Amino acid dipepetide frequency for Lonepinella koalarum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.716AlaAla: 5.716 ± 0.116
0.949AlaCys: 0.949 ± 0.039
4.432AlaAsp: 4.432 ± 0.085
5.652AlaGlu: 5.652 ± 0.108
3.387AlaPhe: 3.387 ± 0.083
5.582AlaGly: 5.582 ± 0.098
1.444AlaHis: 1.444 ± 0.046
6.221AlaIle: 6.221 ± 0.111
5.652AlaLys: 5.652 ± 0.112
9.389AlaLeu: 9.389 ± 0.143
2.453AlaMet: 2.453 ± 0.061
4.001AlaAsn: 4.001 ± 0.113
2.303AlaPro: 2.303 ± 0.057
3.963AlaGln: 3.963 ± 0.082
3.29AlaArg: 3.29 ± 0.076
4.144AlaSer: 4.144 ± 0.078
4.435AlaThr: 4.435 ± 0.093
6.202AlaVal: 6.202 ± 0.092
0.867AlaTrp: 0.867 ± 0.033
2.441AlaTyr: 2.441 ± 0.061
0.0AlaXaa: 0.0 ± 0.0
Cys
0.759CysAla: 0.759 ± 0.031
0.161CysCys: 0.161 ± 0.015
0.55CysAsp: 0.55 ± 0.028
0.56CysGlu: 0.56 ± 0.024
0.497CysPhe: 0.497 ± 0.029
1.008CysGly: 1.008 ± 0.04
0.338CysHis: 0.338 ± 0.024
0.621CysIle: 0.621 ± 0.034
0.409CysLys: 0.409 ± 0.024
1.048CysLeu: 1.048 ± 0.039
0.184CysMet: 0.184 ± 0.017
0.343CysAsn: 0.343 ± 0.026
0.461CysPro: 0.461 ± 0.026
0.545CysGln: 0.545 ± 0.031
0.432CysArg: 0.432 ± 0.022
0.622CysSer: 0.622 ± 0.032
0.484CysThr: 0.484 ± 0.023
0.71CysVal: 0.71 ± 0.034
0.122CysTrp: 0.122 ± 0.013
0.382CysTyr: 0.382 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
3.531AspAla: 3.531 ± 0.078
0.569AspCys: 0.569 ± 0.031
2.71AspAsp: 2.71 ± 0.067
3.656AspGlu: 3.656 ± 0.078
2.636AspPhe: 2.636 ± 0.058
3.361AspGly: 3.361 ± 0.088
0.912AspHis: 0.912 ± 0.039
3.872AspIle: 3.872 ± 0.073
3.273AspLys: 3.273 ± 0.075
5.339AspLeu: 5.339 ± 0.11
1.164AspMet: 1.164 ± 0.033
2.688AspAsn: 2.688 ± 0.069
2.104AspPro: 2.104 ± 0.059
2.029AspGln: 2.029 ± 0.052
2.171AspArg: 2.171 ± 0.058
2.544AspSer: 2.544 ± 0.061
2.292AspThr: 2.292 ± 0.071
3.806AspVal: 3.806 ± 0.083
0.786AspTrp: 0.786 ± 0.033
2.25AspTyr: 2.25 ± 0.061
0.0AspXaa: 0.0 ± 0.0
Glu
3.498GluAla: 3.498 ± 0.091
0.443GluCys: 0.443 ± 0.027
2.381GluAsp: 2.381 ± 0.065
2.891GluGlu: 2.891 ± 0.065
2.478GluPhe: 2.478 ± 0.062
2.424GluGly: 2.424 ± 0.071
1.269GluHis: 1.269 ± 0.042
4.796GluIle: 4.796 ± 0.094
4.874GluLys: 4.874 ± 0.099
6.303GluLeu: 6.303 ± 0.116
1.728GluMet: 1.728 ± 0.049
3.74GluAsn: 3.74 ± 0.082
1.805GluPro: 1.805 ± 0.06
4.608GluGln: 4.608 ± 0.09
3.117GluArg: 3.117 ± 0.07
2.817GluSer: 2.817 ± 0.062
3.054GluThr: 3.054 ± 0.078
3.534GluVal: 3.534 ± 0.079
0.693GluTrp: 0.693 ± 0.028
1.769GluTyr: 1.769 ± 0.053
0.0GluXaa: 0.0 ± 0.0
Phe
3.957PheAla: 3.957 ± 0.081
0.6PheCys: 0.6 ± 0.027
2.815PheAsp: 2.815 ± 0.061
2.338PheGlu: 2.338 ± 0.065
1.965PhePhe: 1.965 ± 0.063
3.348PheGly: 3.348 ± 0.079
0.847PheHis: 0.847 ± 0.035
3.344PheIle: 3.344 ± 0.074
2.199PheLys: 2.199 ± 0.058
3.963PheLeu: 3.963 ± 0.095
1.049PheMet: 1.049 ± 0.039
2.358PheAsn: 2.358 ± 0.055
1.458PhePro: 1.458 ± 0.046
1.434PheGln: 1.434 ± 0.045
1.498PheArg: 1.498 ± 0.041
3.269PheSer: 3.269 ± 0.074
2.467PheThr: 2.467 ± 0.063
2.975PheVal: 2.975 ± 0.077
0.552PheTrp: 0.552 ± 0.029
1.572PheTyr: 1.572 ± 0.05
0.0PheXaa: 0.0 ± 0.0
Gly
4.939GlyAla: 4.939 ± 0.102
0.858GlyCys: 0.858 ± 0.04
3.233GlyAsp: 3.233 ± 0.077
4.104GlyGlu: 4.104 ± 0.077
3.134GlyPhe: 3.134 ± 0.07
4.703GlyGly: 4.703 ± 0.093
1.29GlyHis: 1.29 ± 0.041
5.319GlyIle: 5.319 ± 0.102
4.627GlyLys: 4.627 ± 0.079
7.149GlyLeu: 7.149 ± 0.114
1.814GlyMet: 1.814 ± 0.048
2.924GlyAsn: 2.924 ± 0.079
1.121GlyPro: 1.121 ± 0.041
2.498GlyGln: 2.498 ± 0.057
2.769GlyArg: 2.769 ± 0.071
3.767GlySer: 3.767 ± 0.089
3.547GlyThr: 3.547 ± 0.101
5.199GlyVal: 5.199 ± 0.091
0.862GlyTrp: 0.862 ± 0.041
2.593GlyTyr: 2.593 ± 0.066
0.0GlyXaa: 0.0 ± 0.0
His
1.303HisAla: 1.303 ± 0.044
0.363HisCys: 0.363 ± 0.023
0.928HisAsp: 0.928 ± 0.037
0.862HisGlu: 0.862 ± 0.034
1.262HisPhe: 1.262 ± 0.043
1.372HisGly: 1.372 ± 0.05
0.713HisHis: 0.713 ± 0.036
1.69HisIle: 1.69 ± 0.048
1.076HisLys: 1.076 ± 0.042
2.333HisLeu: 2.333 ± 0.061
0.332HisMet: 0.332 ± 0.022
1.023HisAsn: 1.023 ± 0.038
1.046HisPro: 1.046 ± 0.034
1.262HisGln: 1.262 ± 0.048
0.989HisArg: 0.989 ± 0.04
1.372HisSer: 1.372 ± 0.039
0.984HisThr: 0.984 ± 0.031
0.911HisVal: 0.911 ± 0.041
0.343HisTrp: 0.343 ± 0.021
0.954HisTyr: 0.954 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
6.915IleAla: 6.915 ± 0.121
0.853IleCys: 0.853 ± 0.033
4.139IleAsp: 4.139 ± 0.076
4.53IleGlu: 4.53 ± 0.082
2.916IlePhe: 2.916 ± 0.08
5.286IleGly: 5.286 ± 0.118
1.383IleHis: 1.383 ± 0.045
4.782IleIle: 4.782 ± 0.097
4.065IleLys: 4.065 ± 0.076
6.838IleLeu: 6.838 ± 0.119
1.472IleMet: 1.472 ± 0.055
3.496IleAsn: 3.496 ± 0.076
2.935IlePro: 2.935 ± 0.071
2.902IleGln: 2.902 ± 0.068
2.821IleArg: 2.821 ± 0.068
4.611IleSer: 4.611 ± 0.09
4.003IleThr: 4.003 ± 0.082
4.703IleVal: 4.703 ± 0.092
0.739IleTrp: 0.739 ± 0.036
2.245IleTyr: 2.245 ± 0.056
0.0IleXaa: 0.0 ± 0.0
Lys
5.254LysAla: 5.254 ± 0.092
0.393LysCys: 0.393 ± 0.025
3.039LysAsp: 3.039 ± 0.073
3.311LysGlu: 3.311 ± 0.066
2.048LysPhe: 2.048 ± 0.053
3.645LysGly: 3.645 ± 0.066
1.181LysHis: 1.181 ± 0.04
4.413LysIle: 4.413 ± 0.085
3.615LysLys: 3.615 ± 0.097
6.049LysLeu: 6.049 ± 0.101
1.765LysMet: 1.765 ± 0.049
3.202LysAsn: 3.202 ± 0.08
2.392LysPro: 2.392 ± 0.069
3.581LysGln: 3.581 ± 0.082
2.57LysArg: 2.57 ± 0.065
3.181LysSer: 3.181 ± 0.073
3.412LysThr: 3.412 ± 0.077
3.996LysVal: 3.996 ± 0.085
0.633LysTrp: 0.633 ± 0.033
1.782LysTyr: 1.782 ± 0.047
0.0LysXaa: 0.0 ± 0.0
Leu
9.815LeuAla: 9.815 ± 0.13
1.133LeuCys: 1.133 ± 0.033
5.682LeuAsp: 5.682 ± 0.108
5.434LeuGlu: 5.434 ± 0.09
4.77LeuPhe: 4.77 ± 0.111
7.184LeuGly: 7.184 ± 0.122
2.06LeuHis: 2.06 ± 0.053
6.892LeuIle: 6.892 ± 0.125
5.759LeuLys: 5.759 ± 0.107
10.955LeuLeu: 10.955 ± 0.204
2.47LeuMet: 2.47 ± 0.068
5.235LeuAsn: 5.235 ± 0.091
4.641LeuPro: 4.641 ± 0.088
4.797LeuGln: 4.797 ± 0.1
4.416LeuArg: 4.416 ± 0.099
7.215LeuSer: 7.215 ± 0.118
6.151LeuThr: 6.151 ± 0.103
6.793LeuVal: 6.793 ± 0.102
1.134LeuTrp: 1.134 ± 0.047
2.802LeuTyr: 2.802 ± 0.063
0.0LeuXaa: 0.0 ± 0.0
Met
2.326MetAla: 2.326 ± 0.072
0.197MetCys: 0.197 ± 0.016
0.988MetAsp: 0.988 ± 0.035
1.053MetGlu: 1.053 ± 0.042
0.855MetPhe: 0.855 ± 0.039
1.598MetGly: 1.598 ± 0.047
0.454MetHis: 0.454 ± 0.025
1.639MetIle: 1.639 ± 0.052
1.597MetLys: 1.597 ± 0.046
2.681MetLeu: 2.681 ± 0.075
0.686MetMet: 0.686 ± 0.031
1.158MetAsn: 1.158 ± 0.04
1.087MetPro: 1.087 ± 0.041
1.414MetGln: 1.414 ± 0.043
0.992MetArg: 0.992 ± 0.034
1.572MetSer: 1.572 ± 0.047
1.593MetThr: 1.593 ± 0.049
1.545MetVal: 1.545 ± 0.049
0.213MetTrp: 0.213 ± 0.018
0.492MetTyr: 0.492 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
3.929AsnAla: 3.929 ± 0.091
0.412AsnCys: 0.412 ± 0.025
2.415AsnAsp: 2.415 ± 0.068
2.639AsnGlu: 2.639 ± 0.061
1.941AsnPhe: 1.941 ± 0.049
3.412AsnGly: 3.412 ± 0.087
1.026AsnHis: 1.026 ± 0.038
3.634AsnIle: 3.634 ± 0.079
2.804AsnLys: 2.804 ± 0.06
4.882AsnLeu: 4.882 ± 0.083
1.185AsnMet: 1.185 ± 0.037
2.566AsnAsn: 2.566 ± 0.087
2.579AsnPro: 2.579 ± 0.078
2.727AsnGln: 2.727 ± 0.071
2.036AsnArg: 2.036 ± 0.063
2.691AsnSer: 2.691 ± 0.071
2.612AsnThr: 2.612 ± 0.085
3.359AsnVal: 3.359 ± 0.088
0.671AsnTrp: 0.671 ± 0.031
1.598AsnTyr: 1.598 ± 0.056
0.0AsnXaa: 0.0 ± 0.0
Pro
2.769ProAla: 2.769 ± 0.074
0.295ProCys: 0.295 ± 0.02
2.106ProAsp: 2.106 ± 0.057
2.948ProGlu: 2.948 ± 0.085
1.811ProPhe: 1.811 ± 0.052
1.368ProGly: 1.368 ± 0.055
0.953ProHis: 0.953 ± 0.033
2.695ProIle: 2.695 ± 0.066
2.227ProLys: 2.227 ± 0.05
3.86ProLeu: 3.86 ± 0.083
0.942ProMet: 0.942 ± 0.04
2.253ProAsn: 2.253 ± 0.06
1.05ProPro: 1.05 ± 0.047
1.876ProGln: 1.876 ± 0.053
1.235ProArg: 1.235 ± 0.041
2.011ProSer: 2.011 ± 0.051
2.516ProThr: 2.516 ± 0.061
2.831ProVal: 2.831 ± 0.079
0.401ProTrp: 0.401 ± 0.026
1.324ProTyr: 1.324 ± 0.048
0.0ProXaa: 0.0 ± 0.0
Gln
4.861GlnAla: 4.861 ± 0.092
0.398GlnCys: 0.398 ± 0.024
2.467GlnAsp: 2.467 ± 0.061
2.509GlnGlu: 2.509 ± 0.072
2.167GlnPhe: 2.167 ± 0.059
3.608GlnGly: 3.608 ± 0.086
1.388GlnHis: 1.388 ± 0.051
3.601GlnIle: 3.601 ± 0.074
3.066GlnLys: 3.066 ± 0.079
5.282GlnLeu: 5.282 ± 0.098
1.014GlnMet: 1.014 ± 0.04
2.376GlnAsn: 2.376 ± 0.066
1.904GlnPro: 1.904 ± 0.061
4.343GlnGln: 4.343 ± 0.145
2.463GlnArg: 2.463 ± 0.066
2.718GlnSer: 2.718 ± 0.06
2.657GlnThr: 2.657 ± 0.069
3.025GlnVal: 3.025 ± 0.057
0.72GlnTrp: 0.72 ± 0.035
1.643GlnTyr: 1.643 ± 0.051
0.0GlnXaa: 0.0 ± 0.0
Arg
2.944ArgAla: 2.944 ± 0.056
0.434ArgCys: 0.434 ± 0.026
2.047ArgAsp: 2.047 ± 0.062
2.799ArgGlu: 2.799 ± 0.072
2.135ArgPhe: 2.135 ± 0.044
2.338ArgGly: 2.338 ± 0.057
1.097ArgHis: 1.097 ± 0.037
3.032ArgIle: 3.032 ± 0.071
2.395ArgLys: 2.395 ± 0.059
4.871ArgLeu: 4.871 ± 0.087
0.999ArgMet: 0.999 ± 0.035
1.95ArgAsn: 1.95 ± 0.059
1.488ArgPro: 1.488 ± 0.042
2.406ArgGln: 2.406 ± 0.064
2.028ArgArg: 2.028 ± 0.054
2.234ArgSer: 2.234 ± 0.059
2.161ArgThr: 2.161 ± 0.054
2.621ArgVal: 2.621 ± 0.06
0.544ArgTrp: 0.544 ± 0.026
1.74ArgTyr: 1.74 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
5.011SerAla: 5.011 ± 0.087
0.526SerCys: 0.526 ± 0.028
2.917SerAsp: 2.917 ± 0.074
3.188SerGlu: 3.188 ± 0.074
2.647SerPhe: 2.647 ± 0.067
4.379SerGly: 4.379 ± 0.083
1.351SerHis: 1.351 ± 0.047
3.919SerIle: 3.919 ± 0.078
2.974SerLys: 2.974 ± 0.065
6.234SerLeu: 6.234 ± 0.091
1.29SerMet: 1.29 ± 0.043
2.436SerAsn: 2.436 ± 0.052
2.339SerPro: 2.339 ± 0.059
2.993SerGln: 2.993 ± 0.062
2.413SerArg: 2.413 ± 0.067
3.57SerSer: 3.57 ± 0.076
3.126SerThr: 3.126 ± 0.089
3.974SerVal: 3.974 ± 0.088
0.68SerTrp: 0.68 ± 0.034
1.896SerTyr: 1.896 ± 0.055
0.0SerXaa: 0.0 ± 0.0
Thr
5.384ThrAla: 5.384 ± 0.103
0.409ThrCys: 0.409 ± 0.024
2.911ThrAsp: 2.911 ± 0.071
3.448ThrGlu: 3.448 ± 0.081
2.302ThrPhe: 2.302 ± 0.064
4.107ThrGly: 4.107 ± 0.093
1.133ThrHis: 1.133 ± 0.039
3.634ThrIle: 3.634 ± 0.094
2.749ThrLys: 2.749 ± 0.071
6.061ThrLeu: 6.061 ± 0.097
1.063ThrMet: 1.063 ± 0.036
2.269ThrAsn: 2.269 ± 0.083
2.635ThrPro: 2.635 ± 0.066
2.586ThrGln: 2.586 ± 0.066
1.826ThrArg: 1.826 ± 0.052
2.837ThrSer: 2.837 ± 0.067
3.158ThrThr: 3.158 ± 0.102
3.874ThrVal: 3.874 ± 0.103
0.489ThrTrp: 0.489 ± 0.029
1.475ThrTyr: 1.475 ± 0.05
0.0ThrXaa: 0.0 ± 0.0
Val
6.143ValAla: 6.143 ± 0.102
0.676ValCys: 0.676 ± 0.03
3.661ValAsp: 3.661 ± 0.078
4.333ValGlu: 4.333 ± 0.084
2.722ValPhe: 2.722 ± 0.07
4.778ValGly: 4.778 ± 0.08
1.082ValHis: 1.082 ± 0.035
4.916ValIle: 4.916 ± 0.077
4.042ValLys: 4.042 ± 0.081
6.849ValLeu: 6.849 ± 0.122
1.679ValMet: 1.679 ± 0.046
3.3ValAsn: 3.3 ± 0.082
2.503ValPro: 2.503 ± 0.057
2.907ValGln: 2.907 ± 0.072
2.944ValArg: 2.944 ± 0.065
4.19ValSer: 4.19 ± 0.092
3.666ValThr: 3.666 ± 0.082
5.023ValVal: 5.023 ± 0.103
0.63ValTrp: 0.63 ± 0.03
1.8ValTyr: 1.8 ± 0.048
0.0ValXaa: 0.0 ± 0.0
Trp
0.821TrpAla: 0.821 ± 0.033
0.133TrpCys: 0.133 ± 0.014
0.598TrpAsp: 0.598 ± 0.026
0.48TrpGlu: 0.48 ± 0.022
0.569TrpPhe: 0.569 ± 0.03
0.758TrpGly: 0.758 ± 0.041
0.305TrpHis: 0.305 ± 0.019
0.718TrpIle: 0.718 ± 0.027
0.628TrpLys: 0.628 ± 0.028
1.753TrpLeu: 1.753 ± 0.062
0.209TrpMet: 0.209 ± 0.016
0.48TrpAsn: 0.48 ± 0.028
0.152TrpPro: 0.152 ± 0.016
1.158TrpGln: 1.158 ± 0.041
0.583TrpArg: 0.583 ± 0.026
0.558TrpSer: 0.558 ± 0.029
0.554TrpThr: 0.554 ± 0.031
0.758TrpVal: 0.758 ± 0.031
0.182TrpTrp: 0.182 ± 0.017
0.34TrpTyr: 0.34 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.65TyrAla: 2.65 ± 0.064
0.434TyrCys: 0.434 ± 0.027
1.674TyrAsp: 1.674 ± 0.055
1.486TyrGlu: 1.486 ± 0.045
1.767TyrPhe: 1.767 ± 0.053
2.192TyrGly: 2.192 ± 0.06
0.895TyrHis: 0.895 ± 0.036
1.894TyrIle: 1.894 ± 0.056
1.43TyrLys: 1.43 ± 0.043
3.498TyrLeu: 3.498 ± 0.071
0.64TyrMet: 0.64 ± 0.029
1.322TyrAsn: 1.322 ± 0.05
1.467TyrPro: 1.467 ± 0.047
2.182TyrGln: 2.182 ± 0.059
1.67TyrArg: 1.67 ± 0.053
1.941TyrSer: 1.941 ± 0.054
1.48TyrThr: 1.48 ± 0.055
2.005TyrVal: 2.005 ± 0.05
0.474TyrTrp: 0.474 ± 0.026
1.217TyrTyr: 1.217 ± 0.05
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2301 proteins (737773 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski