Amino acid dipepetide frequency for Streptococcus ferus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.967AlaAla: 6.967 ± 0.153
0.505AlaCys: 0.505 ± 0.03
4.847AlaAsp: 4.847 ± 0.097
5.15AlaGlu: 5.15 ± 0.112
3.672AlaPhe: 3.672 ± 0.086
5.629AlaGly: 5.629 ± 0.127
1.251AlaHis: 1.251 ± 0.05
5.952AlaIle: 5.952 ± 0.103
5.476AlaLys: 5.476 ± 0.128
8.077AlaLeu: 8.077 ± 0.151
1.839AlaMet: 1.839 ± 0.056
3.207AlaAsn: 3.207 ± 0.085
2.17AlaPro: 2.17 ± 0.07
3.479AlaGln: 3.479 ± 0.088
2.971AlaArg: 2.971 ± 0.072
5.108AlaSer: 5.108 ± 0.109
4.27AlaThr: 4.27 ± 0.112
5.929AlaVal: 5.929 ± 0.105
0.573AlaTrp: 0.573 ± 0.03
3.355AlaTyr: 3.355 ± 0.074
0.0AlaXaa: 0.0 ± 0.0
Cys
0.294CysAla: 0.294 ± 0.025
0.047CysCys: 0.047 ± 0.009
0.265CysAsp: 0.265 ± 0.025
0.184CysGlu: 0.184 ± 0.018
0.24CysPhe: 0.24 ± 0.019
0.456CysGly: 0.456 ± 0.031
0.193CysHis: 0.193 ± 0.022
0.279CysIle: 0.279 ± 0.023
0.142CysLys: 0.142 ± 0.019
0.645CysLeu: 0.645 ± 0.037
0.097CysMet: 0.097 ± 0.012
0.15CysAsn: 0.15 ± 0.015
0.247CysPro: 0.247 ± 0.022
0.397CysGln: 0.397 ± 0.027
0.233CysArg: 0.233 ± 0.02
0.299CysSer: 0.299 ± 0.02
0.202CysThr: 0.202 ± 0.021
0.243CysVal: 0.243 ± 0.024
0.032CysTrp: 0.032 ± 0.008
0.175CysTyr: 0.175 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
3.836AspAla: 3.836 ± 0.087
0.308AspCys: 0.308 ± 0.028
3.205AspAsp: 3.205 ± 0.093
3.67AspGlu: 3.67 ± 0.109
3.486AspPhe: 3.486 ± 0.08
3.875AspGly: 3.875 ± 0.098
1.098AspHis: 1.098 ± 0.039
4.569AspIle: 4.569 ± 0.094
4.173AspLys: 4.173 ± 0.087
6.57AspLeu: 6.57 ± 0.115
1.554AspMet: 1.554 ± 0.056
2.489AspAsn: 2.489 ± 0.071
1.748AspPro: 1.748 ± 0.059
2.525AspGln: 2.525 ± 0.063
2.388AspArg: 2.388 ± 0.074
3.416AspSer: 3.416 ± 0.094
2.817AspThr: 2.817 ± 0.076
3.834AspVal: 3.834 ± 0.084
0.73AspTrp: 0.73 ± 0.036
3.068AspTyr: 3.068 ± 0.085
0.0AspXaa: 0.0 ± 0.0
Glu
6.105GluAla: 6.105 ± 0.116
0.222GluCys: 0.222 ± 0.02
3.798GluAsp: 3.798 ± 0.088
5.664GluGlu: 5.664 ± 0.108
2.233GluPhe: 2.233 ± 0.066
3.735GluGly: 3.735 ± 0.094
1.226GluHis: 1.226 ± 0.049
4.687GluIle: 4.687 ± 0.112
5.418GluLys: 5.418 ± 0.117
6.612GluLeu: 6.612 ± 0.122
1.707GluMet: 1.707 ± 0.054
3.365GluAsn: 3.365 ± 0.076
1.489GluPro: 1.489 ± 0.064
2.524GluGln: 2.524 ± 0.075
3.162GluArg: 3.162 ± 0.087
3.149GluSer: 3.149 ± 0.073
4.081GluThr: 4.081 ± 0.087
4.387GluVal: 4.387 ± 0.113
0.508GluTrp: 0.508 ± 0.027
1.676GluTyr: 1.676 ± 0.063
0.0GluXaa: 0.0 ± 0.0
Phe
3.582PheAla: 3.582 ± 0.088
0.24PheCys: 0.24 ± 0.02
3.172PheAsp: 3.172 ± 0.076
3.019PheGlu: 3.019 ± 0.087
2.17PhePhe: 2.17 ± 0.073
3.282PheGly: 3.282 ± 0.074
0.773PheHis: 0.773 ± 0.034
3.167PheIle: 3.167 ± 0.08
2.547PheLys: 2.547 ± 0.062
4.703PheLeu: 4.703 ± 0.109
0.999PheMet: 0.999 ± 0.042
1.855PheAsn: 1.855 ± 0.062
1.563PhePro: 1.563 ± 0.057
1.631PheGln: 1.631 ± 0.054
1.485PheArg: 1.485 ± 0.057
3.346PheSer: 3.346 ± 0.074
2.396PheThr: 2.396 ± 0.066
3.045PheVal: 3.045 ± 0.083
0.46PheTrp: 0.46 ± 0.031
1.842PheTyr: 1.842 ± 0.067
0.0PheXaa: 0.0 ± 0.0
Gly
4.651GlyAla: 4.651 ± 0.109
0.388GlyCys: 0.388 ± 0.029
3.711GlyAsp: 3.711 ± 0.082
3.574GlyGlu: 3.574 ± 0.085
3.401GlyPhe: 3.401 ± 0.078
4.362GlyGly: 4.362 ± 0.123
1.366GlyHis: 1.366 ± 0.05
5.229GlyIle: 5.229 ± 0.107
4.524GlyLys: 4.524 ± 0.096
7.291GlyLeu: 7.291 ± 0.148
1.709GlyMet: 1.709 ± 0.061
2.67GlyAsn: 2.67 ± 0.076
1.437GlyPro: 1.437 ± 0.054
3.43GlyGln: 3.43 ± 0.084
2.956GlyArg: 2.956 ± 0.076
4.054GlySer: 4.054 ± 0.09
3.672GlyThr: 3.672 ± 0.095
4.724GlyVal: 4.724 ± 0.109
0.649GlyTrp: 0.649 ± 0.039
2.632GlyTyr: 2.632 ± 0.069
0.0GlyXaa: 0.0 ± 0.0
His
1.164HisAla: 1.164 ± 0.05
0.097HisCys: 0.097 ± 0.012
0.975HisAsp: 0.975 ± 0.041
1.02HisGlu: 1.02 ± 0.043
1.255HisPhe: 1.255 ± 0.048
1.222HisGly: 1.222 ± 0.055
0.588HisHis: 0.588 ± 0.034
1.307HisIle: 1.307 ± 0.052
0.964HisLys: 0.964 ± 0.04
2.28HisLeu: 2.28 ± 0.071
0.395HisMet: 0.395 ± 0.021
0.672HisAsn: 0.672 ± 0.034
0.912HisPro: 0.912 ± 0.04
1.074HisGln: 1.074 ± 0.054
0.916HisArg: 0.916 ± 0.047
1.022HisSer: 1.022 ± 0.045
0.84HisThr: 0.84 ± 0.04
1.1HisVal: 1.1 ± 0.046
0.178HisTrp: 0.178 ± 0.019
0.984HisTyr: 0.984 ± 0.052
0.0HisXaa: 0.0 ± 0.0
Ile
6.019IleAla: 6.019 ± 0.124
0.478IleCys: 0.478 ± 0.029
4.232IleAsp: 4.232 ± 0.09
4.542IleGlu: 4.542 ± 0.103
3.266IlePhe: 3.266 ± 0.092
4.982IleGly: 4.982 ± 0.102
1.219IleHis: 1.219 ± 0.046
4.724IleIle: 4.724 ± 0.101
4.393IleLys: 4.393 ± 0.083
7.12IleLeu: 7.12 ± 0.127
1.64IleMet: 1.64 ± 0.063
2.935IleAsn: 2.935 ± 0.075
2.758IlePro: 2.758 ± 0.074
2.41IleGln: 2.41 ± 0.068
2.9IleArg: 2.9 ± 0.073
4.982IleSer: 4.982 ± 0.091
3.731IleThr: 3.731 ± 0.085
4.454IleVal: 4.454 ± 0.106
0.625IleTrp: 0.625 ± 0.04
2.48IleTyr: 2.48 ± 0.072
0.0IleXaa: 0.0 ± 0.0
Lys
5.799LysAla: 5.799 ± 0.116
0.184LysCys: 0.184 ± 0.019
4.095LysAsp: 4.095 ± 0.091
5.644LysGlu: 5.644 ± 0.112
1.772LysPhe: 1.772 ± 0.051
4.112LysGly: 4.112 ± 0.083
1.118LysHis: 1.118 ± 0.039
4.44LysIle: 4.44 ± 0.087
5.018LysLys: 5.018 ± 0.122
5.624LysLeu: 5.624 ± 0.112
1.853LysMet: 1.853 ± 0.059
3.1LysAsn: 3.1 ± 0.091
2.048LysPro: 2.048 ± 0.065
2.576LysGln: 2.576 ± 0.069
3.142LysArg: 3.142 ± 0.083
3.72LysSer: 3.72 ± 0.079
4.29LysThr: 4.29 ± 0.091
4.56LysVal: 4.56 ± 0.097
0.597LysTrp: 0.597 ± 0.034
2.078LysTyr: 2.078 ± 0.064
0.0LysXaa: 0.0 ± 0.0
Leu
9.662LeuAla: 9.662 ± 0.137
0.483LeuCys: 0.483 ± 0.03
6.087LeuAsp: 6.087 ± 0.115
7.136LeuGlu: 7.136 ± 0.143
4.542LeuPhe: 4.542 ± 0.127
6.704LeuGly: 6.704 ± 0.133
1.565LeuHis: 1.565 ± 0.058
7.025LeuIle: 7.025 ± 0.127
6.689LeuLys: 6.689 ± 0.126
10.895LeuLeu: 10.895 ± 0.221
2.455LeuMet: 2.455 ± 0.059
4.081LeuAsn: 4.081 ± 0.083
4.108LeuPro: 4.108 ± 0.096
3.501LeuGln: 3.501 ± 0.084
3.852LeuArg: 3.852 ± 0.095
7.888LeuSer: 7.888 ± 0.137
6.48LeuThr: 6.48 ± 0.119
7.111LeuVal: 7.111 ± 0.127
0.735LeuTrp: 0.735 ± 0.041
3.227LeuTyr: 3.227 ± 0.084
0.0LeuXaa: 0.0 ± 0.0
Met
2.221MetAla: 2.221 ± 0.064
0.099MetCys: 0.099 ± 0.015
1.273MetAsp: 1.273 ± 0.053
1.283MetGlu: 1.283 ± 0.049
0.741MetPhe: 0.741 ± 0.038
1.673MetGly: 1.673 ± 0.057
0.35MetHis: 0.35 ± 0.024
1.72MetIle: 1.72 ± 0.059
1.754MetLys: 1.754 ± 0.065
2.194MetLeu: 2.194 ± 0.07
0.671MetMet: 0.671 ± 0.04
1.112MetAsn: 1.112 ± 0.046
0.836MetPro: 0.836 ± 0.035
0.813MetGln: 0.813 ± 0.036
1.011MetArg: 1.011 ± 0.037
1.63MetSer: 1.63 ± 0.055
2.116MetThr: 2.116 ± 0.066
1.658MetVal: 1.658 ± 0.053
0.141MetTrp: 0.141 ± 0.017
0.588MetTyr: 0.588 ± 0.036
0.0MetXaa: 0.0 ± 0.0
Asn
2.913AsnAla: 2.913 ± 0.086
0.222AsnCys: 0.222 ± 0.02
2.314AsnAsp: 2.314 ± 0.075
2.19AsnGlu: 2.19 ± 0.069
1.653AsnPhe: 1.653 ± 0.057
3.093AsnGly: 3.093 ± 0.097
1.069AsnHis: 1.069 ± 0.044
2.807AsnIle: 2.807 ± 0.074
2.415AsnLys: 2.415 ± 0.076
4.58AsnLeu: 4.58 ± 0.109
1.076AsnMet: 1.076 ± 0.04
1.777AsnAsn: 1.777 ± 0.072
2.286AsnPro: 2.286 ± 0.071
2.524AsnGln: 2.524 ± 0.074
2.051AsnArg: 2.051 ± 0.064
2.269AsnSer: 2.269 ± 0.076
2.017AsnThr: 2.017 ± 0.077
2.534AsnVal: 2.534 ± 0.073
0.517AsnTrp: 0.517 ± 0.037
1.763AsnTyr: 1.763 ± 0.067
0.0AsnXaa: 0.0 ± 0.0
Pro
2.48ProAla: 2.48 ± 0.073
0.13ProCys: 0.13 ± 0.016
2.343ProAsp: 2.343 ± 0.073
2.745ProGlu: 2.745 ± 0.071
1.736ProPhe: 1.736 ± 0.058
1.819ProGly: 1.819 ± 0.057
0.726ProHis: 0.726 ± 0.042
2.259ProIle: 2.259 ± 0.069
2.156ProLys: 2.156 ± 0.067
3.299ProLeu: 3.299 ± 0.078
0.716ProMet: 0.716 ± 0.038
1.563ProAsn: 1.563 ± 0.047
0.604ProPro: 0.604 ± 0.041
1.493ProGln: 1.493 ± 0.053
1.087ProArg: 1.087 ± 0.051
2.136ProSer: 2.136 ± 0.056
1.801ProThr: 1.801 ± 0.066
2.545ProVal: 2.545 ± 0.073
0.279ProTrp: 0.279 ± 0.022
1.411ProTyr: 1.411 ± 0.052
0.0ProXaa: 0.0 ± 0.0
Gln
3.957GlnAla: 3.957 ± 0.097
0.115GlnCys: 0.115 ± 0.014
2.385GlnAsp: 2.385 ± 0.067
3.508GlnGlu: 3.508 ± 0.097
1.709GlnPhe: 1.709 ± 0.057
2.561GlnGly: 2.561 ± 0.081
0.717GlnHis: 0.717 ± 0.037
3.021GlnIle: 3.021 ± 0.076
3.4GlnLys: 3.4 ± 0.082
4.613GlnLeu: 4.613 ± 0.103
1.091GlnMet: 1.091 ± 0.048
1.757GlnAsn: 1.757 ± 0.059
1.379GlnPro: 1.379 ± 0.047
1.712GlnGln: 1.712 ± 0.065
1.538GlnArg: 1.538 ± 0.056
2.332GlnSer: 2.332 ± 0.072
2.762GlnThr: 2.762 ± 0.085
3.187GlnVal: 3.187 ± 0.085
0.342GlnTrp: 0.342 ± 0.027
1.305GlnTyr: 1.305 ± 0.05
0.0GlnXaa: 0.0 ± 0.0
Arg
2.675ArgAla: 2.675 ± 0.081
0.159ArgCys: 0.159 ± 0.016
2.356ArgAsp: 2.356 ± 0.066
2.873ArgGlu: 2.873 ± 0.08
2.114ArgPhe: 2.114 ± 0.064
2.32ArgGly: 2.32 ± 0.08
1.065ArgHis: 1.065 ± 0.043
2.911ArgIle: 2.911 ± 0.08
2.592ArgLys: 2.592 ± 0.079
4.735ArgLeu: 4.735 ± 0.12
1.015ArgMet: 1.015 ± 0.045
1.523ArgAsn: 1.523 ± 0.052
1.424ArgPro: 1.424 ± 0.054
2.441ArgGln: 2.441 ± 0.082
2.069ArgArg: 2.069 ± 0.069
2.188ArgSer: 2.188 ± 0.063
2.008ArgThr: 2.008 ± 0.062
2.615ArgVal: 2.615 ± 0.067
0.292ArgTrp: 0.292 ± 0.02
1.711ArgTyr: 1.711 ± 0.052
0.0ArgXaa: 0.0 ± 0.0
Ser
4.294SerAla: 4.294 ± 0.101
0.287SerCys: 0.287 ± 0.024
3.935SerAsp: 3.935 ± 0.104
3.421SerGlu: 3.421 ± 0.081
3.131SerPhe: 3.131 ± 0.081
4.923SerGly: 4.923 ± 0.1
1.383SerHis: 1.383 ± 0.048
3.984SerIle: 3.984 ± 0.086
4.094SerLys: 4.094 ± 0.091
7.228SerLeu: 7.228 ± 0.167
1.325SerMet: 1.325 ± 0.045
2.588SerAsn: 2.588 ± 0.079
2.066SerPro: 2.066 ± 0.062
3.674SerGln: 3.674 ± 0.098
2.625SerArg: 2.625 ± 0.076
4.593SerSer: 4.593 ± 0.148
3.057SerThr: 3.057 ± 0.105
3.987SerVal: 3.987 ± 0.087
0.629SerTrp: 0.629 ± 0.038
2.547SerTyr: 2.547 ± 0.073
0.0SerXaa: 0.0 ± 0.0
Thr
4.78ThrAla: 4.78 ± 0.104
0.251ThrCys: 0.251 ± 0.027
3.376ThrAsp: 3.376 ± 0.078
3.376ThrGlu: 3.376 ± 0.078
2.628ThrPhe: 2.628 ± 0.081
4.236ThrGly: 4.236 ± 0.095
1.009ThrHis: 1.009 ± 0.041
4.423ThrIle: 4.423 ± 0.09
3.349ThrLys: 3.349 ± 0.086
5.438ThrLeu: 5.438 ± 0.1
1.116ThrMet: 1.116 ± 0.046
2.457ThrAsn: 2.457 ± 0.087
2.186ThrPro: 2.186 ± 0.069
1.943ThrGln: 1.943 ± 0.062
1.853ThrArg: 1.853 ± 0.054
3.937ThrSer: 3.937 ± 0.115
3.585ThrThr: 3.585 ± 0.215
4.353ThrVal: 4.353 ± 0.105
0.516ThrTrp: 0.516 ± 0.029
2.441ThrTyr: 2.441 ± 0.078
0.0ThrXaa: 0.0 ± 0.0
Val
5.802ValAla: 5.802 ± 0.116
0.355ValCys: 0.355 ± 0.026
4.018ValAsp: 4.018 ± 0.089
4.101ValGlu: 4.101 ± 0.093
3.082ValPhe: 3.082 ± 0.081
4.348ValGly: 4.348 ± 0.102
1.103ValHis: 1.103 ± 0.055
4.719ValIle: 4.719 ± 0.102
4.317ValLys: 4.317 ± 0.105
6.891ValLeu: 6.891 ± 0.109
1.635ValMet: 1.635 ± 0.06
2.88ValAsn: 2.88 ± 0.085
2.417ValPro: 2.417 ± 0.077
2.219ValGln: 2.219 ± 0.06
2.666ValArg: 2.666 ± 0.078
4.885ValSer: 4.885 ± 0.1
4.638ValThr: 4.638 ± 0.108
4.539ValVal: 4.539 ± 0.098
0.589ValTrp: 0.589 ± 0.036
2.369ValTyr: 2.369 ± 0.07
0.0ValXaa: 0.0 ± 0.0
Trp
0.566TrpAla: 0.566 ± 0.029
0.054TrpCys: 0.054 ± 0.009
0.481TrpAsp: 0.481 ± 0.032
0.546TrpGlu: 0.546 ± 0.033
0.442TrpPhe: 0.442 ± 0.027
0.618TrpGly: 0.618 ± 0.034
0.169TrpHis: 0.169 ± 0.015
0.537TrpIle: 0.537 ± 0.032
0.472TrpLys: 0.472 ± 0.034
1.116TrpLeu: 1.116 ± 0.052
0.225TrpMet: 0.225 ± 0.022
0.424TrpAsn: 0.424 ± 0.028
0.195TrpPro: 0.195 ± 0.021
0.512TrpGln: 0.512 ± 0.027
0.344TrpArg: 0.344 ± 0.021
0.575TrpSer: 0.575 ± 0.035
0.575TrpThr: 0.575 ± 0.034
0.505TrpVal: 0.505 ± 0.034
0.112TrpTrp: 0.112 ± 0.013
0.391TrpTyr: 0.391 ± 0.031
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.661TyrAla: 2.661 ± 0.079
0.198TyrCys: 0.198 ± 0.021
2.493TyrAsp: 2.493 ± 0.069
2.1TyrGlu: 2.1 ± 0.061
2.003TyrPhe: 2.003 ± 0.072
2.48TyrGly: 2.48 ± 0.062
0.979TyrHis: 0.979 ± 0.044
2.132TyrIle: 2.132 ± 0.056
1.875TyrLys: 1.875 ± 0.054
4.313TyrLeu: 4.313 ± 0.098
0.764TyrMet: 0.764 ± 0.035
1.465TyrAsn: 1.465 ± 0.052
1.455TyrPro: 1.455 ± 0.058
2.515TyrGln: 2.515 ± 0.07
1.839TyrArg: 1.839 ± 0.063
2.239TyrSer: 2.239 ± 0.064
1.916TyrThr: 1.916 ± 0.066
2.262TyrVal: 2.262 ± 0.067
0.353TyrTrp: 0.353 ± 0.027
1.826TyrTyr: 1.826 ± 0.071
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1812 proteins (554771 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski