Amino acid dipepetide frequency for Microdochium bolleyi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.33AlaAla: 12.33 ± 0.074	1.28AlaCys: 1.28 ± 0.016	5.042AlaAsp: 5.042 ± 0.028	5.493AlaGlu: 5.493 ± 0.039	3.155AlaPhe: 3.155 ± 0.027	7.29AlaGly: 7.29 ± 0.042	2.042AlaHis: 2.042 ± 0.019	4.25AlaIle: 4.25 ± 0.031	4.1AlaLys: 4.1 ± 0.033	8.3AlaLeu: 8.3 ± 0.043	2.262AlaMet: 2.262 ± 0.021	2.928AlaAsn: 2.928 ± 0.025	5.317AlaPro: 5.317 ± 0.045	3.796AlaGln: 3.796 ± 0.03	5.829AlaArg: 5.829 ± 0.037	8.014AlaSer: 8.014 ± 0.045	6.202AlaThr: 6.202 ± 0.04	6.287AlaVal: 6.287 ± 0.036	1.354AlaTrp: 1.354 ± 0.017	2.214AlaTyr: 2.214 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	1.094CysAla: 1.094 ± 0.016	0.315CysCys: 0.315 ± 0.009	0.7CysAsp: 0.7 ± 0.011	0.604CysGlu: 0.604 ± 0.012	0.543CysPhe: 0.543 ± 0.01	1.047CysGly: 1.047 ± 0.016	0.357CysHis: 0.357 ± 0.009	0.704CysIle: 0.704 ± 0.012	0.507CysLys: 0.507 ± 0.011	1.319CysLeu: 1.319 ± 0.016	0.288CysMet: 0.288 ± 0.007	0.435CysAsn: 0.435 ± 0.01	0.718CysPro: 0.718 ± 0.012	0.463CysGln: 0.463 ± 0.01	0.871CysArg: 0.871 ± 0.014	0.991CysSer: 0.991 ± 0.017	0.762CysThr: 0.762 ± 0.012	0.877CysVal: 0.877 ± 0.014	0.231CysTrp: 0.231 ± 0.006	0.371CysTyr: 0.371 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	5.228AspAla: 5.228 ± 0.026	0.649AspCys: 0.649 ± 0.011	4.771AspAsp: 4.771 ± 0.055	4.329AspGlu: 4.329 ± 0.04	2.227AspPhe: 2.227 ± 0.021	4.405AspGly: 4.405 ± 0.031	1.32AspHis: 1.32 ± 0.018	2.809AspIle: 2.809 ± 0.024	2.455AspLys: 2.455 ± 0.027	4.89AspLeu: 4.89 ± 0.03	1.312AspMet: 1.312 ± 0.015	1.927AspAsn: 1.927 ± 0.02	3.204AspPro: 3.204 ± 0.023	1.803AspGln: 1.803 ± 0.017	3.171AspArg: 3.171 ± 0.032	4.071AspSer: 4.071 ± 0.033	2.992AspThr: 2.992 ± 0.025	3.753AspVal: 3.753 ± 0.026	0.909AspTrp: 0.909 ± 0.014	1.541AspTyr: 1.541 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	5.539GluAla: 5.539 ± 0.041	0.624GluCys: 0.624 ± 0.011	3.976GluAsp: 3.976 ± 0.04	4.426GluGlu: 4.426 ± 0.046	1.765GluPhe: 1.765 ± 0.018	3.59GluGly: 3.59 ± 0.031	1.523GluHis: 1.523 ± 0.016	2.607GluIle: 2.607 ± 0.02	3.024GluLys: 3.024 ± 0.024	5.037GluLeu: 5.037 ± 0.042	1.348GluMet: 1.348 ± 0.015	1.821GluAsn: 1.821 ± 0.019	2.668GluPro: 2.668 ± 0.024	2.481GluGln: 2.481 ± 0.024	3.675GluArg: 3.675 ± 0.026	3.814GluSer: 3.814 ± 0.027	3.225GluThr: 3.225 ± 0.027	3.388GluVal: 3.388 ± 0.027	0.836GluTrp: 0.836 ± 0.013	1.501GluTyr: 1.501 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.211PheAla: 3.211 ± 0.025	0.565PheCys: 0.565 ± 0.011	2.239PheAsp: 2.239 ± 0.022	2.009PheGlu: 2.009 ± 0.019	1.544PhePhe: 1.544 ± 0.02	2.881PheGly: 2.881 ± 0.028	0.845PheHis: 0.845 ± 0.012	1.585PheIle: 1.585 ± 0.017	1.326PheLys: 1.326 ± 0.016	3.259PheLeu: 3.259 ± 0.027	0.806PheMet: 0.806 ± 0.013	1.269PheAsn: 1.269 ± 0.016	1.838PhePro: 1.838 ± 0.019	1.269PheGln: 1.269 ± 0.017	1.965PheArg: 1.965 ± 0.02	2.767PheSer: 2.767 ± 0.026	2.045PheThr: 2.045 ± 0.02	2.458PheVal: 2.458 ± 0.022	0.637PheTrp: 0.637 ± 0.012	1.049PheTyr: 1.049 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	6.435GlyAla: 6.435 ± 0.042	0.987GlyCys: 0.987 ± 0.016	3.969GlyAsp: 3.969 ± 0.028	3.597GlyGlu: 3.597 ± 0.032	2.881GlyPhe: 2.881 ± 0.027	7.279GlyGly: 7.279 ± 0.07	1.841GlyHis: 1.841 ± 0.019	3.327GlyIle: 3.327 ± 0.027	3.317GlyLys: 3.317 ± 0.03	6.329GlyLeu: 6.329 ± 0.038	1.686GlyMet: 1.686 ± 0.018	2.547GlyAsn: 2.547 ± 0.025	3.658GlyPro: 3.658 ± 0.027	2.745GlyGln: 2.745 ± 0.023	4.552GlyArg: 4.552 ± 0.03	6.31GlySer: 6.31 ± 0.045	4.331GlyThr: 4.331 ± 0.031	4.669GlyVal: 4.669 ± 0.035	1.208GlyTrp: 1.208 ± 0.015	2.07GlyTyr: 2.07 ± 0.021	0.0GlyXaa: 0.0 ± 0.0
His	2.136HisAla: 2.136 ± 0.022	0.36HisCys: 0.36 ± 0.009	1.528HisAsp: 1.528 ± 0.015	1.369HisGlu: 1.369 ± 0.018	0.916HisPhe: 0.916 ± 0.013	2.026HisGly: 2.026 ± 0.02	0.988HisHis: 0.988 ± 0.015	1.155HisIle: 1.155 ± 0.014	0.933HisLys: 0.933 ± 0.012	2.17HisLeu: 2.17 ± 0.022	0.537HisMet: 0.537 ± 0.01	0.871HisAsn: 0.871 ± 0.012	1.571HisPro: 1.571 ± 0.017	1.027HisGln: 1.027 ± 0.016	1.601HisArg: 1.601 ± 0.018	1.759HisSer: 1.759 ± 0.02	1.249HisThr: 1.249 ± 0.015	1.564HisVal: 1.564 ± 0.017	0.371HisTrp: 0.371 ± 0.008	0.689HisTyr: 0.689 ± 0.01	0.0HisXaa: 0.0 ± 0.0
Ile	4.303IleAla: 4.303 ± 0.031	0.709IleCys: 0.709 ± 0.012	2.651IleAsp: 2.651 ± 0.024	2.547IleGlu: 2.547 ± 0.024	1.75IlePhe: 1.75 ± 0.018	3.038IleGly: 3.038 ± 0.027	1.029IleHis: 1.029 ± 0.013	2.215IleIle: 2.215 ± 0.022	1.914IleLys: 1.914 ± 0.022	4.047IleLeu: 4.047 ± 0.031	1.05IleMet: 1.05 ± 0.015	1.546IleAsn: 1.546 ± 0.017	2.665IlePro: 2.665 ± 0.023	1.585IleGln: 1.585 ± 0.018	2.633IleArg: 2.633 ± 0.022	3.366IleSer: 3.366 ± 0.025	2.754IleThr: 2.754 ± 0.023	3.149IleVal: 3.149 ± 0.027	0.685IleTrp: 0.685 ± 0.011	1.213IleTyr: 1.213 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	4.193LysAla: 4.193 ± 0.036	0.482LysCys: 0.482 ± 0.009	2.561LysAsp: 2.561 ± 0.021	2.701LysGlu: 2.701 ± 0.025	1.327LysPhe: 1.327 ± 0.018	2.823LysGly: 2.823 ± 0.026	1.095LysHis: 1.095 ± 0.016	1.994LysIle: 1.994 ± 0.018	2.904LysLys: 2.904 ± 0.038	3.761LysLeu: 3.761 ± 0.027	0.933LysMet: 0.933 ± 0.012	1.483LysAsn: 1.483 ± 0.016	2.576LysPro: 2.576 ± 0.026	1.741LysGln: 1.741 ± 0.021	2.948LysArg: 2.948 ± 0.028	3.045LysSer: 3.045 ± 0.025	2.735LysThr: 2.735 ± 0.023	2.599LysVal: 2.599 ± 0.023	0.632LysTrp: 0.632 ± 0.01	1.198LysTyr: 1.198 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	8.766LeuAla: 8.766 ± 0.046	1.269LeuCys: 1.269 ± 0.015	5.16LeuAsp: 5.16 ± 0.037	5.092LeuGlu: 5.092 ± 0.04	3.177LeuPhe: 3.177 ± 0.025	6.257LeuGly: 6.257 ± 0.036	2.228LeuHis: 2.228 ± 0.023	3.499LeuIle: 3.499 ± 0.026	3.608LeuLys: 3.608 ± 0.028	8.321LeuLeu: 8.321 ± 0.061	1.808LeuMet: 1.808 ± 0.02	2.735LeuAsn: 2.735 ± 0.023	5.501LeuPro: 5.501 ± 0.033	3.628LeuGln: 3.628 ± 0.031	5.955LeuArg: 5.955 ± 0.034	6.867LeuSer: 6.867 ± 0.041	4.621LeuThr: 4.621 ± 0.032	5.762LeuVal: 5.762 ± 0.038	1.26LeuTrp: 1.26 ± 0.017	2.258LeuTyr: 2.258 ± 0.02	0.0LeuXaa: 0.0 ± 0.0
Met	2.538MetAla: 2.538 ± 0.02	0.265MetCys: 0.265 ± 0.007	1.195MetAsp: 1.195 ± 0.015	1.107MetGlu: 1.107 ± 0.014	0.77MetPhe: 0.77 ± 0.013	1.534MetGly: 1.534 ± 0.017	0.548MetHis: 0.548 ± 0.01	0.966MetIle: 0.966 ± 0.014	0.876MetLys: 0.876 ± 0.013	2.008MetLeu: 2.008 ± 0.021	0.61MetMet: 0.61 ± 0.011	0.701MetAsn: 0.701 ± 0.012	1.406MetPro: 1.406 ± 0.017	0.875MetGln: 0.875 ± 0.012	1.368MetArg: 1.368 ± 0.018	1.876MetSer: 1.876 ± 0.02	1.4MetThr: 1.4 ± 0.015	1.39MetVal: 1.39 ± 0.015	0.281MetTrp: 0.281 ± 0.007	0.55MetTyr: 0.55 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.012AsnAla: 3.012 ± 0.024	0.419AsnCys: 0.419 ± 0.009	1.873AsnAsp: 1.873 ± 0.021	1.676AsnGlu: 1.676 ± 0.017	1.219AsnPhe: 1.219 ± 0.016	2.815AsnGly: 2.815 ± 0.028	0.793AsnHis: 0.793 ± 0.011	1.749AsnIle: 1.749 ± 0.018	1.431AsnLys: 1.431 ± 0.016	2.834AsnLeu: 2.834 ± 0.025	0.801AsnMet: 0.801 ± 0.012	1.505AsnAsn: 1.505 ± 0.024	2.137AsnPro: 2.137 ± 0.021	1.132AsnGln: 1.132 ± 0.015	1.737AsnArg: 1.737 ± 0.019	2.454AsnSer: 2.454 ± 0.023	2.061AsnThr: 2.061 ± 0.019	2.11AsnVal: 2.11 ± 0.02	0.493AsnTrp: 0.493 ± 0.01	0.925AsnTyr: 0.925 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	6.267ProAla: 6.267 ± 0.04	0.596ProCys: 0.596 ± 0.013	3.132ProAsp: 3.132 ± 0.026	3.562ProGlu: 3.562 ± 0.027	1.898ProPhe: 1.898 ± 0.021	4.474ProGly: 4.474 ± 0.032	1.323ProHis: 1.323 ± 0.02	2.231ProIle: 2.231 ± 0.02	2.315ProLys: 2.315 ± 0.02	4.701ProLeu: 4.701 ± 0.032	1.121ProMet: 1.121 ± 0.014	1.83ProAsn: 1.83 ± 0.019	5.063ProPro: 5.063 ± 0.059	2.491ProGln: 2.491 ± 0.026	3.626ProArg: 3.626 ± 0.026	5.692ProSer: 5.692 ± 0.04	3.902ProThr: 3.902 ± 0.03	3.681ProVal: 3.681 ± 0.028	0.804ProTrp: 0.804 ± 0.013	1.421ProTyr: 1.421 ± 0.015	0.0ProXaa: 0.0 ± 0.0
Gln	3.821GlnAla: 3.821 ± 0.028	0.48GlnCys: 0.48 ± 0.01	2.142GlnAsp: 2.142 ± 0.021	2.102GlnGlu: 2.102 ± 0.025	1.213GlnPhe: 1.213 ± 0.014	2.518GlnGly: 2.518 ± 0.02	1.271GlnHis: 1.271 ± 0.017	1.74GlnIle: 1.74 ± 0.021	1.693GlnLys: 1.693 ± 0.019	3.479GlnLeu: 3.479 ± 0.026	0.881GlnMet: 0.881 ± 0.015	1.344GlnAsn: 1.344 ± 0.017	2.635GlnPro: 2.635 ± 0.032	3.015GlnGln: 3.015 ± 0.059	2.698GlnArg: 2.698 ± 0.025	2.925GlnSer: 2.925 ± 0.027	2.212GlnThr: 2.212 ± 0.02	2.197GlnVal: 2.197 ± 0.019	0.6GlnTrp: 0.6 ± 0.01	1.109GlnTyr: 1.109 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	5.452ArgAla: 5.452 ± 0.031	0.828ArgCys: 0.828 ± 0.014	3.675ArgAsp: 3.675 ± 0.031	3.738ArgGlu: 3.738 ± 0.03	2.063ArgPhe: 2.063 ± 0.02	4.129ArgGly: 4.129 ± 0.031	1.808ArgHis: 1.808 ± 0.02	2.75ArgIle: 2.75 ± 0.021	3.158ArgLys: 3.158 ± 0.027	5.565ArgLeu: 5.565 ± 0.038	1.361ArgMet: 1.361 ± 0.017	2.099ArgAsn: 2.099 ± 0.019	3.768ArgPro: 3.768 ± 0.03	2.757ArgGln: 2.757 ± 0.025	5.404ArgArg: 5.404 ± 0.046	4.802ArgSer: 4.802 ± 0.038	3.44ArgThr: 3.44 ± 0.026	3.489ArgVal: 3.489 ± 0.027	1.0ArgTrp: 1.0 ± 0.014	1.613ArgTyr: 1.613 ± 0.017	0.0ArgXaa: 0.0 ± 0.0
Ser	7.436SerAla: 7.436 ± 0.041	0.971SerCys: 0.971 ± 0.013	4.064SerAsp: 4.064 ± 0.029	3.653SerGlu: 3.653 ± 0.026	2.809SerPhe: 2.809 ± 0.024	5.953SerGly: 5.953 ± 0.038	1.918SerHis: 1.918 ± 0.021	3.521SerIle: 3.521 ± 0.026	3.258SerLys: 3.258 ± 0.027	6.735SerLeu: 6.735 ± 0.038	1.747SerMet: 1.747 ± 0.018	2.598SerAsn: 2.598 ± 0.024	5.3SerPro: 5.3 ± 0.043	3.101SerGln: 3.101 ± 0.027	5.2SerArg: 5.2 ± 0.042	8.965SerSer: 8.965 ± 0.074	5.547SerThr: 5.547 ± 0.048	4.558SerVal: 4.558 ± 0.032	1.213SerTrp: 1.213 ± 0.016	1.931SerTyr: 1.931 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	6.162ThrAla: 6.162 ± 0.038	0.815ThrCys: 0.815 ± 0.013	2.837ThrAsp: 2.837 ± 0.024	2.942ThrGlu: 2.942 ± 0.027	2.144ThrPhe: 2.144 ± 0.021	4.454ThrGly: 4.454 ± 0.031	1.287ThrHis: 1.287 ± 0.016	2.949ThrIle: 2.949 ± 0.023	2.488ThrLys: 2.488 ± 0.021	5.083ThrLeu: 5.083 ± 0.034	1.294ThrMet: 1.294 ± 0.016	1.939ThrAsn: 1.939 ± 0.02	4.221ThrPro: 4.221 ± 0.031	2.091ThrGln: 2.091 ± 0.023	3.371ThrArg: 3.371 ± 0.026	5.317ThrSer: 5.317 ± 0.042	5.067ThrThr: 5.067 ± 0.079	3.856ThrVal: 3.856 ± 0.033	0.917ThrTrp: 0.917 ± 0.013	1.554ThrTyr: 1.554 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	6.032ValAla: 6.032 ± 0.039	0.932ValCys: 0.932 ± 0.014	3.742ValAsp: 3.742 ± 0.025	3.712ValGlu: 3.712 ± 0.031	2.457ValPhe: 2.457 ± 0.024	4.227ValGly: 4.227 ± 0.033	1.48ValHis: 1.48 ± 0.016	2.789ValIle: 2.789 ± 0.024	2.67ValLys: 2.67 ± 0.022	5.974ValLeu: 5.974 ± 0.038	1.422ValMet: 1.422 ± 0.016	2.015ValAsn: 2.015 ± 0.019	3.803ValPro: 3.803 ± 0.028	2.415ValGln: 2.415 ± 0.021	3.711ValArg: 3.711 ± 0.031	4.537ValSer: 4.537 ± 0.032	3.664ValThr: 3.664 ± 0.031	4.8ValVal: 4.8 ± 0.036	0.931ValTrp: 0.931 ± 0.013	1.732ValTyr: 1.732 ± 0.016	0.0ValXaa: 0.0 ± 0.0
Trp	1.325TrpAla: 1.325 ± 0.018	0.225TrpCys: 0.225 ± 0.007	0.913TrpAsp: 0.913 ± 0.015	0.791TrpGlu: 0.791 ± 0.013	0.575TrpPhe: 0.575 ± 0.009	0.967TrpGly: 0.967 ± 0.014	0.406TrpHis: 0.406 ± 0.009	0.724TrpIle: 0.724 ± 0.012	0.711TrpLys: 0.711 ± 0.009	1.486TrpLeu: 1.486 ± 0.018	0.369TrpMet: 0.369 ± 0.008	0.563TrpAsn: 0.563 ± 0.01	0.674TrpPro: 0.674 ± 0.011	0.643TrpGln: 0.643 ± 0.011	1.049TrpArg: 1.049 ± 0.015	1.058TrpSer: 1.058 ± 0.014	0.984TrpThr: 0.984 ± 0.016	0.885TrpVal: 0.885 ± 0.012	0.301TrpTrp: 0.301 ± 0.007	0.437TrpTyr: 0.437 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.203TyrAla: 2.203 ± 0.02	0.425TyrCys: 0.425 ± 0.01	1.597TyrAsp: 1.597 ± 0.018	1.419TyrGlu: 1.419 ± 0.017	1.13TyrPhe: 1.13 ± 0.016	2.03TyrGly: 2.03 ± 0.021	0.722TyrHis: 0.722 ± 0.012	1.283TyrIle: 1.283 ± 0.016	1.04TyrLys: 1.04 ± 0.014	2.477TyrLeu: 2.477 ± 0.022	0.629TyrMet: 0.629 ± 0.01	1.02TyrAsn: 1.02 ± 0.014	1.407TyrPro: 1.407 ± 0.019	1.019TyrGln: 1.019 ± 0.013	1.533TyrArg: 1.533 ± 0.016	1.85TyrSer: 1.85 ± 0.018	1.597TyrThr: 1.597 ± 0.017	1.574TyrVal: 1.574 ± 0.018	0.422TyrTrp: 0.422 ± 0.008	0.89TyrTyr: 0.89 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 13164 proteins (5816858 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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