Amino acid dipepetide frequency for Mycoplasma columborale

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.254AlaAla: 3.254 ± 0.161
0.305AlaCys: 0.305 ± 0.038
2.887AlaAsp: 2.887 ± 0.131
3.178AlaGlu: 3.178 ± 0.148
2.863AlaPhe: 2.863 ± 0.115
2.63AlaGly: 2.63 ± 0.111
0.809AlaHis: 0.809 ± 0.053
5.132AlaIle: 5.132 ± 0.168
6.247AlaLys: 6.247 ± 0.226
6.583AlaLeu: 6.583 ± 0.196
1.042AlaMet: 1.042 ± 0.07
4.028AlaAsn: 4.028 ± 0.213
1.491AlaPro: 1.491 ± 0.082
2.856AlaGln: 2.856 ± 0.137
2.074AlaArg: 2.074 ± 0.092
3.95AlaSer: 3.95 ± 0.154
3.449AlaThr: 3.449 ± 0.165
3.209AlaVal: 3.209 ± 0.113
0.411AlaTrp: 0.411 ± 0.037
2.235AlaTyr: 2.235 ± 0.086
0.0AlaXaa: 0.0 ± 0.0
Cys
0.291CysAla: 0.291 ± 0.034
0.048CysCys: 0.048 ± 0.014
0.192CysAsp: 0.192 ± 0.025
0.213CysGlu: 0.213 ± 0.032
0.243CysPhe: 0.243 ± 0.03
0.288CysGly: 0.288 ± 0.034
0.089CysHis: 0.089 ± 0.018
0.291CysIle: 0.291 ± 0.035
0.326CysLys: 0.326 ± 0.042
0.415CysLeu: 0.415 ± 0.046
0.069CysMet: 0.069 ± 0.017
0.195CysAsn: 0.195 ± 0.031
0.103CysPro: 0.103 ± 0.02
0.154CysGln: 0.154 ± 0.026
0.113CysArg: 0.113 ± 0.02
0.394CysSer: 0.394 ± 0.045
0.141CysThr: 0.141 ± 0.025
0.261CysVal: 0.261 ± 0.036
0.065CysTrp: 0.065 ± 0.015
0.137CysTyr: 0.137 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
3.518AspAla: 3.518 ± 0.225
0.168AspCys: 0.168 ± 0.027
2.513AspAsp: 2.513 ± 0.137
3.668AspGlu: 3.668 ± 0.172
3.603AspPhe: 3.603 ± 0.125
2.16AspGly: 2.16 ± 0.103
0.765AspHis: 0.765 ± 0.053
4.303AspIle: 4.303 ± 0.135
5.773AspLys: 5.773 ± 0.217
6.504AspLeu: 6.504 ± 0.229
0.675AspMet: 0.675 ± 0.057
4.056AspAsn: 4.056 ± 0.194
1.69AspPro: 1.69 ± 0.092
2.276AspGln: 2.276 ± 0.129
1.467AspArg: 1.467 ± 0.092
3.823AspSer: 3.823 ± 0.16
2.612AspThr: 2.612 ± 0.147
3.422AspVal: 3.422 ± 0.117
0.459AspTrp: 0.459 ± 0.041
2.575AspTyr: 2.575 ± 0.101
0.0AspXaa: 0.0 ± 0.0
Glu
3.627GluAla: 3.627 ± 0.179
0.278GluCys: 0.278 ± 0.035
3.295GluAsp: 3.295 ± 0.123
5.156GluGlu: 5.156 ± 0.18
3.727GluPhe: 3.727 ± 0.142
2.434GluGly: 2.434 ± 0.087
1.039GluHis: 1.039 ± 0.061
6.363GluIle: 6.363 ± 0.18
6.541GluLys: 6.541 ± 0.175
7.097GluLeu: 7.097 ± 0.187
1.142GluMet: 1.142 ± 0.088
5.931GluAsn: 5.931 ± 0.158
1.385GluPro: 1.385 ± 0.097
3.511GluGln: 3.511 ± 0.152
1.923GluArg: 1.923 ± 0.087
3.583GluSer: 3.583 ± 0.104
3.13GluThr: 3.13 ± 0.114
4.166GluVal: 4.166 ± 0.125
0.453GluTrp: 0.453 ± 0.04
3.182GluTyr: 3.182 ± 0.12
0.0GluXaa: 0.0 ± 0.0
Phe
3.336PheAla: 3.336 ± 0.131
0.219PheCys: 0.219 ± 0.03
3.459PheAsp: 3.459 ± 0.117
3.782PheGlu: 3.782 ± 0.123
2.486PhePhe: 2.486 ± 0.16
2.609PheGly: 2.609 ± 0.127
0.525PheHis: 0.525 ± 0.052
4.193PheIle: 4.193 ± 0.195
4.906PheLys: 4.906 ± 0.169
4.844PheLeu: 4.844 ± 0.188
0.867PheMet: 0.867 ± 0.064
4.059PheAsn: 4.059 ± 0.162
1.094PhePro: 1.094 ± 0.061
1.365PheGln: 1.365 ± 0.081
1.354PheArg: 1.354 ± 0.08
3.624PheSer: 3.624 ± 0.14
2.647PheThr: 2.647 ± 0.1
3.668PheVal: 3.668 ± 0.168
0.638PheTrp: 0.638 ± 0.047
2.345PheTyr: 2.345 ± 0.105
0.0PheXaa: 0.0 ± 0.0
Gly
2.722GlyAla: 2.722 ± 0.102
0.182GlyCys: 0.182 ± 0.025
2.249GlyAsp: 2.249 ± 0.104
2.595GlyGlu: 2.595 ± 0.106
2.732GlyPhe: 2.732 ± 0.116
2.554GlyGly: 2.554 ± 0.143
0.758GlyHis: 0.758 ± 0.052
3.812GlyIle: 3.812 ± 0.166
3.73GlyLys: 3.73 ± 0.132
3.734GlyLeu: 3.734 ± 0.155
0.802GlyMet: 0.802 ± 0.062
2.297GlyAsn: 2.297 ± 0.103
0.867GlyPro: 0.867 ± 0.067
1.423GlyGln: 1.423 ± 0.072
1.519GlyArg: 1.519 ± 0.099
2.996GlySer: 2.996 ± 0.109
2.876GlyThr: 2.876 ± 0.128
2.986GlyVal: 2.986 ± 0.116
0.384GlyTrp: 0.384 ± 0.043
1.947GlyTyr: 1.947 ± 0.095
0.0GlyXaa: 0.0 ± 0.0
His
0.795HisAla: 0.795 ± 0.054
0.072HisCys: 0.072 ± 0.014
0.641HisAsp: 0.641 ± 0.045
0.823HisGlu: 0.823 ± 0.056
0.854HisPhe: 0.854 ± 0.058
0.789HisGly: 0.789 ± 0.062
0.247HisHis: 0.247 ± 0.027
1.001HisIle: 1.001 ± 0.07
1.33HisLys: 1.33 ± 0.074
1.721HisLeu: 1.721 ± 0.081
0.206HisMet: 0.206 ± 0.03
1.039HisAsn: 1.039 ± 0.055
0.559HisPro: 0.559 ± 0.045
0.549HisGln: 0.549 ± 0.042
0.398HisArg: 0.398 ± 0.044
0.963HisSer: 0.963 ± 0.063
0.737HisThr: 0.737 ± 0.049
0.703HisVal: 0.703 ± 0.056
0.171HisTrp: 0.171 ± 0.02
0.645HisTyr: 0.645 ± 0.049
0.0HisXaa: 0.0 ± 0.0
Ile
5.431IleAla: 5.431 ± 0.13
0.377IleCys: 0.377 ± 0.041
5.3IleAsp: 5.3 ± 0.171
5.163IleGlu: 5.163 ± 0.157
4.31IlePhe: 4.31 ± 0.178
3.662IleGly: 3.662 ± 0.168
1.09IleHis: 1.09 ± 0.069
6.497IleIle: 6.497 ± 0.254
7.577IleLys: 7.577 ± 0.213
7.532IleLeu: 7.532 ± 0.27
1.135IleMet: 1.135 ± 0.069
6.62IleAsn: 6.62 ± 0.206
2.259IlePro: 2.259 ± 0.096
2.924IleGln: 2.924 ± 0.111
2.187IleArg: 2.187 ± 0.089
6.037IleSer: 6.037 ± 0.195
4.632IleThr: 4.632 ± 0.141
5.17IleVal: 5.17 ± 0.184
0.669IleTrp: 0.669 ± 0.055
3.25IleTyr: 3.25 ± 0.138
0.0IleXaa: 0.0 ± 0.0
Lys
5.537LysAla: 5.537 ± 0.258
0.291LysCys: 0.291 ± 0.04
5.969LysAsp: 5.969 ± 0.222
8.221LysGlu: 8.221 ± 0.22
3.799LysPhe: 3.799 ± 0.156
3.507LysGly: 3.507 ± 0.138
1.563LysHis: 1.563 ± 0.078
8.177LysIle: 8.177 ± 0.247
7.282LysLys: 7.282 ± 0.222
9.02LysLeu: 9.02 ± 0.197
2.16LysMet: 2.16 ± 0.106
8.064LysAsn: 8.064 ± 0.187
2.15LysPro: 2.15 ± 0.089
3.833LysGln: 3.833 ± 0.127
2.894LysArg: 2.894 ± 0.136
5.578LysSer: 5.578 ± 0.143
5.698LysThr: 5.698 ± 0.18
5.561LysVal: 5.561 ± 0.146
0.963LysTrp: 0.963 ± 0.067
4.642LysTyr: 4.642 ± 0.12
0.0LysXaa: 0.0 ± 0.0
Leu
5.633LeuAla: 5.633 ± 0.161
0.384LeuCys: 0.384 ± 0.044
5.911LeuAsp: 5.911 ± 0.195
6.603LeuGlu: 6.603 ± 0.185
4.909LeuPhe: 4.909 ± 0.22
4.08LeuGly: 4.08 ± 0.167
1.262LeuHis: 1.262 ± 0.08
8.787LeuIle: 8.787 ± 0.278
10.381LeuLys: 10.381 ± 0.26
8.633LeuLeu: 8.633 ± 0.279
1.505LeuMet: 1.505 ± 0.095
9.099LeuAsn: 9.099 ± 0.283
2.828LeuPro: 2.828 ± 0.107
3.881LeuGln: 3.881 ± 0.161
3.027LeuArg: 3.027 ± 0.111
7.817LeuSer: 7.817 ± 0.189
5.88LeuThr: 5.88 ± 0.171
5.842LeuVal: 5.842 ± 0.162
0.806LeuTrp: 0.806 ± 0.06
3.35LeuTyr: 3.35 ± 0.114
0.0LeuXaa: 0.0 ± 0.0
Met
0.775MetAla: 0.775 ± 0.064
0.12MetCys: 0.12 ± 0.021
0.71MetAsp: 0.71 ± 0.06
0.658MetGlu: 0.658 ± 0.048
0.957MetPhe: 0.957 ± 0.069
0.658MetGly: 0.658 ± 0.059
0.357MetHis: 0.357 ± 0.042
1.248MetIle: 1.248 ± 0.082
1.79MetLys: 1.79 ± 0.068
1.81MetLeu: 1.81 ± 0.087
0.326MetMet: 0.326 ± 0.037
1.097MetAsn: 1.097 ± 0.067
0.552MetPro: 0.552 ± 0.044
0.758MetGln: 0.758 ± 0.058
0.518MetArg: 0.518 ± 0.052
1.258MetSer: 1.258 ± 0.083
0.686MetThr: 0.686 ± 0.054
0.943MetVal: 0.943 ± 0.059
0.113MetTrp: 0.113 ± 0.019
0.545MetTyr: 0.545 ± 0.053
0.0MetXaa: 0.0 ± 0.0
Asn
4.58AsnAla: 4.58 ± 0.259
0.281AsnCys: 0.281 ± 0.034
4.597AsnAsp: 4.597 ± 0.23
5.468AsnGlu: 5.468 ± 0.166
3.761AsnPhe: 3.761 ± 0.14
3.308AsnGly: 3.308 ± 0.139
0.895AsnHis: 0.895 ± 0.066
5.537AsnIle: 5.537 ± 0.157
7.899AsnLys: 7.899 ± 0.181
8.664AsnLeu: 8.664 ± 0.243
0.987AsnMet: 0.987 ± 0.072
6.5AsnAsn: 6.5 ± 0.312
2.76AsnPro: 2.76 ± 0.104
2.976AsnGln: 2.976 ± 0.113
1.892AsnArg: 1.892 ± 0.072
5.77AsnSer: 5.77 ± 0.23
4.196AsnThr: 4.196 ± 0.173
4.388AsnVal: 4.388 ± 0.159
0.871AsnTrp: 0.871 ± 0.053
3.583AsnTyr: 3.583 ± 0.114
0.0AsnXaa: 0.0 ± 0.0
Pro
1.488ProAla: 1.488 ± 0.094
0.065ProCys: 0.065 ± 0.015
1.176ProAsp: 1.176 ± 0.069
2.232ProGlu: 2.232 ± 0.121
1.351ProPhe: 1.351 ± 0.083
1.231ProGly: 1.231 ± 0.086
0.528ProHis: 0.528 ± 0.04
2.17ProIle: 2.17 ± 0.091
2.307ProLys: 2.307 ± 0.107
2.448ProLeu: 2.448 ± 0.09
0.346ProMet: 0.346 ± 0.036
2.28ProAsn: 2.28 ± 0.128
0.336ProPro: 0.336 ± 0.039
1.306ProGln: 1.306 ± 0.078
0.703ProArg: 0.703 ± 0.053
2.091ProSer: 2.091 ± 0.107
1.776ProThr: 1.776 ± 0.094
1.591ProVal: 1.591 ± 0.088
0.219ProTrp: 0.219 ± 0.029
1.197ProTyr: 1.197 ± 0.071
0.0ProXaa: 0.0 ± 0.0
Gln
2.554GlnAla: 2.554 ± 0.172
0.075GlnCys: 0.075 ± 0.015
1.961GlnAsp: 1.961 ± 0.107
2.966GlnGlu: 2.966 ± 0.127
1.502GlnPhe: 1.502 ± 0.073
1.495GlnGly: 1.495 ± 0.073
0.521GlnHis: 0.521 ± 0.039
3.61GlnIle: 3.61 ± 0.131
4.207GlnLys: 4.207 ± 0.105
3.939GlnLeu: 3.939 ± 0.128
0.723GlnMet: 0.723 ± 0.055
3.603GlnAsn: 3.603 ± 0.122
1.025GlnPro: 1.025 ± 0.074
1.762GlnGln: 1.762 ± 0.082
1.409GlnArg: 1.409 ± 0.079
2.396GlnSer: 2.396 ± 0.106
2.366GlnThr: 2.366 ± 0.109
2.064GlnVal: 2.064 ± 0.1
0.295GlnTrp: 0.295 ± 0.035
1.591GlnTyr: 1.591 ± 0.081
0.0GlnXaa: 0.0 ± 0.0
Arg
1.639ArgAla: 1.639 ± 0.076
0.11ArgCys: 0.11 ± 0.024
1.8ArgAsp: 1.8 ± 0.088
2.18ArgGlu: 2.18 ± 0.096
1.46ArgPhe: 1.46 ± 0.068
1.217ArgGly: 1.217 ± 0.08
0.398ArgHis: 0.398 ± 0.036
2.372ArgIle: 2.372 ± 0.108
2.863ArgLys: 2.863 ± 0.136
2.784ArgLeu: 2.784 ± 0.11
0.624ArgMet: 0.624 ± 0.056
2.153ArgAsn: 2.153 ± 0.107
0.826ArgPro: 0.826 ± 0.063
0.991ArgGln: 0.991 ± 0.066
1.066ArgArg: 1.066 ± 0.079
1.81ArgSer: 1.81 ± 0.073
1.539ArgThr: 1.539 ± 0.078
1.848ArgVal: 1.848 ± 0.098
0.298ArgTrp: 0.298 ± 0.036
1.251ArgTyr: 1.251 ± 0.069
0.0ArgXaa: 0.0 ± 0.0
Ser
3.71SerAla: 3.71 ± 0.145
0.346SerCys: 0.346 ± 0.036
4.2SerAsp: 4.2 ± 0.15
4.954SerGlu: 4.954 ± 0.131
3.902SerPhe: 3.902 ± 0.144
3.326SerGly: 3.326 ± 0.126
0.895SerHis: 0.895 ± 0.062
5.239SerIle: 5.239 ± 0.175
6.319SerLys: 6.319 ± 0.17
7.536SerLeu: 7.536 ± 0.192
0.991SerMet: 0.991 ± 0.068
5.331SerAsn: 5.331 ± 0.188
1.67SerPro: 1.67 ± 0.093
2.859SerGln: 2.859 ± 0.113
1.889SerArg: 1.889 ± 0.077
5.091SerSer: 5.091 ± 0.161
3.826SerThr: 3.826 ± 0.205
4.018SerVal: 4.018 ± 0.132
0.597SerTrp: 0.597 ± 0.042
2.856SerTyr: 2.856 ± 0.103
0.0SerXaa: 0.0 ± 0.0
Thr
2.942ThrAla: 2.942 ± 0.126
0.171ThrCys: 0.171 ± 0.027
2.674ThrAsp: 2.674 ± 0.166
2.894ThrGlu: 2.894 ± 0.13
2.976ThrPhe: 2.976 ± 0.096
2.359ThrGly: 2.359 ± 0.108
0.939ThrHis: 0.939 ± 0.064
4.666ThrIle: 4.666 ± 0.131
5.204ThrLys: 5.204 ± 0.166
6.219ThrLeu: 6.219 ± 0.165
0.583ThrMet: 0.583 ± 0.057
4.292ThrAsn: 4.292 ± 0.234
2.064ThrPro: 2.064 ± 0.117
2.571ThrGln: 2.571 ± 0.139
1.526ThrArg: 1.526 ± 0.085
3.891ThrSer: 3.891 ± 0.145
3.473ThrThr: 3.473 ± 0.179
2.815ThrVal: 2.815 ± 0.117
0.459ThrTrp: 0.459 ± 0.036
2.294ThrTyr: 2.294 ± 0.096
0.0ThrXaa: 0.0 ± 0.0
Val
4.083ValAla: 4.083 ± 0.127
0.305ValCys: 0.305 ± 0.031
3.638ValAsp: 3.638 ± 0.173
3.871ValGlu: 3.871 ± 0.133
3.339ValPhe: 3.339 ± 0.141
2.647ValGly: 2.647 ± 0.12
0.85ValHis: 0.85 ± 0.069
4.817ValIle: 4.817 ± 0.166
5.208ValLys: 5.208 ± 0.147
5.667ValLeu: 5.667 ± 0.196
0.919ValMet: 0.919 ± 0.064
4.532ValAsn: 4.532 ± 0.13
1.663ValPro: 1.663 ± 0.084
1.944ValGln: 1.944 ± 0.076
1.563ValArg: 1.563 ± 0.071
4.711ValSer: 4.711 ± 0.125
2.907ValThr: 2.907 ± 0.144
4.275ValVal: 4.275 ± 0.172
0.466ValTrp: 0.466 ± 0.039
2.417ValTyr: 2.417 ± 0.103
0.0ValXaa: 0.0 ± 0.0
Trp
0.418TrpAla: 0.418 ± 0.033
0.034TrpCys: 0.034 ± 0.011
0.559TrpAsp: 0.559 ± 0.044
0.631TrpGlu: 0.631 ± 0.06
0.569TrpPhe: 0.569 ± 0.053
0.401TrpGly: 0.401 ± 0.039
0.11TrpHis: 0.11 ± 0.019
0.857TrpIle: 0.857 ± 0.055
0.826TrpLys: 0.826 ± 0.058
0.617TrpLeu: 0.617 ± 0.054
0.223TrpMet: 0.223 ± 0.028
0.778TrpAsn: 0.778 ± 0.05
0.213TrpPro: 0.213 ± 0.027
0.254TrpGln: 0.254 ± 0.034
0.322TrpArg: 0.322 ± 0.034
0.535TrpSer: 0.535 ± 0.043
0.466TrpThr: 0.466 ± 0.046
0.576TrpVal: 0.576 ± 0.047
0.195TrpTrp: 0.195 ± 0.029
0.401TrpTyr: 0.401 ± 0.034
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.3TyrAla: 2.3 ± 0.105
0.195TyrCys: 0.195 ± 0.027
2.3TyrAsp: 2.3 ± 0.094
2.705TyrGlu: 2.705 ± 0.103
2.678TyrPhe: 2.678 ± 0.119
1.814TyrGly: 1.814 ± 0.09
0.603TyrHis: 0.603 ± 0.052
2.75TyrIle: 2.75 ± 0.115
4.193TyrLys: 4.193 ± 0.137
4.855TyrLeu: 4.855 ± 0.169
0.549TyrMet: 0.549 ± 0.045
2.959TyrAsn: 2.959 ± 0.101
1.306TyrPro: 1.306 ± 0.063
1.872TyrGln: 1.872 ± 0.089
1.385TyrArg: 1.385 ± 0.071
3.233TyrSer: 3.233 ± 0.124
1.975TyrThr: 1.975 ± 0.084
2.318TyrVal: 2.318 ± 0.073
0.453TyrTrp: 0.453 ± 0.039
1.831TyrTyr: 1.831 ± 0.09
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 753 proteins (291682 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski