Amino acid dipepetide frequency for Mycoplasma haemolamae (strain Purdue)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.573AlaAla: 3.573 ± 0.135
0.66AlaCys: 0.66 ± 0.061
1.891AlaAsp: 1.891 ± 0.091
3.453AlaGlu: 3.453 ± 0.14
2.514AlaPhe: 2.514 ± 0.109
3.996AlaGly: 3.996 ± 0.152
0.781AlaHis: 0.781 ± 0.058
3.75AlaIle: 3.75 ± 0.137
4.415AlaLys: 4.415 ± 0.144
6.111AlaLeu: 6.111 ± 0.171
0.799AlaMet: 0.799 ± 0.066
2.319AlaAsn: 2.319 ± 0.107
1.812AlaPro: 1.812 ± 0.117
2.389AlaGln: 2.389 ± 0.105
2.007AlaArg: 2.007 ± 0.118
4.791AlaSer: 4.791 ± 0.158
3.053AlaThr: 3.053 ± 0.127
3.573AlaVal: 3.573 ± 0.149
0.604AlaTrp: 0.604 ± 0.052
1.812AlaTyr: 1.812 ± 0.099
0.0AlaXaa: 0.0 ± 0.0
Cys
0.757CysAla: 0.757 ± 0.055
0.599CysCys: 0.599 ± 0.124
0.725CysAsp: 0.725 ± 0.056
1.125CysGlu: 1.125 ± 0.067
0.609CysPhe: 0.609 ± 0.049
0.776CysGly: 0.776 ± 0.061
0.158CysHis: 0.158 ± 0.025
0.688CysIle: 0.688 ± 0.057
1.431CysLys: 1.431 ± 0.101
1.222CysLeu: 1.222 ± 0.084
0.158CysMet: 0.158 ± 0.025
0.553CysAsn: 0.553 ± 0.049
0.869CysPro: 0.869 ± 0.061
0.497CysGln: 0.497 ± 0.048
0.553CysArg: 0.553 ± 0.051
1.729CysSer: 1.729 ± 0.105
1.32CysThr: 1.32 ± 0.084
0.799CysVal: 0.799 ± 0.062
0.153CysTrp: 0.153 ± 0.03
0.302CysTyr: 0.302 ± 0.038
0.0CysXaa: 0.0 ± 0.0
Asp
1.836AspAla: 1.836 ± 0.105
0.776AspCys: 0.776 ± 0.055
2.31AspAsp: 2.31 ± 0.128
3.564AspGlu: 3.564 ± 0.141
2.565AspPhe: 2.565 ± 0.107
2.068AspGly: 2.068 ± 0.1
0.939AspHis: 0.939 ± 0.071
2.481AspIle: 2.481 ± 0.121
4.257AspLys: 4.257 ± 0.143
5.297AspLeu: 5.297 ± 0.163
0.604AspMet: 0.604 ± 0.047
1.956AspAsn: 1.956 ± 0.094
1.924AspPro: 1.924 ± 0.096
2.43AspGln: 2.43 ± 0.108
2.068AspArg: 2.068 ± 0.121
5.507AspSer: 5.507 ± 0.181
1.989AspThr: 1.989 ± 0.098
2.351AspVal: 2.351 ± 0.121
1.264AspTrp: 1.264 ± 0.084
2.258AspTyr: 2.258 ± 0.11
0.0AspXaa: 0.0 ± 0.0
Glu
4.359GluAla: 4.359 ± 0.16
1.208GluCys: 1.208 ± 0.081
4.071GluAsp: 4.071 ± 0.164
8.132GluGlu: 8.132 ± 0.259
2.918GluPhe: 2.918 ± 0.121
5.525GluGly: 5.525 ± 0.161
1.283GluHis: 1.283 ± 0.079
5.451GluIle: 5.451 ± 0.172
7.644GluLys: 7.644 ± 0.195
8.397GluLeu: 8.397 ± 0.25
1.078GluMet: 1.078 ± 0.063
2.89GluAsn: 2.89 ± 0.121
1.803GluPro: 1.803 ± 0.107
3.025GluGln: 3.025 ± 0.113
3.471GluArg: 3.471 ± 0.147
6.106GluSer: 6.106 ± 0.168
3.69GluThr: 3.69 ± 0.135
4.861GluVal: 4.861 ± 0.159
1.041GluTrp: 1.041 ± 0.072
2.296GluTyr: 2.296 ± 0.099
0.0GluXaa: 0.0 ± 0.0
Phe
2.063PheAla: 2.063 ± 0.094
0.688PheCys: 0.688 ± 0.052
2.277PheAsp: 2.277 ± 0.12
3.09PheGlu: 3.09 ± 0.124
2.928PhePhe: 2.928 ± 0.123
2.77PheGly: 2.77 ± 0.113
0.604PheHis: 0.604 ± 0.052
2.296PheIle: 2.296 ± 0.121
4.252PheLys: 4.252 ± 0.159
5.613PheLeu: 5.613 ± 0.196
0.511PheMet: 0.511 ± 0.048
2.1PheAsn: 2.1 ± 0.094
1.487PhePro: 1.487 ± 0.092
1.84PheGln: 1.84 ± 0.097
1.952PheArg: 1.952 ± 0.11
5.218PheSer: 5.218 ± 0.165
2.365PheThr: 2.365 ± 0.105
2.509PheVal: 2.509 ± 0.103
0.739PheTrp: 0.739 ± 0.059
1.543PheTyr: 1.543 ± 0.087
0.0PheXaa: 0.0 ± 0.0
Gly
4.289GlyAla: 4.289 ± 0.172
0.878GlyCys: 0.878 ± 0.07
2.746GlyAsp: 2.746 ± 0.108
3.973GlyGlu: 3.973 ± 0.15
2.709GlyPhe: 2.709 ± 0.089
6.31GlyGly: 6.31 ± 0.241
1.018GlyHis: 1.018 ± 0.076
4.08GlyIle: 4.08 ± 0.146
5.13GlyLys: 5.13 ± 0.162
5.502GlyLeu: 5.502 ± 0.159
0.934GlyMet: 0.934 ± 0.068
2.593GlyAsn: 2.593 ± 0.113
1.654GlyPro: 1.654 ± 0.092
2.463GlyGln: 2.463 ± 0.111
2.356GlyArg: 2.356 ± 0.093
6.087GlySer: 6.087 ± 0.192
4.122GlyThr: 4.122 ± 0.17
4.182GlyVal: 4.182 ± 0.149
0.953GlyTrp: 0.953 ± 0.069
2.063GlyTyr: 2.063 ± 0.101
0.0GlyXaa: 0.0 ± 0.0
His
0.544HisAla: 0.544 ± 0.046
0.195HisCys: 0.195 ± 0.03
0.516HisAsp: 0.516 ± 0.044
0.897HisGlu: 0.897 ± 0.064
0.799HisPhe: 0.799 ± 0.065
0.488HisGly: 0.488 ± 0.048
0.302HisHis: 0.302 ± 0.044
0.99HisIle: 0.99 ± 0.082
1.422HisLys: 1.422 ± 0.085
1.678HisLeu: 1.678 ± 0.086
0.251HisMet: 0.251 ± 0.031
0.781HisAsn: 0.781 ± 0.059
0.781HisPro: 0.781 ± 0.07
0.525HisGln: 0.525 ± 0.049
0.804HisArg: 0.804 ± 0.061
1.552HisSer: 1.552 ± 0.092
0.688HisThr: 0.688 ± 0.056
0.59HisVal: 0.59 ± 0.055
0.274HisTrp: 0.274 ± 0.041
0.753HisTyr: 0.753 ± 0.06
0.0HisXaa: 0.0 ± 0.0
Ile
3.55IleAla: 3.55 ± 0.131
1.013IleCys: 1.013 ± 0.067
3.234IleAsp: 3.234 ± 0.133
4.308IleGlu: 4.308 ± 0.16
3.137IlePhe: 3.137 ± 0.143
3.62IleGly: 3.62 ± 0.129
0.929IleHis: 0.929 ± 0.077
3.016IleIle: 3.016 ± 0.149
4.94IleLys: 4.94 ± 0.159
5.047IleLeu: 5.047 ± 0.16
0.734IleMet: 0.734 ± 0.061
2.593IleAsn: 2.593 ± 0.106
2.57IlePro: 2.57 ± 0.113
2.063IleGln: 2.063 ± 0.094
2.365IleArg: 2.365 ± 0.109
5.363IleSer: 5.363 ± 0.163
3.025IleThr: 3.025 ± 0.12
3.927IleVal: 3.927 ± 0.153
0.716IleTrp: 0.716 ± 0.057
2.426IleTyr: 2.426 ± 0.113
0.0IleXaa: 0.0 ± 0.0
Lys
5.014LysAla: 5.014 ± 0.181
1.468LysCys: 1.468 ± 0.093
5.009LysAsp: 5.009 ± 0.158
9.15LysGlu: 9.15 ± 0.227
3.369LysPhe: 3.369 ± 0.132
5.363LysGly: 5.363 ± 0.149
1.236LysHis: 1.236 ± 0.073
5.827LysIle: 5.827 ± 0.163
8.662LysLys: 8.662 ± 0.246
8.917LysLeu: 8.917 ± 0.218
1.459LysMet: 1.459 ± 0.085
4.192LysAsn: 4.192 ± 0.154
2.667LysPro: 2.667 ± 0.118
2.974LysGln: 2.974 ± 0.129
3.406LysArg: 3.406 ± 0.138
6.255LysSer: 6.255 ± 0.162
5.102LysThr: 5.102 ± 0.164
5.586LysVal: 5.586 ± 0.169
1.069LysTrp: 1.069 ± 0.06
3.211LysTyr: 3.211 ± 0.136
0.0LysXaa: 0.0 ± 0.0
Leu
5.59LeuAla: 5.59 ± 0.172
0.962LeuCys: 0.962 ± 0.069
5.293LeuAsp: 5.293 ± 0.158
8.56LeuGlu: 8.56 ± 0.203
4.61LeuPhe: 4.61 ± 0.154
7.114LeuGly: 7.114 ± 0.181
1.31LeuHis: 1.31 ± 0.078
5.665LeuIle: 5.665 ± 0.218
10.516LeuLys: 10.516 ± 0.221
9.563LeuLeu: 9.563 ± 0.285
1.427LeuMet: 1.427 ± 0.09
4.754LeuAsn: 4.754 ± 0.165
3.578LeuPro: 3.578 ± 0.136
3.35LeuGln: 3.35 ± 0.13
4.466LeuArg: 4.466 ± 0.158
9.559LeuSer: 9.559 ± 0.257
5.827LeuThr: 5.827 ± 0.157
6.055LeuVal: 6.055 ± 0.165
1.259LeuTrp: 1.259 ± 0.069
2.742LeuTyr: 2.742 ± 0.133
0.0LeuXaa: 0.0 ± 0.0
Met
0.92MetAla: 0.92 ± 0.072
0.139MetCys: 0.139 ± 0.027
0.451MetAsp: 0.451 ± 0.046
0.757MetGlu: 0.757 ± 0.055
0.855MetPhe: 0.855 ± 0.055
0.878MetGly: 0.878 ± 0.075
0.209MetHis: 0.209 ± 0.032
1.306MetIle: 1.306 ± 0.074
1.506MetLys: 1.506 ± 0.083
1.18MetLeu: 1.18 ± 0.074
0.167MetMet: 0.167 ± 0.025
0.943MetAsn: 0.943 ± 0.064
0.613MetPro: 0.613 ± 0.053
0.414MetGln: 0.414 ± 0.04
0.692MetArg: 0.692 ± 0.052
1.417MetSer: 1.417 ± 0.082
1.166MetThr: 1.166 ± 0.072
0.832MetVal: 0.832 ± 0.064
0.181MetTrp: 0.181 ± 0.032
0.353MetTyr: 0.353 ± 0.038
0.0MetXaa: 0.0 ± 0.0
Asn
1.645AsnAla: 1.645 ± 0.095
0.678AsnCys: 0.678 ± 0.062
1.808AsnAsp: 1.808 ± 0.094
2.639AsnGlu: 2.639 ± 0.118
1.938AsnPhe: 1.938 ± 0.101
2.323AsnGly: 2.323 ± 0.131
0.609AsnHis: 0.609 ± 0.061
2.5AsnIle: 2.5 ± 0.115
4.117AsnLys: 4.117 ± 0.15
5.009AsnLeu: 5.009 ± 0.177
0.716AsnMet: 0.716 ± 0.061
1.915AsnAsn: 1.915 ± 0.098
1.984AsnPro: 1.984 ± 0.087
2.226AsnGln: 2.226 ± 0.103
1.831AsnArg: 1.831 ± 0.105
3.959AsnSer: 3.959 ± 0.149
2.059AsnThr: 2.059 ± 0.094
2.179AsnVal: 2.179 ± 0.082
0.86AsnTrp: 0.86 ± 0.064
2.026AsnTyr: 2.026 ± 0.098
0.0AsnXaa: 0.0 ± 0.0
Pro
1.91ProAla: 1.91 ± 0.104
0.265ProCys: 0.265 ± 0.037
1.743ProAsp: 1.743 ± 0.095
3.285ProGlu: 3.285 ± 0.132
1.501ProPhe: 1.501 ± 0.08
1.691ProGly: 1.691 ± 0.097
0.525ProHis: 0.525 ± 0.056
2.017ProIle: 2.017 ± 0.102
3.597ProLys: 3.597 ± 0.152
3.309ProLeu: 3.309 ± 0.122
0.437ProMet: 0.437 ± 0.052
1.51ProAsn: 1.51 ± 0.087
1.143ProPro: 1.143 ± 0.075
1.417ProGln: 1.417 ± 0.096
1.087ProArg: 1.087 ± 0.076
3.165ProSer: 3.165 ± 0.125
1.724ProThr: 1.724 ± 0.088
2.231ProVal: 2.231 ± 0.103
0.428ProTrp: 0.428 ± 0.048
1.134ProTyr: 1.134 ± 0.072
0.0ProXaa: 0.0 ± 0.0
Gln
2.17GlnAla: 2.17 ± 0.094
0.595GlnCys: 0.595 ± 0.049
1.933GlnAsp: 1.933 ± 0.09
3.848GlnGlu: 3.848 ± 0.124
1.278GlnPhe: 1.278 ± 0.068
2.579GlnGly: 2.579 ± 0.122
0.641GlnHis: 0.641 ± 0.058
2.147GlnIle: 2.147 ± 0.098
3.546GlnLys: 3.546 ± 0.143
4.326GlnLeu: 4.326 ± 0.138
0.716GlnMet: 0.716 ± 0.056
1.733GlnAsn: 1.733 ± 0.092
1.273GlnPro: 1.273 ± 0.098
1.826GlnGln: 1.826 ± 0.152
1.524GlnArg: 1.524 ± 0.086
3.011GlnSer: 3.011 ± 0.144
2.142GlnThr: 2.142 ± 0.108
1.938GlnVal: 1.938 ± 0.109
0.474GlnTrp: 0.474 ± 0.046
1.134GlnTyr: 1.134 ± 0.07
0.0GlnXaa: 0.0 ± 0.0
Arg
1.97ArgAla: 1.97 ± 0.1
0.52ArgCys: 0.52 ± 0.047
2.193ArgAsp: 2.193 ± 0.104
4.8ArgGlu: 4.8 ± 0.172
1.687ArgPhe: 1.687 ± 0.102
2.337ArgGly: 2.337 ± 0.109
0.595ArgHis: 0.595 ± 0.058
2.272ArgIle: 2.272 ± 0.101
3.406ArgLys: 3.406 ± 0.129
4.006ArgLeu: 4.006 ± 0.132
0.915ArgMet: 0.915 ± 0.065
1.798ArgAsn: 1.798 ± 0.081
1.194ArgPro: 1.194 ± 0.073
1.594ArgGln: 1.594 ± 0.089
1.952ArgArg: 1.952 ± 0.108
3.058ArgSer: 3.058 ± 0.135
1.854ArgThr: 1.854 ± 0.093
2.272ArgVal: 2.272 ± 0.103
0.544ArgTrp: 0.544 ± 0.052
1.822ArgTyr: 1.822 ± 0.094
0.0ArgXaa: 0.0 ± 0.0
Ser
4.758SerAla: 4.758 ± 0.156
1.375SerCys: 1.375 ± 0.095
4.54SerAsp: 4.54 ± 0.173
6.91SerGlu: 6.91 ± 0.194
4.605SerPhe: 4.605 ± 0.154
5.716SerGly: 5.716 ± 0.171
1.217SerHis: 1.217 ± 0.069
4.995SerIle: 4.995 ± 0.182
7.547SerLys: 7.547 ± 0.188
10.084SerLeu: 10.084 ± 0.269
1.691SerMet: 1.691 ± 0.088
3.69SerAsn: 3.69 ± 0.146
3.146SerPro: 3.146 ± 0.133
3.573SerGln: 3.573 ± 0.146
3.783SerArg: 3.783 ± 0.118
11.394SerSer: 11.394 ± 0.402
4.675SerThr: 4.675 ± 0.169
4.684SerVal: 4.684 ± 0.156
1.399SerTrp: 1.399 ± 0.086
3.058SerTyr: 3.058 ± 0.11
0.0SerXaa: 0.0 ± 0.0
Thr
3.216ThrAla: 3.216 ± 0.124
1.059ThrCys: 1.059 ± 0.083
2.402ThrAsp: 2.402 ± 0.102
3.415ThrGlu: 3.415 ± 0.146
2.76ThrPhe: 2.76 ± 0.11
3.699ThrGly: 3.699 ± 0.142
0.939ThrHis: 0.939 ± 0.06
3.202ThrIle: 3.202 ± 0.149
4.35ThrLys: 4.35 ± 0.132
5.618ThrLeu: 5.618 ± 0.166
0.762ThrMet: 0.762 ± 0.05
2.277ThrAsn: 2.277 ± 0.104
2.198ThrPro: 2.198 ± 0.113
2.3ThrGln: 2.3 ± 0.115
1.952ThrArg: 1.952 ± 0.094
4.21ThrSer: 4.21 ± 0.134
3.188ThrThr: 3.188 ± 0.151
3.313ThrVal: 3.313 ± 0.131
0.785ThrTrp: 0.785 ± 0.06
2.407ThrTyr: 2.407 ± 0.104
0.0ThrXaa: 0.0 ± 0.0
Val
3.927ValAla: 3.927 ± 0.125
1.194ValCys: 1.194 ± 0.076
2.793ValAsp: 2.793 ± 0.112
3.694ValGlu: 3.694 ± 0.133
3.183ValPhe: 3.183 ± 0.135
4.266ValGly: 4.266 ± 0.161
0.827ValHis: 0.827 ± 0.053
3.318ValIle: 3.318 ± 0.144
4.777ValLys: 4.777 ± 0.173
5.376ValLeu: 5.376 ± 0.136
0.73ValMet: 0.73 ± 0.058
2.737ValAsn: 2.737 ± 0.115
1.947ValPro: 1.947 ± 0.108
1.854ValGln: 1.854 ± 0.101
2.086ValArg: 2.086 ± 0.095
5.646ValSer: 5.646 ± 0.19
3.522ValThr: 3.522 ± 0.135
3.968ValVal: 3.968 ± 0.149
0.757ValTrp: 0.757 ± 0.067
1.733ValTyr: 1.733 ± 0.084
0.0ValXaa: 0.0 ± 0.0
Trp
0.734TrpAla: 0.734 ± 0.058
0.093TrpCys: 0.093 ± 0.02
1.087TrpAsp: 1.087 ± 0.066
1.162TrpGlu: 1.162 ± 0.072
0.706TrpPhe: 0.706 ± 0.054
0.957TrpGly: 0.957 ± 0.079
0.144TrpHis: 0.144 ± 0.024
0.73TrpIle: 0.73 ± 0.052
1.301TrpLys: 1.301 ± 0.082
1.352TrpLeu: 1.352 ± 0.085
0.404TrpMet: 0.404 ± 0.043
0.702TrpAsn: 0.702 ± 0.057
0.228TrpPro: 0.228 ± 0.03
0.441TrpGln: 0.441 ± 0.045
0.744TrpArg: 0.744 ± 0.065
1.296TrpSer: 1.296 ± 0.084
0.799TrpThr: 0.799 ± 0.062
0.748TrpVal: 0.748 ± 0.06
0.279TrpTrp: 0.279 ± 0.035
0.572TrpTyr: 0.572 ± 0.048
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.478TyrAla: 1.478 ± 0.071
0.655TyrCys: 0.655 ± 0.052
1.422TyrAsp: 1.422 ± 0.077
2.486TyrGlu: 2.486 ± 0.099
2.175TyrPhe: 2.175 ± 0.112
1.566TyrGly: 1.566 ± 0.083
0.562TyrHis: 0.562 ± 0.053
1.845TyrIle: 1.845 ± 0.098
3.123TyrLys: 3.123 ± 0.11
4.591TyrLeu: 4.591 ± 0.152
0.483TyrMet: 0.483 ± 0.042
0.985TyrAsn: 0.985 ± 0.076
1.245TyrPro: 1.245 ± 0.069
1.631TyrGln: 1.631 ± 0.082
1.691TyrArg: 1.691 ± 0.088
3.522TyrSer: 3.522 ± 0.157
1.743TyrThr: 1.743 ± 0.087
1.738TyrVal: 1.738 ± 0.088
0.702TyrTrp: 0.702 ± 0.062
1.454TyrTyr: 1.454 ± 0.089
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 923 proteins (215198 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski