Amino acid dipepetide frequency for Human papillomavirus 116

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.34AlaAla: 3.34 ± 1.479
0.835AlaCys: 0.835 ± 0.53
5.846AlaAsp: 5.846 ± 0.939
4.175AlaGlu: 4.175 ± 0.892
2.923AlaPhe: 2.923 ± 0.736
2.088AlaGly: 2.088 ± 1.107
0.418AlaHis: 0.418 ± 0.335
3.758AlaIle: 3.758 ± 1.843
2.505AlaLys: 2.505 ± 0.522
5.01AlaLeu: 5.01 ± 1.252
0.418AlaMet: 0.418 ± 0.335
5.01AlaAsn: 5.01 ± 0.795
2.505AlaPro: 2.505 ± 1.205
2.088AlaGln: 2.088 ± 0.457
2.923AlaArg: 2.923 ± 1.305
3.758AlaSer: 3.758 ± 1.135
3.758AlaThr: 3.758 ± 1.766
2.505AlaVal: 2.505 ± 0.74
0.835AlaTrp: 0.835 ± 0.407
2.088AlaTyr: 2.088 ± 1.037
0.0AlaXaa: 0.0 ± 0.0
Cys
1.67CysAla: 1.67 ± 0.712
1.67CysCys: 1.67 ± 1.078
1.253CysAsp: 1.253 ± 1.048
1.67CysGlu: 1.67 ± 1.397
1.67CysPhe: 1.67 ± 0.583
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
2.088CysIle: 2.088 ± 1.157
3.34CysLys: 3.34 ± 1.439
2.088CysLeu: 2.088 ± 1.378
0.418CysMet: 0.418 ± 0.349
2.505CysAsn: 2.505 ± 1.314
0.835CysPro: 0.835 ± 0.67
0.0CysGln: 0.0 ± 0.0
0.418CysArg: 0.418 ± 0.454
0.835CysSer: 0.835 ± 0.779
1.253CysThr: 1.253 ± 1.088
0.418CysVal: 0.418 ± 0.349
0.835CysTrp: 0.835 ± 0.441
0.418CysTyr: 0.418 ± 0.454
0.0CysXaa: 0.0 ± 0.0
Asp
4.175AspAla: 4.175 ± 1.023
3.34AspCys: 3.34 ± 1.686
4.175AspAsp: 4.175 ± 0.791
7.098AspGlu: 7.098 ± 2.472
2.505AspPhe: 2.505 ± 0.466
3.34AspGly: 3.34 ± 0.749
0.418AspHis: 0.418 ± 0.381
3.758AspIle: 3.758 ± 1.514
1.253AspLys: 1.253 ± 0.658
7.516AspLeu: 7.516 ± 2.788
0.418AspMet: 0.418 ± 0.335
1.253AspAsn: 1.253 ± 0.374
3.758AspPro: 3.758 ± 1.314
1.67AspGln: 1.67 ± 0.878
2.505AspArg: 2.505 ± 1.261
4.593AspSer: 4.593 ± 1.092
5.01AspThr: 5.01 ± 1.559
6.263AspVal: 6.263 ± 1.597
0.418AspTrp: 0.418 ± 0.349
2.088AspTyr: 2.088 ± 0.76
0.0AspXaa: 0.0 ± 0.0
Glu
7.098GluAla: 7.098 ± 1.515
0.418GluCys: 0.418 ± 0.349
2.088GluAsp: 2.088 ± 0.546
7.933GluGlu: 7.933 ± 2.506
1.67GluPhe: 1.67 ± 0.982
2.923GluGly: 2.923 ± 0.7
1.67GluHis: 1.67 ± 0.982
2.088GluIle: 2.088 ± 0.922
1.67GluLys: 1.67 ± 0.778
7.098GluLeu: 7.098 ± 1.878
0.835GluMet: 0.835 ± 0.699
6.263GluAsn: 6.263 ± 1.497
2.088GluPro: 2.088 ± 0.76
2.923GluGln: 2.923 ± 0.964
2.505GluArg: 2.505 ± 0.817
4.175GluSer: 4.175 ± 1.159
3.34GluThr: 3.34 ± 1.057
4.175GluVal: 4.175 ± 0.607
0.835GluTrp: 0.835 ± 0.762
2.088GluTyr: 2.088 ± 0.906
0.0GluXaa: 0.0 ± 0.0
Phe
2.088PheAla: 2.088 ± 0.921
0.835PheCys: 0.835 ± 0.53
3.758PheAsp: 3.758 ± 1.255
4.175PheGlu: 4.175 ± 1.729
2.505PhePhe: 2.505 ± 1.249
2.505PheGly: 2.505 ± 0.859
1.253PheHis: 1.253 ± 0.554
2.088PheIle: 2.088 ± 0.891
2.505PheLys: 2.505 ± 0.884
4.593PheLeu: 4.593 ± 1.243
0.835PheMet: 0.835 ± 0.617
2.505PheAsn: 2.505 ± 0.494
2.505PhePro: 2.505 ± 1.076
2.505PheGln: 2.505 ± 1.738
1.253PheArg: 1.253 ± 0.68
2.088PheSer: 2.088 ± 0.922
0.835PheThr: 0.835 ± 0.407
2.923PheVal: 2.923 ± 0.912
0.835PheTrp: 0.835 ± 0.407
1.253PheTyr: 1.253 ± 0.383
0.0PheXaa: 0.0 ± 0.0
Gly
2.923GlyAla: 2.923 ± 0.911
0.835GlyCys: 0.835 ± 0.615
3.34GlyAsp: 3.34 ± 0.832
3.34GlyGlu: 3.34 ± 1.513
0.0GlyPhe: 0.0 ± 0.0
5.428GlyGly: 5.428 ± 1.615
1.253GlyHis: 1.253 ± 0.655
4.175GlyIle: 4.175 ± 0.437
3.758GlyLys: 3.758 ± 1.099
5.428GlyLeu: 5.428 ± 1.306
0.835GlyMet: 0.835 ± 0.432
3.758GlyAsn: 3.758 ± 1.479
3.758GlyPro: 3.758 ± 1.091
2.088GlyGln: 2.088 ± 1.391
3.34GlyArg: 3.34 ± 1.597
2.923GlySer: 2.923 ± 0.873
5.01GlyThr: 5.01 ± 1.335
2.088GlyVal: 2.088 ± 0.729
0.0GlyTrp: 0.0 ± 0.0
2.505GlyTyr: 2.505 ± 0.586
0.0GlyXaa: 0.0 ± 0.0
His
1.253HisAla: 1.253 ± 0.419
0.835HisCys: 0.835 ± 0.53
0.835HisAsp: 0.835 ± 0.698
1.67HisGlu: 1.67 ± 0.235
1.67HisPhe: 1.67 ± 0.826
1.253HisGly: 1.253 ± 0.644
0.0HisHis: 0.0 ± 0.0
1.253HisIle: 1.253 ± 0.419
1.67HisLys: 1.67 ± 0.774
2.088HisLeu: 2.088 ± 0.834
0.418HisMet: 0.418 ± 0.335
0.835HisAsn: 0.835 ± 0.419
2.088HisPro: 2.088 ± 1.13
1.253HisGln: 1.253 ± 0.575
1.67HisArg: 1.67 ± 0.577
2.088HisSer: 2.088 ± 0.511
0.418HisThr: 0.418 ± 0.335
0.835HisVal: 0.835 ± 0.386
0.418HisTrp: 0.418 ± 0.335
0.418HisTyr: 0.418 ± 0.356
0.0HisXaa: 0.0 ± 0.0
Ile
2.505IleAla: 2.505 ± 0.494
0.418IleCys: 0.418 ± 0.454
6.263IleAsp: 6.263 ± 2.356
1.67IleGlu: 1.67 ± 0.607
1.253IlePhe: 1.253 ± 0.817
2.088IleGly: 2.088 ± 1.13
0.418IleHis: 0.418 ± 0.356
1.253IleIle: 1.253 ± 0.419
1.67IleLys: 1.67 ± 0.556
7.098IleLeu: 7.098 ± 1.727
0.835IleMet: 0.835 ± 0.524
2.505IleAsn: 2.505 ± 0.719
3.34IlePro: 3.34 ± 1.26
2.923IleGln: 2.923 ± 1.241
3.34IleArg: 3.34 ± 1.457
5.01IleSer: 5.01 ± 1.068
1.253IleThr: 1.253 ± 0.686
3.34IleVal: 3.34 ± 0.759
0.418IleTrp: 0.418 ± 0.349
2.088IleTyr: 2.088 ± 1.065
0.0IleXaa: 0.0 ± 0.0
Lys
2.088LysAla: 2.088 ± 0.713
2.923LysCys: 2.923 ± 1.315
1.67LysAsp: 1.67 ± 0.805
4.175LysGlu: 4.175 ± 1.309
3.758LysPhe: 3.758 ± 1.631
2.505LysGly: 2.505 ± 0.634
1.67LysHis: 1.67 ± 0.674
1.253LysIle: 1.253 ± 0.68
2.505LysLys: 2.505 ± 0.849
4.175LysLeu: 4.175 ± 1.717
1.253LysMet: 1.253 ± 0.626
2.923LysAsn: 2.923 ± 1.104
1.67LysPro: 1.67 ± 0.751
2.088LysGln: 2.088 ± 1.222
5.846LysArg: 5.846 ± 1.089
3.34LysSer: 3.34 ± 1.213
2.088LysThr: 2.088 ± 1.065
2.505LysVal: 2.505 ± 0.849
0.835LysTrp: 0.835 ± 0.419
1.253LysTyr: 1.253 ± 0.68
0.0LysXaa: 0.0 ± 0.0
Leu
5.01LeuAla: 5.01 ± 1.591
2.088LeuCys: 2.088 ± 1.069
6.681LeuAsp: 6.681 ± 0.833
6.263LeuGlu: 6.263 ± 1.421
5.846LeuPhe: 5.846 ± 2.464
5.846LeuGly: 5.846 ± 1.661
3.758LeuHis: 3.758 ± 1.058
3.758LeuIle: 3.758 ± 1.059
3.758LeuLys: 3.758 ± 1.014
7.516LeuLeu: 7.516 ± 1.825
2.088LeuMet: 2.088 ± 0.736
2.505LeuAsn: 2.505 ± 0.667
7.098LeuPro: 7.098 ± 1.295
5.428LeuGln: 5.428 ± 1.685
6.263LeuArg: 6.263 ± 1.874
9.186LeuSer: 9.186 ± 2.732
4.593LeuThr: 4.593 ± 0.818
4.175LeuVal: 4.175 ± 1.522
0.0LeuTrp: 0.0 ± 0.0
4.593LeuTyr: 4.593 ± 0.605
0.0LeuXaa: 0.0 ± 0.0
Met
0.835MetAla: 0.835 ± 0.407
1.253MetCys: 1.253 ± 0.68
0.835MetAsp: 0.835 ± 0.407
0.835MetGlu: 0.835 ± 0.57
0.0MetPhe: 0.0 ± 0.0
0.835MetGly: 0.835 ± 0.419
0.418MetHis: 0.418 ± 0.335
0.835MetIle: 0.835 ± 0.386
0.418MetLys: 0.418 ± 0.574
1.253MetLeu: 1.253 ± 0.727
0.418MetMet: 0.418 ± 0.435
1.253MetAsn: 1.253 ± 0.962
0.0MetPro: 0.0 ± 0.0
0.418MetGln: 0.418 ± 0.335
2.088MetArg: 2.088 ± 0.722
1.253MetSer: 1.253 ± 0.658
0.835MetThr: 0.835 ± 0.407
0.418MetVal: 0.418 ± 0.349
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
1.67AsnAla: 1.67 ± 0.235
0.835AsnCys: 0.835 ± 0.441
1.67AsnAsp: 1.67 ± 0.663
2.923AsnGlu: 2.923 ± 1.193
3.758AsnPhe: 3.758 ± 1.601
2.923AsnGly: 2.923 ± 0.662
1.67AsnHis: 1.67 ± 1.04
4.175AsnIle: 4.175 ± 1.333
3.758AsnLys: 3.758 ± 1.403
3.34AsnLeu: 3.34 ± 0.895
0.835AsnMet: 0.835 ± 0.407
2.088AsnAsn: 2.088 ± 0.891
2.505AsnPro: 2.505 ± 0.785
1.67AsnGln: 1.67 ± 0.584
2.505AsnArg: 2.505 ± 0.631
4.593AsnSer: 4.593 ± 1.519
4.175AsnThr: 4.175 ± 1.406
3.34AsnVal: 3.34 ± 0.694
1.67AsnTrp: 1.67 ± 0.66
0.835AsnTyr: 0.835 ± 0.49
0.0AsnXaa: 0.0 ± 0.0
Pro
7.516ProAla: 7.516 ± 2.135
1.253ProCys: 1.253 ± 0.575
3.34ProAsp: 3.34 ± 1.084
2.505ProGlu: 2.505 ± 0.718
2.923ProPhe: 2.923 ± 0.577
2.088ProGly: 2.088 ± 1.371
0.418ProHis: 0.418 ± 0.335
0.835ProIle: 0.835 ± 0.432
2.923ProLys: 2.923 ± 0.554
5.846ProLeu: 5.846 ± 1.538
0.418ProMet: 0.418 ± 0.335
2.505ProAsn: 2.505 ± 1.744
7.516ProPro: 7.516 ± 1.85
2.505ProGln: 2.505 ± 0.817
2.505ProArg: 2.505 ± 0.44
3.34ProSer: 3.34 ± 1.483
6.263ProThr: 6.263 ± 2.15
2.923ProVal: 2.923 ± 1.606
0.0ProTrp: 0.0 ± 0.0
2.505ProTyr: 2.505 ± 1.23
0.0ProXaa: 0.0 ± 0.0
Gln
0.835GlnAla: 0.835 ± 0.419
1.253GlnCys: 1.253 ± 0.923
2.088GlnAsp: 2.088 ± 0.511
2.505GlnGlu: 2.505 ± 0.93
2.505GlnPhe: 2.505 ± 1.21
2.923GlnGly: 2.923 ± 0.779
1.253GlnHis: 1.253 ± 0.68
2.505GlnIle: 2.505 ± 0.586
1.253GlnLys: 1.253 ± 0.746
4.593GlnLeu: 4.593 ± 1.348
0.418GlnMet: 0.418 ± 0.335
2.505GlnAsn: 2.505 ± 0.915
1.67GlnPro: 1.67 ± 0.772
1.253GlnGln: 1.253 ± 0.644
0.835GlnArg: 0.835 ± 0.713
2.505GlnSer: 2.505 ± 1.042
3.34GlnThr: 3.34 ± 1.347
3.758GlnVal: 3.758 ± 1.151
0.835GlnTrp: 0.835 ± 0.699
1.253GlnTyr: 1.253 ± 0.644
0.0GlnXaa: 0.0 ± 0.0
Arg
2.505ArgAla: 2.505 ± 1.43
1.67ArgCys: 1.67 ± 1.094
2.923ArgAsp: 2.923 ± 1.15
2.923ArgGlu: 2.923 ± 0.413
0.418ArgPhe: 0.418 ± 0.574
2.923ArgGly: 2.923 ± 1.111
1.67ArgHis: 1.67 ± 0.751
2.505ArgIle: 2.505 ± 0.966
4.593ArgLys: 4.593 ± 1.004
7.933ArgLeu: 7.933 ± 1.347
0.835ArgMet: 0.835 ± 0.407
0.835ArgAsn: 0.835 ± 0.7
2.505ArgPro: 2.505 ± 1.086
2.505ArgGln: 2.505 ± 1.21
7.098ArgArg: 7.098 ± 3.587
6.681ArgSer: 6.681 ± 1.506
2.505ArgThr: 2.505 ± 0.823
5.01ArgVal: 5.01 ± 1.619
0.0ArgTrp: 0.0 ± 0.0
2.505ArgTyr: 2.505 ± 0.819
0.0ArgXaa: 0.0 ± 0.0
Ser
2.088SerAla: 2.088 ± 0.364
1.253SerCys: 1.253 ± 0.374
5.428SerAsp: 5.428 ± 0.5
2.088SerGlu: 2.088 ± 0.434
2.923SerPhe: 2.923 ± 0.739
5.01SerGly: 5.01 ± 0.971
2.088SerHis: 2.088 ± 0.668
4.593SerIle: 4.593 ± 1.725
4.175SerLys: 4.175 ± 2.078
7.933SerLeu: 7.933 ± 1.762
0.0SerMet: 0.0 ± 0.0
2.505SerAsn: 2.505 ± 1.207
4.593SerPro: 4.593 ± 1.198
0.835SerGln: 0.835 ± 0.441
5.846SerArg: 5.846 ± 0.903
5.846SerSer: 5.846 ± 1.67
3.758SerThr: 3.758 ± 1.026
7.516SerVal: 7.516 ± 1.394
0.418SerTrp: 0.418 ± 0.349
2.088SerTyr: 2.088 ± 0.709
0.0SerXaa: 0.0 ± 0.0
Thr
1.67ThrAla: 1.67 ± 1.037
0.418ThrCys: 0.418 ± 0.349
5.01ThrAsp: 5.01 ± 1.466
4.175ThrGlu: 4.175 ± 0.662
1.67ThrPhe: 1.67 ± 0.594
4.593ThrGly: 4.593 ± 1.652
2.505ThrHis: 2.505 ± 0.584
2.088ThrIle: 2.088 ± 0.994
2.923ThrLys: 2.923 ± 1.085
5.846ThrLeu: 5.846 ± 1.253
1.67ThrMet: 1.67 ± 0.814
3.34ThrAsn: 3.34 ± 0.722
5.846ThrPro: 5.846 ± 1.788
2.505ThrGln: 2.505 ± 0.766
2.505ThrArg: 2.505 ± 0.909
2.505ThrSer: 2.505 ± 0.898
3.758ThrThr: 3.758 ± 1.439
5.846ThrVal: 5.846 ± 0.597
0.835ThrTrp: 0.835 ± 0.419
2.088ThrTyr: 2.088 ± 0.891
0.0ThrXaa: 0.0 ± 0.0
Val
3.758ValAla: 3.758 ± 0.974
0.835ValCys: 0.835 ± 0.615
5.846ValAsp: 5.846 ± 1.853
2.923ValGlu: 2.923 ± 0.897
1.67ValPhe: 1.67 ± 0.982
4.175ValGly: 4.175 ± 1.462
0.835ValHis: 0.835 ± 0.445
2.923ValIle: 2.923 ± 0.72
3.758ValLys: 3.758 ± 1.554
5.01ValLeu: 5.01 ± 0.879
0.418ValMet: 0.418 ± 0.335
2.505ValAsn: 2.505 ± 0.559
4.593ValPro: 4.593 ± 1.669
4.175ValGln: 4.175 ± 1.332
3.34ValArg: 3.34 ± 1.098
4.175ValSer: 4.175 ± 0.971
4.175ValThr: 4.175 ± 1.544
2.088ValVal: 2.088 ± 0.78
2.505ValTrp: 2.505 ± 0.849
3.758ValTyr: 3.758 ± 1.168
0.0ValXaa: 0.0 ± 0.0
Trp
0.418TrpAla: 0.418 ± 0.349
0.0TrpCys: 0.0 ± 0.0
0.835TrpAsp: 0.835 ± 0.67
0.0TrpGlu: 0.0 ± 0.0
1.253TrpPhe: 1.253 ± 0.394
0.418TrpGly: 0.418 ± 0.335
0.418TrpHis: 0.418 ± 0.381
1.253TrpIle: 1.253 ± 0.698
1.67TrpLys: 1.67 ± 1.012
0.835TrpLeu: 0.835 ± 0.407
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.418TrpPro: 0.418 ± 0.335
0.835TrpGln: 0.835 ± 0.407
1.67TrpArg: 1.67 ± 1.011
0.418TrpSer: 0.418 ± 0.381
1.253TrpThr: 1.253 ± 0.727
0.835TrpVal: 0.835 ± 0.441
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.34TyrAla: 3.34 ± 0.962
0.418TyrCys: 0.418 ± 0.454
1.67TyrAsp: 1.67 ± 0.594
0.835TyrGlu: 0.835 ± 0.597
2.923TyrPhe: 2.923 ± 0.797
2.923TyrGly: 2.923 ± 0.54
0.835TyrHis: 0.835 ± 0.762
2.505TyrIle: 2.505 ± 0.931
0.418TyrLys: 0.418 ± 0.335
1.253TyrLeu: 1.253 ± 0.374
0.835TyrMet: 0.835 ± 0.849
3.34TyrAsn: 3.34 ± 0.842
0.835TyrPro: 0.835 ± 0.386
0.418TyrGln: 0.418 ± 0.381
2.088TyrArg: 2.088 ± 1.114
1.67TyrSer: 1.67 ± 0.607
4.175TyrThr: 4.175 ± 1.527
2.505TyrVal: 2.505 ± 0.867
0.835TyrTrp: 0.835 ± 0.57
1.67TyrTyr: 1.67 ± 0.674
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (2396 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski