Amino acid dipepetide frequency for Hymenolepis diminuta (Rat tapeworm)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.901AlaAla: 5.901 ± 0.062	1.238AlaCys: 1.238 ± 0.016	3.253AlaAsp: 3.253 ± 0.03	4.229AlaGlu: 4.229 ± 0.037	2.79AlaPhe: 2.79 ± 0.026	3.432AlaGly: 3.432 ± 0.036	1.291AlaHis: 1.291 ± 0.018	3.687AlaIle: 3.687 ± 0.033	3.561AlaLys: 3.561 ± 0.032	6.181AlaLeu: 6.181 ± 0.055	1.443AlaMet: 1.443 ± 0.017	3.052AlaAsn: 3.052 ± 0.027	3.19AlaPro: 3.19 ± 0.031	2.365AlaGln: 2.365 ± 0.026	3.27AlaArg: 3.27 ± 0.031	6.031AlaSer: 6.031 ± 0.043	3.956AlaThr: 3.956 ± 0.033	4.275AlaVal: 4.275 ± 0.033	0.636AlaTrp: 0.636 ± 0.011	1.814AlaTyr: 1.814 ± 0.02	0.0AlaXaa: 0.0 ± 0.0
Cys	1.095CysAla: 1.095 ± 0.017	0.537CysCys: 0.537 ± 0.015	0.993CysAsp: 0.993 ± 0.021	1.117CysGlu: 1.117 ± 0.021	0.878CysPhe: 0.878 ± 0.015	1.251CysGly: 1.251 ± 0.019	0.515CysHis: 0.515 ± 0.012	1.184CysIle: 1.184 ± 0.019	0.94CysLys: 0.94 ± 0.015	2.266CysLeu: 2.266 ± 0.025	0.379CysMet: 0.379 ± 0.009	0.786CysAsn: 0.786 ± 0.013	1.106CysPro: 1.106 ± 0.023	0.846CysGln: 0.846 ± 0.015	1.224CysArg: 1.224 ± 0.017	1.626CysSer: 1.626 ± 0.017	0.924CysThr: 0.924 ± 0.015	1.176CysVal: 1.176 ± 0.021	0.212CysTrp: 0.212 ± 0.007	0.565CysTyr: 0.565 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	3.279AspAla: 3.279 ± 0.029	0.964AspCys: 0.964 ± 0.018	3.386AspAsp: 3.386 ± 0.039	4.08AspGlu: 4.08 ± 0.043	2.504AspPhe: 2.504 ± 0.023	3.1AspGly: 3.1 ± 0.037	1.025AspHis: 1.025 ± 0.014	3.15AspIle: 3.15 ± 0.024	2.54AspLys: 2.54 ± 0.024	5.189AspLeu: 5.189 ± 0.04	1.077AspMet: 1.077 ± 0.015	2.203AspAsn: 2.203 ± 0.025	2.737AspPro: 2.737 ± 0.028	1.747AspGln: 1.747 ± 0.02	2.65AspArg: 2.65 ± 0.023	4.481AspSer: 4.481 ± 0.032	2.4AspThr: 2.4 ± 0.025	3.303AspVal: 3.303 ± 0.028	0.626AspTrp: 0.626 ± 0.012	1.658AspTyr: 1.658 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	4.488GluAla: 4.488 ± 0.046	1.165GluCys: 1.165 ± 0.021	3.809GluAsp: 3.809 ± 0.034	6.043GluGlu: 6.043 ± 0.056	2.388GluPhe: 2.388 ± 0.024	3.167GluGly: 3.167 ± 0.03	1.271GluHis: 1.271 ± 0.017	4.016GluIle: 4.016 ± 0.035	4.194GluLys: 4.194 ± 0.046	5.602GluLeu: 5.602 ± 0.042	1.635GluMet: 1.635 ± 0.017	3.453GluAsn: 3.453 ± 0.033	2.493GluPro: 2.493 ± 0.032	2.327GluGln: 2.327 ± 0.025	3.569GluArg: 3.569 ± 0.036	5.282GluSer: 5.282 ± 0.043	3.468GluThr: 3.468 ± 0.037	4.012GluVal: 4.012 ± 0.032	0.633GluTrp: 0.633 ± 0.013	1.719GluTyr: 1.719 ± 0.02	0.001GluXaa: 0.001 ± 0.0
Phe	2.601PheAla: 2.601 ± 0.023	0.932PheCys: 0.932 ± 0.015	2.368PheAsp: 2.368 ± 0.023	2.411PheGlu: 2.411 ± 0.021	1.888PhePhe: 1.888 ± 0.028	2.399PheGly: 2.399 ± 0.025	1.037PheHis: 1.037 ± 0.016	2.43PheIle: 2.43 ± 0.026	1.982PheLys: 1.982 ± 0.023	4.082PheLeu: 4.082 ± 0.036	0.869PheMet: 0.869 ± 0.015	1.925PheAsn: 1.925 ± 0.024	2.018PhePro: 2.018 ± 0.022	1.556PheGln: 1.556 ± 0.021	2.201PheArg: 2.201 ± 0.025	3.723PheSer: 3.723 ± 0.033	2.378PheThr: 2.378 ± 0.027	2.583PheVal: 2.583 ± 0.028	0.459PheTrp: 0.459 ± 0.01	1.414PheTyr: 1.414 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	3.225GlyAla: 3.225 ± 0.036	1.077GlyCys: 1.077 ± 0.018	3.122GlyAsp: 3.122 ± 0.035	3.44GlyGlu: 3.44 ± 0.048	2.326GlyPhe: 2.326 ± 0.025	4.59GlyGly: 4.59 ± 0.055	1.271GlyHis: 1.271 ± 0.021	3.053GlyIle: 3.053 ± 0.031	2.88GlyLys: 2.88 ± 0.028	4.78GlyLeu: 4.78 ± 0.044	1.209GlyMet: 1.209 ± 0.019	2.627GlyAsn: 2.627 ± 0.028	2.553GlyPro: 2.553 ± 0.105	1.991GlyGln: 1.991 ± 0.021	3.18GlyArg: 3.18 ± 0.03	5.111GlySer: 5.111 ± 0.045	2.952GlyThr: 2.952 ± 0.025	3.405GlyVal: 3.405 ± 0.03	0.588GlyTrp: 0.588 ± 0.012	1.669GlyTyr: 1.669 ± 0.025	0.0GlyXaa: 0.0 ± 0.0
His	1.232HisAla: 1.232 ± 0.015	0.519HisCys: 0.519 ± 0.012	0.953HisAsp: 0.953 ± 0.015	1.194HisGlu: 1.194 ± 0.014	1.144HisPhe: 1.144 ± 0.016	1.188HisGly: 1.188 ± 0.017	0.899HisHis: 0.899 ± 0.018	1.269HisIle: 1.269 ± 0.015	0.989HisLys: 0.989 ± 0.015	2.603HisLeu: 2.603 ± 0.024	0.474HisMet: 0.474 ± 0.012	0.892HisAsn: 0.892 ± 0.013	1.467HisPro: 1.467 ± 0.02	1.139HisGln: 1.139 ± 0.014	1.562HisArg: 1.562 ± 0.021	2.122HisSer: 2.122 ± 0.02	1.086HisThr: 1.086 ± 0.015	1.244HisVal: 1.244 ± 0.019	0.288HisTrp: 0.288 ± 0.007	0.736HisTyr: 0.736 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	3.607IleAla: 3.607 ± 0.03	1.354IleCys: 1.354 ± 0.018	3.158IleAsp: 3.158 ± 0.027	3.483IleGlu: 3.483 ± 0.029	2.613IlePhe: 2.613 ± 0.028	2.946IleGly: 2.946 ± 0.03	1.311IleHis: 1.311 ± 0.017	3.166IleIle: 3.166 ± 0.031	2.834IleLys: 2.834 ± 0.029	5.356IleLeu: 5.356 ± 0.046	1.097IleMet: 1.097 ± 0.015	2.604IleAsn: 2.604 ± 0.024	3.343IlePro: 3.343 ± 0.029	2.253IleGln: 2.253 ± 0.022	3.218IleArg: 3.218 ± 0.024	5.332IleSer: 5.332 ± 0.037	3.211IleThr: 3.211 ± 0.028	3.331IleVal: 3.331 ± 0.029	0.594IleTrp: 0.594 ± 0.013	1.79IleTyr: 1.79 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	3.471LysAla: 3.471 ± 0.034	1.032LysCys: 1.032 ± 0.017	2.599LysAsp: 2.599 ± 0.028	3.81LysGlu: 3.81 ± 0.04	2.001LysPhe: 2.001 ± 0.023	2.326LysGly: 2.326 ± 0.032	1.188LysHis: 1.188 ± 0.018	3.107LysIle: 3.107 ± 0.026	3.715LysLys: 3.715 ± 0.045	4.886LysLeu: 4.886 ± 0.034	1.396LysMet: 1.396 ± 0.018	2.495LysAsn: 2.495 ± 0.027	2.841LysPro: 2.841 ± 0.034	2.062LysGln: 2.062 ± 0.022	3.692LysArg: 3.692 ± 0.034	4.84LysSer: 4.84 ± 0.044	2.963LysThr: 2.963 ± 0.027	3.047LysVal: 3.047 ± 0.028	0.564LysTrp: 0.564 ± 0.013	1.57LysTyr: 1.57 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	6.311LeuAla: 6.311 ± 0.045	1.854LeuCys: 1.854 ± 0.023	4.774LeuAsp: 4.774 ± 0.039	5.941LeuGlu: 5.941 ± 0.048	3.839LeuPhe: 3.839 ± 0.038	4.438LeuGly: 4.438 ± 0.034	2.34LeuHis: 2.34 ± 0.029	5.388LeuIle: 5.388 ± 0.043	5.435LeuLys: 5.435 ± 0.043	9.55LeuLeu: 9.55 ± 0.073	2.058LeuMet: 2.058 ± 0.023	4.497LeuAsn: 4.497 ± 0.034	5.678LeuPro: 5.678 ± 0.036	4.124LeuGln: 4.124 ± 0.036	5.926LeuArg: 5.926 ± 0.044	8.399LeuSer: 8.399 ± 0.053	5.485LeuThr: 5.485 ± 0.035	5.29LeuVal: 5.29 ± 0.036	0.93LeuTrp: 0.93 ± 0.017	2.472LeuTyr: 2.472 ± 0.022	0.001LeuXaa: 0.001 ± 0.0
Met	1.647MetAla: 1.647 ± 0.017	0.369MetCys: 0.369 ± 0.01	1.264MetAsp: 1.264 ± 0.017	1.601MetGlu: 1.601 ± 0.017	0.734MetPhe: 0.734 ± 0.012	1.172MetGly: 1.172 ± 0.017	0.486MetHis: 0.486 ± 0.01	1.113MetIle: 1.113 ± 0.016	1.285MetLys: 1.285 ± 0.017	1.932MetLeu: 1.932 ± 0.02	0.566MetMet: 0.566 ± 0.012	1.106MetAsn: 1.106 ± 0.014	1.189MetPro: 1.189 ± 0.016	0.902MetGln: 0.902 ± 0.014	1.287MetArg: 1.287 ± 0.015	1.822MetSer: 1.822 ± 0.022	1.28MetThr: 1.28 ± 0.018	1.263MetVal: 1.263 ± 0.017	0.2MetTrp: 0.2 ± 0.007	0.54MetTyr: 0.54 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.106AsnAla: 3.106 ± 0.028	0.929AsnCys: 0.929 ± 0.015	2.354AsnAsp: 2.354 ± 0.024	3.008AsnGlu: 3.008 ± 0.028	2.092AsnPhe: 2.092 ± 0.023	3.055AsnGly: 3.055 ± 0.036	1.074AsnHis: 1.074 ± 0.019	2.661AsnIle: 2.661 ± 0.026	2.166AsnLys: 2.166 ± 0.024	4.621AsnLeu: 4.621 ± 0.036	0.947AsnMet: 0.947 ± 0.013	2.249AsnAsn: 2.249 ± 0.029	2.656AsnPro: 2.656 ± 0.028	1.976AsnGln: 1.976 ± 0.022	2.641AsnArg: 2.641 ± 0.025	4.479AsnSer: 4.479 ± 0.037	2.465AsnThr: 2.465 ± 0.026	2.752AsnVal: 2.752 ± 0.028	0.529AsnTrp: 0.529 ± 0.011	1.433AsnTyr: 1.433 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	3.211ProAla: 3.211 ± 0.031	0.83ProCys: 0.83 ± 0.017	2.67ProAsp: 2.67 ± 0.025	3.434ProGlu: 3.434 ± 0.031	2.049ProPhe: 2.049 ± 0.023	2.907ProGly: 2.907 ± 0.081	1.249ProHis: 1.249 ± 0.017	3.088ProIle: 3.088 ± 0.029	2.887ProLys: 2.887 ± 0.029	4.835ProLeu: 4.835 ± 0.037	1.092ProMet: 1.092 ± 0.015	2.614ProAsn: 2.614 ± 0.028	5.447ProPro: 5.447 ± 0.071	2.452ProGln: 2.452 ± 0.028	2.809ProArg: 2.809 ± 0.028	5.926ProSer: 5.926 ± 0.044	3.649ProThr: 3.649 ± 0.029	3.412ProVal: 3.412 ± 0.029	0.513ProTrp: 0.513 ± 0.009	1.438ProTyr: 1.438 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	2.477GlnAla: 2.477 ± 0.028	0.741GlnCys: 0.741 ± 0.013	1.564GlnAsp: 1.564 ± 0.018	2.335GlnGlu: 2.335 ± 0.028	1.499GlnPhe: 1.499 ± 0.018	1.695GlnGly: 1.695 ± 0.033	1.053GlnHis: 1.053 ± 0.016	2.384GlnIle: 2.384 ± 0.024	2.185GlnLys: 2.185 ± 0.026	4.019GlnLeu: 4.019 ± 0.034	1.09GlnMet: 1.09 ± 0.015	2.048GlnAsn: 2.048 ± 0.021	2.458GlnPro: 2.458 ± 0.031	2.988GlnGln: 2.988 ± 0.057	2.606GlnArg: 2.606 ± 0.028	3.602GlnSer: 3.602 ± 0.032	2.344GlnThr: 2.344 ± 0.023	2.194GlnVal: 2.194 ± 0.025	0.451GlnTrp: 0.451 ± 0.011	1.054GlnTyr: 1.054 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	3.321ArgAla: 3.321 ± 0.029	1.202ArgCys: 1.202 ± 0.018	2.653ArgAsp: 2.653 ± 0.023	3.325ArgGlu: 3.325 ± 0.028	2.436ArgPhe: 2.436 ± 0.024	3.016ArgGly: 3.016 ± 0.036	1.556ArgHis: 1.556 ± 0.023	3.403ArgIle: 3.403 ± 0.026	3.501ArgLys: 3.501 ± 0.028	6.105ArgLeu: 6.105 ± 0.051	1.304ArgMet: 1.304 ± 0.018	2.657ArgAsn: 2.657 ± 0.024	2.94ArgPro: 2.94 ± 0.029	2.548ArgGln: 2.548 ± 0.026	5.004ArgArg: 5.004 ± 0.052	4.94ArgSer: 4.94 ± 0.047	2.818ArgThr: 2.818 ± 0.023	3.223ArgVal: 3.223 ± 0.029	0.65ArgTrp: 0.65 ± 0.013	1.725ArgTyr: 1.725 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	6.086SerAla: 6.086 ± 0.046	1.559SerCys: 1.559 ± 0.021	4.708SerAsp: 4.708 ± 0.039	5.486SerGlu: 5.486 ± 0.05	3.349SerPhe: 3.349 ± 0.031	5.683SerGly: 5.683 ± 0.048	1.96SerHis: 1.96 ± 0.023	4.746SerIle: 4.746 ± 0.031	4.639SerLys: 4.639 ± 0.038	8.295SerLeu: 8.295 ± 0.052	1.831SerMet: 1.831 ± 0.019	4.585SerAsn: 4.585 ± 0.034	5.517SerPro: 5.517 ± 0.048	3.667SerGln: 3.667 ± 0.036	5.099SerArg: 5.099 ± 0.041	11.261SerSer: 11.261 ± 0.105	6.238SerThr: 6.238 ± 0.052	5.491SerVal: 5.491 ± 0.04	0.848SerTrp: 0.848 ± 0.016	2.207SerTyr: 2.207 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	4.162ThrAla: 4.162 ± 0.034	1.099ThrCys: 1.099 ± 0.021	2.903ThrAsp: 2.903 ± 0.031	3.52ThrGlu: 3.52 ± 0.04	2.261ThrPhe: 2.261 ± 0.022	3.296ThrGly: 3.296 ± 0.033	1.147ThrHis: 1.147 ± 0.015	2.998ThrIle: 2.998 ± 0.028	2.674ThrLys: 2.674 ± 0.027	5.086ThrLeu: 5.086 ± 0.037	1.104ThrMet: 1.104 ± 0.015	2.673ThrAsn: 2.673 ± 0.027	3.758ThrPro: 3.758 ± 0.036	2.083ThrGln: 2.083 ± 0.024	2.71ThrArg: 2.71 ± 0.022	5.957ThrSer: 5.957 ± 0.045	4.086ThrThr: 4.086 ± 0.051	3.658ThrVal: 3.658 ± 0.032	0.571ThrTrp: 0.571 ± 0.012	1.5ThrTyr: 1.5 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	4.037ValAla: 4.037 ± 0.037	1.329ValCys: 1.329 ± 0.017	3.505ValAsp: 3.505 ± 0.029	4.027ValGlu: 4.027 ± 0.035	2.564ValPhe: 2.564 ± 0.027	3.285ValGly: 3.285 ± 0.03	1.338ValHis: 1.338 ± 0.016	3.482ValIle: 3.482 ± 0.03	3.266ValLys: 3.266 ± 0.03	5.241ValLeu: 5.241 ± 0.045	1.275ValMet: 1.275 ± 0.016	2.955ValAsn: 2.955 ± 0.033	3.153ValPro: 3.153 ± 0.025	2.196ValGln: 2.196 ± 0.025	3.151ValArg: 3.151 ± 0.026	5.142ValSer: 5.142 ± 0.038	3.473ValThr: 3.473 ± 0.028	3.985ValVal: 3.985 ± 0.038	0.598ValTrp: 0.598 ± 0.012	1.801ValTyr: 1.801 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	0.541TrpAla: 0.541 ± 0.009	0.231TrpCys: 0.231 ± 0.007	0.539TrpAsp: 0.539 ± 0.012	0.546TrpGlu: 0.546 ± 0.013	0.461TrpPhe: 0.461 ± 0.011	0.444TrpGly: 0.444 ± 0.009	0.246TrpHis: 0.246 ± 0.007	0.687TrpIle: 0.687 ± 0.013	0.639TrpLys: 0.639 ± 0.014	1.082TrpLeu: 1.082 ± 0.016	0.297TrpMet: 0.297 ± 0.008	0.553TrpAsn: 0.553 ± 0.011	0.5TrpPro: 0.5 ± 0.01	0.411TrpGln: 0.411 ± 0.01	0.754TrpArg: 0.754 ± 0.012	0.886TrpSer: 0.886 ± 0.014	0.602TrpThr: 0.602 ± 0.012	0.509TrpVal: 0.509 ± 0.01	0.153TrpTrp: 0.153 ± 0.006	0.302TrpTyr: 0.302 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.796TyrAla: 1.796 ± 0.018	0.662TyrCys: 0.662 ± 0.014	1.524TyrAsp: 1.524 ± 0.02	1.704TyrGlu: 1.704 ± 0.021	1.438TyrPhe: 1.438 ± 0.02	1.662TyrGly: 1.662 ± 0.023	0.74TyrHis: 0.74 ± 0.013	1.584TyrIle: 1.584 ± 0.021	1.294TyrLys: 1.294 ± 0.017	3.017TyrLeu: 3.017 ± 0.028	0.617TyrMet: 0.617 ± 0.012	1.219TyrAsn: 1.219 ± 0.017	1.469TyrPro: 1.469 ± 0.02	1.152TyrGln: 1.152 ± 0.017	1.778TyrArg: 1.778 ± 0.021	2.295TyrSer: 2.295 ± 0.024	1.468TyrThr: 1.468 ± 0.017	1.649TyrVal: 1.649 ± 0.021	0.337TyrTrp: 0.337 ± 0.009	1.021TyrTyr: 1.021 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.021XaaXaa: 0.021 ± 0.013

Statistics based on 11238 proteins (4879823 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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