Amino acid dipepetide frequency for Circoviridae 7 LDMD-2013

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.02AlaAla: 7.02 ± 2.101
0.0AlaCys: 0.0 ± 0.0
1.276AlaAsp: 1.276 ± 1.217
3.829AlaGlu: 3.829 ± 1.875
2.553AlaPhe: 2.553 ± 2.265
5.743AlaGly: 5.743 ± 1.627
1.276AlaHis: 1.276 ± 0.896
2.553AlaIle: 2.553 ± 1.127
3.191AlaLys: 3.191 ± 1.447
3.191AlaLeu: 3.191 ± 1.104
1.914AlaMet: 1.914 ± 1.065
3.829AlaAsn: 3.829 ± 1.099
6.382AlaPro: 6.382 ± 1.291
3.191AlaGln: 3.191 ± 1.072
7.02AlaArg: 7.02 ± 0.802
5.743AlaSer: 5.743 ± 0.811
6.382AlaThr: 6.382 ± 2.313
4.467AlaVal: 4.467 ± 2.426
0.638AlaTrp: 0.638 ± 0.608
2.553AlaTyr: 2.553 ± 1.053
0.638AlaXaa: 0.638 ± 0.566
Cys
1.914CysAla: 1.914 ± 1.049
0.0CysCys: 0.0 ± 0.0
1.276CysAsp: 1.276 ± 0.683
1.914CysGlu: 1.914 ± 1.268
0.638CysPhe: 0.638 ± 0.634
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
1.276CysIle: 1.276 ± 0.767
0.638CysLys: 0.638 ± 0.634
0.638CysLeu: 0.638 ± 0.634
0.0CysMet: 0.0 ± 0.0
0.638CysAsn: 0.638 ± 0.57
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.638CysArg: 0.638 ± 0.634
1.914CysSer: 1.914 ± 1.268
0.638CysThr: 0.638 ± 0.608
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.638CysTyr: 0.638 ± 0.57
0.638CysXaa: 0.638 ± 0.57
Asp
3.191AspAla: 3.191 ± 0.604
0.0AspCys: 0.0 ± 0.0
4.467AspAsp: 4.467 ± 1.938
3.191AspGlu: 3.191 ± 1.701
3.829AspPhe: 3.829 ± 1.361
4.467AspGly: 4.467 ± 0.906
0.0AspHis: 0.0 ± 0.0
2.553AspIle: 2.553 ± 0.869
1.914AspLys: 1.914 ± 0.67
3.191AspLeu: 3.191 ± 1.958
0.638AspMet: 0.638 ± 0.704
1.276AspAsn: 1.276 ± 0.767
5.105AspPro: 5.105 ± 2.165
1.276AspGln: 1.276 ± 0.752
1.914AspArg: 1.914 ± 0.966
3.829AspSer: 3.829 ± 0.656
3.829AspThr: 3.829 ± 1.377
1.914AspVal: 1.914 ± 1.065
0.0AspTrp: 0.0 ± 0.0
2.553AspTyr: 2.553 ± 1.415
0.0AspXaa: 0.0 ± 0.0
Glu
5.743GluAla: 5.743 ± 2.38
0.0GluCys: 0.0 ± 0.0
2.553GluAsp: 2.553 ± 1.686
3.191GluGlu: 3.191 ± 1.211
1.914GluPhe: 1.914 ± 1.364
3.829GluGly: 3.829 ± 1.603
0.638GluHis: 0.638 ± 0.704
1.276GluIle: 1.276 ± 0.722
1.276GluLys: 1.276 ± 0.752
3.829GluLeu: 3.829 ± 1.099
1.914GluMet: 1.914 ± 0.519
3.829GluAsn: 3.829 ± 1.357
3.191GluPro: 3.191 ± 0.924
3.191GluGln: 3.191 ± 1.166
1.276GluArg: 1.276 ± 0.931
5.105GluSer: 5.105 ± 2.097
3.191GluThr: 3.191 ± 1.438
3.191GluVal: 3.191 ± 0.791
0.0GluTrp: 0.0 ± 0.0
1.914GluTyr: 1.914 ± 0.966
0.0GluXaa: 0.0 ± 0.0
Phe
2.553PheAla: 2.553 ± 0.842
0.0PheCys: 0.0 ± 0.0
5.105PheAsp: 5.105 ± 2.111
1.914PheGlu: 1.914 ± 1.235
1.276PhePhe: 1.276 ± 0.722
2.553PheGly: 2.553 ± 1.241
0.0PheHis: 0.0 ± 0.0
1.914PheIle: 1.914 ± 0.966
3.829PheLys: 3.829 ± 1.117
3.829PheLeu: 3.829 ± 1.975
0.638PheMet: 0.638 ± 0.608
1.276PheAsn: 1.276 ± 1.132
1.914PhePro: 1.914 ± 1.174
0.0PheGln: 0.0 ± 0.0
3.829PheArg: 3.829 ± 1.465
1.914PheSer: 1.914 ± 0.966
3.191PheThr: 3.191 ± 1.438
1.276PheVal: 1.276 ± 0.683
0.0PheTrp: 0.0 ± 0.0
0.638PheTyr: 0.638 ± 0.608
0.638PheXaa: 0.638 ± 0.57
Gly
5.743GlyAla: 5.743 ± 2.407
0.638GlyCys: 0.638 ± 0.57
1.914GlyAsp: 1.914 ± 0.724
7.02GlyGlu: 7.02 ± 2.596
1.276GlyPhe: 1.276 ± 0.752
1.914GlyGly: 1.914 ± 0.517
1.914GlyHis: 1.914 ± 1.231
1.914GlyIle: 1.914 ± 1.825
5.743GlyLys: 5.743 ± 1.154
4.467GlyLeu: 4.467 ± 2.192
0.0GlyMet: 0.0 ± 0.0
5.743GlyAsn: 5.743 ± 2.407
4.467GlyPro: 4.467 ± 1.004
1.914GlyGln: 1.914 ± 0.517
5.743GlyArg: 5.743 ± 1.864
4.467GlySer: 4.467 ± 0.987
6.382GlyThr: 6.382 ± 2.876
4.467GlyVal: 4.467 ± 0.825
0.638GlyTrp: 0.638 ± 0.634
2.553GlyTyr: 2.553 ± 0.352
0.0GlyXaa: 0.0 ± 0.0
His
1.914HisAla: 1.914 ± 1.525
0.638HisCys: 0.638 ± 0.634
0.638HisAsp: 0.638 ± 0.57
1.276HisGlu: 1.276 ± 0.683
0.638HisPhe: 0.638 ± 0.634
0.0HisGly: 0.0 ± 0.0
0.0HisHis: 0.0 ± 0.0
0.0HisIle: 0.0 ± 0.0
0.638HisLys: 0.638 ± 0.608
0.638HisLeu: 0.638 ± 0.634
1.914HisMet: 1.914 ± 1.453
0.638HisAsn: 0.638 ± 0.704
0.638HisPro: 0.638 ± 0.57
0.0HisGln: 0.0 ± 0.0
1.914HisArg: 1.914 ± 1.453
0.0HisSer: 0.0 ± 0.0
0.0HisThr: 0.0 ± 0.0
1.276HisVal: 1.276 ± 0.863
1.276HisTrp: 1.276 ± 1.267
0.638HisTyr: 0.638 ± 0.608
0.0HisXaa: 0.0 ± 0.0
Ile
4.467IleAla: 4.467 ± 1.343
0.638IleCys: 0.638 ± 0.608
1.276IleAsp: 1.276 ± 1.132
1.276IleGlu: 1.276 ± 0.722
0.638IlePhe: 0.638 ± 0.57
4.467IleGly: 4.467 ± 0.853
0.0IleHis: 0.0 ± 0.0
0.638IleIle: 0.638 ± 0.57
1.276IleLys: 1.276 ± 1.14
3.829IleLeu: 3.829 ± 1.194
3.191IleMet: 3.191 ± 1.676
0.638IleAsn: 0.638 ± 0.634
3.191IlePro: 3.191 ± 1.588
1.276IleGln: 1.276 ± 0.683
5.105IleArg: 5.105 ± 1.383
2.553IleSer: 2.553 ± 0.962
3.191IleThr: 3.191 ± 1.806
2.553IleVal: 2.553 ± 0.869
0.638IleTrp: 0.638 ± 0.57
1.276IleTyr: 1.276 ± 0.683
0.638IleXaa: 0.638 ± 0.634
Lys
3.829LysAla: 3.829 ± 1.644
1.276LysCys: 1.276 ± 1.267
1.914LysAsp: 1.914 ± 0.67
1.276LysGlu: 1.276 ± 0.621
1.276LysPhe: 1.276 ± 0.722
3.191LysGly: 3.191 ± 0.67
0.638LysHis: 0.638 ± 0.608
1.276LysIle: 1.276 ± 0.752
3.829LysLys: 3.829 ± 2.904
1.276LysLeu: 1.276 ± 1.132
0.0LysMet: 0.0 ± 0.0
4.467LysAsn: 4.467 ± 1.795
4.467LysPro: 4.467 ± 1.668
1.276LysGln: 1.276 ± 0.752
6.382LysArg: 6.382 ± 0.952
0.638LysSer: 0.638 ± 0.57
2.553LysThr: 2.553 ± 0.944
5.105LysVal: 5.105 ± 2.308
1.276LysTrp: 1.276 ± 0.683
0.0LysTyr: 0.0 ± 0.0
0.0LysXaa: 0.0 ± 0.0
Leu
5.105LeuAla: 5.105 ± 1.926
1.276LeuCys: 1.276 ± 1.14
4.467LeuAsp: 4.467 ± 1.343
0.638LeuGlu: 0.638 ± 0.634
2.553LeuPhe: 2.553 ± 0.636
2.553LeuGly: 2.553 ± 0.989
0.0LeuHis: 0.0 ± 0.0
4.467LeuIle: 4.467 ± 0.618
2.553LeuLys: 2.553 ± 2.281
7.658LeuLeu: 7.658 ± 2.807
2.553LeuMet: 2.553 ± 1.247
5.743LeuAsn: 5.743 ± 2.46
7.658LeuPro: 7.658 ± 0.972
3.191LeuGln: 3.191 ± 1.532
5.743LeuArg: 5.743 ± 1.802
4.467LeuSer: 4.467 ± 0.618
5.105LeuThr: 5.105 ± 2.3
2.553LeuVal: 2.553 ± 1.826
0.638LeuTrp: 0.638 ± 0.57
1.914LeuTyr: 1.914 ± 1.133
0.0LeuXaa: 0.0 ± 0.0
Met
3.829MetAla: 3.829 ± 1.511
0.0MetCys: 0.0 ± 0.0
0.638MetAsp: 0.638 ± 0.566
3.191MetGlu: 3.191 ± 1.699
0.638MetPhe: 0.638 ± 0.704
1.276MetGly: 1.276 ± 0.657
0.0MetHis: 0.0 ± 0.0
1.276MetIle: 1.276 ± 0.683
1.276MetLys: 1.276 ± 1.14
1.276MetLeu: 1.276 ± 0.657
0.0MetMet: 0.0 ± 0.0
0.638MetAsn: 0.638 ± 0.566
1.276MetPro: 1.276 ± 0.863
0.638MetGln: 0.638 ± 0.634
2.553MetArg: 2.553 ± 1.147
1.914MetSer: 1.914 ± 1.065
2.553MetThr: 2.553 ± 1.474
1.276MetVal: 1.276 ± 0.657
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
1.914AsnAla: 1.914 ± 0.876
0.0AsnCys: 0.0 ± 0.0
1.914AsnAsp: 1.914 ± 1.065
3.191AsnGlu: 3.191 ± 1.368
2.553AsnPhe: 2.553 ± 0.975
2.553AsnGly: 2.553 ± 2.265
0.638AsnHis: 0.638 ± 0.704
3.829AsnIle: 3.829 ± 1.556
3.191AsnLys: 3.191 ± 1.104
2.553AsnLeu: 2.553 ± 1.259
1.914AsnMet: 1.914 ± 0.958
0.638AsnAsn: 0.638 ± 0.634
5.743AsnPro: 5.743 ± 2.38
0.0AsnGln: 0.0 ± 0.0
3.191AsnArg: 3.191 ± 2.032
3.829AsnSer: 3.829 ± 0.738
3.191AsnThr: 3.191 ± 0.967
6.382AsnVal: 6.382 ± 2.914
1.914AsnTrp: 1.914 ± 1.042
3.191AsnTyr: 3.191 ± 1.299
0.0AsnXaa: 0.0 ± 0.0
Pro
5.105ProAla: 5.105 ± 1.546
1.914ProCys: 1.914 ± 0.517
1.914ProAsp: 1.914 ± 0.67
4.467ProGlu: 4.467 ± 1.48
0.638ProPhe: 0.638 ± 0.57
5.743ProGly: 5.743 ± 1.684
1.914ProHis: 1.914 ± 1.525
3.191ProIle: 3.191 ± 1.477
2.553ProLys: 2.553 ± 1.126
7.658ProLeu: 7.658 ± 1.311
1.276ProMet: 1.276 ± 0.896
3.191ProAsn: 3.191 ± 1.339
1.914ProPro: 1.914 ± 1.525
2.553ProGln: 2.553 ± 0.869
5.105ProArg: 5.105 ± 2.404
5.105ProSer: 5.105 ± 1.036
6.382ProThr: 6.382 ± 1.806
5.105ProVal: 5.105 ± 1.769
1.276ProTrp: 1.276 ± 0.771
3.191ProTyr: 3.191 ± 2.113
0.638ProXaa: 0.638 ± 0.57
Gln
3.191GlnAla: 3.191 ± 0.604
0.638GlnCys: 0.638 ± 0.634
4.467GlnAsp: 4.467 ± 2.005
2.553GlnGlu: 2.553 ± 1.57
0.638GlnPhe: 0.638 ± 0.608
3.829GlnGly: 3.829 ± 1.787
0.638GlnHis: 0.638 ± 0.608
0.638GlnIle: 0.638 ± 0.608
0.638GlnLys: 0.638 ± 0.57
2.553GlnLeu: 2.553 ± 2.281
0.0GlnMet: 0.0 ± 0.0
3.829GlnAsn: 3.829 ± 2.266
1.276GlnPro: 1.276 ± 0.752
1.914GlnGln: 1.914 ± 0.517
2.553GlnArg: 2.553 ± 1.474
1.276GlnSer: 1.276 ± 1.132
3.191GlnThr: 3.191 ± 2.281
1.914GlnVal: 1.914 ± 0.67
0.0GlnTrp: 0.0 ± 0.0
1.276GlnTyr: 1.276 ± 1.132
0.638GlnXaa: 0.638 ± 0.634
Arg
5.105ArgAla: 5.105 ± 1.535
2.553ArgCys: 2.553 ± 1.534
1.914ArgAsp: 1.914 ± 0.966
2.553ArgGlu: 2.553 ± 1.506
4.467ArgPhe: 4.467 ± 1.774
6.382ArgGly: 6.382 ± 2.195
3.191ArgHis: 3.191 ± 1.798
1.914ArgIle: 1.914 ± 1.049
1.276ArgLys: 1.276 ± 1.267
6.382ArgLeu: 6.382 ± 2.885
2.553ArgMet: 2.553 ± 1.861
1.276ArgAsn: 1.276 ± 0.931
5.743ArgPro: 5.743 ± 2.229
3.191ArgGln: 3.191 ± 1.48
10.849ArgArg: 10.849 ± 6.024
6.382ArgSer: 6.382 ± 1.668
7.02ArgThr: 7.02 ± 1.711
4.467ArgVal: 4.467 ± 2.024
1.914ArgTrp: 1.914 ± 0.802
1.914ArgTyr: 1.914 ± 1.156
0.0ArgXaa: 0.0 ± 0.0
Ser
4.467SerAla: 4.467 ± 1.026
0.0SerCys: 0.0 ± 0.0
4.467SerAsp: 4.467 ± 2.285
3.829SerGlu: 3.829 ± 1.303
5.105SerPhe: 5.105 ± 2.65
5.105SerGly: 5.105 ± 1.378
0.638SerHis: 0.638 ± 0.634
5.105SerIle: 5.105 ± 1.352
3.191SerLys: 3.191 ± 0.67
4.467SerLeu: 4.467 ± 1.395
1.914SerMet: 1.914 ± 0.823
3.829SerAsn: 3.829 ± 1.22
3.829SerPro: 3.829 ± 0.973
1.276SerGln: 1.276 ± 0.722
3.829SerArg: 3.829 ± 0.734
5.743SerSer: 5.743 ± 2.578
9.572SerThr: 9.572 ± 1.615
2.553SerVal: 2.553 ± 1.616
1.276SerTrp: 1.276 ± 0.683
0.638SerTyr: 0.638 ± 0.566
0.0SerXaa: 0.0 ± 0.0
Thr
5.743ThrAla: 5.743 ± 2.432
0.0ThrCys: 0.0 ± 0.0
3.191ThrAsp: 3.191 ± 1.168
1.276ThrGlu: 1.276 ± 0.896
2.553ThrPhe: 2.553 ± 1.616
3.829ThrGly: 3.829 ± 1.833
1.914ThrHis: 1.914 ± 0.724
4.467ThrIle: 4.467 ± 1.026
4.467ThrLys: 4.467 ± 1.278
3.191ThrLeu: 3.191 ± 0.967
1.914ThrMet: 1.914 ± 1.063
5.743ThrAsn: 5.743 ± 1.318
4.467ThrPro: 4.467 ± 1.727
4.467ThrGln: 4.467 ± 1.426
7.02ThrArg: 7.02 ± 1.584
10.211ThrSer: 10.211 ± 2.481
2.553ThrThr: 2.553 ± 0.989
5.743ThrVal: 5.743 ± 2.296
0.638ThrTrp: 0.638 ± 0.634
1.914ThrTyr: 1.914 ± 1.825
0.638ThrXaa: 0.638 ± 0.634
Val
1.914ValAla: 1.914 ± 1.065
1.276ValCys: 1.276 ± 0.683
3.191ValAsp: 3.191 ± 1.058
3.829ValGlu: 3.829 ± 1.117
1.276ValPhe: 1.276 ± 1.14
6.382ValGly: 6.382 ± 1.427
0.0ValHis: 0.0 ± 0.0
1.276ValIle: 1.276 ± 0.621
2.553ValLys: 2.553 ± 0.352
4.467ValLeu: 4.467 ± 1.07
0.638ValMet: 0.638 ± 0.517
3.829ValAsn: 3.829 ± 0.734
3.829ValPro: 3.829 ± 1.117
6.382ValGln: 6.382 ± 2.894
4.467ValArg: 4.467 ± 1.736
2.553ValSer: 2.553 ± 1.056
4.467ValThr: 4.467 ± 2.039
7.02ValVal: 7.02 ± 1.406
0.638ValTrp: 0.638 ± 0.566
3.829ValTyr: 3.829 ± 1.556
0.0ValXaa: 0.0 ± 0.0
Trp
0.638TrpAla: 0.638 ± 0.57
1.276TrpCys: 1.276 ± 0.752
0.638TrpAsp: 0.638 ± 0.566
0.638TrpGlu: 0.638 ± 0.634
1.914TrpPhe: 1.914 ± 1.102
1.276TrpGly: 1.276 ± 0.683
0.0TrpHis: 0.0 ± 0.0
0.638TrpIle: 0.638 ± 0.634
0.638TrpLys: 0.638 ± 0.566
1.914TrpLeu: 1.914 ± 1.042
0.638TrpMet: 0.638 ± 0.566
0.0TrpAsn: 0.0 ± 0.0
0.638TrpPro: 0.638 ± 0.566
0.0TrpGln: 0.0 ± 0.0
0.638TrpArg: 0.638 ± 0.704
1.276TrpSer: 1.276 ± 0.683
0.638TrpThr: 0.638 ± 0.608
0.638TrpVal: 0.638 ± 0.634
0.0TrpTrp: 0.0 ± 0.0
1.276TrpTyr: 1.276 ± 0.771
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.0TyrAla: 0.0 ± 0.0
1.276TyrCys: 1.276 ± 1.267
1.276TyrAsp: 1.276 ± 0.771
0.0TyrGlu: 0.0 ± 0.0
0.638TyrPhe: 0.638 ± 0.566
2.553TyrGly: 2.553 ± 0.636
1.276TyrHis: 1.276 ± 0.896
2.553TyrIle: 2.553 ± 1.056
1.276TyrLys: 1.276 ± 0.621
3.829TyrLeu: 3.829 ± 0.928
0.0TyrMet: 0.0 ± 0.0
1.914TyrAsn: 1.914 ± 1.042
3.829TyrPro: 3.829 ± 1.22
1.914TyrGln: 1.914 ± 1.317
1.276TyrArg: 1.276 ± 0.863
1.914TyrSer: 1.914 ± 1.132
1.914TyrThr: 1.914 ± 0.876
1.914TyrVal: 1.914 ± 1.699
2.553TyrTrp: 2.553 ± 0.842
2.553TyrTyr: 2.553 ± 1.259
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.638XaaAsp: 0.638 ± 0.57
0.0XaaGlu: 0.0 ± 0.0
1.276XaaPhe: 1.276 ± 0.752
1.276XaaGly: 1.276 ± 0.722
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
1.276XaaPro: 1.276 ± 0.752
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.638XaaXaa: 0.638 ± 0.57
Statistics based on 5 proteins (1568 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski