Amino acid dipepetide frequency for Gemmobacter sp. HYN0069

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.825AlaAla: 19.825 ± 0.226
1.145AlaCys: 1.145 ± 0.032
7.348AlaAsp: 7.348 ± 0.096
8.353AlaGlu: 8.353 ± 0.119
4.491AlaPhe: 4.491 ± 0.067
12.743AlaGly: 12.743 ± 0.289
2.376AlaHis: 2.376 ± 0.052
5.768AlaIle: 5.768 ± 0.074
4.312AlaLys: 4.312 ± 0.081
14.987AlaLeu: 14.987 ± 0.151
4.132AlaMet: 4.132 ± 0.071
2.844AlaAsn: 2.844 ± 0.057
6.02AlaPro: 6.02 ± 0.089
4.348AlaGln: 4.348 ± 0.072
9.505AlaArg: 9.505 ± 0.123
5.979AlaSer: 5.979 ± 0.097
7.093AlaThr: 7.093 ± 0.117
9.849AlaVal: 9.849 ± 0.107
1.538AlaTrp: 1.538 ± 0.037
2.534AlaTyr: 2.534 ± 0.054
0.0AlaXaa: 0.0 ± 0.0
Cys
1.091CysAla: 1.091 ± 0.035
0.109CysCys: 0.109 ± 0.01
0.6CysAsp: 0.6 ± 0.024
0.401CysGlu: 0.401 ± 0.019
0.33CysPhe: 0.33 ± 0.015
0.956CysGly: 0.956 ± 0.033
0.234CysHis: 0.234 ± 0.016
0.433CysIle: 0.433 ± 0.02
0.191CysLys: 0.191 ± 0.013
0.878CysLeu: 0.878 ± 0.026
0.164CysMet: 0.164 ± 0.011
0.22CysAsn: 0.22 ± 0.013
0.496CysPro: 0.496 ± 0.023
0.203CysGln: 0.203 ± 0.015
0.552CysArg: 0.552 ± 0.021
0.45CysSer: 0.45 ± 0.02
0.484CysThr: 0.484 ± 0.023
0.565CysVal: 0.565 ± 0.024
0.114CysTrp: 0.114 ± 0.009
0.191CysTyr: 0.191 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
7.772AspAla: 7.772 ± 0.103
0.52AspCys: 0.52 ± 0.023
3.155AspAsp: 3.155 ± 0.128
3.131AspGlu: 3.131 ± 0.059
2.27AspPhe: 2.27 ± 0.048
5.534AspGly: 5.534 ± 0.15
1.262AspHis: 1.262 ± 0.038
2.767AspIle: 2.767 ± 0.054
1.408AspLys: 1.408 ± 0.034
6.369AspLeu: 6.369 ± 0.087
1.54AspMet: 1.54 ± 0.038
1.033AspAsn: 1.033 ± 0.033
3.661AspPro: 3.661 ± 0.064
1.69AspGln: 1.69 ± 0.038
4.447AspArg: 4.447 ± 0.069
2.113AspSer: 2.113 ± 0.111
3.084AspThr: 3.084 ± 0.145
4.153AspVal: 4.153 ± 0.071
1.179AspTrp: 1.179 ± 0.033
1.44AspTyr: 1.44 ± 0.036
0.0AspXaa: 0.0 ± 0.0
Glu
8.187GluAla: 8.187 ± 0.105
0.314GluCys: 0.314 ± 0.016
2.582GluAsp: 2.582 ± 0.048
2.568GluGlu: 2.568 ± 0.06
1.651GluPhe: 1.651 ± 0.041
4.494GluGly: 4.494 ± 0.073
0.937GluHis: 0.937 ± 0.029
2.969GluIle: 2.969 ± 0.056
1.825GluLys: 1.825 ± 0.039
4.53GluLeu: 4.53 ± 0.076
1.635GluMet: 1.635 ± 0.042
1.357GluAsn: 1.357 ± 0.033
2.266GluPro: 2.266 ± 0.05
1.632GluGln: 1.632 ± 0.043
4.003GluArg: 4.003 ± 0.083
2.008GluSer: 2.008 ± 0.041
3.506GluThr: 3.506 ± 0.06
4.269GluVal: 4.269 ± 0.067
0.715GluTrp: 0.715 ± 0.023
0.902GluTyr: 0.902 ± 0.029
0.0GluXaa: 0.0 ± 0.0
Phe
4.891PheAla: 4.891 ± 0.073
0.408PheCys: 0.408 ± 0.018
2.816PheAsp: 2.816 ± 0.053
1.855PheGlu: 1.855 ± 0.043
1.32PhePhe: 1.32 ± 0.039
3.771PheGly: 3.771 ± 0.066
0.744PheHis: 0.744 ± 0.023
1.475PheIle: 1.475 ± 0.042
0.855PheLys: 0.855 ± 0.027
3.41PheLeu: 3.41 ± 0.058
0.779PheMet: 0.779 ± 0.027
0.946PheAsn: 0.946 ± 0.029
1.576PhePro: 1.576 ± 0.035
0.919PheGln: 0.919 ± 0.028
2.321PheArg: 2.321 ± 0.052
2.057PheSer: 2.057 ± 0.039
2.115PheThr: 2.115 ± 0.041
2.717PheVal: 2.717 ± 0.053
0.544PheTrp: 0.544 ± 0.026
0.89PheTyr: 0.89 ± 0.026
0.0PheXaa: 0.0 ± 0.0
Gly
10.943GlyAla: 10.943 ± 0.215
0.909GlyCys: 0.909 ± 0.035
4.92GlyAsp: 4.92 ± 0.202
4.517GlyGlu: 4.517 ± 0.071
3.84GlyPhe: 3.84 ± 0.058
8.311GlyGly: 8.311 ± 0.278
1.957GlyHis: 1.957 ± 0.047
4.406GlyIle: 4.406 ± 0.059
3.151GlyLys: 3.151 ± 0.06
9.67GlyLeu: 9.67 ± 0.097
2.684GlyMet: 2.684 ± 0.052
2.488GlyAsn: 2.488 ± 0.196
3.822GlyPro: 3.822 ± 0.065
3.243GlyGln: 3.243 ± 0.051
6.083GlyArg: 6.083 ± 0.081
4.498GlySer: 4.498 ± 0.116
5.004GlyThr: 5.004 ± 0.107
6.793GlyVal: 6.793 ± 0.086
1.602GlyTrp: 1.602 ± 0.042
2.256GlyTyr: 2.256 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
2.422HisAla: 2.422 ± 0.049
0.22HisCys: 0.22 ± 0.014
1.255HisAsp: 1.255 ± 0.031
0.943HisGlu: 0.943 ± 0.032
0.763HisPhe: 0.763 ± 0.028
1.965HisGly: 1.965 ± 0.042
0.551HisHis: 0.551 ± 0.022
0.925HisIle: 0.925 ± 0.029
0.423HisLys: 0.423 ± 0.021
2.111HisLeu: 2.111 ± 0.05
0.542HisMet: 0.542 ± 0.023
0.412HisAsn: 0.412 ± 0.018
1.362HisPro: 1.362 ± 0.036
0.498HisGln: 0.498 ± 0.022
1.445HisArg: 1.445 ± 0.035
0.911HisSer: 0.911 ± 0.027
0.771HisThr: 0.771 ± 0.025
1.477HisVal: 1.477 ± 0.041
0.352HisTrp: 0.352 ± 0.016
0.528HisTyr: 0.528 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
6.947IleAla: 6.947 ± 0.092
0.55IleCys: 0.55 ± 0.021
3.387IleAsp: 3.387 ± 0.059
3.007IleGlu: 3.007 ± 0.054
1.571IlePhe: 1.571 ± 0.04
4.795IleGly: 4.795 ± 0.071
0.871IleHis: 0.871 ± 0.029
2.012IleIle: 2.012 ± 0.039
1.268IleLys: 1.268 ± 0.035
4.447IleLeu: 4.447 ± 0.072
0.923IleMet: 0.923 ± 0.033
1.199IleAsn: 1.199 ± 0.037
2.154IlePro: 2.154 ± 0.05
0.935IleGln: 0.935 ± 0.03
3.059IleArg: 3.059 ± 0.048
2.466IleSer: 2.466 ± 0.057
2.88IleThr: 2.88 ± 0.058
3.575IleVal: 3.575 ± 0.062
0.605IleTrp: 0.605 ± 0.025
1.003IleTyr: 1.003 ± 0.031
0.0IleXaa: 0.0 ± 0.0
Lys
4.177LysAla: 4.177 ± 0.072
0.165LysCys: 0.165 ± 0.01
1.5LysAsp: 1.5 ± 0.038
1.23LysGlu: 1.23 ± 0.04
0.817LysPhe: 0.817 ± 0.025
2.816LysGly: 2.816 ± 0.056
0.599LysHis: 0.599 ± 0.024
1.436LysIle: 1.436 ± 0.032
1.061LysLys: 1.061 ± 0.035
2.849LysLeu: 2.849 ± 0.055
0.835LysMet: 0.835 ± 0.028
0.701LysAsn: 0.701 ± 0.026
1.901LysPro: 1.901 ± 0.049
0.805LysGln: 0.805 ± 0.027
2.194LysArg: 2.194 ± 0.052
1.629LysSer: 1.629 ± 0.045
1.778LysThr: 1.778 ± 0.041
2.159LysVal: 2.159 ± 0.051
0.369LysTrp: 0.369 ± 0.02
0.545LysTyr: 0.545 ± 0.023
0.0LysXaa: 0.0 ± 0.0
Leu
14.74LeuAla: 14.74 ± 0.149
1.026LeuCys: 1.026 ± 0.031
5.811LeuAsp: 5.811 ± 0.091
4.537LeuGlu: 4.537 ± 0.075
3.479LeuPhe: 3.479 ± 0.063
8.87LeuGly: 8.87 ± 0.1
1.978LeuHis: 1.978 ± 0.043
4.73LeuIle: 4.73 ± 0.069
2.885LeuLys: 2.885 ± 0.068
9.018LeuLeu: 9.018 ± 0.123
2.646LeuMet: 2.646 ± 0.047
2.422LeuAsn: 2.422 ± 0.046
6.031LeuPro: 6.031 ± 0.08
2.752LeuGln: 2.752 ± 0.051
7.611LeuArg: 7.611 ± 0.105
6.411LeuSer: 6.411 ± 0.095
6.371LeuThr: 6.371 ± 0.086
7.544LeuVal: 7.544 ± 0.09
1.488LeuTrp: 1.488 ± 0.038
1.939LeuTyr: 1.939 ± 0.04
0.0LeuXaa: 0.0 ± 0.0
Met
3.765MetAla: 3.765 ± 0.064
0.158MetCys: 0.158 ± 0.011
1.334MetAsp: 1.334 ± 0.033
1.235MetGlu: 1.235 ± 0.033
0.739MetPhe: 0.739 ± 0.025
2.323MetGly: 2.323 ± 0.044
0.461MetHis: 0.461 ± 0.019
1.391MetIle: 1.391 ± 0.037
0.992MetLys: 0.992 ± 0.03
2.67MetLeu: 2.67 ± 0.056
0.731MetMet: 0.731 ± 0.026
0.778MetAsn: 0.778 ± 0.025
1.501MetPro: 1.501 ± 0.036
1.009MetGln: 1.009 ± 0.029
1.903MetArg: 1.903 ± 0.044
1.508MetSer: 1.508 ± 0.041
2.074MetThr: 2.074 ± 0.044
2.067MetVal: 2.067 ± 0.046
0.219MetTrp: 0.219 ± 0.015
0.306MetTyr: 0.306 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
3.117AsnAla: 3.117 ± 0.056
0.207AsnCys: 0.207 ± 0.013
1.64AsnAsp: 1.64 ± 0.202
0.991AsnGlu: 0.991 ± 0.028
0.88AsnPhe: 0.88 ± 0.033
2.302AsnGly: 2.302 ± 0.051
0.474AsnHis: 0.474 ± 0.022
1.2AsnIle: 1.2 ± 0.043
0.53AsnLys: 0.53 ± 0.023
2.473AsnLeu: 2.473 ± 0.041
0.628AsnMet: 0.628 ± 0.023
0.531AsnAsn: 0.531 ± 0.02
1.754AsnPro: 1.754 ± 0.046
0.579AsnGln: 0.579 ± 0.021
1.72AsnArg: 1.72 ± 0.035
1.041AsnSer: 1.041 ± 0.042
1.173AsnThr: 1.173 ± 0.041
1.689AsnVal: 1.689 ± 0.046
0.401AsnTrp: 0.401 ± 0.018
0.536AsnTyr: 0.536 ± 0.023
0.0AsnXaa: 0.0 ± 0.0
Pro
6.989ProAla: 6.989 ± 0.104
0.397ProCys: 0.397 ± 0.017
4.058ProAsp: 4.058 ± 0.066
3.65ProGlu: 3.65 ± 0.069
2.02ProPhe: 2.02 ± 0.041
3.906ProGly: 3.906 ± 0.056
1.079ProHis: 1.079 ± 0.033
1.867ProIle: 1.867 ± 0.039
1.665ProLys: 1.665 ± 0.042
4.905ProLeu: 4.905 ± 0.073
1.39ProMet: 1.39 ± 0.035
1.185ProAsn: 1.185 ± 0.031
2.298ProPro: 2.298 ± 0.052
1.631ProGln: 1.631 ± 0.038
2.936ProArg: 2.936 ± 0.064
2.373ProSer: 2.373 ± 0.045
2.434ProThr: 2.434 ± 0.044
4.809ProVal: 4.809 ± 0.076
0.702ProTrp: 0.702 ± 0.026
1.09ProTyr: 1.09 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
4.117GlnAla: 4.117 ± 0.066
0.18GlnCys: 0.18 ± 0.013
1.474GlnAsp: 1.474 ± 0.036
1.186GlnGlu: 1.186 ± 0.036
0.965GlnPhe: 0.965 ± 0.025
2.86GlnGly: 2.86 ± 0.053
0.543GlnHis: 0.543 ± 0.021
1.784GlnIle: 1.784 ± 0.047
0.953GlnLys: 0.953 ± 0.027
2.443GlnLeu: 2.443 ± 0.048
0.956GlnMet: 0.956 ± 0.032
0.796GlnAsn: 0.796 ± 0.025
1.595GlnPro: 1.595 ± 0.043
0.866GlnGln: 0.866 ± 0.031
2.177GlnArg: 2.177 ± 0.052
1.852GlnSer: 1.852 ± 0.046
1.839GlnThr: 1.839 ± 0.036
2.29GlnVal: 2.29 ± 0.05
0.361GlnTrp: 0.361 ± 0.018
0.509GlnTyr: 0.509 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
8.819ArgAla: 8.819 ± 0.11
0.479ArgCys: 0.479 ± 0.021
4.225ArgAsp: 4.225 ± 0.076
3.42ArgGlu: 3.42 ± 0.072
2.882ArgPhe: 2.882 ± 0.054
5.022ArgGly: 5.022 ± 0.07
1.584ArgHis: 1.584 ± 0.037
3.857ArgIle: 3.857 ± 0.064
2.042ArgLys: 2.042 ± 0.052
7.975ArgLeu: 7.975 ± 0.105
2.119ArgMet: 2.119 ± 0.045
1.662ArgAsn: 1.662 ± 0.037
3.426ArgPro: 3.426 ± 0.056
2.227ArgGln: 2.227 ± 0.044
5.034ArgArg: 5.034 ± 0.087
3.426ArgSer: 3.426 ± 0.063
2.935ArgThr: 2.935 ± 0.053
5.106ArgVal: 5.106 ± 0.063
0.962ArgTrp: 0.962 ± 0.033
1.508ArgTyr: 1.508 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
5.947SerAla: 5.947 ± 0.103
0.404SerCys: 0.404 ± 0.019
2.953SerAsp: 2.953 ± 0.053
2.34SerGlu: 2.34 ± 0.05
2.167SerPhe: 2.167 ± 0.044
5.595SerGly: 5.595 ± 0.114
0.999SerHis: 0.999 ± 0.03
2.272SerIle: 2.272 ± 0.051
1.275SerLys: 1.275 ± 0.037
5.228SerLeu: 5.228 ± 0.094
1.208SerMet: 1.208 ± 0.035
1.211SerAsn: 1.211 ± 0.039
2.521SerPro: 2.521 ± 0.052
1.451SerGln: 1.451 ± 0.037
3.229SerArg: 3.229 ± 0.059
2.401SerSer: 2.401 ± 0.059
2.538SerThr: 2.538 ± 0.062
4.105SerVal: 4.105 ± 0.073
0.605SerTrp: 0.605 ± 0.022
1.201SerTyr: 1.201 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
7.074ThrAla: 7.074 ± 0.113
0.474ThrCys: 0.474 ± 0.022
3.245ThrAsp: 3.245 ± 0.054
3.004ThrGlu: 3.004 ± 0.046
1.995ThrPhe: 1.995 ± 0.041
6.011ThrGly: 6.011 ± 0.124
1.088ThrHis: 1.088 ± 0.032
2.687ThrIle: 2.687 ± 0.055
1.403ThrLys: 1.403 ± 0.033
6.495ThrLeu: 6.495 ± 0.106
1.245ThrMet: 1.245 ± 0.035
1.212ThrAsn: 1.212 ± 0.036
3.404ThrPro: 3.404 ± 0.05
1.405ThrGln: 1.405 ± 0.04
3.448ThrArg: 3.448 ± 0.056
2.544ThrSer: 2.544 ± 0.068
3.005ThrThr: 3.005 ± 0.075
4.795ThrVal: 4.795 ± 0.092
0.671ThrTrp: 0.671 ± 0.02
1.157ThrTyr: 1.157 ± 0.03
0.0ThrXaa: 0.0 ± 0.0
Val
10.326ValAla: 10.326 ± 0.102
0.634ValCys: 0.634 ± 0.026
4.045ValAsp: 4.045 ± 0.065
4.319ValGlu: 4.319 ± 0.069
2.842ValPhe: 2.842 ± 0.052
5.641ValGly: 5.641 ± 0.085
1.273ValHis: 1.273 ± 0.036
4.181ValIle: 4.181 ± 0.068
2.365ValLys: 2.365 ± 0.049
8.041ValLeu: 8.041 ± 0.104
2.183ValMet: 2.183 ± 0.044
1.935ValAsn: 1.935 ± 0.046
3.781ValPro: 3.781 ± 0.062
2.316ValGln: 2.316 ± 0.042
4.358ValArg: 4.358 ± 0.069
4.125ValSer: 4.125 ± 0.071
5.471ValThr: 5.471 ± 0.096
6.172ValVal: 6.172 ± 0.083
1.091ValTrp: 1.091 ± 0.032
1.487ValTyr: 1.487 ± 0.039
0.0ValXaa: 0.0 ± 0.0
Trp
1.501TrpAla: 1.501 ± 0.04
0.142TrpCys: 0.142 ± 0.012
0.69TrpAsp: 0.69 ± 0.024
0.624TrpGlu: 0.624 ± 0.024
0.598TrpPhe: 0.598 ± 0.022
1.031TrpGly: 1.031 ± 0.029
0.382TrpHis: 0.382 ± 0.016
0.621TrpIle: 0.621 ± 0.025
0.466TrpLys: 0.466 ± 0.021
1.701TrpLeu: 1.701 ± 0.039
0.377TrpMet: 0.377 ± 0.017
0.409TrpAsn: 0.409 ± 0.02
0.768TrpPro: 0.768 ± 0.029
0.648TrpGln: 0.648 ± 0.025
1.151TrpArg: 1.151 ± 0.035
0.799TrpSer: 0.799 ± 0.029
0.749TrpThr: 0.749 ± 0.028
0.969TrpVal: 0.969 ± 0.029
0.234TrpTrp: 0.234 ± 0.016
0.258TrpTyr: 0.258 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.541TyrAla: 2.541 ± 0.046
0.218TyrCys: 0.218 ± 0.013
1.492TyrAsp: 1.492 ± 0.035
1.04TyrGlu: 1.04 ± 0.035
0.789TyrPhe: 0.789 ± 0.027
2.15TyrGly: 2.15 ± 0.044
0.481TyrHis: 0.481 ± 0.022
0.872TyrIle: 0.872 ± 0.032
0.497TyrLys: 0.497 ± 0.022
2.088TyrLeu: 2.088 ± 0.05
0.447TyrMet: 0.447 ± 0.021
0.526TyrAsn: 0.526 ± 0.021
1.051TyrPro: 1.051 ± 0.032
0.589TyrGln: 0.589 ± 0.025
1.534TyrArg: 1.534 ± 0.043
1.058TyrSer: 1.058 ± 0.032
1.057TyrThr: 1.057 ± 0.031
1.483TyrVal: 1.483 ± 0.041
0.369TyrTrp: 0.369 ± 0.019
0.508TyrTyr: 0.508 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3779 proteins (1180242 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski