Amino acid dipepetide frequency for Candidatus Marinimicrobia bacterium MT.SAG.4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.616AlaAla: 5.616 ± 0.159
0.485AlaCys: 0.485 ± 0.035
3.795AlaAsp: 3.795 ± 0.108
5.05AlaGlu: 5.05 ± 0.123
2.747AlaPhe: 2.747 ± 0.1
5.403AlaGly: 5.403 ± 0.127
1.056AlaHis: 1.056 ± 0.056
5.454AlaIle: 5.454 ± 0.13
3.901AlaLys: 3.901 ± 0.121
6.981AlaLeu: 6.981 ± 0.141
1.742AlaMet: 1.742 ± 0.074
2.592AlaAsn: 2.592 ± 0.08
1.901AlaPro: 1.901 ± 0.054
1.73AlaGln: 1.73 ± 0.067
2.722AlaArg: 2.722 ± 0.091
4.256AlaSer: 4.256 ± 0.101
3.188AlaThr: 3.188 ± 0.106
5.04AlaVal: 5.04 ± 0.136
0.598AlaTrp: 0.598 ± 0.04
2.115AlaTyr: 2.115 ± 0.074
0.0AlaXaa: 0.0 ± 0.0
Cys
0.426CysAla: 0.426 ± 0.041
0.086CysCys: 0.086 ± 0.014
0.38CysAsp: 0.38 ± 0.031
0.363CysGlu: 0.363 ± 0.034
0.211CysPhe: 0.211 ± 0.021
0.728CysGly: 0.728 ± 0.053
0.221CysHis: 0.221 ± 0.043
0.399CysIle: 0.399 ± 0.033
0.375CysLys: 0.375 ± 0.031
0.443CysLeu: 0.443 ± 0.034
0.132CysMet: 0.132 ± 0.017
0.25CysAsn: 0.25 ± 0.025
0.363CysPro: 0.363 ± 0.035
0.145CysGln: 0.145 ± 0.019
0.296CysArg: 0.296 ± 0.028
0.505CysSer: 0.505 ± 0.036
0.306CysThr: 0.306 ± 0.028
0.404CysVal: 0.404 ± 0.031
0.054CysTrp: 0.054 ± 0.012
0.198CysTyr: 0.198 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
3.663AspAla: 3.663 ± 0.096
0.35AspCys: 0.35 ± 0.034
3.455AspAsp: 3.455 ± 0.09
4.633AspGlu: 4.633 ± 0.128
2.862AspPhe: 2.862 ± 0.081
4.374AspGly: 4.374 ± 0.132
0.887AspHis: 0.887 ± 0.05
4.969AspIle: 4.969 ± 0.114
3.788AspLys: 3.788 ± 0.096
5.814AspLeu: 5.814 ± 0.142
1.5AspMet: 1.5 ± 0.06
2.494AspAsn: 2.494 ± 0.099
2.244AspPro: 2.244 ± 0.09
1.176AspGln: 1.176 ± 0.052
2.614AspArg: 2.614 ± 0.083
4.623AspSer: 4.623 ± 0.124
2.531AspThr: 2.531 ± 0.086
3.629AspVal: 3.629 ± 0.108
0.642AspTrp: 0.642 ± 0.04
2.286AspTyr: 2.286 ± 0.071
0.0AspXaa: 0.0 ± 0.0
Glu
4.511GluAla: 4.511 ± 0.14
0.345GluCys: 0.345 ± 0.029
3.761GluAsp: 3.761 ± 0.1
5.868GluGlu: 5.868 ± 0.176
3.124GluPhe: 3.124 ± 0.091
4.56GluGly: 4.56 ± 0.115
1.11GluHis: 1.11 ± 0.052
6.304GluIle: 6.304 ± 0.135
5.731GluLys: 5.731 ± 0.143
7.36GluLeu: 7.36 ± 0.154
2.137GluMet: 2.137 ± 0.074
3.827GluAsn: 3.827 ± 0.1
2.137GluPro: 2.137 ± 0.073
1.789GluGln: 1.789 ± 0.068
3.511GluArg: 3.511 ± 0.116
4.866GluSer: 4.866 ± 0.13
3.45GluThr: 3.45 ± 0.092
4.462GluVal: 4.462 ± 0.112
0.855GluTrp: 0.855 ± 0.056
2.607GluTyr: 2.607 ± 0.083
0.0GluXaa: 0.0 ± 0.0
Phe
2.896PheAla: 2.896 ± 0.091
0.316PheCys: 0.316 ± 0.031
2.994PheAsp: 2.994 ± 0.099
2.94PheGlu: 2.94 ± 0.085
2.016PhePhe: 2.016 ± 0.093
3.692PheGly: 3.692 ± 0.101
0.806PheHis: 0.806 ± 0.047
3.518PheIle: 3.518 ± 0.101
2.619PheLys: 2.619 ± 0.088
4.244PheLeu: 4.244 ± 0.121
1.144PheMet: 1.144 ± 0.052
2.286PheAsn: 2.286 ± 0.069
1.647PhePro: 1.647 ± 0.066
1.188PheGln: 1.188 ± 0.049
2.213PheArg: 2.213 ± 0.081
3.928PheSer: 3.928 ± 0.114
2.458PheThr: 2.458 ± 0.084
2.685PheVal: 2.685 ± 0.081
0.5PheTrp: 0.5 ± 0.036
1.703PheTyr: 1.703 ± 0.064
0.0PheXaa: 0.0 ± 0.0
Gly
5.001GlyAla: 5.001 ± 0.125
0.571GlyCys: 0.571 ± 0.038
4.278GlyAsp: 4.278 ± 0.121
5.087GlyGlu: 5.087 ± 0.113
3.636GlyPhe: 3.636 ± 0.11
5.621GlyGly: 5.621 ± 0.153
1.254GlyHis: 1.254 ± 0.06
6.608GlyIle: 6.608 ± 0.153
5.062GlyLys: 5.062 ± 0.139
6.444GlyLeu: 6.444 ± 0.119
2.078GlyMet: 2.078 ± 0.08
3.197GlyAsn: 3.197 ± 0.085
1.813GlyPro: 1.813 ± 0.081
1.617GlyGln: 1.617 ± 0.066
3.246GlyArg: 3.246 ± 0.092
5.199GlySer: 5.199 ± 0.113
3.955GlyThr: 3.955 ± 0.109
5.126GlyVal: 5.126 ± 0.134
0.951GlyTrp: 0.951 ± 0.058
2.845GlyTyr: 2.845 ± 0.093
0.0GlyXaa: 0.0 ± 0.0
His
1.032HisAla: 1.032 ± 0.051
0.13HisCys: 0.13 ± 0.017
0.926HisAsp: 0.926 ± 0.057
1.078HisGlu: 1.078 ± 0.048
0.858HisPhe: 0.858 ± 0.047
1.223HisGly: 1.223 ± 0.059
0.341HisHis: 0.341 ± 0.029
1.205HisIle: 1.205 ± 0.063
0.919HisLys: 0.919 ± 0.048
1.722HisLeu: 1.722 ± 0.07
0.394HisMet: 0.394 ± 0.029
0.637HisAsn: 0.637 ± 0.038
0.924HisPro: 0.924 ± 0.049
0.483HisGln: 0.483 ± 0.04
0.799HisArg: 0.799 ± 0.05
1.259HisSer: 1.259 ± 0.062
0.887HisThr: 0.887 ± 0.052
0.882HisVal: 0.882 ± 0.048
0.167HisTrp: 0.167 ± 0.021
0.681HisTyr: 0.681 ± 0.039
0.0HisXaa: 0.0 ± 0.0
Ile
5.986IleAla: 5.986 ± 0.141
0.541IleCys: 0.541 ± 0.041
5.175IleAsp: 5.175 ± 0.137
6.17IleGlu: 6.17 ± 0.121
3.621IlePhe: 3.621 ± 0.106
6.206IleGly: 6.206 ± 0.13
1.375IleHis: 1.375 ± 0.054
6.745IleIle: 6.745 ± 0.161
5.038IleLys: 5.038 ± 0.123
7.821IleLeu: 7.821 ± 0.146
1.553IleMet: 1.553 ± 0.064
3.59IleAsn: 3.59 ± 0.103
3.45IlePro: 3.45 ± 0.101
1.916IleGln: 1.916 ± 0.069
3.803IleArg: 3.803 ± 0.12
6.807IleSer: 6.807 ± 0.136
4.371IleThr: 4.371 ± 0.112
5.101IleVal: 5.101 ± 0.132
0.794IleTrp: 0.794 ± 0.05
2.872IleTyr: 2.872 ± 0.096
0.0IleXaa: 0.0 ± 0.0
Lys
3.999LysAla: 3.999 ± 0.114
0.377LysCys: 0.377 ± 0.032
3.46LysAsp: 3.46 ± 0.103
5.3LysGlu: 5.3 ± 0.136
2.668LysPhe: 2.668 ± 0.088
4.126LysGly: 4.126 ± 0.105
1.032LysHis: 1.032 ± 0.058
6.189LysIle: 6.189 ± 0.147
5.172LysLys: 5.172 ± 0.158
5.983LysLeu: 5.983 ± 0.125
1.776LysMet: 1.776 ± 0.075
3.278LysAsn: 3.278 ± 0.078
2.217LysPro: 2.217 ± 0.085
1.561LysGln: 1.561 ± 0.059
3.332LysArg: 3.332 ± 0.092
4.871LysSer: 4.871 ± 0.108
3.175LysThr: 3.175 ± 0.097
4.067LysVal: 4.067 ± 0.097
0.662LysTrp: 0.662 ± 0.046
2.573LysTyr: 2.573 ± 0.079
0.0LysXaa: 0.0 ± 0.0
Leu
6.177LeuAla: 6.177 ± 0.147
0.541LeuCys: 0.541 ± 0.036
5.185LeuAsp: 5.185 ± 0.114
6.336LeuGlu: 6.336 ± 0.142
4.842LeuPhe: 4.842 ± 0.138
6.726LeuGly: 6.726 ± 0.135
1.438LeuHis: 1.438 ± 0.06
7.921LeuIle: 7.921 ± 0.168
6.821LeuLys: 6.821 ± 0.139
9.997LeuLeu: 9.997 ± 0.19
2.487LeuMet: 2.487 ± 0.082
4.903LeuAsn: 4.903 ± 0.124
3.896LeuPro: 3.896 ± 0.11
2.533LeuGln: 2.533 ± 0.082
4.638LeuArg: 4.638 ± 0.108
8.252LeuSer: 8.252 ± 0.158
5.809LeuThr: 5.809 ± 0.124
5.287LeuVal: 5.287 ± 0.115
0.823LeuTrp: 0.823 ± 0.043
2.96LeuTyr: 2.96 ± 0.091
0.0LeuXaa: 0.0 ± 0.0
Met
1.791MetAla: 1.791 ± 0.075
0.115MetCys: 0.115 ± 0.016
1.228MetAsp: 1.228 ± 0.056
1.769MetGlu: 1.769 ± 0.07
0.938MetPhe: 0.938 ± 0.052
1.916MetGly: 1.916 ± 0.066
0.35MetHis: 0.35 ± 0.029
1.992MetIle: 1.992 ± 0.066
2.122MetLys: 2.122 ± 0.068
2.242MetLeu: 2.242 ± 0.086
0.791MetMet: 0.791 ± 0.048
1.524MetAsn: 1.524 ± 0.061
0.985MetPro: 0.985 ± 0.054
0.666MetGln: 0.666 ± 0.04
1.277MetArg: 1.277 ± 0.059
1.791MetSer: 1.791 ± 0.067
1.46MetThr: 1.46 ± 0.051
1.541MetVal: 1.541 ± 0.064
0.184MetTrp: 0.184 ± 0.021
0.603MetTyr: 0.603 ± 0.043
0.0MetXaa: 0.0 ± 0.0
Asn
2.688AsnAla: 2.688 ± 0.084
0.319AsnCys: 0.319 ± 0.027
2.622AsnAsp: 2.622 ± 0.083
3.063AsnGlu: 3.063 ± 0.082
2.176AsnPhe: 2.176 ± 0.079
3.398AsnGly: 3.398 ± 0.122
0.747AsnHis: 0.747 ± 0.046
4.141AsnIle: 4.141 ± 0.107
2.734AsnLys: 2.734 ± 0.077
4.846AsnLeu: 4.846 ± 0.116
1.218AsnMet: 1.218 ± 0.05
2.203AsnAsn: 2.203 ± 0.077
2.288AsnPro: 2.288 ± 0.077
1.09AsnGln: 1.09 ± 0.052
2.301AsnArg: 2.301 ± 0.085
3.729AsnSer: 3.729 ± 0.101
1.95AsnThr: 1.95 ± 0.067
2.825AsnVal: 2.825 ± 0.081
0.59AsnTrp: 0.59 ± 0.047
1.852AsnTyr: 1.852 ± 0.067
0.0AsnXaa: 0.0 ± 0.0
Pro
2.232ProAla: 2.232 ± 0.094
0.174ProCys: 0.174 ± 0.021
2.416ProAsp: 2.416 ± 0.081
3.322ProGlu: 3.322 ± 0.094
1.921ProPhe: 1.921 ± 0.065
2.742ProGly: 2.742 ± 0.095
0.615ProHis: 0.615 ± 0.041
2.825ProIle: 2.825 ± 0.095
2.004ProLys: 2.004 ± 0.064
3.313ProLeu: 3.313 ± 0.093
0.921ProMet: 0.921 ± 0.048
1.691ProAsn: 1.691 ± 0.061
1.144ProPro: 1.144 ± 0.051
0.926ProGln: 0.926 ± 0.049
1.313ProArg: 1.313 ± 0.064
2.384ProSer: 2.384 ± 0.078
1.811ProThr: 1.811 ± 0.071
2.627ProVal: 2.627 ± 0.08
0.394ProTrp: 0.394 ± 0.027
1.242ProTyr: 1.242 ± 0.052
0.0ProXaa: 0.0 ± 0.0
Gln
1.509GlnAla: 1.509 ± 0.07
0.127GlnCys: 0.127 ± 0.021
1.22GlnAsp: 1.22 ± 0.059
1.634GlnGlu: 1.634 ± 0.062
1.213GlnPhe: 1.213 ± 0.052
1.48GlnGly: 1.48 ± 0.062
0.365GlnHis: 0.365 ± 0.027
1.955GlnIle: 1.955 ± 0.072
1.82GlnLys: 1.82 ± 0.068
2.575GlnLeu: 2.575 ± 0.077
0.693GlnMet: 0.693 ± 0.043
1.365GlnAsn: 1.365 ± 0.056
0.916GlnPro: 0.916 ± 0.042
0.742GlnGln: 0.742 ± 0.045
1.191GlnArg: 1.191 ± 0.064
1.691GlnSer: 1.691 ± 0.064
1.35GlnThr: 1.35 ± 0.06
1.507GlnVal: 1.507 ± 0.059
0.255GlnTrp: 0.255 ± 0.025
0.865GlnTyr: 0.865 ± 0.048
0.0GlnXaa: 0.0 ± 0.0
Arg
2.992ArgAla: 2.992 ± 0.101
0.255ArgCys: 0.255 ± 0.025
2.514ArgAsp: 2.514 ± 0.084
3.472ArgGlu: 3.472 ± 0.1
2.134ArgPhe: 2.134 ± 0.073
2.948ArgGly: 2.948 ± 0.091
0.809ArgHis: 0.809 ± 0.046
3.884ArgIle: 3.884 ± 0.1
3.291ArgLys: 3.291 ± 0.089
4.472ArgLeu: 4.472 ± 0.099
1.301ArgMet: 1.301 ± 0.06
2.303ArgAsn: 2.303 ± 0.086
1.289ArgPro: 1.289 ± 0.056
1.218ArgGln: 1.218 ± 0.061
2.391ArgArg: 2.391 ± 0.111
3.193ArgSer: 3.193 ± 0.1
2.311ArgThr: 2.311 ± 0.076
2.992ArgVal: 2.992 ± 0.093
0.524ArgTrp: 0.524 ± 0.034
1.718ArgTyr: 1.718 ± 0.074
0.0ArgXaa: 0.0 ± 0.0
Ser
5.121SerAla: 5.121 ± 0.103
0.512SerCys: 0.512 ± 0.038
4.793SerAsp: 4.793 ± 0.108
5.405SerGlu: 5.405 ± 0.111
3.455SerPhe: 3.455 ± 0.1
6.027SerGly: 6.027 ± 0.129
1.188SerHis: 1.188 ± 0.061
5.954SerIle: 5.954 ± 0.14
4.616SerLys: 4.616 ± 0.106
7.201SerLeu: 7.201 ± 0.133
1.664SerMet: 1.664 ± 0.07
3.291SerAsn: 3.291 ± 0.102
2.688SerPro: 2.688 ± 0.085
1.715SerGln: 1.715 ± 0.064
3.097SerArg: 3.097 ± 0.101
5.748SerSer: 5.748 ± 0.144
3.763SerThr: 3.763 ± 0.103
5.118SerVal: 5.118 ± 0.124
0.85SerTrp: 0.85 ± 0.049
2.455SerTyr: 2.455 ± 0.078
0.0SerXaa: 0.0 ± 0.0
Thr
3.71ThrAla: 3.71 ± 0.122
0.289ThrCys: 0.289 ± 0.029
3.408ThrAsp: 3.408 ± 0.107
3.42ThrGlu: 3.42 ± 0.105
2.44ThrPhe: 2.44 ± 0.089
4.464ThrGly: 4.464 ± 0.105
0.899ThrHis: 0.899 ± 0.054
4.298ThrIle: 4.298 ± 0.102
2.788ThrLys: 2.788 ± 0.087
5.537ThrLeu: 5.537 ± 0.122
1.181ThrMet: 1.181 ± 0.049
2.097ThrAsn: 2.097 ± 0.076
2.208ThrPro: 2.208 ± 0.075
1.232ThrGln: 1.232 ± 0.054
1.936ThrArg: 1.936 ± 0.067
3.207ThrSer: 3.207 ± 0.093
2.962ThrThr: 2.962 ± 0.096
3.492ThrVal: 3.492 ± 0.095
0.451ThrTrp: 0.451 ± 0.035
1.691ThrTyr: 1.691 ± 0.072
0.0ThrXaa: 0.0 ± 0.0
Val
4.28ValAla: 4.28 ± 0.117
0.451ValCys: 0.451 ± 0.035
3.908ValAsp: 3.908 ± 0.097
4.44ValGlu: 4.44 ± 0.103
2.6ValPhe: 2.6 ± 0.098
4.702ValGly: 4.702 ± 0.128
1.029ValHis: 1.029 ± 0.046
5.376ValIle: 5.376 ± 0.116
4.102ValLys: 4.102 ± 0.114
5.861ValLeu: 5.861 ± 0.125
1.539ValMet: 1.539 ± 0.064
2.982ValAsn: 2.982 ± 0.072
2.279ValPro: 2.279 ± 0.076
1.531ValGln: 1.531 ± 0.056
3.06ValArg: 3.06 ± 0.093
4.672ValSer: 4.672 ± 0.104
3.67ValThr: 3.67 ± 0.102
4.295ValVal: 4.295 ± 0.119
0.649ValTrp: 0.649 ± 0.039
2.129ValTyr: 2.129 ± 0.074
0.0ValXaa: 0.0 ± 0.0
Trp
0.617TrpAla: 0.617 ± 0.039
0.054TrpCys: 0.054 ± 0.012
0.701TrpAsp: 0.701 ± 0.041
0.659TrpGlu: 0.659 ± 0.039
0.47TrpPhe: 0.47 ± 0.042
0.713TrpGly: 0.713 ± 0.044
0.257TrpHis: 0.257 ± 0.024
0.84TrpIle: 0.84 ± 0.05
0.745TrpLys: 0.745 ± 0.046
1.044TrpLeu: 1.044 ± 0.062
0.301TrpMet: 0.301 ± 0.028
0.652TrpAsn: 0.652 ± 0.051
0.221TrpPro: 0.221 ± 0.024
0.287TrpGln: 0.287 ± 0.025
0.485TrpArg: 0.485 ± 0.034
0.762TrpSer: 0.762 ± 0.049
0.59TrpThr: 0.59 ± 0.051
0.676TrpVal: 0.676 ± 0.046
0.115TrpTrp: 0.115 ± 0.017
0.328TrpTyr: 0.328 ± 0.032
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.124TyrAla: 2.124 ± 0.069
0.245TyrCys: 0.245 ± 0.025
2.318TyrAsp: 2.318 ± 0.074
2.306TyrGlu: 2.306 ± 0.082
1.862TyrPhe: 1.862 ± 0.083
2.541TyrGly: 2.541 ± 0.078
0.767TyrHis: 0.767 ± 0.044
2.355TyrIle: 2.355 ± 0.076
2.171TyrLys: 2.171 ± 0.066
3.673TyrLeu: 3.673 ± 0.103
0.73TyrMet: 0.73 ± 0.045
1.62TyrAsn: 1.62 ± 0.074
1.409TyrPro: 1.409 ± 0.063
0.929TyrGln: 0.929 ± 0.046
1.781TyrArg: 1.781 ± 0.068
2.921TyrSer: 2.921 ± 0.09
1.713TyrThr: 1.713 ± 0.072
1.798TyrVal: 1.798 ± 0.064
0.461TyrTrp: 0.461 ± 0.034
1.504TyrTyr: 1.504 ± 0.074
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1311 proteins (408134 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski