Amino acid dipepetide frequency for Parachlamydia acanthamoebae (strain UV7)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.186AlaAla: 5.186 ± 0.091	1.099AlaCys: 1.099 ± 0.043	2.964AlaAsp: 2.964 ± 0.059	4.498AlaGlu: 4.498 ± 0.081	3.854AlaPhe: 3.854 ± 0.074	3.992AlaGly: 3.992 ± 0.087	1.715AlaHis: 1.715 ± 0.046	5.418AlaIle: 5.418 ± 0.083	4.817AlaLys: 4.817 ± 0.089	8.225AlaLeu: 8.225 ± 0.118	1.556AlaMet: 1.556 ± 0.04	2.661AlaAsn: 2.661 ± 0.057	2.325AlaPro: 2.325 ± 0.048	3.039AlaGln: 3.039 ± 0.076	2.728AlaArg: 2.728 ± 0.056	4.557AlaSer: 4.557 ± 0.081	3.541AlaThr: 3.541 ± 0.173	3.902AlaVal: 3.902 ± 0.079	0.783AlaTrp: 0.783 ± 0.032	2.497AlaTyr: 2.497 ± 0.058	0.01AlaXaa: 0.01 ± 0.003
Cys	0.857CysAla: 0.857 ± 0.032	0.234CysCys: 0.234 ± 0.017	0.62CysAsp: 0.62 ± 0.024	0.786CysGlu: 0.786 ± 0.03	0.713CysPhe: 0.713 ± 0.031	0.848CysGly: 0.848 ± 0.034	0.385CysHis: 0.385 ± 0.021	0.86CysIle: 0.86 ± 0.032	0.691CysLys: 0.691 ± 0.028	1.644CysLeu: 1.644 ± 0.053	0.272CysMet: 0.272 ± 0.017	0.399CysAsn: 0.399 ± 0.024	0.594CysPro: 0.594 ± 0.034	0.571CysGln: 0.571 ± 0.028	0.552CysArg: 0.552 ± 0.024	0.855CysSer: 0.855 ± 0.03	0.583CysThr: 0.583 ± 0.028	0.717CysVal: 0.717 ± 0.031	0.175CysTrp: 0.175 ± 0.014	0.475CysTyr: 0.475 ± 0.023	0.004CysXaa: 0.004 ± 0.002
Asp	3.312AspAla: 3.312 ± 0.066	0.627AspCys: 0.627 ± 0.028	2.095AspAsp: 2.095 ± 0.059	3.337AspGlu: 3.337 ± 0.065	2.91AspPhe: 2.91 ± 0.057	2.728AspGly: 2.728 ± 0.061	1.25AspHis: 1.25 ± 0.043	3.298AspIle: 3.298 ± 0.068	2.739AspLys: 2.739 ± 0.066	5.688AspLeu: 5.688 ± 0.099	0.913AspMet: 0.913 ± 0.033	1.561AspAsn: 1.561 ± 0.047	2.57AspPro: 2.57 ± 0.054	2.337AspGln: 2.337 ± 0.048	2.284AspArg: 2.284 ± 0.055	2.871AspSer: 2.871 ± 0.069	2.013AspThr: 2.013 ± 0.047	2.872AspVal: 2.872 ± 0.052	0.704AspTrp: 0.704 ± 0.028	1.923AspTyr: 1.923 ± 0.045	0.012AspXaa: 0.012 ± 0.003
Glu	4.89GluAla: 4.89 ± 0.084	0.679GluCys: 0.679 ± 0.033	3.303GluAsp: 3.303 ± 0.065	5.763GluGlu: 5.763 ± 0.103	2.794GluPhe: 2.794 ± 0.054	3.867GluGly: 3.867 ± 0.073	1.532GluHis: 1.532 ± 0.045	5.588GluIle: 5.588 ± 0.073	6.732GluLys: 6.732 ± 0.113	6.365GluLeu: 6.365 ± 0.086	1.815GluMet: 1.815 ± 0.04	3.744GluAsn: 3.744 ± 0.068	1.793GluPro: 1.793 ± 0.053	2.967GluGln: 2.967 ± 0.065	3.141GluArg: 3.141 ± 0.06	3.851GluSer: 3.851 ± 0.078	3.507GluThr: 3.507 ± 0.066	3.75GluVal: 3.75 ± 0.063	0.854GluTrp: 0.854 ± 0.03	1.92GluTyr: 1.92 ± 0.057	0.017GluXaa: 0.017 ± 0.005
Phe	3.403PheAla: 3.403 ± 0.065	0.818PheCys: 0.818 ± 0.025	2.592PheAsp: 2.592 ± 0.053	3.219PheGlu: 3.219 ± 0.057	3.32PhePhe: 3.32 ± 0.084	3.008PheGly: 3.008 ± 0.057	1.26PheHis: 1.26 ± 0.041	3.378PheIle: 3.378 ± 0.073	3.032PheLys: 3.032 ± 0.063	5.85PheLeu: 5.85 ± 0.099	1.03PheMet: 1.03 ± 0.033	2.192PheAsn: 2.192 ± 0.047	2.25PhePro: 2.25 ± 0.056	2.124PheGln: 2.124 ± 0.046	1.9PheArg: 1.9 ± 0.046	4.252PheSer: 4.252 ± 0.072	2.441PheThr: 2.441 ± 0.053	2.805PheVal: 2.805 ± 0.064	0.652PheTrp: 0.652 ± 0.029	2.006PheTyr: 2.006 ± 0.05	0.013PheXaa: 0.013 ± 0.004
Gly	4.137GlyAla: 4.137 ± 0.17	0.878GlyCys: 0.878 ± 0.034	2.655GlyAsp: 2.655 ± 0.077	3.43GlyGlu: 3.43 ± 0.065	2.967GlyPhe: 2.967 ± 0.061	3.703GlyGly: 3.703 ± 0.092	1.473GlyHis: 1.473 ± 0.041	5.044GlyIle: 5.044 ± 0.093	4.465GlyLys: 4.465 ± 0.069	5.72GlyLeu: 5.72 ± 0.088	1.618GlyMet: 1.618 ± 0.047	2.558GlyAsn: 2.558 ± 0.076	1.854GlyPro: 1.854 ± 0.145	2.101GlyGln: 2.101 ± 0.05	2.48GlyArg: 2.48 ± 0.061	3.663GlySer: 3.663 ± 0.069	3.051GlyThr: 3.051 ± 0.063	3.604GlyVal: 3.604 ± 0.068	0.854GlyTrp: 0.854 ± 0.031	2.25GlyTyr: 2.25 ± 0.053	0.009GlyXaa: 0.009 ± 0.003
His	1.912HisAla: 1.912 ± 0.043	0.345HisCys: 0.345 ± 0.018	1.094HisAsp: 1.094 ± 0.035	1.561HisGlu: 1.561 ± 0.042	1.668HisPhe: 1.668 ± 0.045	1.335HisGly: 1.335 ± 0.043	0.86HisHis: 0.86 ± 0.036	1.752HisIle: 1.752 ± 0.042	1.207HisLys: 1.207 ± 0.043	3.308HisLeu: 3.308 ± 0.061	0.499HisMet: 0.499 ± 0.023	0.831HisAsn: 0.831 ± 0.027	1.552HisPro: 1.552 ± 0.041	1.179HisGln: 1.179 ± 0.041	1.16HisArg: 1.16 ± 0.039	1.614HisSer: 1.614 ± 0.05	1.16HisThr: 1.16 ± 0.035	1.551HisVal: 1.551 ± 0.045	0.357HisTrp: 0.357 ± 0.023	1.063HisTyr: 1.063 ± 0.035	0.002HisXaa: 0.002 ± 0.001
Ile	5.674IleAla: 5.674 ± 0.096	1.122IleCys: 1.122 ± 0.04	3.849IleAsp: 3.849 ± 0.063	5.24IleGlu: 5.24 ± 0.079	3.708IlePhe: 3.708 ± 0.076	4.403IleGly: 4.403 ± 0.092	2.035IleHis: 2.035 ± 0.047	4.129IleIle: 4.129 ± 0.071	4.518IleLys: 4.518 ± 0.081	7.908IleLeu: 7.908 ± 0.118	1.194IleMet: 1.194 ± 0.038	2.857IleAsn: 2.857 ± 0.059	3.804IlePro: 3.804 ± 0.057	3.587IleGln: 3.587 ± 0.067	3.219IleArg: 3.219 ± 0.059	5.212IleSer: 5.212 ± 0.084	3.238IleThr: 3.238 ± 0.062	4.084IleVal: 4.084 ± 0.072	0.727IleTrp: 0.727 ± 0.028	2.302IleTyr: 2.302 ± 0.055	0.013IleXaa: 0.013 ± 0.004
Lys	4.664LysAla: 4.664 ± 0.072	0.653LysCys: 0.653 ± 0.029	3.523LysAsp: 3.523 ± 0.074	5.733LysGlu: 5.733 ± 0.1	2.531LysPhe: 2.531 ± 0.052	3.897LysGly: 3.897 ± 0.072	1.643LysHis: 1.643 ± 0.042	5.819LysIle: 5.819 ± 0.098	6.601LysLys: 6.601 ± 0.114	6.032LysLeu: 6.032 ± 0.09	1.879LysMet: 1.879 ± 0.039	4.101LysAsn: 4.101 ± 0.085	2.282LysPro: 2.282 ± 0.055	3.124LysGln: 3.124 ± 0.062	3.185LysArg: 3.185 ± 0.06	4.138LysSer: 4.138 ± 0.067	3.806LysThr: 3.806 ± 0.073	3.867LysVal: 3.867 ± 0.071	0.837LysTrp: 0.837 ± 0.033	1.958LysTyr: 1.958 ± 0.049	0.01LysXaa: 0.01 ± 0.003
Leu	7.718LeuAla: 7.718 ± 0.118	1.374LeuCys: 1.374 ± 0.047	5.277LeuAsp: 5.277 ± 0.071	7.359LeuGlu: 7.359 ± 0.086	5.677LeuPhe: 5.677 ± 0.095	6.105LeuGly: 6.105 ± 0.091	2.657LeuHis: 2.657 ± 0.061	7.697LeuIle: 7.697 ± 0.107	8.124LeuLys: 8.124 ± 0.114	11.057LeuLeu: 11.057 ± 0.147	2.424LeuMet: 2.424 ± 0.055	5.141LeuAsn: 5.141 ± 0.074	4.687LeuPro: 4.687 ± 0.069	4.644LeuGln: 4.644 ± 0.089	4.403LeuArg: 4.403 ± 0.072	8.215LeuSer: 8.215 ± 0.109	5.618LeuThr: 5.618 ± 0.086	5.453LeuVal: 5.453 ± 0.092	1.065LeuTrp: 1.065 ± 0.039	3.13LeuTyr: 3.13 ± 0.054	0.021LeuXaa: 0.021 ± 0.005
Met	1.642MetAla: 1.642 ± 0.042	0.166MetCys: 0.166 ± 0.016	1.067MetAsp: 1.067 ± 0.033	1.391MetGlu: 1.391 ± 0.033	0.801MetPhe: 0.801 ± 0.03	1.508MetGly: 1.508 ± 0.044	0.707MetHis: 0.707 ± 0.029	1.585MetIle: 1.585 ± 0.043	1.563MetLys: 1.563 ± 0.037	2.234MetLeu: 2.234 ± 0.054	0.515MetMet: 0.515 ± 0.025	0.959MetAsn: 0.959 ± 0.027	0.953MetPro: 0.953 ± 0.038	1.192MetGln: 1.192 ± 0.037	1.144MetArg: 1.144 ± 0.033	1.383MetSer: 1.383 ± 0.041	1.334MetThr: 1.334 ± 0.034	1.176MetVal: 1.176 ± 0.034	0.187MetTrp: 0.187 ± 0.015	0.464MetTyr: 0.464 ± 0.022	0.004MetXaa: 0.004 ± 0.002
Asn	3.09AsnAla: 3.09 ± 0.059	0.523AsnCys: 0.523 ± 0.022	1.915AsnAsp: 1.915 ± 0.047	2.803AsnGlu: 2.803 ± 0.064	2.3AsnPhe: 2.3 ± 0.049	2.573AsnGly: 2.573 ± 0.068	1.331AsnHis: 1.331 ± 0.039	2.829AsnIle: 2.829 ± 0.06	2.471AsnLys: 2.471 ± 0.061	5.092AsnLeu: 5.092 ± 0.086	0.833AsnMet: 0.833 ± 0.032	1.55AsnAsn: 1.55 ± 0.041	2.653AsnPro: 2.653 ± 0.063	2.302AsnGln: 2.302 ± 0.053	2.171AsnArg: 2.171 ± 0.045	2.597AsnSer: 2.597 ± 0.054	2.022AsnThr: 2.022 ± 0.06	2.539AsnVal: 2.539 ± 0.06	0.614AsnTrp: 0.614 ± 0.027	1.411AsnTyr: 1.411 ± 0.039	0.012AsnXaa: 0.012 ± 0.004
Pro	2.472ProAla: 2.472 ± 0.059	0.538ProCys: 0.538 ± 0.025	2.156ProAsp: 2.156 ± 0.05	3.276ProGlu: 3.276 ± 0.061	2.417ProPhe: 2.417 ± 0.055	2.244ProGly: 2.244 ± 0.055	1.218ProHis: 1.218 ± 0.035	3.075ProIle: 3.075 ± 0.058	2.682ProLys: 2.682 ± 0.052	4.725ProLeu: 4.725 ± 0.079	0.74ProMet: 0.74 ± 0.029	1.751ProAsn: 1.751 ± 0.044	1.893ProPro: 1.893 ± 0.056	1.845ProGln: 1.845 ± 0.047	1.439ProArg: 1.439 ± 0.046	3.259ProSer: 3.259 ± 0.063	2.319ProThr: 2.319 ± 0.111	2.347ProVal: 2.347 ± 0.057	0.493ProTrp: 0.493 ± 0.025	1.435ProTyr: 1.435 ± 0.039	0.017ProXaa: 0.017 ± 0.005
Gln	3.535GlnAla: 3.535 ± 0.078	0.382GlnCys: 0.382 ± 0.022	2.056GlnAsp: 2.056 ± 0.044	3.515GlnGlu: 3.515 ± 0.081	1.982GlnPhe: 1.982 ± 0.044	2.455GlnGly: 2.455 ± 0.054	1.02GlnHis: 1.02 ± 0.038	3.521GlnIle: 3.521 ± 0.062	4.009GlnLys: 4.009 ± 0.078	4.441GlnLeu: 4.441 ± 0.076	0.999GlnMet: 0.999 ± 0.035	2.487GlnAsn: 2.487 ± 0.056	1.426GlnPro: 1.426 ± 0.043	2.162GlnGln: 2.162 ± 0.07	1.868GlnArg: 1.868 ± 0.049	2.617GlnSer: 2.617 ± 0.056	2.456GlnThr: 2.456 ± 0.054	2.514GlnVal: 2.514 ± 0.054	0.463GlnTrp: 0.463 ± 0.023	1.263GlnTyr: 1.263 ± 0.037	0.013GlnXaa: 0.013 ± 0.004
Arg	2.529ArgAla: 2.529 ± 0.059	0.503ArgCys: 0.503 ± 0.026	2.158ArgAsp: 2.158 ± 0.051	3.134ArgGlu: 3.134 ± 0.065	2.281ArgPhe: 2.281 ± 0.054	2.281ArgGly: 2.281 ± 0.053	1.091ArgHis: 1.091 ± 0.033	3.272ArgIle: 3.272 ± 0.058	3.121ArgLys: 3.121 ± 0.067	4.834ArgLeu: 4.834 ± 0.072	1.094ArgMet: 1.094 ± 0.035	1.885ArgAsn: 1.885 ± 0.045	1.487ArgPro: 1.487 ± 0.043	1.999ArgGln: 1.999 ± 0.051	1.937ArgArg: 1.937 ± 0.055	2.499ArgSer: 2.499 ± 0.055	2.003ArgThr: 2.003 ± 0.052	2.312ArgVal: 2.312 ± 0.056	0.552ArgTrp: 0.552 ± 0.026	1.64ArgTyr: 1.64 ± 0.04	0.004ArgXaa: 0.004 ± 0.002
Ser	4.23SerAla: 4.23 ± 0.073	0.829SerCys: 0.829 ± 0.028	2.994SerAsp: 2.994 ± 0.058	4.169SerGlu: 4.169 ± 0.069	3.679SerPhe: 3.679 ± 0.077	3.78SerGly: 3.78 ± 0.076	1.838SerHis: 1.838 ± 0.043	4.846SerIle: 4.846 ± 0.072	4.33SerLys: 4.33 ± 0.079	7.878SerLeu: 7.878 ± 0.107	1.412SerMet: 1.412 ± 0.036	2.658SerAsn: 2.658 ± 0.06	3.323SerPro: 3.323 ± 0.059	3.142SerGln: 3.142 ± 0.062	2.635SerArg: 2.635 ± 0.059	5.194SerSer: 5.194 ± 0.097	3.372SerThr: 3.372 ± 0.075	3.431SerVal: 3.431 ± 0.056	0.768SerTrp: 0.768 ± 0.03	2.272SerTyr: 2.272 ± 0.06	0.015SerXaa: 0.015 ± 0.004
Thr	3.33ThrAla: 3.33 ± 0.06	0.667ThrCys: 0.667 ± 0.024	2.269ThrAsp: 2.269 ± 0.045	2.846ThrGlu: 2.846 ± 0.055	2.643ThrPhe: 2.643 ± 0.06	3.623ThrGly: 3.623 ± 0.334	1.399ThrHis: 1.399 ± 0.041	3.762ThrIle: 3.762 ± 0.072	2.852ThrLys: 2.852 ± 0.059	5.828ThrLeu: 5.828 ± 0.083	0.898ThrMet: 0.898 ± 0.034	1.949ThrAsn: 1.949 ± 0.043	2.71ThrPro: 2.71 ± 0.067	2.12ThrGln: 2.12 ± 0.055	1.969ThrArg: 1.969 ± 0.046	3.372ThrSer: 3.372 ± 0.063	2.693ThrThr: 2.693 ± 0.067	2.786ThrVal: 2.786 ± 0.061	0.627ThrTrp: 0.627 ± 0.027	1.861ThrTyr: 1.861 ± 0.074	0.012ThrXaa: 0.012 ± 0.004
Val	3.79ValAla: 3.79 ± 0.071	0.773ValCys: 0.773 ± 0.029	2.982ValAsp: 2.982 ± 0.059	3.924ValGlu: 3.924 ± 0.069	2.804ValPhe: 2.804 ± 0.062	3.466ValGly: 3.466 ± 0.072	1.319ValHis: 1.319 ± 0.035	4.058ValIle: 4.058 ± 0.069	3.69ValLys: 3.69 ± 0.065	5.827ValLeu: 5.827 ± 0.085	1.283ValMet: 1.283 ± 0.037	2.464ValAsn: 2.464 ± 0.053	2.252ValPro: 2.252 ± 0.06	2.362ValGln: 2.362 ± 0.053	2.161ValArg: 2.161 ± 0.045	3.854ValSer: 3.854 ± 0.063	2.875ValThr: 2.875 ± 0.063	3.597ValVal: 3.597 ± 0.066	0.574ValTrp: 0.574 ± 0.027	1.751ValTyr: 1.751 ± 0.045	0.004ValXaa: 0.004 ± 0.002
Trp	0.632TrpAla: 0.632 ± 0.025	0.127TrpCys: 0.127 ± 0.012	0.624TrpAsp: 0.624 ± 0.024	0.831TrpGlu: 0.831 ± 0.033	0.53TrpPhe: 0.53 ± 0.026	0.758TrpGly: 0.758 ± 0.029	0.311TrpHis: 0.311 ± 0.02	1.007TrpIle: 1.007 ± 0.033	0.997TrpLys: 0.997 ± 0.039	1.285TrpLeu: 1.285 ± 0.036	0.361TrpMet: 0.361 ± 0.021	0.643TrpAsn: 0.643 ± 0.028	0.352TrpPro: 0.352 ± 0.018	0.53TrpGln: 0.53 ± 0.023	0.547TrpArg: 0.547 ± 0.024	0.672TrpSer: 0.672 ± 0.027	0.509TrpThr: 0.509 ± 0.024	0.655TrpVal: 0.655 ± 0.027	0.151TrpTrp: 0.151 ± 0.015	0.359TrpTyr: 0.359 ± 0.022	0.002TrpXaa: 0.002 ± 0.001
Tyr	2.349TyrAla: 2.349 ± 0.056	0.499TyrCys: 0.499 ± 0.021	1.843TyrAsp: 1.843 ± 0.08	2.047TyrGlu: 2.047 ± 0.053	1.953TyrPhe: 1.953 ± 0.045	1.924TyrGly: 1.924 ± 0.051	0.958TyrHis: 0.958 ± 0.036	1.872TyrIle: 1.872 ± 0.045	1.627TyrLys: 1.627 ± 0.048	3.879TyrLeu: 3.879 ± 0.072	0.638TyrMet: 0.638 ± 0.022	1.229TyrAsn: 1.229 ± 0.042	1.573TyrPro: 1.573 ± 0.04	1.849TyrGln: 1.849 ± 0.043	1.689TyrArg: 1.689 ± 0.046	2.104TyrSer: 2.104 ± 0.053	1.66TyrThr: 1.66 ± 0.045	1.837TyrVal: 1.837 ± 0.045	0.446TyrTrp: 0.446 ± 0.02	1.21TyrTyr: 1.21 ± 0.047	0.009TyrXaa: 0.009 ± 0.003
Xaa	0.016XaaAla: 0.016 ± 0.005	0.001XaaCys: 0.001 ± 0.001	0.007XaaAsp: 0.007 ± 0.002	0.011XaaGlu: 0.011 ± 0.005	0.011XaaPhe: 0.011 ± 0.003	0.016XaaGly: 0.016 ± 0.004	0.008XaaHis: 0.008 ± 0.003	0.012XaaIle: 0.012 ± 0.004	0.014XaaLys: 0.014 ± 0.004	0.024XaaLeu: 0.024 ± 0.005	0.001XaaMet: 0.001 ± 0.001	0.012XaaAsn: 0.012 ± 0.004	0.009XaaPro: 0.009 ± 0.003	0.008XaaGln: 0.008 ± 0.003	0.009XaaArg: 0.009 ± 0.003	0.014XaaSer: 0.014 ± 0.004	0.013XaaThr: 0.013 ± 0.004	0.011XaaVal: 0.011 ± 0.004	0.001XaaTrp: 0.001 ± 0.001	0.008XaaTyr: 0.008 ± 0.003	0.003XaaXaa: 0.003 ± 0.002

Statistics based on 2784 proteins (914357 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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