Amino acid dipepetide frequency for Herbiconiux sp. SALV-R1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
21.292AlaAla: 21.292 ± 0.211
0.587AlaCys: 0.587 ± 0.021
7.88AlaAsp: 7.88 ± 0.082
8.533AlaGlu: 8.533 ± 0.101
4.021AlaPhe: 4.021 ± 0.063
13.088AlaGly: 13.088 ± 0.131
2.378AlaHis: 2.378 ± 0.043
5.228AlaIle: 5.228 ± 0.07
2.442AlaLys: 2.442 ± 0.057
14.216AlaLeu: 14.216 ± 0.138
2.343AlaMet: 2.343 ± 0.043
2.221AlaAsn: 2.221 ± 0.046
7.076AlaPro: 7.076 ± 0.106
3.464AlaGln: 3.464 ± 0.06
9.041AlaArg: 9.041 ± 0.107
8.193AlaSer: 8.193 ± 0.086
7.75AlaThr: 7.75 ± 0.097
12.346AlaVal: 12.346 ± 0.118
1.752AlaTrp: 1.752 ± 0.04
2.386AlaTyr: 2.386 ± 0.045
0.0AlaXaa: 0.0 ± 0.0
Cys
0.661CysAla: 0.661 ± 0.026
0.047CysCys: 0.047 ± 0.005
0.294CysAsp: 0.294 ± 0.014
0.234CysGlu: 0.234 ± 0.015
0.179CysPhe: 0.179 ± 0.01
0.559CysGly: 0.559 ± 0.021
0.109CysHis: 0.109 ± 0.009
0.189CysIle: 0.189 ± 0.012
0.053CysLys: 0.053 ± 0.006
0.434CysLeu: 0.434 ± 0.019
0.068CysMet: 0.068 ± 0.007
0.104CysAsn: 0.104 ± 0.009
0.272CysPro: 0.272 ± 0.014
0.105CysGln: 0.105 ± 0.008
0.283CysArg: 0.283 ± 0.017
0.37CysSer: 0.37 ± 0.016
0.317CysThr: 0.317 ± 0.015
0.437CysVal: 0.437 ± 0.019
0.071CysTrp: 0.071 ± 0.008
0.105CysTyr: 0.105 ± 0.008
0.0CysXaa: 0.0 ± 0.0
Asp
8.642AspAla: 8.642 ± 0.091
0.249AspCys: 0.249 ± 0.014
4.668AspAsp: 4.668 ± 0.08
4.378AspGlu: 4.378 ± 0.073
1.805AspPhe: 1.805 ± 0.039
6.075AspGly: 6.075 ± 0.08
1.187AspHis: 1.187 ± 0.029
2.216AspIle: 2.216 ± 0.04
0.867AspLys: 0.867 ± 0.03
5.764AspLeu: 5.764 ± 0.058
0.667AspMet: 0.667 ± 0.022
0.909AspAsn: 0.909 ± 0.026
4.163AspPro: 4.163 ± 0.054
1.443AspGln: 1.443 ± 0.039
4.31AspArg: 4.31 ± 0.064
3.038AspSer: 3.038 ± 0.046
3.091AspThr: 3.091 ± 0.054
4.857AspVal: 4.857 ± 0.058
0.957AspTrp: 0.957 ± 0.024
1.325AspTyr: 1.325 ± 0.033
0.0AspXaa: 0.0 ± 0.0
Glu
7.283GluAla: 7.283 ± 0.083
0.243GluCys: 0.243 ± 0.012
1.802GluAsp: 1.802 ± 0.04
3.047GluGlu: 3.047 ± 0.064
1.825GluPhe: 1.825 ± 0.038
4.333GluGly: 4.333 ± 0.063
1.541GluHis: 1.541 ± 0.031
2.583GluIle: 2.583 ± 0.043
1.344GluLys: 1.344 ± 0.036
7.432GluLeu: 7.432 ± 0.088
0.878GluMet: 0.878 ± 0.027
1.409GluAsn: 1.409 ± 0.034
3.072GluPro: 3.072 ± 0.054
2.156GluGln: 2.156 ± 0.041
5.224GluArg: 5.224 ± 0.075
3.12GluSer: 3.12 ± 0.053
3.18GluThr: 3.18 ± 0.054
4.952GluVal: 4.952 ± 0.069
0.912GluTrp: 0.912 ± 0.026
1.117GluTyr: 1.117 ± 0.033
0.0GluXaa: 0.0 ± 0.0
Phe
4.221PheAla: 4.221 ± 0.06
0.191PheCys: 0.191 ± 0.011
2.502PheAsp: 2.502 ± 0.046
1.904PheGlu: 1.904 ± 0.037
1.128PhePhe: 1.128 ± 0.038
3.602PheGly: 3.602 ± 0.057
0.545PheHis: 0.545 ± 0.018
1.223PheIle: 1.223 ± 0.033
0.484PheLys: 0.484 ± 0.019
2.827PheLeu: 2.827 ± 0.054
0.407PheMet: 0.407 ± 0.015
0.629PheAsn: 0.629 ± 0.023
1.547PhePro: 1.547 ± 0.036
0.736PheGln: 0.736 ± 0.026
1.704PheArg: 1.704 ± 0.04
1.924PheSer: 1.924 ± 0.043
2.22PheThr: 2.22 ± 0.049
3.052PheVal: 3.052 ± 0.057
0.514PheTrp: 0.514 ± 0.023
0.664PheTyr: 0.664 ± 0.026
0.0PheXaa: 0.0 ± 0.0
Gly
11.759GlyAla: 11.759 ± 0.122
0.611GlyCys: 0.611 ± 0.02
5.244GlyAsp: 5.244 ± 0.075
5.115GlyGlu: 5.115 ± 0.068
3.381GlyPhe: 3.381 ± 0.057
8.496GlyGly: 8.496 ± 0.108
1.788GlyHis: 1.788 ± 0.037
4.433GlyIle: 4.433 ± 0.067
1.976GlyLys: 1.976 ± 0.039
8.892GlyLeu: 8.892 ± 0.094
1.702GlyMet: 1.702 ± 0.036
1.667GlyAsn: 1.667 ± 0.039
3.953GlyPro: 3.953 ± 0.056
2.308GlyGln: 2.308 ± 0.049
6.332GlyArg: 6.332 ± 0.076
6.337GlySer: 6.337 ± 0.085
5.81GlyThr: 5.81 ± 0.077
8.436GlyVal: 8.436 ± 0.091
1.602GlyTrp: 1.602 ± 0.037
2.311GlyTyr: 2.311 ± 0.046
0.0GlyXaa: 0.0 ± 0.0
His
2.087HisAla: 2.087 ± 0.04
0.105HisCys: 0.105 ± 0.008
1.383HisAsp: 1.383 ± 0.041
1.124HisGlu: 1.124 ± 0.029
0.563HisPhe: 0.563 ± 0.019
1.916HisGly: 1.916 ± 0.043
0.539HisHis: 0.539 ± 0.022
0.678HisIle: 0.678 ± 0.024
0.253HisLys: 0.253 ± 0.013
2.0HisLeu: 2.0 ± 0.043
0.259HisMet: 0.259 ± 0.014
0.311HisAsn: 0.311 ± 0.015
1.695HisPro: 1.695 ± 0.034
0.471HisGln: 0.471 ± 0.02
1.535HisArg: 1.535 ± 0.034
1.011HisSer: 1.011 ± 0.027
1.002HisThr: 1.002 ± 0.03
1.475HisVal: 1.475 ± 0.033
0.269HisTrp: 0.269 ± 0.014
0.434HisTyr: 0.434 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
6.508IleAla: 6.508 ± 0.077
0.228IleCys: 0.228 ± 0.014
3.356IleAsp: 3.356 ± 0.054
2.656IleGlu: 2.656 ± 0.043
1.066IlePhe: 1.066 ± 0.031
4.3IleGly: 4.3 ± 0.066
0.599IleHis: 0.599 ± 0.021
1.607IleIle: 1.607 ± 0.039
0.73IleLys: 0.73 ± 0.026
3.195IleLeu: 3.195 ± 0.051
0.517IleMet: 0.517 ± 0.02
0.836IleAsn: 0.836 ± 0.031
2.19IlePro: 2.19 ± 0.04
0.908IleGln: 0.908 ± 0.027
2.458IleArg: 2.458 ± 0.046
2.359IleSer: 2.359 ± 0.039
2.647IleThr: 2.647 ± 0.049
4.537IleVal: 4.537 ± 0.067
0.462IleTrp: 0.462 ± 0.019
0.757IleTyr: 0.757 ± 0.026
0.0IleXaa: 0.0 ± 0.0
Lys
2.465LysAla: 2.465 ± 0.046
0.051LysCys: 0.051 ± 0.007
0.925LysAsp: 0.925 ± 0.029
0.948LysGlu: 0.948 ± 0.028
0.485LysPhe: 0.485 ± 0.02
1.488LysGly: 1.488 ± 0.043
0.403LysHis: 0.403 ± 0.018
0.839LysIle: 0.839 ± 0.024
0.695LysLys: 0.695 ± 0.03
1.831LysLeu: 1.831 ± 0.039
0.308LysMet: 0.308 ± 0.017
0.538LysAsn: 0.538 ± 0.018
1.198LysPro: 1.198 ± 0.035
0.637LysGln: 0.637 ± 0.022
1.435LysArg: 1.435 ± 0.032
1.153LysSer: 1.153 ± 0.032
1.269LysThr: 1.269 ± 0.033
1.552LysVal: 1.552 ± 0.043
0.223LysTrp: 0.223 ± 0.015
0.409LysTyr: 0.409 ± 0.019
0.0LysXaa: 0.0 ± 0.0
Leu
14.707LeuAla: 14.707 ± 0.128
0.511LeuCys: 0.511 ± 0.021
6.938LeuAsp: 6.938 ± 0.091
5.491LeuGlu: 5.491 ± 0.071
3.013LeuPhe: 3.013 ± 0.052
9.505LeuGly: 9.505 ± 0.098
1.847LeuHis: 1.847 ± 0.041
3.908LeuIle: 3.908 ± 0.072
1.748LeuLys: 1.748 ± 0.038
10.232LeuLeu: 10.232 ± 0.124
1.497LeuMet: 1.497 ± 0.038
1.816LeuAsn: 1.816 ± 0.041
5.662LeuPro: 5.662 ± 0.07
2.418LeuGln: 2.418 ± 0.045
7.119LeuArg: 7.119 ± 0.087
6.031LeuSer: 6.031 ± 0.074
6.249LeuThr: 6.249 ± 0.075
9.761LeuVal: 9.761 ± 0.108
1.28LeuTrp: 1.28 ± 0.034
1.694LeuTyr: 1.694 ± 0.034
0.0LeuXaa: 0.0 ± 0.0
Met
1.94MetAla: 1.94 ± 0.041
0.078MetCys: 0.078 ± 0.007
0.627MetAsp: 0.627 ± 0.023
0.577MetGlu: 0.577 ± 0.021
0.433MetPhe: 0.433 ± 0.016
1.184MetGly: 1.184 ± 0.033
0.296MetHis: 0.296 ± 0.016
0.729MetIle: 0.729 ± 0.025
0.428MetLys: 0.428 ± 0.017
1.786MetLeu: 1.786 ± 0.04
0.272MetMet: 0.272 ± 0.014
0.451MetAsn: 0.451 ± 0.018
0.983MetPro: 0.983 ± 0.028
0.466MetGln: 0.466 ± 0.019
1.267MetArg: 1.267 ± 0.033
1.33MetSer: 1.33 ± 0.028
1.59MetThr: 1.59 ± 0.031
1.248MetVal: 1.248 ± 0.036
0.164MetTrp: 0.164 ± 0.012
0.244MetTyr: 0.244 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
2.362AsnAla: 2.362 ± 0.041
0.1AsnCys: 0.1 ± 0.008
1.231AsnAsp: 1.231 ± 0.034
0.995AsnGlu: 0.995 ± 0.029
0.58AsnPhe: 0.58 ± 0.021
2.021AsnGly: 2.021 ± 0.048
0.361AsnHis: 0.361 ± 0.017
0.804AsnIle: 0.804 ± 0.026
0.367AsnLys: 0.367 ± 0.019
1.923AsnLeu: 1.923 ± 0.038
0.283AsnMet: 0.283 ± 0.014
0.473AsnAsn: 0.473 ± 0.02
1.563AsnPro: 1.563 ± 0.041
0.561AsnGln: 0.561 ± 0.021
1.248AsnArg: 1.248 ± 0.03
1.038AsnSer: 1.038 ± 0.029
1.15AsnThr: 1.15 ± 0.032
1.622AsnVal: 1.622 ± 0.036
0.313AsnTrp: 0.313 ± 0.017
0.496AsnTyr: 0.496 ± 0.018
0.0AsnXaa: 0.0 ± 0.0
Pro
7.876ProAla: 7.876 ± 0.102
0.186ProCys: 0.186 ± 0.012
3.859ProAsp: 3.859 ± 0.065
3.947ProGlu: 3.947 ± 0.054
1.864ProPhe: 1.864 ± 0.037
5.401ProGly: 5.401 ± 0.079
1.083ProHis: 1.083 ± 0.03
1.926ProIle: 1.926 ± 0.041
0.986ProLys: 0.986 ± 0.032
5.095ProLeu: 5.095 ± 0.065
0.807ProMet: 0.807 ± 0.025
1.038ProAsn: 1.038 ± 0.027
2.55ProPro: 2.55 ± 0.063
1.369ProGln: 1.369 ± 0.031
3.329ProArg: 3.329 ± 0.044
3.431ProSer: 3.431 ± 0.055
3.645ProThr: 3.645 ± 0.065
5.14ProVal: 5.14 ± 0.066
0.824ProTrp: 0.824 ± 0.023
1.021ProTyr: 1.021 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
3.222GlnAla: 3.222 ± 0.051
0.107GlnCys: 0.107 ± 0.009
0.9GlnAsp: 0.9 ± 0.022
1.181GlnGlu: 1.181 ± 0.03
0.88GlnPhe: 0.88 ± 0.023
2.01GlnGly: 2.01 ± 0.041
0.588GlnHis: 0.588 ± 0.021
1.285GlnIle: 1.285 ± 0.036
0.636GlnLys: 0.636 ± 0.022
3.106GlnLeu: 3.106 ± 0.054
0.44GlnMet: 0.44 ± 0.018
0.711GlnAsn: 0.711 ± 0.023
1.508GlnPro: 1.508 ± 0.037
1.153GlnGln: 1.153 ± 0.036
2.066GlnArg: 2.066 ± 0.039
1.532GlnSer: 1.532 ± 0.037
1.522GlnThr: 1.522 ± 0.035
2.267GlnVal: 2.267 ± 0.041
0.406GlnTrp: 0.406 ± 0.018
0.614GlnTyr: 0.614 ± 0.026
0.0GlnXaa: 0.0 ± 0.0
Arg
8.731ArgAla: 8.731 ± 0.103
0.279ArgCys: 0.279 ± 0.015
3.999ArgAsp: 3.999 ± 0.062
4.268ArgGlu: 4.268 ± 0.066
2.472ArgPhe: 2.472 ± 0.047
5.239ArgGly: 5.239 ± 0.066
1.466ArgHis: 1.466 ± 0.037
3.279ArgIle: 3.279 ± 0.052
1.234ArgLys: 1.234 ± 0.035
7.279ArgLeu: 7.279 ± 0.082
1.648ArgMet: 1.648 ± 0.037
1.177ArgAsn: 1.177 ± 0.029
3.621ArgPro: 3.621 ± 0.061
1.867ArgGln: 1.867 ± 0.035
6.256ArgArg: 6.256 ± 0.097
4.379ArgSer: 4.379 ± 0.069
3.872ArgThr: 3.872 ± 0.062
5.882ArgVal: 5.882 ± 0.069
1.138ArgTrp: 1.138 ± 0.032
1.555ArgTyr: 1.555 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
7.918SerAla: 7.918 ± 0.101
0.312SerCys: 0.312 ± 0.017
3.336SerAsp: 3.336 ± 0.048
2.949SerGlu: 2.949 ± 0.049
2.132SerPhe: 2.132 ± 0.044
6.562SerGly: 6.562 ± 0.081
1.044SerHis: 1.044 ± 0.03
2.813SerIle: 2.813 ± 0.044
1.145SerLys: 1.145 ± 0.032
5.722SerLeu: 5.722 ± 0.064
1.114SerMet: 1.114 ± 0.031
1.203SerAsn: 1.203 ± 0.029
3.422SerPro: 3.422 ± 0.054
1.379SerGln: 1.379 ± 0.032
3.933SerArg: 3.933 ± 0.057
4.156SerSer: 4.156 ± 0.078
4.111SerThr: 4.111 ± 0.073
5.198SerVal: 5.198 ± 0.061
1.003SerTrp: 1.003 ± 0.026
1.356SerTyr: 1.356 ± 0.032
0.0SerXaa: 0.0 ± 0.0
Thr
8.246ThrAla: 8.246 ± 0.102
0.282ThrCys: 0.282 ± 0.014
3.668ThrAsp: 3.668 ± 0.063
3.115ThrGlu: 3.115 ± 0.048
1.81ThrPhe: 1.81 ± 0.037
6.004ThrGly: 6.004 ± 0.074
1.044ThrHis: 1.044 ± 0.029
2.742ThrIle: 2.742 ± 0.044
1.181ThrLys: 1.181 ± 0.029
6.077ThrLeu: 6.077 ± 0.067
0.903ThrMet: 0.903 ± 0.025
1.201ThrAsn: 1.201 ± 0.037
4.353ThrPro: 4.353 ± 0.07
1.348ThrGln: 1.348 ± 0.034
3.729ThrArg: 3.729 ± 0.059
3.732ThrSer: 3.732 ± 0.059
4.167ThrThr: 4.167 ± 0.069
6.257ThrVal: 6.257 ± 0.084
0.812ThrTrp: 0.812 ± 0.025
0.985ThrTyr: 0.985 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
12.358ValAla: 12.358 ± 0.11
0.488ValCys: 0.488 ± 0.019
5.944ValAsp: 5.944 ± 0.074
5.157ValGlu: 5.157 ± 0.065
3.111ValPhe: 3.111 ± 0.056
7.352ValGly: 7.352 ± 0.096
1.634ValHis: 1.634 ± 0.038
4.151ValIle: 4.151 ± 0.066
1.637ValLys: 1.637 ± 0.039
9.687ValLeu: 9.687 ± 0.093
1.423ValMet: 1.423 ± 0.036
1.895ValAsn: 1.895 ± 0.035
4.818ValPro: 4.818 ± 0.065
2.184ValGln: 2.184 ± 0.037
5.608ValArg: 5.608 ± 0.072
5.473ValSer: 5.473 ± 0.068
6.094ValThr: 6.094 ± 0.083
9.91ValVal: 9.91 ± 0.109
1.115ValTrp: 1.115 ± 0.029
1.681ValTyr: 1.681 ± 0.035
0.0ValXaa: 0.0 ± 0.0
Trp
1.622TrpAla: 1.622 ± 0.037
0.096TrpCys: 0.096 ± 0.009
0.678TrpAsp: 0.678 ± 0.022
0.686TrpGlu: 0.686 ± 0.025
0.565TrpPhe: 0.565 ± 0.022
1.086TrpGly: 1.086 ± 0.027
0.34TrpHis: 0.34 ± 0.015
0.627TrpIle: 0.627 ± 0.022
0.324TrpLys: 0.324 ± 0.015
1.659TrpLeu: 1.659 ± 0.043
0.296TrpMet: 0.296 ± 0.015
0.479TrpAsn: 0.479 ± 0.018
0.708TrpPro: 0.708 ± 0.026
0.552TrpGln: 0.552 ± 0.02
1.141TrpArg: 1.141 ± 0.034
0.965TrpSer: 0.965 ± 0.028
0.82TrpThr: 0.82 ± 0.024
1.187TrpVal: 1.187 ± 0.033
0.331TrpTrp: 0.331 ± 0.018
0.301TrpTyr: 0.301 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.333TyrAla: 2.333 ± 0.039
0.142TyrCys: 0.142 ± 0.009
1.378TyrAsp: 1.378 ± 0.038
1.148TyrGlu: 1.148 ± 0.035
0.711TyrPhe: 0.711 ± 0.023
1.936TyrGly: 1.936 ± 0.04
0.32TyrHis: 0.32 ± 0.015
0.657TyrIle: 0.657 ± 0.02
0.322TyrLys: 0.322 ± 0.016
2.27TyrLeu: 2.27 ± 0.044
0.262TyrMet: 0.262 ± 0.013
0.421TyrAsn: 0.421 ± 0.018
1.021TyrPro: 1.021 ± 0.028
0.609TyrGln: 0.609 ± 0.021
1.623TyrArg: 1.623 ± 0.036
1.235TyrSer: 1.235 ± 0.031
1.148TyrThr: 1.148 ± 0.032
1.603TyrVal: 1.603 ± 0.037
0.315TyrTrp: 0.315 ± 0.014
0.49TyrTyr: 0.49 ± 0.018
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4153 proteins (1355947 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski