Amino acid dipepetide frequency for Arthrobacter phage Corgi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
29.19AlaAla: 29.19 ± 2.679
0.794AlaCys: 0.794 ± 0.367
8.737AlaAsp: 8.737 ± 1.125
6.95AlaGlu: 6.95 ± 1.489
3.177AlaPhe: 3.177 ± 0.677
13.9AlaGly: 13.9 ± 1.877
1.986AlaHis: 1.986 ± 0.494
3.574AlaIle: 3.574 ± 0.834
4.567AlaLys: 4.567 ± 1.291
11.716AlaLeu: 11.716 ± 1.792
5.361AlaMet: 5.361 ± 1.223
5.759AlaAsn: 5.759 ± 1.54
6.751AlaPro: 6.751 ± 1.338
7.149AlaGln: 7.149 ± 1.19
10.127AlaArg: 10.127 ± 1.628
5.163AlaSer: 5.163 ± 1.319
8.141AlaThr: 8.141 ± 1.333
12.113AlaVal: 12.113 ± 1.521
1.986AlaTrp: 1.986 ± 0.587
2.78AlaTyr: 2.78 ± 0.692
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.397CysAsp: 0.397 ± 0.291
0.199CysGlu: 0.199 ± 0.172
0.0CysPhe: 0.0 ± 0.0
0.794CysGly: 0.794 ± 0.367
0.199CysHis: 0.199 ± 0.172
0.0CysIle: 0.0 ± 0.0
0.199CysLys: 0.199 ± 0.209
0.596CysLeu: 0.596 ± 0.301
0.0CysMet: 0.0 ± 0.0
0.397CysAsn: 0.397 ± 0.276
0.596CysPro: 0.596 ± 0.34
0.993CysGln: 0.993 ± 0.482
0.596CysArg: 0.596 ± 0.348
0.199CysSer: 0.199 ± 0.218
0.199CysThr: 0.199 ± 0.179
0.397CysVal: 0.397 ± 0.285
0.199CysTrp: 0.199 ± 0.176
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
10.723AspAla: 10.723 ± 1.66
0.199AspCys: 0.199 ± 0.172
4.567AspAsp: 4.567 ± 0.896
2.979AspGlu: 2.979 ± 0.965
0.794AspPhe: 0.794 ± 0.478
8.34AspGly: 8.34 ± 0.867
0.596AspHis: 0.596 ± 0.282
2.979AspIle: 2.979 ± 0.765
1.191AspLys: 1.191 ± 0.636
6.751AspLeu: 6.751 ± 0.95
1.589AspMet: 1.589 ± 0.554
1.589AspAsn: 1.589 ± 0.507
2.78AspPro: 2.78 ± 0.791
3.376AspGln: 3.376 ± 0.735
3.376AspArg: 3.376 ± 0.731
3.773AspSer: 3.773 ± 0.88
3.773AspThr: 3.773 ± 0.82
4.964AspVal: 4.964 ± 0.947
1.39AspTrp: 1.39 ± 0.696
2.184AspTyr: 2.184 ± 0.83
0.0AspXaa: 0.0 ± 0.0
Glu
8.539GluAla: 8.539 ± 1.774
0.993GluCys: 0.993 ± 0.556
4.369GluAsp: 4.369 ± 0.918
1.986GluGlu: 1.986 ± 0.588
1.589GluPhe: 1.589 ± 0.622
3.177GluGly: 3.177 ± 0.556
0.397GluHis: 0.397 ± 0.248
2.184GluIle: 2.184 ± 0.594
1.191GluLys: 1.191 ± 0.324
5.759GluLeu: 5.759 ± 0.773
0.596GluMet: 0.596 ± 0.367
1.787GluAsn: 1.787 ± 0.502
1.787GluPro: 1.787 ± 0.757
0.993GluGln: 0.993 ± 0.439
2.581GluArg: 2.581 ± 0.595
2.78GluSer: 2.78 ± 0.645
2.383GluThr: 2.383 ± 0.739
4.369GluVal: 4.369 ± 0.822
1.191GluTrp: 1.191 ± 0.381
0.993GluTyr: 0.993 ± 0.56
0.0GluXaa: 0.0 ± 0.0
Phe
2.581PheAla: 2.581 ± 0.574
0.199PheCys: 0.199 ± 0.195
2.184PheAsp: 2.184 ± 0.611
0.993PheGlu: 0.993 ± 0.338
0.0PhePhe: 0.0 ± 0.0
1.986PheGly: 1.986 ± 0.751
0.199PheHis: 0.199 ± 0.172
0.397PheIle: 0.397 ± 0.226
1.589PheLys: 1.589 ± 0.568
2.184PheLeu: 2.184 ± 0.635
0.993PheMet: 0.993 ± 0.329
0.199PheAsn: 0.199 ± 0.195
0.794PhePro: 0.794 ± 0.33
1.39PheGln: 1.39 ± 0.599
1.39PheArg: 1.39 ± 0.355
0.993PheSer: 0.993 ± 0.479
1.39PheThr: 1.39 ± 0.427
0.596PheVal: 0.596 ± 0.39
0.596PheTrp: 0.596 ± 0.301
0.397PheTyr: 0.397 ± 0.238
0.0PheXaa: 0.0 ± 0.0
Gly
10.127GlyAla: 10.127 ± 1.111
0.596GlyCys: 0.596 ± 0.314
4.369GlyAsp: 4.369 ± 1.117
3.773GlyGlu: 3.773 ± 0.747
1.191GlyPhe: 1.191 ± 0.379
8.141GlyGly: 8.141 ± 1.456
2.581GlyHis: 2.581 ± 1.072
1.986GlyIle: 1.986 ± 0.657
3.971GlyLys: 3.971 ± 0.972
7.744GlyLeu: 7.744 ± 1.309
2.184GlyMet: 2.184 ± 0.43
2.979GlyAsn: 2.979 ± 0.715
4.17GlyPro: 4.17 ± 0.861
3.574GlyGln: 3.574 ± 0.884
6.354GlyArg: 6.354 ± 0.954
5.361GlySer: 5.361 ± 0.96
7.744GlyThr: 7.744 ± 1.518
6.751GlyVal: 6.751 ± 0.931
2.383GlyTrp: 2.383 ± 0.688
1.986GlyTyr: 1.986 ± 0.662
0.0GlyXaa: 0.0 ± 0.0
His
2.184HisAla: 2.184 ± 0.652
0.0HisCys: 0.0 ± 0.0
0.596HisAsp: 0.596 ± 0.357
0.397HisGlu: 0.397 ± 0.278
0.199HisPhe: 0.199 ± 0.195
1.589HisGly: 1.589 ± 0.699
0.0HisHis: 0.0 ± 0.0
0.596HisIle: 0.596 ± 0.394
0.199HisLys: 0.199 ± 0.19
1.787HisLeu: 1.787 ± 0.501
0.397HisMet: 0.397 ± 0.327
0.794HisAsn: 0.794 ± 0.392
0.993HisPro: 0.993 ± 0.508
0.596HisGln: 0.596 ± 0.394
0.993HisArg: 0.993 ± 0.471
0.199HisSer: 0.199 ± 0.181
0.993HisThr: 0.993 ± 0.419
0.993HisVal: 0.993 ± 0.722
0.0HisTrp: 0.0 ± 0.0
0.199HisTyr: 0.199 ± 0.199
0.0HisXaa: 0.0 ± 0.0
Ile
4.17IleAla: 4.17 ± 1.084
0.0IleCys: 0.0 ± 0.0
1.39IleAsp: 1.39 ± 0.407
2.78IleGlu: 2.78 ± 0.648
0.0IlePhe: 0.0 ± 0.0
2.78IleGly: 2.78 ± 0.588
0.397IleHis: 0.397 ± 0.216
0.993IleIle: 0.993 ± 0.354
0.993IleLys: 0.993 ± 0.33
2.383IleLeu: 2.383 ± 0.644
0.199IleMet: 0.199 ± 0.162
0.794IleAsn: 0.794 ± 0.303
1.787IlePro: 1.787 ± 0.539
2.78IleGln: 2.78 ± 0.904
1.986IleArg: 1.986 ± 0.475
1.191IleSer: 1.191 ± 0.38
3.574IleThr: 3.574 ± 0.976
1.986IleVal: 1.986 ± 0.54
0.397IleTrp: 0.397 ± 0.255
1.191IleTyr: 1.191 ± 0.498
0.0IleXaa: 0.0 ± 0.0
Lys
4.766LysAla: 4.766 ± 1.036
0.0LysCys: 0.0 ± 0.0
2.581LysAsp: 2.581 ± 1.178
2.184LysGlu: 2.184 ± 0.819
1.589LysPhe: 1.589 ± 0.544
2.78LysGly: 2.78 ± 0.799
0.794LysHis: 0.794 ± 0.379
0.596LysIle: 0.596 ± 0.378
1.39LysLys: 1.39 ± 0.664
2.184LysLeu: 2.184 ± 0.527
1.589LysMet: 1.589 ± 0.389
0.397LysAsn: 0.397 ± 0.266
0.596LysPro: 0.596 ± 0.319
1.39LysGln: 1.39 ± 0.496
2.581LysArg: 2.581 ± 0.658
3.773LysSer: 3.773 ± 1.031
3.376LysThr: 3.376 ± 0.503
2.383LysVal: 2.383 ± 0.612
0.596LysTrp: 0.596 ± 0.43
0.794LysTyr: 0.794 ± 0.446
0.0LysXaa: 0.0 ± 0.0
Leu
13.701LeuAla: 13.701 ± 1.965
0.397LeuCys: 0.397 ± 0.254
8.936LeuAsp: 8.936 ± 1.114
7.347LeuGlu: 7.347 ± 1.354
1.986LeuPhe: 1.986 ± 0.566
7.347LeuGly: 7.347 ± 1.052
0.794LeuHis: 0.794 ± 0.369
1.589LeuIle: 1.589 ± 0.747
3.376LeuLys: 3.376 ± 0.74
5.56LeuLeu: 5.56 ± 1.363
0.993LeuMet: 0.993 ± 0.446
2.383LeuAsn: 2.383 ± 0.801
5.361LeuPro: 5.361 ± 0.843
1.589LeuGln: 1.589 ± 0.484
4.766LeuArg: 4.766 ± 0.863
5.163LeuSer: 5.163 ± 0.992
4.17LeuThr: 4.17 ± 0.642
6.553LeuVal: 6.553 ± 1.071
2.184LeuTrp: 2.184 ± 0.64
1.191LeuTyr: 1.191 ± 0.433
0.0LeuXaa: 0.0 ± 0.0
Met
3.574MetAla: 3.574 ± 0.881
0.0MetCys: 0.0 ± 0.0
1.787MetAsp: 1.787 ± 0.656
0.993MetGlu: 0.993 ± 0.411
0.397MetPhe: 0.397 ± 0.25
1.191MetGly: 1.191 ± 0.443
0.0MetHis: 0.0 ± 0.0
0.199MetIle: 0.199 ± 0.176
1.787MetLys: 1.787 ± 0.535
1.589MetLeu: 1.589 ± 0.558
0.794MetMet: 0.794 ± 0.422
0.596MetAsn: 0.596 ± 0.281
1.787MetPro: 1.787 ± 0.831
1.191MetGln: 1.191 ± 0.516
1.787MetArg: 1.787 ± 0.617
0.794MetSer: 0.794 ± 0.415
2.184MetThr: 2.184 ± 0.642
2.184MetVal: 2.184 ± 0.724
0.199MetTrp: 0.199 ± 0.19
0.596MetTyr: 0.596 ± 0.287
0.0MetXaa: 0.0 ± 0.0
Asn
3.376AsnAla: 3.376 ± 0.617
0.0AsnCys: 0.0 ± 0.0
1.191AsnAsp: 1.191 ± 0.478
1.787AsnGlu: 1.787 ± 0.522
0.596AsnPhe: 0.596 ± 0.32
2.979AsnGly: 2.979 ± 0.517
0.794AsnHis: 0.794 ± 0.383
1.787AsnIle: 1.787 ± 0.602
0.993AsnLys: 0.993 ± 0.377
2.581AsnLeu: 2.581 ± 0.612
0.397AsnMet: 0.397 ± 0.25
0.199AsnAsn: 0.199 ± 0.191
1.787AsnPro: 1.787 ± 0.605
0.794AsnGln: 0.794 ± 0.547
1.589AsnArg: 1.589 ± 0.578
0.596AsnSer: 0.596 ± 0.301
2.979AsnThr: 2.979 ± 0.957
3.177AsnVal: 3.177 ± 0.743
0.794AsnTrp: 0.794 ± 0.329
0.794AsnTyr: 0.794 ± 0.377
0.0AsnXaa: 0.0 ± 0.0
Pro
5.759ProAla: 5.759 ± 0.984
0.397ProCys: 0.397 ± 0.282
5.163ProAsp: 5.163 ± 0.825
3.177ProGlu: 3.177 ± 0.851
0.794ProPhe: 0.794 ± 0.297
7.149ProGly: 7.149 ± 1.214
0.794ProHis: 0.794 ± 0.475
1.787ProIle: 1.787 ± 0.629
0.596ProLys: 0.596 ± 0.303
4.17ProLeu: 4.17 ± 0.873
1.589ProMet: 1.589 ± 0.525
1.191ProAsn: 1.191 ± 0.377
3.177ProPro: 3.177 ± 0.913
1.589ProGln: 1.589 ± 0.415
3.574ProArg: 3.574 ± 0.989
2.979ProSer: 2.979 ± 0.796
1.787ProThr: 1.787 ± 0.697
4.369ProVal: 4.369 ± 0.894
0.596ProTrp: 0.596 ± 0.281
0.596ProTyr: 0.596 ± 0.409
0.0ProXaa: 0.0 ± 0.0
Gln
5.56GlnAla: 5.56 ± 1.319
0.0GlnCys: 0.0 ± 0.0
3.376GlnAsp: 3.376 ± 0.804
4.17GlnGlu: 4.17 ± 0.734
0.794GlnPhe: 0.794 ± 0.343
3.376GlnGly: 3.376 ± 0.871
0.397GlnHis: 0.397 ± 0.231
0.397GlnIle: 0.397 ± 0.265
1.986GlnLys: 1.986 ± 0.689
4.369GlnLeu: 4.369 ± 0.898
0.794GlnMet: 0.794 ± 0.347
0.199GlnAsn: 0.199 ± 0.17
0.794GlnPro: 0.794 ± 0.319
0.199GlnGln: 0.199 ± 0.17
3.376GlnArg: 3.376 ± 0.694
1.191GlnSer: 1.191 ± 0.454
2.184GlnThr: 2.184 ± 0.699
4.369GlnVal: 4.369 ± 1.027
0.596GlnTrp: 0.596 ± 0.446
0.596GlnTyr: 0.596 ± 0.414
0.0GlnXaa: 0.0 ± 0.0
Arg
9.134ArgAla: 9.134 ± 1.597
1.39ArgCys: 1.39 ± 0.589
4.964ArgAsp: 4.964 ± 1.387
2.184ArgGlu: 2.184 ± 0.665
1.39ArgPhe: 1.39 ± 0.427
4.964ArgGly: 4.964 ± 0.81
0.993ArgHis: 0.993 ± 0.463
3.376ArgIle: 3.376 ± 0.823
2.979ArgLys: 2.979 ± 0.856
4.766ArgLeu: 4.766 ± 1.217
1.787ArgMet: 1.787 ± 0.555
2.581ArgAsn: 2.581 ± 0.832
4.369ArgPro: 4.369 ± 0.862
3.574ArgGln: 3.574 ± 0.981
4.766ArgArg: 4.766 ± 1.308
2.184ArgSer: 2.184 ± 0.618
5.163ArgThr: 5.163 ± 0.754
3.177ArgVal: 3.177 ± 0.7
1.191ArgTrp: 1.191 ± 0.442
2.581ArgTyr: 2.581 ± 0.795
0.0ArgXaa: 0.0 ± 0.0
Ser
6.156SerAla: 6.156 ± 1.199
0.397SerCys: 0.397 ± 0.303
2.581SerAsp: 2.581 ± 0.632
1.589SerGlu: 1.589 ± 0.908
0.993SerPhe: 0.993 ± 0.344
5.361SerGly: 5.361 ± 0.91
0.0SerHis: 0.0 ± 0.0
2.184SerIle: 2.184 ± 0.455
1.191SerLys: 1.191 ± 0.564
4.766SerLeu: 4.766 ± 1.016
0.794SerMet: 0.794 ± 0.32
0.993SerAsn: 0.993 ± 0.436
2.78SerPro: 2.78 ± 0.753
0.596SerGln: 0.596 ± 0.317
4.17SerArg: 4.17 ± 0.929
2.184SerSer: 2.184 ± 0.524
5.163SerThr: 5.163 ± 1.34
3.177SerVal: 3.177 ± 0.81
1.589SerTrp: 1.589 ± 0.488
1.986SerTyr: 1.986 ± 0.6
0.0SerXaa: 0.0 ± 0.0
Thr
12.113ThrAla: 12.113 ± 1.169
0.397ThrCys: 0.397 ± 0.281
2.979ThrAsp: 2.979 ± 0.632
0.993ThrGlu: 0.993 ± 0.486
2.581ThrPhe: 2.581 ± 0.641
4.567ThrGly: 4.567 ± 1.232
0.397ThrHis: 0.397 ± 0.28
2.78ThrIle: 2.78 ± 0.669
2.78ThrLys: 2.78 ± 0.821
5.56ThrLeu: 5.56 ± 0.874
1.787ThrMet: 1.787 ± 0.479
1.39ThrAsn: 1.39 ± 0.459
5.361ThrPro: 5.361 ± 1.382
1.589ThrGln: 1.589 ± 0.658
4.369ThrArg: 4.369 ± 0.824
4.567ThrSer: 4.567 ± 1.278
6.553ThrThr: 6.553 ± 1.106
5.957ThrVal: 5.957 ± 1.318
2.383ThrTrp: 2.383 ± 0.72
3.177ThrTyr: 3.177 ± 0.709
0.0ThrXaa: 0.0 ± 0.0
Val
10.326ValAla: 10.326 ± 1.661
0.0ValCys: 0.0 ± 0.0
5.163ValAsp: 5.163 ± 1.232
3.773ValGlu: 3.773 ± 0.63
1.986ValPhe: 1.986 ± 0.73
5.361ValGly: 5.361 ± 1.326
1.986ValHis: 1.986 ± 0.533
2.581ValIle: 2.581 ± 0.618
2.979ValLys: 2.979 ± 0.866
6.95ValLeu: 6.95 ± 1.521
1.191ValMet: 1.191 ± 0.586
2.78ValAsn: 2.78 ± 0.614
3.773ValPro: 3.773 ± 0.909
3.177ValGln: 3.177 ± 0.933
5.163ValArg: 5.163 ± 0.887
4.17ValSer: 4.17 ± 0.721
6.95ValThr: 6.95 ± 1.309
4.964ValVal: 4.964 ± 0.963
0.596ValTrp: 0.596 ± 0.325
0.993ValTyr: 0.993 ± 0.403
0.0ValXaa: 0.0 ± 0.0
Trp
2.184TrpAla: 2.184 ± 0.596
0.199TrpCys: 0.199 ± 0.176
0.596TrpAsp: 0.596 ± 0.381
0.596TrpGlu: 0.596 ± 0.322
0.397TrpPhe: 0.397 ± 0.235
0.993TrpGly: 0.993 ± 0.38
0.199TrpHis: 0.199 ± 0.176
1.589TrpIle: 1.589 ± 0.435
1.589TrpLys: 1.589 ± 0.483
1.787TrpLeu: 1.787 ± 0.587
0.0TrpMet: 0.0 ± 0.0
0.794TrpAsn: 0.794 ± 0.346
1.39TrpPro: 1.39 ± 0.622
0.794TrpGln: 0.794 ± 0.393
2.581TrpArg: 2.581 ± 0.603
0.596TrpSer: 0.596 ± 0.432
2.184TrpThr: 2.184 ± 0.851
0.199TrpVal: 0.199 ± 0.172
0.596TrpTrp: 0.596 ± 0.327
0.794TrpTyr: 0.794 ± 0.337
0.0TrpXaa: 0.0 ± 0.0
Tyr
5.759TyrAla: 5.759 ± 1.007
0.0TyrCys: 0.0 ± 0.0
1.986TyrAsp: 1.986 ± 0.679
0.794TyrGlu: 0.794 ± 0.327
0.596TyrPhe: 0.596 ± 0.26
1.191TyrGly: 1.191 ± 0.343
0.199TyrHis: 0.199 ± 0.181
0.199TyrIle: 0.199 ± 0.238
0.794TyrLys: 0.794 ± 0.452
2.184TyrLeu: 2.184 ± 0.925
0.397TyrMet: 0.397 ± 0.268
1.39TyrAsn: 1.39 ± 0.47
0.397TyrPro: 0.397 ± 0.28
1.39TyrGln: 1.39 ± 0.436
1.39TyrArg: 1.39 ± 0.573
0.794TyrSer: 0.794 ± 0.444
1.39TyrThr: 1.39 ± 0.496
2.383TyrVal: 2.383 ± 0.677
0.596TyrTrp: 0.596 ± 0.406
0.397TyrTyr: 0.397 ± 0.228
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 26 proteins (5037 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski