Amino acid dipepetide frequency for Boseongicola sp. CCM32

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.113AlaAla: 16.113 ± 0.171	1.205AlaCys: 1.205 ± 0.035	7.425AlaAsp: 7.425 ± 0.097	8.302AlaGlu: 8.302 ± 0.112	4.324AlaPhe: 4.324 ± 0.068	10.971AlaGly: 10.971 ± 0.112	2.389AlaHis: 2.389 ± 0.047	6.065AlaIle: 6.065 ± 0.075	3.096AlaLys: 3.096 ± 0.061	13.822AlaLeu: 13.822 ± 0.144	3.79AlaMet: 3.79 ± 0.067	2.596AlaAsn: 2.596 ± 0.055	5.841AlaPro: 5.841 ± 0.099	4.176AlaGln: 4.176 ± 0.076	9.124AlaArg: 9.124 ± 0.108	5.438AlaSer: 5.438 ± 0.087	5.869AlaThr: 5.869 ± 0.065	7.933AlaVal: 7.933 ± 0.089	1.441AlaTrp: 1.441 ± 0.041	2.608AlaTyr: 2.608 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	1.179CysAla: 1.179 ± 0.032	0.134CysCys: 0.134 ± 0.011	0.63CysAsp: 0.63 ± 0.027	0.434CysGlu: 0.434 ± 0.021	0.392CysPhe: 0.392 ± 0.019	0.998CysGly: 0.998 ± 0.035	0.276CysHis: 0.276 ± 0.017	0.451CysIle: 0.451 ± 0.02	0.19CysLys: 0.19 ± 0.015	0.97CysLeu: 0.97 ± 0.03	0.19CysMet: 0.19 ± 0.012	0.236CysAsn: 0.236 ± 0.014	0.547CysPro: 0.547 ± 0.024	0.274CysGln: 0.274 ± 0.015	0.54CysArg: 0.54 ± 0.019	0.49CysSer: 0.49 ± 0.024	0.504CysThr: 0.504 ± 0.021	0.631CysVal: 0.631 ± 0.028	0.137CysTrp: 0.137 ± 0.012	0.221CysTyr: 0.221 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.115AspAla: 7.115 ± 0.089	0.51AspCys: 0.51 ± 0.019	3.279AspAsp: 3.279 ± 0.076	3.159AspGlu: 3.159 ± 0.054	2.241AspPhe: 2.241 ± 0.051	5.659AspGly: 5.659 ± 0.089	1.636AspHis: 1.636 ± 0.043	3.469AspIle: 3.469 ± 0.056	1.359AspLys: 1.359 ± 0.038	7.001AspLeu: 7.001 ± 0.085	1.879AspMet: 1.879 ± 0.039	1.236AspAsn: 1.236 ± 0.041	3.807AspPro: 3.807 ± 0.061	2.208AspGln: 2.208 ± 0.051	4.709AspArg: 4.709 ± 0.072	2.21AspSer: 2.21 ± 0.048	3.327AspThr: 3.327 ± 0.074	4.151AspVal: 4.151 ± 0.063	1.268AspTrp: 1.268 ± 0.033	1.39AspTyr: 1.39 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	8.088GluAla: 8.088 ± 0.109	0.35GluCys: 0.35 ± 0.019	3.551GluAsp: 3.551 ± 0.06	3.368GluGlu: 3.368 ± 0.071	1.752GluPhe: 1.752 ± 0.041	4.581GluGly: 4.581 ± 0.074	1.05GluHis: 1.05 ± 0.03	3.732GluIle: 3.732 ± 0.067	1.693GluLys: 1.693 ± 0.048	4.63GluLeu: 4.63 ± 0.069	1.998GluMet: 1.998 ± 0.049	1.721GluAsn: 1.721 ± 0.046	2.367GluPro: 2.367 ± 0.05	1.849GluGln: 1.849 ± 0.041	3.717GluArg: 3.717 ± 0.066	1.941GluSer: 1.941 ± 0.047	4.207GluThr: 4.207 ± 0.067	3.96GluVal: 3.96 ± 0.064	0.631GluTrp: 0.631 ± 0.023	1.083GluTyr: 1.083 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	4.468PheAla: 4.468 ± 0.073	0.453PheCys: 0.453 ± 0.02	2.899PheAsp: 2.899 ± 0.052	2.271PheGlu: 2.271 ± 0.043	1.435PhePhe: 1.435 ± 0.046	3.83PheGly: 3.83 ± 0.071	0.798PheHis: 0.798 ± 0.029	1.777PheIle: 1.777 ± 0.045	0.809PheLys: 0.809 ± 0.029	3.655PheLeu: 3.655 ± 0.063	0.885PheMet: 0.885 ± 0.034	1.038PheAsn: 1.038 ± 0.03	1.661PhePro: 1.661 ± 0.046	1.161PheGln: 1.161 ± 0.034	2.188PheArg: 2.188 ± 0.052	2.157PheSer: 2.157 ± 0.045	2.183PheThr: 2.183 ± 0.05	2.545PheVal: 2.545 ± 0.054	0.567PheTrp: 0.567 ± 0.027	0.969PheTyr: 0.969 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	10.068GlyAla: 10.068 ± 0.112	0.926GlyCys: 0.926 ± 0.033	4.881GlyAsp: 4.881 ± 0.079	4.437GlyGlu: 4.437 ± 0.077	4.067GlyPhe: 4.067 ± 0.06	7.376GlyGly: 7.376 ± 0.114	2.071GlyHis: 2.071 ± 0.051	4.556GlyIle: 4.556 ± 0.074	2.666GlyLys: 2.666 ± 0.063	9.895GlyLeu: 9.895 ± 0.106	2.673GlyMet: 2.673 ± 0.054	2.127GlyAsn: 2.127 ± 0.058	3.929GlyPro: 3.929 ± 0.059	3.643GlyGln: 3.643 ± 0.068	5.788GlyArg: 5.788 ± 0.078	4.11GlySer: 4.11 ± 0.063	4.594GlyThr: 4.594 ± 0.078	6.442GlyVal: 6.442 ± 0.086	1.537GlyTrp: 1.537 ± 0.036	2.394GlyTyr: 2.394 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.382HisAla: 2.382 ± 0.056	0.222HisCys: 0.222 ± 0.015	1.332HisAsp: 1.332 ± 0.038	1.054HisGlu: 1.054 ± 0.035	0.776HisPhe: 0.776 ± 0.027	2.006HisGly: 2.006 ± 0.047	0.632HisHis: 0.632 ± 0.025	1.167HisIle: 1.167 ± 0.029	0.541HisLys: 0.541 ± 0.023	2.405HisLeu: 2.405 ± 0.055	0.655HisMet: 0.655 ± 0.022	0.501HisAsn: 0.501 ± 0.021	1.44HisPro: 1.44 ± 0.037	0.667HisGln: 0.667 ± 0.021	1.434HisArg: 1.434 ± 0.038	0.996HisSer: 0.996 ± 0.029	0.87HisThr: 0.87 ± 0.027	1.54HisVal: 1.54 ± 0.034	0.348HisTrp: 0.348 ± 0.021	0.566HisTyr: 0.566 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	7.226IleAla: 7.226 ± 0.083	0.7IleCys: 0.7 ± 0.027	3.438IleAsp: 3.438 ± 0.063	3.315IleGlu: 3.315 ± 0.06	1.887IlePhe: 1.887 ± 0.047	5.182IleGly: 5.182 ± 0.081	0.997IleHis: 0.997 ± 0.033	2.554IleIle: 2.554 ± 0.05	1.259IleLys: 1.259 ± 0.035	5.226IleLeu: 5.226 ± 0.079	1.199IleMet: 1.199 ± 0.036	1.451IleAsn: 1.451 ± 0.036	2.564IlePro: 2.564 ± 0.049	1.192IleGln: 1.192 ± 0.034	3.549IleArg: 3.549 ± 0.056	3.301IleSer: 3.301 ± 0.062	3.32IleThr: 3.32 ± 0.048	3.674IleVal: 3.674 ± 0.063	0.844IleTrp: 0.844 ± 0.03	1.262IleTyr: 1.262 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	3.348LysAla: 3.348 ± 0.069	0.173LysCys: 0.173 ± 0.013	1.544LysAsp: 1.544 ± 0.043	1.202LysGlu: 1.202 ± 0.038	0.69LysPhe: 0.69 ± 0.026	2.353LysGly: 2.353 ± 0.05	0.576LysHis: 0.576 ± 0.023	1.464LysIle: 1.464 ± 0.043	0.887LysLys: 0.887 ± 0.032	2.491LysLeu: 2.491 ± 0.058	0.753LysMet: 0.753 ± 0.027	0.677LysAsn: 0.677 ± 0.03	1.629LysPro: 1.629 ± 0.04	0.79LysGln: 0.79 ± 0.031	1.934LysArg: 1.934 ± 0.043	1.599LysSer: 1.599 ± 0.046	1.995LysThr: 1.995 ± 0.045	1.729LysVal: 1.729 ± 0.056	0.304LysTrp: 0.304 ± 0.017	0.515LysTyr: 0.515 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	12.722LeuAla: 12.722 ± 0.142	1.047LeuCys: 1.047 ± 0.033	6.229LeuAsp: 6.229 ± 0.083	5.285LeuGlu: 5.285 ± 0.078	3.698LeuPhe: 3.698 ± 0.065	8.525LeuGly: 8.525 ± 0.101	2.037LeuHis: 2.037 ± 0.047	5.762LeuIle: 5.762 ± 0.085	2.958LeuLys: 2.958 ± 0.06	8.937LeuLeu: 8.937 ± 0.128	2.774LeuMet: 2.774 ± 0.051	2.835LeuAsn: 2.835 ± 0.061	5.856LeuPro: 5.856 ± 0.083	2.971LeuGln: 2.971 ± 0.058	6.927LeuArg: 6.927 ± 0.092	6.758LeuSer: 6.758 ± 0.089	6.433LeuThr: 6.433 ± 0.089	6.739LeuVal: 6.739 ± 0.085	1.296LeuTrp: 1.296 ± 0.04	2.043LeuTyr: 2.043 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	3.835MetAla: 3.835 ± 0.058	0.19MetCys: 0.19 ± 0.011	1.439MetAsp: 1.439 ± 0.042	1.407MetGlu: 1.407 ± 0.033	0.834MetPhe: 0.834 ± 0.025	2.362MetGly: 2.362 ± 0.049	0.477MetHis: 0.477 ± 0.022	1.794MetIle: 1.794 ± 0.043	0.911MetLys: 0.911 ± 0.029	2.746MetLeu: 2.746 ± 0.052	0.825MetMet: 0.825 ± 0.033	0.812MetAsn: 0.812 ± 0.023	1.654MetPro: 1.654 ± 0.035	1.086MetGln: 1.086 ± 0.03	1.984MetArg: 1.984 ± 0.045	1.724MetSer: 1.724 ± 0.038	2.201MetThr: 2.201 ± 0.042	1.908MetVal: 1.908 ± 0.047	0.242MetTrp: 0.242 ± 0.015	0.366MetTyr: 0.366 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.118AsnAla: 3.118 ± 0.051	0.276AsnCys: 0.276 ± 0.018	1.431AsnAsp: 1.431 ± 0.05	1.069AsnGlu: 1.069 ± 0.034	0.964AsnPhe: 0.964 ± 0.035	2.324AsnGly: 2.324 ± 0.055	0.524AsnHis: 0.524 ± 0.023	1.505AsnIle: 1.505 ± 0.039	0.543AsnLys: 0.543 ± 0.022	2.574AsnLeu: 2.574 ± 0.054	0.698AsnMet: 0.698 ± 0.025	0.66AsnAsn: 0.66 ± 0.025	1.885AsnPro: 1.885 ± 0.042	0.747AsnGln: 0.747 ± 0.029	1.834AsnArg: 1.834 ± 0.043	1.163AsnSer: 1.163 ± 0.028	1.447AsnThr: 1.447 ± 0.037	1.65AsnVal: 1.65 ± 0.04	0.435AsnTrp: 0.435 ± 0.019	0.651AsnTyr: 0.651 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	5.87ProAla: 5.87 ± 0.095	0.417ProCys: 0.417 ± 0.021	4.45ProAsp: 4.45 ± 0.064	3.986ProGlu: 3.986 ± 0.063	2.038ProPhe: 2.038 ± 0.039	5.209ProGly: 5.209 ± 0.083	1.159ProHis: 1.159 ± 0.034	2.264ProIle: 2.264 ± 0.043	1.478ProLys: 1.478 ± 0.043	4.656ProLeu: 4.656 ± 0.07	1.393ProMet: 1.393 ± 0.04	1.296ProAsn: 1.296 ± 0.032	2.527ProPro: 2.527 ± 0.061	1.62ProGln: 1.62 ± 0.041	2.851ProArg: 2.851 ± 0.052	2.443ProSer: 2.443 ± 0.052	2.192ProThr: 2.192 ± 0.042	4.612ProVal: 4.612 ± 0.072	0.69ProTrp: 0.69 ± 0.028	1.21ProTyr: 1.21 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.222GlnAla: 4.222 ± 0.067	0.223GlnCys: 0.223 ± 0.014	1.722GlnAsp: 1.722 ± 0.039	1.482GlnGlu: 1.482 ± 0.038	1.091GlnPhe: 1.091 ± 0.037	2.782GlnGly: 2.782 ± 0.05	0.641GlnHis: 0.641 ± 0.027	2.276GlnIle: 2.276 ± 0.045	0.948GlnLys: 0.948 ± 0.031	2.758GlnLeu: 2.758 ± 0.051	1.214GlnMet: 1.214 ± 0.036	0.984GlnAsn: 0.984 ± 0.028	1.717GlnPro: 1.717 ± 0.036	1.076GlnGln: 1.076 ± 0.04	2.103GlnArg: 2.103 ± 0.045	1.89GlnSer: 1.89 ± 0.041	2.082GlnThr: 2.082 ± 0.041	2.525GlnVal: 2.525 ± 0.047	0.384GlnTrp: 0.384 ± 0.02	0.624GlnTyr: 0.624 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	8.192ArgAla: 8.192 ± 0.105	0.514ArgCys: 0.514 ± 0.021	4.267ArgAsp: 4.267 ± 0.077	3.448ArgGlu: 3.448 ± 0.057	2.815ArgPhe: 2.815 ± 0.051	4.659ArgGly: 4.659 ± 0.069	1.673ArgHis: 1.673 ± 0.041	3.924ArgIle: 3.924 ± 0.061	2.038ArgLys: 2.038 ± 0.053	7.583ArgLeu: 7.583 ± 0.091	2.123ArgMet: 2.123 ± 0.04	1.849ArgAsn: 1.849 ± 0.04	3.445ArgPro: 3.445 ± 0.059	2.501ArgGln: 2.501 ± 0.054	4.788ArgArg: 4.788 ± 0.08	3.222ArgSer: 3.222 ± 0.055	2.796ArgThr: 2.796 ± 0.056	4.787ArgVal: 4.787 ± 0.071	0.876ArgTrp: 0.876 ± 0.029	1.614ArgTyr: 1.614 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	5.783SerAla: 5.783 ± 0.085	0.469SerCys: 0.469 ± 0.024	3.447SerAsp: 3.447 ± 0.059	2.686SerGlu: 2.686 ± 0.054	2.362SerPhe: 2.362 ± 0.05	5.31SerGly: 5.31 ± 0.088	1.102SerHis: 1.102 ± 0.032	2.531SerIle: 2.531 ± 0.052	1.303SerLys: 1.303 ± 0.034	5.003SerLeu: 5.003 ± 0.074	1.351SerMet: 1.351 ± 0.035	1.348SerAsn: 1.348 ± 0.034	2.51SerPro: 2.51 ± 0.051	1.596SerGln: 1.596 ± 0.043	3.166SerArg: 3.166 ± 0.053	2.487SerSer: 2.487 ± 0.063	2.508SerThr: 2.508 ± 0.053	3.741SerVal: 3.741 ± 0.064	0.69SerTrp: 0.69 ± 0.025	1.376SerTyr: 1.376 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	6.469ThrAla: 6.469 ± 0.076	0.556ThrCys: 0.556 ± 0.022	3.383ThrAsp: 3.383 ± 0.057	2.947ThrGlu: 2.947 ± 0.053	1.804ThrPhe: 1.804 ± 0.045	6.058ThrGly: 6.058 ± 0.083	1.297ThrHis: 1.297 ± 0.04	2.79ThrIle: 2.79 ± 0.053	1.264ThrLys: 1.264 ± 0.033	6.142ThrLeu: 6.142 ± 0.069	1.315ThrMet: 1.315 ± 0.034	1.272ThrAsn: 1.272 ± 0.038	3.65ThrPro: 3.65 ± 0.066	1.628ThrGln: 1.628 ± 0.039	4.05ThrArg: 4.05 ± 0.06	2.748ThrSer: 2.748 ± 0.05	2.797ThrThr: 2.797 ± 0.046	4.002ThrVal: 4.002 ± 0.054	0.723ThrTrp: 0.723 ± 0.029	1.305ThrTyr: 1.305 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	8.371ValAla: 8.371 ± 0.101	0.666ValCys: 0.666 ± 0.024	3.876ValAsp: 3.876 ± 0.065	4.508ValGlu: 4.508 ± 0.069	3.043ValPhe: 3.043 ± 0.059	4.878ValGly: 4.878 ± 0.072	1.265ValHis: 1.265 ± 0.036	4.368ValIle: 4.368 ± 0.073	1.831ValLys: 1.831 ± 0.05	7.405ValLeu: 7.405 ± 0.097	2.194ValMet: 2.194 ± 0.054	1.858ValAsn: 1.858 ± 0.041	3.475ValPro: 3.475 ± 0.056	2.159ValGln: 2.159 ± 0.047	3.724ValArg: 3.724 ± 0.057	4.144ValSer: 4.144 ± 0.061	4.928ValThr: 4.928 ± 0.08	5.131ValVal: 5.131 ± 0.071	0.917ValTrp: 0.917 ± 0.035	1.426ValTyr: 1.426 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.445TrpAla: 1.445 ± 0.038	0.157TrpCys: 0.157 ± 0.013	0.765TrpAsp: 0.765 ± 0.029	0.663TrpGlu: 0.663 ± 0.028	0.596TrpPhe: 0.596 ± 0.022	0.979TrpGly: 0.979 ± 0.03	0.348TrpHis: 0.348 ± 0.016	0.682TrpIle: 0.682 ± 0.03	0.374TrpLys: 0.374 ± 0.018	1.628TrpLeu: 1.628 ± 0.044	0.399TrpMet: 0.399 ± 0.022	0.409TrpAsn: 0.409 ± 0.02	0.73TrpPro: 0.73 ± 0.029	0.639TrpGln: 0.639 ± 0.024	1.096TrpArg: 1.096 ± 0.03	0.79TrpSer: 0.79 ± 0.027	0.756TrpThr: 0.756 ± 0.03	0.98TrpVal: 0.98 ± 0.031	0.233TrpTrp: 0.233 ± 0.015	0.28TrpTyr: 0.28 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.512TyrAla: 2.512 ± 0.051	0.239TyrCys: 0.239 ± 0.014	1.624TyrAsp: 1.624 ± 0.044	1.248TyrGlu: 1.248 ± 0.04	0.94TyrPhe: 0.94 ± 0.033	2.138TyrGly: 2.138 ± 0.049	0.59TyrHis: 0.59 ± 0.027	1.01TyrIle: 1.01 ± 0.034	0.505TyrLys: 0.505 ± 0.023	2.303TyrLeu: 2.303 ± 0.049	0.49TyrMet: 0.49 ± 0.025	0.588TyrAsn: 0.588 ± 0.021	1.124TyrPro: 1.124 ± 0.031	0.761TyrGln: 0.761 ± 0.026	1.61TyrArg: 1.61 ± 0.042	1.157TyrSer: 1.157 ± 0.035	1.19TyrThr: 1.19 ± 0.033	1.487TyrVal: 1.487 ± 0.038	0.386TyrTrp: 0.386 ± 0.021	0.573TyrTyr: 0.573 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3500 proteins (1077088 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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