Amino acid dipepetide frequency for Candidatus Marinimicrobia bacterium PRS2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.874AlaAla: 3.874 ± 0.128	0.841AlaCys: 0.841 ± 0.065	3.648AlaAsp: 3.648 ± 0.114	4.039AlaGlu: 4.039 ± 0.113	2.528AlaPhe: 2.528 ± 0.075	4.92AlaGly: 4.92 ± 0.167	0.973AlaHis: 0.973 ± 0.053	4.736AlaIle: 4.736 ± 0.126	3.099AlaLys: 3.099 ± 0.117	5.21AlaLeu: 5.21 ± 0.134	1.485AlaMet: 1.485 ± 0.062	2.698AlaAsn: 2.698 ± 0.079	1.711AlaPro: 1.711 ± 0.072	1.666AlaGln: 1.666 ± 0.06	1.968AlaArg: 1.968 ± 0.08	3.527AlaSer: 3.527 ± 0.105	2.825AlaThr: 2.825 ± 0.085	3.801AlaVal: 3.801 ± 0.106	0.617AlaTrp: 0.617 ± 0.044	2.074AlaTyr: 2.074 ± 0.067	0.0AlaXaa: 0.0 ± 0.0
Cys	0.874CysAla: 0.874 ± 0.086	0.224CysCys: 0.224 ± 0.035	1.433CysAsp: 1.433 ± 0.145	0.917CysGlu: 0.917 ± 0.063	0.492CysPhe: 0.492 ± 0.036	1.619CysGly: 1.619 ± 0.169	0.224CysHis: 0.224 ± 0.034	0.912CysIle: 0.912 ± 0.059	0.457CysLys: 0.457 ± 0.037	0.94CysLeu: 0.94 ± 0.055	0.243CysMet: 0.243 ± 0.026	1.119CysAsn: 1.119 ± 0.121	0.672CysPro: 0.672 ± 0.069	0.311CysGln: 0.311 ± 0.028	0.37CysArg: 0.37 ± 0.031	0.992CysSer: 0.992 ± 0.075	0.747CysThr: 0.747 ± 0.055	0.683CysVal: 0.683 ± 0.069	0.13CysTrp: 0.13 ± 0.023	0.462CysTyr: 0.462 ± 0.043	0.0CysXaa: 0.0 ± 0.0
Asp	3.65AspAla: 3.65 ± 0.125	2.012AspCys: 2.012 ± 0.264	4.154AspAsp: 4.154 ± 0.201	4.765AspGlu: 4.765 ± 0.129	3.143AspPhe: 3.143 ± 0.096	5.775AspGly: 5.775 ± 0.246	1.006AspHis: 1.006 ± 0.055	5.606AspIle: 5.606 ± 0.13	3.388AspLys: 3.388 ± 0.102	5.193AspLeu: 5.193 ± 0.121	1.388AspMet: 1.388 ± 0.056	3.683AspAsn: 3.683 ± 0.166	2.425AspPro: 2.425 ± 0.083	1.51AspGln: 1.51 ± 0.066	1.899AspArg: 1.899 ± 0.077	4.432AspSer: 4.432 ± 0.15	2.938AspThr: 2.938 ± 0.087	3.735AspVal: 3.735 ± 0.102	1.006AspTrp: 1.006 ± 0.056	2.707AspTyr: 2.707 ± 0.099	0.0AspXaa: 0.0 ± 0.0
Glu	3.527GluAla: 3.527 ± 0.091	1.119GluCys: 1.119 ± 0.097	4.091GluAsp: 4.091 ± 0.121	4.602GluGlu: 4.602 ± 0.126	3.198GluPhe: 3.198 ± 0.083	4.117GluGly: 4.117 ± 0.122	0.994GluHis: 0.994 ± 0.047	6.529GluIle: 6.529 ± 0.174	5.073GluLys: 5.073 ± 0.154	6.254GluLeu: 6.254 ± 0.129	1.833GluMet: 1.833 ± 0.077	5.047GluAsn: 5.047 ± 0.12	1.92GluPro: 1.92 ± 0.071	1.734GluGln: 1.734 ± 0.072	2.107GluArg: 2.107 ± 0.081	4.173GluSer: 4.173 ± 0.098	3.346GluThr: 3.346 ± 0.087	3.846GluVal: 3.846 ± 0.096	0.86GluTrp: 0.86 ± 0.047	2.821GluTyr: 2.821 ± 0.093	0.0GluXaa: 0.0 ± 0.0
Phe	2.547PheAla: 2.547 ± 0.085	0.452PheCys: 0.452 ± 0.037	3.021PheAsp: 3.021 ± 0.091	2.863PheGlu: 2.863 ± 0.084	1.951PhePhe: 1.951 ± 0.075	3.497PheGly: 3.497 ± 0.119	1.02PheHis: 1.02 ± 0.06	4.11PheIle: 4.11 ± 0.117	2.394PheLys: 2.394 ± 0.095	3.86PheLeu: 3.86 ± 0.137	1.065PheMet: 1.065 ± 0.065	2.872PheAsn: 2.872 ± 0.091	1.939PhePro: 1.939 ± 0.07	1.793PheGln: 1.793 ± 0.066	1.666PheArg: 1.666 ± 0.066	4.18PheSer: 4.18 ± 0.125	3.049PheThr: 3.049 ± 0.103	2.274PheVal: 2.274 ± 0.069	0.617PheTrp: 0.617 ± 0.041	1.838PheTyr: 1.838 ± 0.081	0.0PheXaa: 0.0 ± 0.0
Gly	4.135GlyAla: 4.135 ± 0.137	1.112GlyCys: 1.112 ± 0.076	5.396GlyAsp: 5.396 ± 0.22	5.142GlyGlu: 5.142 ± 0.146	3.549GlyPhe: 3.549 ± 0.123	6.296GlyGly: 6.296 ± 0.249	1.284GlyHis: 1.284 ± 0.059	6.454GlyIle: 6.454 ± 0.136	4.739GlyLys: 4.739 ± 0.154	5.849GlyLeu: 5.849 ± 0.133	1.932GlyMet: 1.932 ± 0.085	4.675GlyAsn: 4.675 ± 0.153	1.6GlyPro: 1.6 ± 0.074	1.958GlyGln: 1.958 ± 0.078	2.422GlyArg: 2.422 ± 0.086	5.201GlySer: 5.201 ± 0.149	4.23GlyThr: 4.23 ± 0.123	4.689GlyVal: 4.689 ± 0.134	1.096GlyTrp: 1.096 ± 0.052	3.188GlyTyr: 3.188 ± 0.109	0.0GlyXaa: 0.0 ± 0.0
His	1.016HisAla: 1.016 ± 0.055	0.252HisCys: 0.252 ± 0.022	0.886HisAsp: 0.886 ± 0.047	1.077HisGlu: 1.077 ± 0.052	1.096HisPhe: 1.096 ± 0.055	1.19HisGly: 1.19 ± 0.053	0.561HisHis: 0.561 ± 0.039	1.649HisIle: 1.649 ± 0.07	0.98HisLys: 0.98 ± 0.045	1.928HisLeu: 1.928 ± 0.074	0.325HisMet: 0.325 ± 0.027	0.978HisAsn: 0.978 ± 0.045	1.103HisPro: 1.103 ± 0.05	0.653HisGln: 0.653 ± 0.038	0.792HisArg: 0.792 ± 0.051	1.459HisSer: 1.459 ± 0.051	0.921HisThr: 0.921 ± 0.045	0.99HisVal: 0.99 ± 0.046	0.273HisTrp: 0.273 ± 0.024	0.796HisTyr: 0.796 ± 0.041	0.0HisXaa: 0.0 ± 0.0
Ile	4.847IleAla: 4.847 ± 0.12	1.11IleCys: 1.11 ± 0.076	5.351IleAsp: 5.351 ± 0.137	5.387IleGlu: 5.387 ± 0.13	3.862IlePhe: 3.862 ± 0.137	5.775IleGly: 5.775 ± 0.141	1.76IleHis: 1.76 ± 0.069	7.51IleIle: 7.51 ± 0.172	4.885IleLys: 4.885 ± 0.134	8.035IleLeu: 8.035 ± 0.151	1.755IleMet: 1.755 ± 0.071	5.139IleAsn: 5.139 ± 0.135	4.303IlePro: 4.303 ± 0.133	3.311IleGln: 3.311 ± 0.095	2.903IleArg: 2.903 ± 0.106	6.826IleSer: 6.826 ± 0.132	4.97IleThr: 4.97 ± 0.142	4.461IleVal: 4.461 ± 0.106	0.938IleTrp: 0.938 ± 0.052	3.2IleTyr: 3.2 ± 0.115	0.0IleXaa: 0.0 ± 0.0
Lys	3.002LysAla: 3.002 ± 0.104	0.445LysCys: 0.445 ± 0.038	3.252LysAsp: 3.252 ± 0.101	4.093LysGlu: 4.093 ± 0.127	2.323LysPhe: 2.323 ± 0.088	3.499LysGly: 3.499 ± 0.133	1.051LysHis: 1.051 ± 0.053	5.512LysIle: 5.512 ± 0.139	4.725LysLys: 4.725 ± 0.169	5.613LysLeu: 5.613 ± 0.143	1.949LysMet: 1.949 ± 0.074	3.98LysAsn: 3.98 ± 0.114	2.012LysPro: 2.012 ± 0.077	1.925LysGln: 1.925 ± 0.074	2.389LysArg: 2.389 ± 0.092	3.968LysSer: 3.968 ± 0.125	3.127LysThr: 3.127 ± 0.099	3.459LysVal: 3.459 ± 0.101	0.834LysTrp: 0.834 ± 0.053	2.663LysTyr: 2.663 ± 0.104	0.0LysXaa: 0.0 ± 0.0
Leu	5.144LeuAla: 5.144 ± 0.135	0.855LeuCys: 0.855 ± 0.053	5.865LeuAsp: 5.865 ± 0.126	6.183LeuGlu: 6.183 ± 0.127	4.293LeuPhe: 4.293 ± 0.127	6.216LeuGly: 6.216 ± 0.155	1.628LeuHis: 1.628 ± 0.064	7.43LeuIle: 7.43 ± 0.14	5.813LeuLys: 5.813 ± 0.144	7.783LeuLeu: 7.783 ± 0.208	1.869LeuMet: 1.869 ± 0.071	5.596LeuAsn: 5.596 ± 0.129	3.716LeuPro: 3.716 ± 0.11	2.835LeuGln: 2.835 ± 0.094	3.049LeuArg: 3.049 ± 0.099	7.116LeuSer: 7.116 ± 0.144	5.568LeuThr: 5.568 ± 0.157	4.812LeuVal: 4.812 ± 0.095	0.935LeuTrp: 0.935 ± 0.049	3.051LeuTyr: 3.051 ± 0.088	0.0LeuXaa: 0.0 ± 0.0
Met	1.628MetAla: 1.628 ± 0.072	0.17MetCys: 0.17 ± 0.02	1.593MetAsp: 1.593 ± 0.066	1.657MetGlu: 1.657 ± 0.065	0.813MetPhe: 0.813 ± 0.05	2.147MetGly: 2.147 ± 0.088	0.37MetHis: 0.37 ± 0.026	1.628MetIle: 1.628 ± 0.06	1.831MetLys: 1.831 ± 0.071	1.916MetLeu: 1.916 ± 0.078	0.662MetMet: 0.662 ± 0.041	1.459MetAsn: 1.459 ± 0.061	0.858MetPro: 0.858 ± 0.048	0.723MetGln: 0.723 ± 0.042	0.78MetArg: 0.78 ± 0.044	1.548MetSer: 1.548 ± 0.058	1.107MetThr: 1.107 ± 0.05	1.687MetVal: 1.687 ± 0.068	0.193MetTrp: 0.193 ± 0.021	0.674MetTyr: 0.674 ± 0.048	0.0MetXaa: 0.0 ± 0.0
Asn	2.948AsnAla: 2.948 ± 0.084	1.075AsnCys: 1.075 ± 0.126	3.37AsnAsp: 3.37 ± 0.125	3.462AsnGlu: 3.462 ± 0.094	2.634AsnPhe: 2.634 ± 0.083	4.76AsnGly: 4.76 ± 0.152	1.152AsnHis: 1.152 ± 0.053	5.448AsnIle: 5.448 ± 0.154	3.205AsnLys: 3.205 ± 0.085	5.78AsnLeu: 5.78 ± 0.222	1.44AsnMet: 1.44 ± 0.056	3.973AsnAsn: 3.973 ± 0.168	3.127AsnPro: 3.127 ± 0.101	2.269AsnGln: 2.269 ± 0.091	2.019AsnArg: 2.019 ± 0.072	4.258AsnSer: 4.258 ± 0.128	3.073AsnThr: 3.073 ± 0.102	3.04AsnVal: 3.04 ± 0.096	1.004AsnTrp: 1.004 ± 0.058	2.837AsnTyr: 2.837 ± 0.1	0.0AsnXaa: 0.0 ± 0.0
Pro	2.158ProAla: 2.158 ± 0.069	0.37ProCys: 0.37 ± 0.032	2.887ProAsp: 2.887 ± 0.087	3.466ProGlu: 3.466 ± 0.113	2.156ProPhe: 2.156 ± 0.078	2.7ProGly: 2.7 ± 0.078	0.877ProHis: 0.877 ± 0.049	3.066ProIle: 3.066 ± 0.089	1.887ProLys: 1.887 ± 0.09	3.235ProLeu: 3.235 ± 0.106	0.801ProMet: 0.801 ± 0.04	2.149ProAsn: 2.149 ± 0.079	1.501ProPro: 1.501 ± 0.079	1.199ProGln: 1.199 ± 0.047	1.117ProArg: 1.117 ± 0.053	2.507ProSer: 2.507 ± 0.085	1.824ProThr: 1.824 ± 0.078	2.448ProVal: 2.448 ± 0.084	0.431ProTrp: 0.431 ± 0.033	1.437ProTyr: 1.437 ± 0.059	0.0ProXaa: 0.0 ± 0.0
Gln	1.859GlnAla: 1.859 ± 0.08	0.278GlnCys: 0.278 ± 0.028	1.895GlnAsp: 1.895 ± 0.086	1.892GlnGlu: 1.892 ± 0.07	1.805GlnPhe: 1.805 ± 0.073	1.805GlnGly: 1.805 ± 0.069	0.563GlnHis: 0.563 ± 0.036	3.03GlnIle: 3.03 ± 0.085	2.243GlnLys: 2.243 ± 0.082	3.308GlnLeu: 3.308 ± 0.113	0.773GlnMet: 0.773 ± 0.039	1.963GlnAsn: 1.963 ± 0.073	1.056GlnPro: 1.056 ± 0.05	0.994GlnGln: 0.994 ± 0.057	1.098GlnArg: 1.098 ± 0.052	2.161GlnSer: 2.161 ± 0.073	1.661GlnThr: 1.661 ± 0.078	1.741GlnVal: 1.741 ± 0.076	0.391GlnTrp: 0.391 ± 0.03	1.272GlnTyr: 1.272 ± 0.062	0.0GlnXaa: 0.0 ± 0.0
Arg	1.843ArgAla: 1.843 ± 0.071	0.285ArgCys: 0.285 ± 0.029	2.034ArgAsp: 2.034 ± 0.077	2.486ArgGlu: 2.486 ± 0.09	1.755ArgPhe: 1.755 ± 0.068	2.276ArgGly: 2.276 ± 0.071	0.679ArgHis: 0.679 ± 0.045	2.953ArgIle: 2.953 ± 0.099	2.696ArgLys: 2.696 ± 0.111	3.292ArgLeu: 3.292 ± 0.097	0.954ArgMet: 0.954 ± 0.052	1.763ArgAsn: 1.763 ± 0.078	1.049ArgPro: 1.049 ± 0.061	1.19ArgGln: 1.19 ± 0.056	1.546ArgArg: 1.546 ± 0.074	1.928ArgSer: 1.928 ± 0.074	1.558ArgThr: 1.558 ± 0.062	2.008ArgVal: 2.008 ± 0.072	0.478ArgTrp: 0.478 ± 0.033	1.367ArgTyr: 1.367 ± 0.062	0.0ArgXaa: 0.0 ± 0.0
Ser	4.289SerAla: 4.289 ± 0.103	0.924SerCys: 0.924 ± 0.066	4.482SerAsp: 4.482 ± 0.144	4.487SerGlu: 4.487 ± 0.112	3.393SerPhe: 3.393 ± 0.093	6.098SerGly: 6.098 ± 0.162	1.452SerHis: 1.452 ± 0.059	6.376SerIle: 6.376 ± 0.151	3.674SerLys: 3.674 ± 0.116	6.468SerLeu: 6.468 ± 0.135	1.501SerMet: 1.501 ± 0.058	4.15SerAsn: 4.15 ± 0.136	2.792SerPro: 2.792 ± 0.098	2.297SerGln: 2.297 ± 0.08	2.392SerArg: 2.392 ± 0.092	5.031SerSer: 5.031 ± 0.15	3.829SerThr: 3.829 ± 0.112	3.784SerVal: 3.784 ± 0.102	0.95SerTrp: 0.95 ± 0.053	2.502SerTyr: 2.502 ± 0.096	0.0SerXaa: 0.0 ± 0.0
Thr	3.313ThrAla: 3.313 ± 0.092	0.705ThrCys: 0.705 ± 0.068	3.518ThrAsp: 3.518 ± 0.11	3.355ThrGlu: 3.355 ± 0.097	2.491ThrPhe: 2.491 ± 0.08	4.449ThrGly: 4.449 ± 0.097	1.166ThrHis: 1.166 ± 0.057	4.897ThrIle: 4.897 ± 0.116	2.486ThrLys: 2.486 ± 0.092	5.226ThrLeu: 5.226 ± 0.131	1.067ThrMet: 1.067 ± 0.054	2.835ThrAsn: 2.835 ± 0.098	2.34ThrPro: 2.34 ± 0.067	1.73ThrGln: 1.73 ± 0.075	1.706ThrArg: 1.706 ± 0.068	3.452ThrSer: 3.452 ± 0.086	3.019ThrThr: 3.019 ± 0.098	2.986ThrVal: 2.986 ± 0.106	0.688ThrTrp: 0.688 ± 0.044	1.911ThrTyr: 1.911 ± 0.077	0.0ThrXaa: 0.0 ± 0.0
Val	3.12ValAla: 3.12 ± 0.101	0.954ValCys: 0.954 ± 0.077	3.914ValAsp: 3.914 ± 0.091	4.022ValGlu: 4.022 ± 0.1	2.559ValPhe: 2.559 ± 0.091	3.942ValGly: 3.942 ± 0.11	1.011ValHis: 1.011 ± 0.041	4.717ValIle: 4.717 ± 0.118	3.292ValLys: 3.292 ± 0.092	5.057ValLeu: 5.057 ± 0.106	1.371ValMet: 1.371 ± 0.056	3.386ValAsn: 3.386 ± 0.104	1.925ValPro: 1.925 ± 0.07	1.859ValGln: 1.859 ± 0.068	1.996ValArg: 1.996 ± 0.078	4.121ValSer: 4.121 ± 0.119	2.976ValThr: 2.976 ± 0.099	3.504ValVal: 3.504 ± 0.11	0.733ValTrp: 0.733 ± 0.049	2.026ValTyr: 2.026 ± 0.078	0.0ValXaa: 0.0 ± 0.0
Trp	0.65TrpAla: 0.65 ± 0.047	0.123TrpCys: 0.123 ± 0.016	1.105TrpAsp: 1.105 ± 0.069	0.935TrpGlu: 0.935 ± 0.053	0.613TrpPhe: 0.613 ± 0.04	1.169TrpGly: 1.169 ± 0.1	0.238TrpHis: 0.238 ± 0.027	1.013TrpIle: 1.013 ± 0.054	0.747TrpLys: 0.747 ± 0.046	1.105TrpLeu: 1.105 ± 0.06	0.337TrpMet: 0.337 ± 0.03	0.926TrpAsn: 0.926 ± 0.054	0.266TrpPro: 0.266 ± 0.031	0.462TrpGln: 0.462 ± 0.036	0.396TrpArg: 0.396 ± 0.033	0.789TrpSer: 0.789 ± 0.042	0.575TrpThr: 0.575 ± 0.037	0.834TrpVal: 0.834 ± 0.048	0.205TrpTrp: 0.205 ± 0.025	0.525TrpTyr: 0.525 ± 0.036	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.814TyrAla: 1.814 ± 0.07	0.514TyrCys: 0.514 ± 0.038	2.526TyrAsp: 2.526 ± 0.105	2.363TyrGlu: 2.363 ± 0.08	2.354TyrPhe: 2.354 ± 0.094	2.696TyrGly: 2.696 ± 0.094	0.914TyrHis: 0.914 ± 0.049	2.752TyrIle: 2.752 ± 0.076	2.208TyrLys: 2.208 ± 0.087	3.707TyrLeu: 3.707 ± 0.091	0.69TyrMet: 0.69 ± 0.041	2.481TyrAsn: 2.481 ± 0.098	1.904TyrPro: 1.904 ± 0.076	1.369TyrGln: 1.369 ± 0.058	1.522TyrArg: 1.522 ± 0.057	3.2TyrSer: 3.2 ± 0.103	1.996TyrThr: 1.996 ± 0.065	1.708TyrVal: 1.708 ± 0.071	0.634TyrTrp: 0.634 ± 0.042	2.019TyrTyr: 2.019 ± 0.1	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1209 proteins (424383 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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