Amino acid dipepetide frequency for Dinghuibacter silviterrae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.12AlaAla: 9.12 ± 0.101
0.877AlaCys: 0.877 ± 0.023
4.589AlaAsp: 4.589 ± 0.051
3.917AlaGlu: 3.917 ± 0.059
3.957AlaPhe: 3.957 ± 0.041
7.628AlaGly: 7.628 ± 0.071
1.83AlaHis: 1.83 ± 0.032
4.515AlaIle: 4.515 ± 0.055
3.284AlaLys: 3.284 ± 0.051
8.999AlaLeu: 8.999 ± 0.091
1.87AlaMet: 1.87 ± 0.031
3.084AlaAsn: 3.084 ± 0.047
4.06AlaPro: 4.06 ± 0.059
3.391AlaGln: 3.391 ± 0.039
4.44AlaArg: 4.44 ± 0.059
5.399AlaSer: 5.399 ± 0.082
5.277AlaThr: 5.277 ± 0.097
5.756AlaVal: 5.756 ± 0.052
1.259AlaTrp: 1.259 ± 0.024
3.472AlaTyr: 3.472 ± 0.045
0.0AlaXaa: 0.0 ± 0.0
Cys
0.675CysAla: 0.675 ± 0.02
0.139CysCys: 0.139 ± 0.009
0.396CysAsp: 0.396 ± 0.014
0.316CysGlu: 0.316 ± 0.014
0.429CysPhe: 0.429 ± 0.015
0.689CysGly: 0.689 ± 0.021
0.208CysHis: 0.208 ± 0.01
0.601CysIle: 0.601 ± 0.018
0.363CysLys: 0.363 ± 0.014
0.959CysLeu: 0.959 ± 0.023
0.215CysMet: 0.215 ± 0.009
0.355CysAsn: 0.355 ± 0.014
0.401CysPro: 0.401 ± 0.016
0.261CysGln: 0.261 ± 0.011
0.44CysArg: 0.44 ± 0.016
0.558CysSer: 0.558 ± 0.018
0.576CysThr: 0.576 ± 0.021
0.566CysVal: 0.566 ± 0.018
0.144CysTrp: 0.144 ± 0.009
0.377CysTyr: 0.377 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
4.618AspAla: 4.618 ± 0.055
0.401AspCys: 0.401 ± 0.016
2.481AspAsp: 2.481 ± 0.042
2.642AspGlu: 2.642 ± 0.043
2.704AspPhe: 2.704 ± 0.042
4.223AspGly: 4.223 ± 0.059
1.21AspHis: 1.21 ± 0.025
3.395AspIle: 3.395 ± 0.046
2.797AspLys: 2.797 ± 0.047
5.241AspLeu: 5.241 ± 0.058
1.199AspMet: 1.199 ± 0.026
2.323AspAsn: 2.323 ± 0.038
2.997AspPro: 2.997 ± 0.046
1.9AspGln: 1.9 ± 0.033
2.854AspArg: 2.854 ± 0.041
3.443AspSer: 3.443 ± 0.057
3.552AspThr: 3.552 ± 0.054
3.639AspVal: 3.639 ± 0.042
0.888AspTrp: 0.888 ± 0.021
2.409AspTyr: 2.409 ± 0.036
0.0AspXaa: 0.0 ± 0.0
Glu
4.577GluAla: 4.577 ± 0.061
0.317GluCys: 0.317 ± 0.014
2.656GluAsp: 2.656 ± 0.042
3.091GluGlu: 3.091 ± 0.058
1.76GluPhe: 1.76 ± 0.029
3.765GluGly: 3.765 ± 0.05
1.112GluHis: 1.112 ± 0.026
2.652GluIle: 2.652 ± 0.042
3.041GluLys: 3.041 ± 0.048
4.557GluLeu: 4.557 ± 0.064
1.138GluMet: 1.138 ± 0.023
2.105GluAsn: 2.105 ± 0.036
1.823GluPro: 1.823 ± 0.032
2.008GluGln: 2.008 ± 0.032
2.897GluArg: 2.897 ± 0.048
2.264GluSer: 2.264 ± 0.036
2.708GluThr: 2.708 ± 0.038
3.57GluVal: 3.57 ± 0.06
0.714GluTrp: 0.714 ± 0.02
1.737GluTyr: 1.737 ± 0.029
0.0GluXaa: 0.0 ± 0.0
Phe
3.464PheAla: 3.464 ± 0.041
0.492PheCys: 0.492 ± 0.018
2.756PheAsp: 2.756 ± 0.032
2.056PheGlu: 2.056 ± 0.036
2.371PhePhe: 2.371 ± 0.039
3.396PheGly: 3.396 ± 0.043
1.032PheHis: 1.032 ± 0.022
2.542PheIle: 2.542 ± 0.042
1.943PheLys: 1.943 ± 0.037
4.451PheLeu: 4.451 ± 0.057
0.995PheMet: 0.995 ± 0.024
2.154PheAsn: 2.154 ± 0.033
1.986PhePro: 1.986 ± 0.029
1.586PheGln: 1.586 ± 0.03
2.355PheArg: 2.355 ± 0.032
3.31PheSer: 3.31 ± 0.044
3.187PheThr: 3.187 ± 0.044
3.01PheVal: 3.01 ± 0.043
0.669PheTrp: 0.669 ± 0.019
2.001PheTyr: 2.001 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
6.726GlyAla: 6.726 ± 0.082
0.76GlyCys: 0.76 ± 0.027
4.235GlyAsp: 4.235 ± 0.056
3.449GlyGlu: 3.449 ± 0.051
3.72GlyPhe: 3.72 ± 0.046
6.495GlyGly: 6.495 ± 0.08
1.655GlyHis: 1.655 ± 0.031
4.854GlyIle: 4.854 ± 0.054
4.239GlyLys: 4.239 ± 0.046
7.473GlyLeu: 7.473 ± 0.067
1.835GlyMet: 1.835 ± 0.035
3.603GlyAsn: 3.603 ± 0.054
2.742GlyPro: 2.742 ± 0.051
2.905GlyGln: 2.905 ± 0.039
4.016GlyArg: 4.016 ± 0.05
5.001GlySer: 5.001 ± 0.07
5.229GlyThr: 5.229 ± 0.093
5.582GlyVal: 5.582 ± 0.055
1.303GlyTrp: 1.303 ± 0.028
3.527GlyTyr: 3.527 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
1.615HisAla: 1.615 ± 0.029
0.223HisCys: 0.223 ± 0.011
0.999HisAsp: 0.999 ± 0.024
1.008HisGlu: 1.008 ± 0.022
1.345HisPhe: 1.345 ± 0.032
1.467HisGly: 1.467 ± 0.031
0.643HisHis: 0.643 ± 0.018
1.386HisIle: 1.386 ± 0.025
0.87HisLys: 0.87 ± 0.023
2.399HisLeu: 2.399 ± 0.04
0.368HisMet: 0.368 ± 0.014
0.792HisAsn: 0.792 ± 0.018
1.394HisPro: 1.394 ± 0.03
0.852HisGln: 0.852 ± 0.022
1.218HisArg: 1.218 ± 0.027
1.125HisSer: 1.125 ± 0.03
1.296HisThr: 1.296 ± 0.028
1.344HisVal: 1.344 ± 0.025
0.419HisTrp: 0.419 ± 0.015
1.024HisTyr: 1.024 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
4.998IleAla: 4.998 ± 0.063
0.529IleCys: 0.529 ± 0.018
3.46IleAsp: 3.46 ± 0.051
2.771IleGlu: 2.771 ± 0.045
2.332IlePhe: 2.332 ± 0.039
4.301IleGly: 4.301 ± 0.052
1.381IleHis: 1.381 ± 0.03
2.91IleIle: 2.91 ± 0.043
2.581IleLys: 2.581 ± 0.044
5.324IleLeu: 5.324 ± 0.063
0.985IleMet: 0.985 ± 0.025
2.541IleAsn: 2.541 ± 0.038
3.051IlePro: 3.051 ± 0.036
2.133IleGln: 2.133 ± 0.037
3.621IleArg: 3.621 ± 0.045
3.383IleSer: 3.383 ± 0.042
3.669IleThr: 3.669 ± 0.056
3.699IleVal: 3.699 ± 0.047
0.636IleTrp: 0.636 ± 0.022
2.019IleTyr: 2.019 ± 0.034
0.0IleXaa: 0.0 ± 0.0
Lys
4.239LysAla: 4.239 ± 0.054
0.23LysCys: 0.23 ± 0.013
3.173LysAsp: 3.173 ± 0.047
3.03LysGlu: 3.03 ± 0.044
1.452LysPhe: 1.452 ± 0.029
4.051LysGly: 4.051 ± 0.046
0.875LysHis: 0.875 ± 0.02
2.788LysIle: 2.788 ± 0.046
2.931LysLys: 2.931 ± 0.054
3.641LysLeu: 3.641 ± 0.049
1.216LysMet: 1.216 ± 0.027
2.167LysAsn: 2.167 ± 0.037
2.12LysPro: 2.12 ± 0.036
1.537LysGln: 1.537 ± 0.03
2.328LysArg: 2.328 ± 0.037
2.321LysSer: 2.321 ± 0.037
3.131LysThr: 3.131 ± 0.038
3.469LysVal: 3.469 ± 0.038
0.581LysTrp: 0.581 ± 0.018
1.736LysTyr: 1.736 ± 0.033
0.0LysXaa: 0.0 ± 0.0
Leu
8.12LeuAla: 8.12 ± 0.077
1.009LeuCys: 1.009 ± 0.023
5.454LeuAsp: 5.454 ± 0.058
4.934LeuGlu: 4.934 ± 0.07
4.502LeuPhe: 4.502 ± 0.06
6.936LeuGly: 6.936 ± 0.051
2.33LeuHis: 2.33 ± 0.036
4.921LeuIle: 4.921 ± 0.065
4.831LeuLys: 4.831 ± 0.052
10.586LeuLeu: 10.586 ± 0.101
2.115LeuMet: 2.115 ± 0.037
3.98LeuAsn: 3.98 ± 0.051
4.993LeuPro: 4.993 ± 0.054
4.061LeuGln: 4.061 ± 0.049
5.359LeuArg: 5.359 ± 0.066
7.082LeuSer: 7.082 ± 0.07
6.093LeuThr: 6.093 ± 0.075
6.472LeuVal: 6.472 ± 0.075
1.272LeuTrp: 1.272 ± 0.027
3.608LeuTyr: 3.608 ± 0.046
0.0LeuXaa: 0.0 ± 0.0
Met
1.954MetAla: 1.954 ± 0.031
0.129MetCys: 0.129 ± 0.008
1.326MetAsp: 1.326 ± 0.028
1.344MetGlu: 1.344 ± 0.029
0.663MetPhe: 0.663 ± 0.019
1.697MetGly: 1.697 ± 0.029
0.495MetHis: 0.495 ± 0.016
1.264MetIle: 1.264 ± 0.023
1.348MetLys: 1.348 ± 0.025
1.845MetLeu: 1.845 ± 0.034
0.557MetMet: 0.557 ± 0.02
1.029MetAsn: 1.029 ± 0.026
1.083MetPro: 1.083 ± 0.026
0.864MetGln: 0.864 ± 0.022
1.254MetArg: 1.254 ± 0.025
1.275MetSer: 1.275 ± 0.022
1.466MetThr: 1.466 ± 0.029
1.401MetVal: 1.401 ± 0.024
0.175MetTrp: 0.175 ± 0.01
0.695MetTyr: 0.695 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
3.583AsnAla: 3.583 ± 0.05
0.353AsnCys: 0.353 ± 0.014
2.174AsnAsp: 2.174 ± 0.031
1.873AsnGlu: 1.873 ± 0.032
1.924AsnPhe: 1.924 ± 0.036
3.839AsnGly: 3.839 ± 0.063
0.846AsnHis: 0.846 ± 0.02
2.712AsnIle: 2.712 ± 0.043
1.788AsnLys: 1.788 ± 0.027
3.979AsnLeu: 3.979 ± 0.047
0.916AsnMet: 0.916 ± 0.02
2.226AsnAsn: 2.226 ± 0.045
2.685AsnPro: 2.685 ± 0.049
1.557AsnGln: 1.557 ± 0.033
2.082AsnArg: 2.082 ± 0.032
2.301AsnSer: 2.301 ± 0.047
2.853AsnThr: 2.853 ± 0.05
2.721AsnVal: 2.721 ± 0.045
0.645AsnTrp: 0.645 ± 0.02
2.034AsnTyr: 2.034 ± 0.042
0.0AsnXaa: 0.0 ± 0.0
Pro
4.914ProAla: 4.914 ± 0.062
0.314ProCys: 0.314 ± 0.013
3.161ProAsp: 3.161 ± 0.045
2.742ProGlu: 2.742 ± 0.036
2.227ProPhe: 2.227 ± 0.034
4.662ProGly: 4.662 ± 0.056
0.958ProHis: 0.958 ± 0.025
2.149ProIle: 2.149 ± 0.034
1.689ProLys: 1.689 ± 0.03
4.472ProLeu: 4.472 ± 0.046
0.974ProMet: 0.974 ± 0.022
1.799ProAsn: 1.799 ± 0.037
1.995ProPro: 1.995 ± 0.047
1.575ProGln: 1.575 ± 0.027
1.855ProArg: 1.855 ± 0.029
3.091ProSer: 3.091 ± 0.046
2.538ProThr: 2.538 ± 0.048
4.054ProVal: 4.054 ± 0.053
0.655ProTrp: 0.655 ± 0.018
1.907ProTyr: 1.907 ± 0.037
0.0ProXaa: 0.0 ± 0.0
Gln
3.227GlnAla: 3.227 ± 0.042
0.218GlnCys: 0.218 ± 0.01
1.856GlnAsp: 1.856 ± 0.031
1.868GlnGlu: 1.868 ± 0.037
1.614GlnPhe: 1.614 ± 0.027
2.678GlnGly: 2.678 ± 0.037
0.85GlnHis: 0.85 ± 0.021
1.834GlnIle: 1.834 ± 0.031
1.944GlnLys: 1.944 ± 0.028
3.599GlnLeu: 3.599 ± 0.049
0.926GlnMet: 0.926 ± 0.022
1.62GlnAsn: 1.62 ± 0.038
1.884GlnPro: 1.884 ± 0.034
1.839GlnGln: 1.839 ± 0.037
1.895GlnArg: 1.895 ± 0.036
1.965GlnSer: 1.965 ± 0.036
2.332GlnThr: 2.332 ± 0.041
2.83GlnVal: 2.83 ± 0.035
0.567GlnTrp: 0.567 ± 0.021
1.641GlnTyr: 1.641 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
3.823ArgAla: 3.823 ± 0.053
0.37ArgCys: 0.37 ± 0.013
2.719ArgAsp: 2.719 ± 0.043
2.936ArgGlu: 2.936 ± 0.046
2.664ArgPhe: 2.664 ± 0.045
3.059ArgGly: 3.059 ± 0.045
1.204ArgHis: 1.204 ± 0.028
3.383ArgIle: 3.383 ± 0.047
2.906ArgLys: 2.906 ± 0.043
5.522ArgLeu: 5.522 ± 0.068
1.428ArgMet: 1.428 ± 0.027
2.171ArgAsn: 2.171 ± 0.033
2.255ArgPro: 2.255 ± 0.039
2.117ArgGln: 2.117 ± 0.036
2.853ArgArg: 2.853 ± 0.054
2.821ArgSer: 2.821 ± 0.044
2.886ArgThr: 2.886 ± 0.037
3.574ArgVal: 3.574 ± 0.049
0.966ArgTrp: 0.966 ± 0.023
2.413ArgTyr: 2.413 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
5.274SerAla: 5.274 ± 0.065
0.577SerCys: 0.577 ± 0.02
3.079SerAsp: 3.079 ± 0.037
2.411SerGlu: 2.411 ± 0.04
3.178SerPhe: 3.178 ± 0.041
5.594SerGly: 5.594 ± 0.083
1.092SerHis: 1.092 ± 0.021
3.701SerIle: 3.701 ± 0.047
2.332SerLys: 2.332 ± 0.035
6.501SerLeu: 6.501 ± 0.065
1.316SerMet: 1.316 ± 0.023
2.54SerAsn: 2.54 ± 0.044
2.909SerPro: 2.909 ± 0.04
1.822SerGln: 1.822 ± 0.029
2.814SerArg: 2.814 ± 0.042
3.9SerSer: 3.9 ± 0.071
3.853SerThr: 3.853 ± 0.065
4.583SerVal: 4.583 ± 0.065
0.921SerTrp: 0.921 ± 0.025
2.604SerTyr: 2.604 ± 0.049
0.0SerXaa: 0.0 ± 0.0
Thr
5.851ThrAla: 5.851 ± 0.09
0.476ThrCys: 0.476 ± 0.016
3.442ThrAsp: 3.442 ± 0.047
2.551ThrGlu: 2.551 ± 0.036
2.889ThrPhe: 2.889 ± 0.038
6.147ThrGly: 6.147 ± 0.09
1.273ThrHis: 1.273 ± 0.027
3.656ThrIle: 3.656 ± 0.053
2.251ThrLys: 2.251 ± 0.035
6.596ThrLeu: 6.596 ± 0.068
1.086ThrMet: 1.086 ± 0.019
2.5ThrAsn: 2.5 ± 0.051
3.496ThrPro: 3.496 ± 0.053
2.089ThrGln: 2.089 ± 0.037
2.844ThrArg: 2.844 ± 0.035
3.671ThrSer: 3.671 ± 0.071
4.18ThrThr: 4.18 ± 0.086
4.946ThrVal: 4.946 ± 0.097
0.93ThrTrp: 0.93 ± 0.025
2.767ThrTyr: 2.767 ± 0.059
0.0ThrXaa: 0.0 ± 0.0
Val
5.599ValAla: 5.599 ± 0.061
0.73ValCys: 0.73 ± 0.022
3.794ValAsp: 3.794 ± 0.05
3.131ValGlu: 3.131 ± 0.046
3.351ValPhe: 3.351 ± 0.044
4.501ValGly: 4.501 ± 0.056
1.558ValHis: 1.558 ± 0.032
4.03ValIle: 4.03 ± 0.048
3.12ValLys: 3.12 ± 0.041
7.111ValLeu: 7.111 ± 0.065
1.473ValMet: 1.473 ± 0.027
3.164ValAsn: 3.164 ± 0.053
3.29ValPro: 3.29 ± 0.043
2.419ValGln: 2.419 ± 0.033
3.938ValArg: 3.938 ± 0.049
4.783ValSer: 4.783 ± 0.061
4.876ValThr: 4.876 ± 0.101
5.069ValVal: 5.069 ± 0.053
0.943ValTrp: 0.943 ± 0.023
2.854ValTyr: 2.854 ± 0.04
0.0ValXaa: 0.0 ± 0.0
Trp
1.045TrpAla: 1.045 ± 0.026
0.147TrpCys: 0.147 ± 0.009
0.778TrpAsp: 0.778 ± 0.02
0.698TrpGlu: 0.698 ± 0.019
0.645TrpPhe: 0.645 ± 0.02
1.123TrpGly: 1.123 ± 0.03
0.31TrpHis: 0.31 ± 0.013
0.841TrpIle: 0.841 ± 0.022
0.807TrpLys: 0.807 ± 0.025
1.453TrpLeu: 1.453 ± 0.03
0.444TrpMet: 0.444 ± 0.015
0.758TrpAsn: 0.758 ± 0.022
0.514TrpPro: 0.514 ± 0.018
0.6TrpGln: 0.6 ± 0.018
0.672TrpArg: 0.672 ± 0.017
0.856TrpSer: 0.856 ± 0.022
0.932TrpThr: 0.932 ± 0.026
1.023TrpVal: 1.023 ± 0.022
0.335TrpTrp: 0.335 ± 0.014
0.619TrpTyr: 0.619 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.303TyrAla: 3.303 ± 0.044
0.378TyrCys: 0.378 ± 0.013
2.386TyrAsp: 2.386 ± 0.041
1.728TyrGlu: 1.728 ± 0.029
2.027TyrPhe: 2.027 ± 0.032
3.096TyrGly: 3.096 ± 0.044
0.924TyrHis: 0.924 ± 0.022
2.187TyrIle: 2.187 ± 0.034
1.951TyrLys: 1.951 ± 0.03
3.951TyrLeu: 3.951 ± 0.046
0.806TyrMet: 0.806 ± 0.022
2.181TyrAsn: 2.181 ± 0.047
2.053TyrPro: 2.053 ± 0.035
1.671TyrGln: 1.671 ± 0.037
2.334TyrArg: 2.334 ± 0.034
2.451TyrSer: 2.451 ± 0.044
3.005TyrThr: 3.005 ± 0.055
2.43TyrVal: 2.43 ± 0.038
0.582TyrTrp: 0.582 ± 0.018
1.949TyrTyr: 1.949 ± 0.036
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5399 proteins (2034043 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski