyr: 1.486 ± 0.037
0.0AspXaa: 0.0 ± 0.0
Glu
7.444GluAla: 7.444 ± 0.115
0.241GluCys: 0.241 ± 0.016
2.303GluAsp: 2.303 ± 0.05
2.644GluGlu: 2.644 ± 0.063
1.288GluPhe: 1.288 ± 0.041
4.123GluGly: 4.123 ± 0.067
1.072GluHis: 1.072 ± 0.03
2.358GluIle: 2.358 ± 0.052
1.388GluLys: 1.388 ± 0.038
5.031GluLeu: 5.031 ± 0.087
1.048GluMet: 1.048 ± 0.036
1.134GluAsn: 1.134 ± 0.031
2.637GluPro: 2.637 ± 0.055
2.165GluGln: 2.165 ± 0.042
5.591GluArg: 5.591 ± 0.079
1.932GluSer: 1.932 ± 0.044
2.744GluThr: 2.744 ± 0.042
3.89GluVal: 3.89 ± 0.063
0.743GluTrp: 0.743 ± 0.027
0.878GluTyr: 0.878 ± 0.029
0.0GluXaa: 0.0 ± 0.0
Phe
4.99PheAla: 4.99 ± 0.075
0.271PheCys: 0.271 ± 0.017
2.533PheAsp: 2.533 ± 0.053
1.789PheGlu: 1.789 ± 0.04
1.157PhePhe: 1.157 ± 0.033
3.498PheGly: 3.498 ± 0.064
0.623PheHis: 0.623 ± 0.026
1.145PheIle: 1.145 ± 0.034
0.676PheLys: 0.676 ± 0.026
2.923PheLeu: 2.923 ± 0.059
0.592PheMet: 0.592 ± 0.025
0.984PheAsn: 0.984 ± 0.039
1.428PhePro: 1.428 ± 0.036
0.769PheGln: 0.769 ± 0.028
2.363PheArg: 2.363 ± 0.045
1.68PheSer: 1.68 ± 0.039
2.003PheThr: 2.003 ± 0.049
2.643PheVal: 2.643 ± 0.04
0.464PheTrp: 0.464 ± 0.023
0.814PheTyr: 0.814 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
11.183GlyAla: 11.183 ± 0.121
0.833GlyCys: 0.833 ± 0.028
5.175GlyAsp: 5.175 ± 0.083
4.847GlyGlu: 4.847 ± 0.075
3.418GlyPhe: 3.418 ± 0.057
8.722GlyGly: 8.722 ± 0.128
1.725GlyHis: 1.725 ± 0.045
3.956GlyIle: 3.956 ± 0.068
2.508GlyLys: 2.508 ± 0.059
8.453GlyLeu: 8.453 ± 0.1
2.06GlyMet: 2.06 ± 0.056
2.138GlyAsn: 2.138 ± 0.076
3.602GlyPro: 3.602 ± 0.064
2.825GlyGln: 2.825 ± 0.052
7.331GlyArg: 7.331 ± 0.082
4.966GlySer: 4.966 ± 0.078
5.551GlyThr: 5.551 ± 0.094
6.975GlyVal: 6.975 ± 0.087
1.732GlyTrp: 1.732 ± 0.045
2.318GlyTyr: 2.318 ± 0.054
0.0GlyXaa: 0.0 ± 0.0
His
2.479HisAla: 2.479 ± 0.053
0.182HisCys: 0.182 ± 0.012
1.149HisAsp: 1.149 ± 0.039
0.935HisGlu: 0.935 ± 0.033
0.678HisPhe: 0.678 ± 0.024
1.869HisGly: 1.869 ± 0.045
0.545HisHis: 0.545 ± 0.025
0.652HisIle: 0.652 ± 0.026
0.352HisLys: 0.352 ± 0.02
1.871HisLeu: 1.871 ± 0.047
0.333HisMet: 0.333 ± 0.019
0.394HisAsn: 0.394 ± 0.019
1.234HisPro: 1.234 ± 0.034
0.525HisGln: 0.525 ± 0.021
1.547HisArg: 1.547 ± 0.048
0.769HisSer: 0.769 ± 0.026
0.675HisThr: 0.675 ± 0.03
1.474HisVal: 1.474 ± 0.034
0.322HisTrp: 0.322 ± 0.016
0.478HisTyr: 0.478 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
7.505IleAla: 7.505 ± 0.097
0.311IleCys: 0.311 ± 0.017
3.685IleAsp: 3.685 ± 0.061
2.913IleGlu: 2.913 ± 0.047
1.194IlePhe: 1.194 ± 0.035
4.848IleGly: 4.848 ± 0.073
0.74IleHis: 0.74 ± 0.029
1.573IleIle: 1.573 ± 0.044
0.858IleLys: 0.858 ± 0.03
3.287IleLeu: 3.287 ± 0.059
0.702IleMet: 0.702 ± 0.027
1.171IleAsn: 1.171 ± 0.035
1.835IlePro: 1.835 ± 0.039
0.96IleGln: 0.96 ± 0.03
2.92IleArg: 2.92 ± 0.059
1.92IleSer: 1.92 ± 0.054
2.461IleThr: 2.461 ± 0.051
3.986IleVal: 3.986 ± 0.064
0.502IleTrp: 0.502 ± 0.021
0.836IleTyr: 0.836 ± 0.032
0.0IleXaa: 0.0 ± 0.0
Lys
3.237LysAla: 3.237 ± 0.065
0.116LysCys: 0.116 ± 0.012
1.191LysAsp: 1.191 ± 0.036
1.0LysGlu: 1.0 ± 0.032
0.59LysPhe: 0.59 ± 0.023
2.034LysGly: 2.034 ± 0.048
0.388LysHis: 0.388 ± 0.017
0.953LysIle: 0.953 ± 0.032
0.799LysLys: 0.799 ± 0.043
2.66LysLeu: 2.66 ± 0.052
0.511LysMet: 0.511 ± 0.024
0.503LysAsn: 0.503 ± 0.025
1.649LysPro: 1.649 ± 0.044
0.684LysGln: 0.684 ± 0.026
2.045LysArg: 2.045 ± 0.043
1.214LysSer: 1.214 ± 0.036
1.353LysThr: 1.353 ± 0.039
1.776LysVal: 1.776 ± 0.044
0.293LysTrp: 0.293 ± 0.015
0.434LysTyr: 0.434 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
15.542LeuAla: 15.542 ± 0.155
0.719LeuCys: 0.719 ± 0.027
6.212LeuAsp: 6.212 ± 0.094
4.412LeuGlu: 4.412 ± 0.071
3.546LeuPhe: 3.546 ± 0.067
8.508LeuGly: 8.508 ± 0.116
1.789LeuHis: 1.789 ± 0.044
4.502LeuIle: 4.502 ± 0.078
2.551LeuLys: 2.551 ± 0.054
10.632LeuLeu: 10.632 ± 0.138
1.854LeuMet: 1.854 ± 0.046
2.244LeuAsn: 2.244 ± 0.049
5.986LeuPro: 5.986 ± 0.077
2.629LeuGln: 2.629 ± 0.053
7.463LeuArg: 7.463 ± 0.085
6.054LeuSer: 6.054 ± 0.079
5.807LeuThr: 5.807 ± 0.071
7.726LeuVal: 7.726 ± 0.099
1.257LeuTrp: 1.257 ± 0.043
1.981LeuTyr: 1.981 ± 0.043
0.0LeuXaa: 0.0 ± 0.0
Met
2.869MetAla: 2.869 ± 0.053
0.123MetCys: 0.123 ± 0.011
0.878MetAsp: 0.878 ± 0.028
0.801MetGlu: 0.801 ± 0.026
0.577MetPhe: 0.577 ± 0.026
1.558MetGly: 1.558 ± 0.041
0.322MetHis: 0.322 ± 0.016
1.185MetIle: 1.185 ± 0.033
0.724MetLys: 0.724 ± 0.026
2.218MetLeu: 2.218 ± 0.049
0.481MetMet: 0.481 ± 0.026
0.532MetAsn: 0.532 ± 0.024
1.248MetPro: 1.248 ± 0.036
0.552MetGln: 0.552 ± 0.022
1.683MetArg: 1.683 ± 0.036
1.296MetSer: 1.296 ± 0.035
1.687MetThr: 1.687 ± 0.041
1.431MetVal: 1.431 ± 0.035
0.198MetTrp: 0.198 ± 0.014
0.257MetTyr: 0.257 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
3.103AsnAla: 3.103 ± 0.062
0.184AsnCys: 0.184 ± 0.013
1.374AsnAsp: 1.374 ± 0.054
0.98AsnGlu: 0.98 ± 0.031
0.787AsnPhe: 0.787 ± 0.029
2.302AsnGly: 2.302 ± 0.067
0.431AsnHis: 0.431 ± 0.019
1.062AsnIle: 1.062 ± 0.038
0.542AsnLys: 0.542 ± 0.022
2.346AsnLeu: 2.346 ± 0.05
0.462AsnMet: 0.462 ± 0.021
0.637AsnAsn: 0.637 ± 0.036
1.631AsnPro: 1.631 ± 0.044
0.711AsnGln: 0.711 ± 0.028
1.709AsnArg: 1.709 ± 0.039
1.032AsnSer: 1.032 ± 0.034
1.139AsnThr: 1.139 ± 0.039
1.789AsnVal: 1.789 ± 0.044
0.375AsnTrp: 0.375 ± 0.019
0.635AsnTyr: 0.635 ± 0.028
0.0AsnXaa: 0.0 ± 0.0
Pro
8.441ProAla: 8.441 ± 0.108
0.315ProCys: 0.315 ± 0.018
3.827ProAsp: 3.827 ± 0.064
3.136ProGlu: 3.136 ± 0.052
1.878ProPhe: 1.878 ± 0.044
4.911ProGly: 4.911 ± 0.075
0.969ProHis: 0.969 ± 0.024
2.347ProIle: 2.347 ± 0.051
1.262ProLys: 1.262 ± 0.039
5.236ProLeu: 5.236 ± 0.082
1.03ProMet: 1.03 ± 0.034
1.27ProAsn: 1.27 ± 0.036
3.176ProPro: 3.176 ± 0.08
1.539ProGln: 1.539 ± 0.041
3.467ProArg: 3.467 ± 0.06
2.674ProSer: 2.674 ± 0.049
2.968ProThr: 2.968 ± 0.066
4.677ProVal: 4.677 ± 0.071
0.652ProTrp: 0.652 ± 0.026
1.08ProTyr: 1.08 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
4.312GlnAla: 4.312 ± 0.07
0.174GlnCys: 0.174 ± 0.012
1.234GlnAsp: 1.234 ± 0.029
1.174GlnGlu: 1.174 ± 0.032
0.992GlnPhe: 0.992 ± 0.035
2.248GlnGly: 2.248 ± 0.044
0.562GlnHis: 0.562 ± 0.021
1.418GlnIle: 1.418 ± 0.034
0.644GlnLys: 0.644 ± 0.027
3.172GlnLeu: 3.172 ± 0.057
0.693GlnMet: 0.693 ± 0.026
0.647GlnAsn: 0.647 ± 0.03
1.918GlnPro: 1.918 ± 0.046
1.146GlnGln: 1.146 ± 0.039
2.576GlnArg: 2.576 ± 0.056
1.537GlnSer: 1.537 ± 0.036
1.561GlnThr: 1.561 ± 0.042
2.592GlnVal: 2.592 ± 0.048
0.366GlnTrp: 0.366 ± 0.017
0.522GlnTyr: 0.522 ± 0.026
0.0GlnXaa: 0.0 ± 0.0
Arg
10.906ArgAla: 10.906 ± 0.125
0.517ArgCys: 0.517 ± 0.025
4.634ArgAsp: 4.634 ± 0.071
4.021ArgGlu: 4.021 ± 0.073
3.312ArgPhe: 3.312 ± 0.056
5.83ArgGly: 5.83 ± 0.075
1.699ArgHis: 1.699 ± 0.04
3.88ArgIle: 3.88 ± 0.066
1.601ArgLys: 1.601 ± 0.033
9.056ArgLeu: 9.056 ± 0.097
1.876ArgMet: 1.876 ± 0.046
1.713ArgAsn: 1.713 ± 0.042
4.095ArgPro: 4.095 ± 0.072
2.482ArgGln: 2.482 ± 0.05
6.629ArgArg: 6.629 ± 0.107
3.946ArgSer: 3.946 ± 0.062
4.22ArgThr: 4.22 ± 0.057
5.883ArgVal: 5.883 ± 0.082
1.479ArgTrp: 1.479 ± 0.037
2.073ArgTyr: 2.073 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
6.546SerAla: 6.546 ± 0.078
0.362SerCys: 0.362 ± 0.021
3.019SerAsp: 3.019 ± 0.057
2.279SerGlu: 2.279 ± 0.046
2.096SerPhe: 2.096 ± 0.049
5.439SerGly: 5.439 ± 0.082
0.812SerHis: 0.812 ± 0.028
2.345SerIle: 2.345 ± 0.049
1.053SerLys: 1.053 ± 0.033
4.786SerLeu: 4.786 ± 0.064
1.026SerMet: 1.026 ± 0.034
1.257SerAsn: 1.257 ± 0.038
2.835SerPro: 2.835 ± 0.057
1.258SerGln: 1.258 ± 0.036
3.437SerArg: 3.437 ± 0.056
2.531SerSer: 2.531 ± 0.057
2.666SerThr: 2.666 ± 0.058
3.817SerVal: 3.817 ± 0.063
0.773SerTrp: 0.773 ± 0.025
1.229SerTyr: 1.229 ± 0.032
0.0SerXaa: 0.0 ± 0.0
Thr
7.457ThrAla: 7.457 ± 0.094
0.349ThrCys: 0.349 ± 0.018
3.046ThrAsp: 3.046 ± 0.061
2.204ThrGlu: 2.204 ± 0.046
1.791ThrPhe: 1.791 ± 0.045
5.675ThrGly: 5.675 ± 0.079
0.945ThrHis: 0.945 ± 0.029
2.929ThrIle: 2.929 ± 0.05
1.125ThrLys: 1.125 ± 0.039
6.558ThrLeu: 6.558 ± 0.08
1.068ThrMet: 1.068 ± 0.038
1.283ThrAsn: 1.283 ± 0.051
3.85ThrPro: 3.85 ± 0.072
1.415ThrGln: 1.415 ± 0.036
4.068ThrArg: 4.068 ± 0.061
2.736ThrSer: 2.736 ± 0.062
3.082ThrThr: 3.082 ± 0.066
4.634ThrVal: 4.634 ± 0.07
0.665ThrTrp: 0.665 ± 0.026
1.182ThrTyr: 1.182 ± 0.039
0.0ThrXaa: 0.0 ± 0.0
Val
11.796ValAla: 11.796 ± 0.118
0.485ValCys: 0.485 ± 0.022
4.494ValAsp: 4.494 ± 0.069
4.478ValGlu: 4.478 ± 0.082
2.223ValPhe: 2.223 ± 0.045
6.09ValGly: 6.09 ± 0.08
1.316ValHis: 1.316 ± 0.034
3.583ValIle: 3.583 ± 0.07
1.722ValLys: 1.722 ± 0.047
7.425ValLeu: 7.425 ± 0.108
1.477ValMet: 1.477 ± 0.039
1.899ValAsn: 1.899 ± 0.052
4.512ValPro: 4.512 ± 0.066
2.183ValGln: 2.183 ± 0.053
6.03ValArg: 6.03 ± 0.081
4.068ValSer: 4.068 ± 0.07
5.124ValThr: 5.124 ± 0.072
6.154ValVal: 6.154 ± 0.087
0.902ValTrp: 0.902 ± 0.031
1.352ValTyr: 1.352 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
1.448TrpAla: 1.448 ± 0.042
0.136TrpCys: 0.136 ± 0.012
0.678TrpAsp: 0.678 ± 0.025
0.564TrpGlu: 0.564 ± 0.023
0.568TrpPhe: 0.568 ± 0.021
1.047TrpGly: 1.047 ± 0.029
0.329TrpHis: 0.329 ± 0.015
0.598TrpIle: 0.598 ± 0.024
0.349TrpLys: 0.349 ± 0.016
1.781TrpLeu: 1.781 ± 0.048
0.299TrpMet: 0.299 ± 0.021
0.453TrpAsn: 0.453 ± 0.02
0.676TrpPro: 0.676 ± 0.029
0.595TrpGln: 0.595 ± 0.021
1.511TrpArg: 1.511 ± 0.041
1.011TrpSer: 1.011 ± 0.035
0.87TrpThr: 0.87 ± 0.03
0.9TrpVal: 0.9 ± 0.028
0.332TrpTrp: 0.332 ± 0.019
0.308TrpTyr: 0.308 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.719TyrAla: 2.719 ± 0.054
0.171TyrCys: 0.171 ± 0.012
1.478TyrAsp: 1.478 ± 0.038
1.002TyrGlu: 1.002 ± 0.029
0.742TyrPhe: 0.742 ± 0.028
2.137TyrGly: 2.137 ± 0.05
0.448TyrHis: 0.448 ± 0.021
0.66TyrIle: 0.66 ± 0.023
0.454TyrLys: 0.454 ± 0.022
2.165TyrLeu: 2.165 ± 0.047
0.327TyrMet: 0.327 ± 0.018
0.558TyrAsn: 0.558 ± 0.024
1.004TyrPro: 1.004 ± 0.031
0.714TyrGln: 0.714 ± 0.03
1.966TyrArg: 1.966 ± 0.045
1.068TyrSer: 1.068 ± 0.035
1.007TyrThr: 1.007 ± 0.029
1.595TyrVal: 1.595 ± 0.038
0.314TyrTrp: 0.314 ± 0.019
0.549TyrTyr: 0.549 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3454 proteins (1075973 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski