Amino acid dipepetide frequency for Desulfonatronospira thiodismutans ASO3-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.836AlaAla: 6.836 ± 0.097	1.154AlaCys: 1.154 ± 0.035	4.032AlaAsp: 4.032 ± 0.078	5.057AlaGlu: 5.057 ± 0.071	2.885AlaPhe: 2.885 ± 0.065	7.455AlaGly: 7.455 ± 0.101	1.568AlaHis: 1.568 ± 0.041	3.608AlaIle: 3.608 ± 0.061	2.758AlaLys: 2.758 ± 0.051	8.526AlaLeu: 8.526 ± 0.107	2.461AlaMet: 2.461 ± 0.048	1.866AlaAsn: 1.866 ± 0.049	2.542AlaPro: 2.542 ± 0.054	2.875AlaGln: 2.875 ± 0.057	6.022AlaArg: 6.022 ± 0.088	4.265AlaSer: 4.265 ± 0.064	2.801AlaThr: 2.801 ± 0.058	5.739AlaVal: 5.739 ± 0.084	1.058AlaTrp: 1.058 ± 0.032	2.15AlaTyr: 2.15 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.879CysAla: 0.879 ± 0.031	0.212CysCys: 0.212 ± 0.013	0.46CysAsp: 0.46 ± 0.019	0.507CysGlu: 0.507 ± 0.021	0.492CysPhe: 0.492 ± 0.024	1.131CysGly: 1.131 ± 0.04	0.351CysHis: 0.351 ± 0.023	0.728CysIle: 0.728 ± 0.026	0.515CysLys: 0.515 ± 0.022	1.43CysLeu: 1.43 ± 0.042	0.408CysMet: 0.408 ± 0.019	0.372CysAsn: 0.372 ± 0.021	0.816CysPro: 0.816 ± 0.038	0.361CysGln: 0.361 ± 0.02	1.086CysArg: 1.086 ± 0.035	0.949CysSer: 0.949 ± 0.032	0.582CysThr: 0.582 ± 0.021	0.669CysVal: 0.669 ± 0.025	0.135CysTrp: 0.135 ± 0.012	0.317CysTyr: 0.317 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.542AspAla: 3.542 ± 0.07	0.697AspCys: 0.697 ± 0.026	2.957AspAsp: 2.957 ± 0.071	4.087AspGlu: 4.087 ± 0.079	3.127AspPhe: 3.127 ± 0.061	3.388AspGly: 3.388 ± 0.094	1.294AspHis: 1.294 ± 0.037	4.205AspIle: 4.205 ± 0.063	3.025AspLys: 3.025 ± 0.058	6.977AspLeu: 6.977 ± 0.088	2.01AspMet: 2.01 ± 0.048	1.983AspAsn: 1.983 ± 0.048	3.318AspPro: 3.318 ± 0.057	2.575AspGln: 2.575 ± 0.052	3.559AspArg: 3.559 ± 0.068	3.483AspSer: 3.483 ± 0.059	2.603AspThr: 2.603 ± 0.057	3.469AspVal: 3.469 ± 0.073	0.81AspTrp: 0.81 ± 0.027	2.196AspTyr: 2.196 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	5.52GluAla: 5.52 ± 0.089	0.657GluCys: 0.657 ± 0.026	4.349GluAsp: 4.349 ± 0.097	5.97GluGlu: 5.97 ± 0.113	2.728GluPhe: 2.728 ± 0.056	4.034GluGly: 4.034 ± 0.086	1.95GluHis: 1.95 ± 0.047	4.937GluIle: 4.937 ± 0.079	5.4GluLys: 5.4 ± 0.085	7.701GluLeu: 7.701 ± 0.088	2.33GluMet: 2.33 ± 0.044	3.172GluAsn: 3.172 ± 0.055	2.747GluPro: 2.747 ± 0.071	3.375GluGln: 3.375 ± 0.069	3.535GluArg: 3.535 ± 0.06	3.73GluSer: 3.73 ± 0.063	3.21GluThr: 3.21 ± 0.059	4.878GluVal: 4.878 ± 0.076	0.769GluTrp: 0.769 ± 0.027	2.379GluTyr: 2.379 ± 0.057	0.0GluXaa: 0.0 ± 0.0
Phe	2.901PheAla: 2.901 ± 0.051	0.627PheCys: 0.627 ± 0.024	2.503PheAsp: 2.503 ± 0.049	2.804PheGlu: 2.804 ± 0.056	2.317PhePhe: 2.317 ± 0.054	2.633PheGly: 2.633 ± 0.048	0.811PheHis: 0.811 ± 0.028	2.363PheIle: 2.363 ± 0.054	1.97PheLys: 1.97 ± 0.043	4.384PheLeu: 4.384 ± 0.069	1.236PheMet: 1.236 ± 0.035	1.503PheAsn: 1.503 ± 0.037	1.765PhePro: 1.765 ± 0.043	1.65PheGln: 1.65 ± 0.043	2.177PheArg: 2.177 ± 0.043	3.191PheSer: 3.191 ± 0.059	2.265PheThr: 2.265 ± 0.049	2.668PheVal: 2.668 ± 0.056	0.696PheTrp: 0.696 ± 0.027	1.452PheTyr: 1.452 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	4.782GlyAla: 4.782 ± 0.076	1.106GlyCys: 1.106 ± 0.038	3.813GlyAsp: 3.813 ± 0.095	4.799GlyGlu: 4.799 ± 0.082	3.382GlyPhe: 3.382 ± 0.058	4.941GlyGly: 4.941 ± 0.099	1.841GlyHis: 1.841 ± 0.048	4.702GlyIle: 4.702 ± 0.065	3.821GlyLys: 3.821 ± 0.059	8.027GlyLeu: 8.027 ± 0.104	2.444GlyMet: 2.444 ± 0.053	2.288GlyAsn: 2.288 ± 0.057	2.524GlyPro: 2.524 ± 0.053	2.964GlyGln: 2.964 ± 0.051	4.875GlyArg: 4.875 ± 0.073	4.383GlySer: 4.383 ± 0.07	3.459GlyThr: 3.459 ± 0.078	4.797GlyVal: 4.797 ± 0.077	0.967GlyTrp: 0.967 ± 0.033	2.534GlyTyr: 2.534 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	1.598HisAla: 1.598 ± 0.042	0.317HisCys: 0.317 ± 0.015	1.216HisAsp: 1.216 ± 0.035	1.579HisGlu: 1.579 ± 0.048	1.029HisPhe: 1.029 ± 0.03	1.729HisGly: 1.729 ± 0.042	0.565HisHis: 0.565 ± 0.024	1.373HisIle: 1.373 ± 0.033	1.064HisLys: 1.064 ± 0.037	2.548HisLeu: 2.548 ± 0.047	0.549HisMet: 0.549 ± 0.027	0.809HisAsn: 0.809 ± 0.029	1.384HisPro: 1.384 ± 0.039	0.931HisGln: 0.931 ± 0.028	1.38HisArg: 1.38 ± 0.036	1.279HisSer: 1.279 ± 0.032	1.0HisThr: 1.0 ± 0.032	1.401HisVal: 1.401 ± 0.034	0.299HisTrp: 0.299 ± 0.019	0.746HisTyr: 0.746 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	3.882IleAla: 3.882 ± 0.068	0.829IleCys: 0.829 ± 0.029	3.111IleAsp: 3.111 ± 0.059	3.487IleGlu: 3.487 ± 0.078	2.661IlePhe: 2.661 ± 0.059	3.234IleGly: 3.234 ± 0.06	1.275IleHis: 1.275 ± 0.035	3.604IleIle: 3.604 ± 0.063	3.377IleLys: 3.377 ± 0.063	6.292IleLeu: 6.292 ± 0.08	1.57IleMet: 1.57 ± 0.038	2.484IleAsn: 2.484 ± 0.059	2.741IlePro: 2.741 ± 0.062	2.579IleGln: 2.579 ± 0.047	3.651IleArg: 3.651 ± 0.063	4.282IleSer: 4.282 ± 0.069	3.102IleThr: 3.102 ± 0.066	3.388IleVal: 3.388 ± 0.055	0.653IleTrp: 0.653 ± 0.026	1.847IleTyr: 1.847 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	4.188LysAla: 4.188 ± 0.073	0.529LysCys: 0.529 ± 0.026	3.317LysAsp: 3.317 ± 0.052	3.886LysGlu: 3.886 ± 0.074	1.59LysPhe: 1.59 ± 0.039	3.382LysGly: 3.382 ± 0.062	1.133LysHis: 1.133 ± 0.035	3.381LysIle: 3.381 ± 0.058	4.214LysLys: 4.214 ± 0.087	4.112LysLeu: 4.112 ± 0.067	1.405LysMet: 1.405 ± 0.038	2.372LysAsn: 2.372 ± 0.051	2.109LysPro: 2.109 ± 0.041	1.843LysGln: 1.843 ± 0.052	2.782LysArg: 2.782 ± 0.06	3.257LysSer: 3.257 ± 0.062	2.704LysThr: 2.704 ± 0.052	3.315LysVal: 3.315 ± 0.061	0.569LysTrp: 0.569 ± 0.024	1.616LysTyr: 1.616 ± 0.043	0.0LysXaa: 0.0 ± 0.0
Leu	9.093LeuAla: 9.093 ± 0.12	1.342LeuCys: 1.342 ± 0.039	7.216LeuAsp: 7.216 ± 0.093	8.879LeuGlu: 8.879 ± 0.099	4.013LeuPhe: 4.013 ± 0.072	7.754LeuGly: 7.754 ± 0.109	2.122LeuHis: 2.122 ± 0.052	4.956LeuIle: 4.956 ± 0.075	5.772LeuLys: 5.772 ± 0.095	9.67LeuLeu: 9.67 ± 0.114	2.557LeuMet: 2.557 ± 0.052	3.614LeuAsn: 3.614 ± 0.069	4.896LeuPro: 4.896 ± 0.064	4.731LeuGln: 4.731 ± 0.071	5.534LeuArg: 5.534 ± 0.078	6.732LeuSer: 6.732 ± 0.086	4.629LeuThr: 4.629 ± 0.077	7.032LeuVal: 7.032 ± 0.087	1.008LeuTrp: 1.008 ± 0.034	2.606LeuTyr: 2.606 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	2.517MetAla: 2.517 ± 0.045	0.234MetCys: 0.234 ± 0.016	2.061MetAsp: 2.061 ± 0.042	2.045MetGlu: 2.045 ± 0.044	0.979MetPhe: 0.979 ± 0.028	2.225MetGly: 2.225 ± 0.05	0.838MetHis: 0.838 ± 0.029	1.38MetIle: 1.38 ± 0.042	1.343MetLys: 1.343 ± 0.037	2.756MetLeu: 2.756 ± 0.055	0.534MetMet: 0.534 ± 0.022	1.124MetAsn: 1.124 ± 0.029	1.482MetPro: 1.482 ± 0.037	1.825MetGln: 1.825 ± 0.038	1.389MetArg: 1.389 ± 0.041	1.892MetSer: 1.892 ± 0.045	1.326MetThr: 1.326 ± 0.034	1.943MetVal: 1.943 ± 0.041	0.225MetTrp: 0.225 ± 0.016	0.607MetTyr: 0.607 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	2.353AsnAla: 2.353 ± 0.041	0.418AsnCys: 0.418 ± 0.021	1.61AsnAsp: 1.61 ± 0.044	1.822AsnGlu: 1.822 ± 0.049	1.509AsnPhe: 1.509 ± 0.045	1.772AsnGly: 1.772 ± 0.042	0.777AsnHis: 0.777 ± 0.032	2.66AsnIle: 2.66 ± 0.056	1.724AsnLys: 1.724 ± 0.046	3.97AsnLeu: 3.97 ± 0.063	1.112AsnMet: 1.112 ± 0.035	1.317AsnAsn: 1.317 ± 0.039	2.17AsnPro: 2.17 ± 0.046	1.474AsnGln: 1.474 ± 0.043	2.198AsnArg: 2.198 ± 0.049	2.039AsnSer: 2.039 ± 0.041	1.734AsnThr: 1.734 ± 0.04	2.17AsnVal: 2.17 ± 0.052	0.494AsnTrp: 0.494 ± 0.023	1.108AsnTyr: 1.108 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	3.587ProAla: 3.587 ± 0.062	0.518ProCys: 0.518 ± 0.024	3.514ProAsp: 3.514 ± 0.054	4.911ProGlu: 4.911 ± 0.068	1.858ProPhe: 1.858 ± 0.043	4.888ProGly: 4.888 ± 0.07	0.905ProHis: 0.905 ± 0.026	1.614ProIle: 1.614 ± 0.044	1.444ProLys: 1.444 ± 0.037	3.988ProLeu: 3.988 ± 0.066	1.02ProMet: 1.02 ± 0.032	0.979ProAsn: 0.979 ± 0.029	1.786ProPro: 1.786 ± 0.046	1.621ProGln: 1.621 ± 0.043	2.594ProArg: 2.594 ± 0.05	2.248ProSer: 2.248 ± 0.046	1.43ProThr: 1.43 ± 0.036	3.824ProVal: 3.824 ± 0.059	0.635ProTrp: 0.635 ± 0.024	1.212ProTyr: 1.212 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.466GlnAla: 4.466 ± 0.073	0.337GlnCys: 0.337 ± 0.02	3.162GlnAsp: 3.162 ± 0.061	4.827GlnGlu: 4.827 ± 0.07	1.088GlnPhe: 1.088 ± 0.036	3.74GlnGly: 3.74 ± 0.059	0.821GlnHis: 0.821 ± 0.03	1.969GlnIle: 1.969 ± 0.043	2.773GlnLys: 2.773 ± 0.061	2.965GlnLeu: 2.965 ± 0.058	1.124GlnMet: 1.124 ± 0.035	1.621GlnAsn: 1.621 ± 0.039	1.359GlnPro: 1.359 ± 0.038	1.819GlnGln: 1.819 ± 0.048	2.23GlnArg: 2.23 ± 0.052	2.377GlnSer: 2.377 ± 0.045	1.838GlnThr: 1.838 ± 0.039	3.198GlnVal: 3.198 ± 0.06	0.47GlnTrp: 0.47 ± 0.024	0.916GlnTyr: 0.916 ± 0.03	0.001GlnXaa: 0.001 ± 0.001
Arg	4.305ArgAla: 4.305 ± 0.066	0.622ArgCys: 0.622 ± 0.026	3.877ArgAsp: 3.877 ± 0.063	5.22ArgGlu: 5.22 ± 0.087	2.611ArgPhe: 2.611 ± 0.058	3.501ArgGly: 3.501 ± 0.069	1.466ArgHis: 1.466 ± 0.04	4.232ArgIle: 4.232 ± 0.06	3.448ArgLys: 3.448 ± 0.058	6.624ArgLeu: 6.624 ± 0.097	1.845ArgMet: 1.845 ± 0.042	2.082ArgAsn: 2.082 ± 0.042	2.485ArgPro: 2.485 ± 0.045	2.969ArgGln: 2.969 ± 0.06	3.492ArgArg: 3.492 ± 0.061	3.457ArgSer: 3.457 ± 0.058	2.615ArgThr: 2.615 ± 0.042	4.022ArgVal: 4.022 ± 0.065	0.658ArgTrp: 0.658 ± 0.025	1.959ArgTyr: 1.959 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	4.129SerAla: 4.129 ± 0.065	0.755SerCys: 0.755 ± 0.03	3.064SerAsp: 3.064 ± 0.068	3.633SerGlu: 3.633 ± 0.067	2.777SerPhe: 2.777 ± 0.055	5.39SerGly: 5.39 ± 0.084	1.306SerHis: 1.306 ± 0.038	3.733SerIle: 3.733 ± 0.054	2.498SerLys: 2.498 ± 0.049	6.97SerLeu: 6.97 ± 0.091	2.039SerMet: 2.039 ± 0.043	1.654SerAsn: 1.654 ± 0.036	2.946SerPro: 2.946 ± 0.055	2.466SerGln: 2.466 ± 0.057	5.12SerArg: 5.12 ± 0.08	4.362SerSer: 4.362 ± 0.07	2.779SerThr: 2.779 ± 0.051	3.614SerVal: 3.614 ± 0.066	0.831SerTrp: 0.831 ± 0.03	1.707SerTyr: 1.707 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	3.676ThrAla: 3.676 ± 0.063	0.573ThrCys: 0.573 ± 0.023	2.545ThrAsp: 2.545 ± 0.063	2.575ThrGlu: 2.575 ± 0.051	1.741ThrPhe: 1.741 ± 0.043	4.691ThrGly: 4.691 ± 0.079	1.013ThrHis: 1.013 ± 0.029	2.477ThrIle: 2.477 ± 0.053	1.538ThrLys: 1.538 ± 0.037	4.83ThrLeu: 4.83 ± 0.077	1.185ThrMet: 1.185 ± 0.035	1.283ThrAsn: 1.283 ± 0.045	2.494ThrPro: 2.494 ± 0.046	1.637ThrGln: 1.637 ± 0.039	3.083ThrArg: 3.083 ± 0.057	2.735ThrSer: 2.735 ± 0.048	2.153ThrThr: 2.153 ± 0.055	3.15ThrVal: 3.15 ± 0.074	0.52ThrTrp: 0.52 ± 0.021	1.336ThrTyr: 1.336 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	4.491ValAla: 4.491 ± 0.076	0.911ValCys: 0.911 ± 0.032	4.164ValAsp: 4.164 ± 0.08	4.501ValGlu: 4.501 ± 0.086	3.095ValPhe: 3.095 ± 0.052	3.833ValGly: 3.833 ± 0.073	1.67ValHis: 1.67 ± 0.036	3.692ValIle: 3.692 ± 0.056	3.076ValLys: 3.076 ± 0.064	7.598ValLeu: 7.598 ± 0.1	1.806ValMet: 1.806 ± 0.043	2.33ValAsn: 2.33 ± 0.05	2.884ValPro: 2.884 ± 0.048	3.402ValGln: 3.402 ± 0.06	4.144ValArg: 4.144 ± 0.06	4.353ValSer: 4.353 ± 0.074	2.98ValThr: 2.98 ± 0.067	4.731ValVal: 4.731 ± 0.086	0.725ValTrp: 0.725 ± 0.027	2.104ValTyr: 2.104 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.831TrpAla: 0.831 ± 0.03	0.149TrpCys: 0.149 ± 0.011	0.728TrpAsp: 0.728 ± 0.033	0.979TrpGlu: 0.979 ± 0.031	0.449TrpPhe: 0.449 ± 0.022	0.772TrpGly: 0.772 ± 0.034	0.311TrpHis: 0.311 ± 0.015	0.724TrpIle: 0.724 ± 0.028	0.654TrpLys: 0.654 ± 0.025	1.265TrpLeu: 1.265 ± 0.041	0.406TrpMet: 0.406 ± 0.019	0.494TrpAsn: 0.494 ± 0.021	0.585TrpPro: 0.585 ± 0.022	0.596TrpGln: 0.596 ± 0.025	0.656TrpArg: 0.656 ± 0.026	0.793TrpSer: 0.793 ± 0.027	0.548TrpThr: 0.548 ± 0.023	0.704TrpVal: 0.704 ± 0.026	0.183TrpTrp: 0.183 ± 0.018	0.302TrpTyr: 0.302 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.081TyrAla: 2.081 ± 0.05	0.413TyrCys: 0.413 ± 0.022	1.605TyrAsp: 1.605 ± 0.041	1.801TyrGlu: 1.801 ± 0.042	1.587TyrPhe: 1.587 ± 0.045	1.956TyrGly: 1.956 ± 0.042	0.78TyrHis: 0.78 ± 0.03	1.712TyrIle: 1.712 ± 0.04	1.289TyrLys: 1.289 ± 0.04	3.524TyrLeu: 3.524 ± 0.066	0.684TyrMet: 0.684 ± 0.026	1.085TyrAsn: 1.085 ± 0.033	1.545TyrPro: 1.545 ± 0.038	1.407TyrGln: 1.407 ± 0.037	1.979TyrArg: 1.979 ± 0.04	1.964TyrSer: 1.964 ± 0.045	1.477TyrThr: 1.477 ± 0.039	1.781TyrVal: 1.781 ± 0.037	0.426TyrTrp: 0.426 ± 0.021	1.149TyrTyr: 1.149 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.008XaaXaa: 0.008 ± 0.006

Statistics based on 3577 proteins (1095486 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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