Amino acid dipepetide frequency for Bacteroidaceae bacterium

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.687AlaAla: 5.687 ± 0.098	1.065AlaCys: 1.065 ± 0.032	4.25AlaAsp: 4.25 ± 0.062	4.721AlaGlu: 4.721 ± 0.069	3.087AlaPhe: 3.087 ± 0.053	5.145AlaGly: 5.145 ± 0.075	1.303AlaHis: 1.303 ± 0.034	4.614AlaIle: 4.614 ± 0.074	4.006AlaLys: 4.006 ± 0.066	6.42AlaLeu: 6.42 ± 0.093	1.988AlaMet: 1.988 ± 0.043	3.122AlaAsn: 3.122 ± 0.058	2.307AlaPro: 2.307 ± 0.041	2.568AlaGln: 2.568 ± 0.045	3.098AlaArg: 3.098 ± 0.063	4.188AlaSer: 4.188 ± 0.069	3.709AlaThr: 3.709 ± 0.061	4.77AlaVal: 4.77 ± 0.072	0.87AlaTrp: 0.87 ± 0.029	2.992AlaTyr: 2.992 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.837CysAla: 0.837 ± 0.024	0.24CysCys: 0.24 ± 0.016	0.655CysAsp: 0.655 ± 0.023	0.707CysGlu: 0.707 ± 0.023	0.697CysPhe: 0.697 ± 0.025	1.111CysGly: 1.111 ± 0.033	0.326CysHis: 0.326 ± 0.016	0.95CysIle: 0.95 ± 0.029	0.759CysLys: 0.759 ± 0.023	1.213CysLeu: 1.213 ± 0.035	0.429CysMet: 0.429 ± 0.019	0.606CysAsn: 0.606 ± 0.026	0.56CysPro: 0.56 ± 0.023	0.362CysGln: 0.362 ± 0.018	0.696CysArg: 0.696 ± 0.026	0.818CysSer: 0.818 ± 0.027	0.731CysThr: 0.731 ± 0.025	0.774CysVal: 0.774 ± 0.026	0.163CysTrp: 0.163 ± 0.011	0.576CysTyr: 0.576 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	3.806AspAla: 3.806 ± 0.058	0.655AspCys: 0.655 ± 0.023	2.583AspAsp: 2.583 ± 0.05	3.91AspGlu: 3.91 ± 0.059	2.967AspPhe: 2.967 ± 0.054	4.181AspGly: 4.181 ± 0.07	0.872AspHis: 0.872 ± 0.026	4.037AspIle: 4.037 ± 0.064	4.134AspLys: 4.134 ± 0.06	4.446AspLeu: 4.446 ± 0.062	1.698AspMet: 1.698 ± 0.039	2.802AspAsn: 2.802 ± 0.051	1.814AspPro: 1.814 ± 0.051	1.205AspGln: 1.205 ± 0.035	2.478AspArg: 2.478 ± 0.046	2.995AspSer: 2.995 ± 0.062	2.744AspThr: 2.744 ± 0.052	3.481AspVal: 3.481 ± 0.055	0.923AspTrp: 0.923 ± 0.029	3.009AspTyr: 3.009 ± 0.057	0.0AspXaa: 0.0 ± 0.0
Glu	4.839GluAla: 4.839 ± 0.071	0.701GluCys: 0.701 ± 0.023	3.277GluAsp: 3.277 ± 0.059	5.237GluGlu: 5.237 ± 0.091	2.518GluPhe: 2.518 ± 0.05	4.195GluGly: 4.195 ± 0.065	1.292GluHis: 1.292 ± 0.036	4.605GluIle: 4.605 ± 0.07	5.421GluLys: 5.421 ± 0.069	6.198GluLeu: 6.198 ± 0.086	2.092GluMet: 2.092 ± 0.039	3.686GluAsn: 3.686 ± 0.064	1.752GluPro: 1.752 ± 0.041	2.704GluGln: 2.704 ± 0.051	3.328GluArg: 3.328 ± 0.056	3.114GluSer: 3.114 ± 0.054	3.408GluThr: 3.408 ± 0.053	4.347GluVal: 4.347 ± 0.067	0.945GluTrp: 0.945 ± 0.029	2.867GluTyr: 2.867 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	2.979PheAla: 2.979 ± 0.063	0.729PheCys: 0.729 ± 0.025	2.768PheAsp: 2.768 ± 0.053	2.506PheGlu: 2.506 ± 0.042	2.249PhePhe: 2.249 ± 0.056	3.209PheGly: 3.209 ± 0.064	0.996PheHis: 0.996 ± 0.033	3.247PheIle: 3.247 ± 0.055	2.54PheLys: 2.54 ± 0.047	4.057PheLeu: 4.057 ± 0.068	1.342PheMet: 1.342 ± 0.036	2.432PheAsn: 2.432 ± 0.053	1.796PhePro: 1.796 ± 0.046	1.325PheGln: 1.325 ± 0.036	2.168PheArg: 2.168 ± 0.04	3.277PheSer: 3.277 ± 0.055	2.731PheThr: 2.731 ± 0.044	2.822PheVal: 2.822 ± 0.05	0.582PheTrp: 0.582 ± 0.025	2.087PheTyr: 2.087 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	4.266GlyAla: 4.266 ± 0.069	0.99GlyCys: 0.99 ± 0.032	3.388GlyAsp: 3.388 ± 0.065	4.231GlyGlu: 4.231 ± 0.064	3.121GlyPhe: 3.121 ± 0.052	4.765GlyGly: 4.765 ± 0.073	1.321GlyHis: 1.321 ± 0.031	5.273GlyIle: 5.273 ± 0.07	5.613GlyLys: 5.613 ± 0.076	5.726GlyLeu: 5.726 ± 0.07	2.341GlyMet: 2.341 ± 0.046	3.786GlyAsn: 3.786 ± 0.065	1.277GlyPro: 1.277 ± 0.034	2.087GlyGln: 2.087 ± 0.04	2.974GlyArg: 2.974 ± 0.053	3.855GlySer: 3.855 ± 0.063	4.211GlyThr: 4.211 ± 0.066	4.759GlyVal: 4.759 ± 0.073	1.05GlyTrp: 1.05 ± 0.031	3.46GlyTyr: 3.46 ± 0.063	0.0GlyXaa: 0.0 ± 0.0
His	1.202HisAla: 1.202 ± 0.034	0.326HisCys: 0.326 ± 0.02	1.017HisAsp: 1.017 ± 0.031	1.073HisGlu: 1.073 ± 0.034	1.085HisPhe: 1.085 ± 0.029	1.263HisGly: 1.263 ± 0.029	0.533HisHis: 0.533 ± 0.024	1.605HisIle: 1.605 ± 0.038	1.201HisLys: 1.201 ± 0.035	1.847HisLeu: 1.847 ± 0.042	0.326HisMet: 0.326 ± 0.017	1.025HisAsn: 1.025 ± 0.029	1.102HisPro: 1.102 ± 0.032	0.655HisGln: 0.655 ± 0.024	0.974HisArg: 0.974 ± 0.03	1.197HisSer: 1.197 ± 0.034	1.196HisThr: 1.196 ± 0.03	1.105HisVal: 1.105 ± 0.03	0.288HisTrp: 0.288 ± 0.016	1.05HisTyr: 1.05 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.0IleAla: 5.0 ± 0.076	1.038IleCys: 1.038 ± 0.03	4.155IleAsp: 4.155 ± 0.056	4.462IleGlu: 4.462 ± 0.064	2.755IlePhe: 2.755 ± 0.053	4.658IleGly: 4.658 ± 0.08	1.494IleHis: 1.494 ± 0.037	4.576IleIle: 4.576 ± 0.078	4.312IleLys: 4.312 ± 0.069	5.956IleLeu: 5.956 ± 0.086	1.605IleMet: 1.605 ± 0.041	3.443IleAsn: 3.443 ± 0.06	3.174IlePro: 3.174 ± 0.052	2.144IleGln: 2.144 ± 0.043	3.42IleArg: 3.42 ± 0.056	4.424IleSer: 4.424 ± 0.069	3.948IleThr: 3.948 ± 0.065	4.292IleVal: 4.292 ± 0.071	0.74IleTrp: 0.74 ± 0.028	2.893IleTyr: 2.893 ± 0.053	0.0IleXaa: 0.0 ± 0.0
Lys	4.995LysAla: 4.995 ± 0.079	0.608LysCys: 0.608 ± 0.028	4.094LysAsp: 4.094 ± 0.063	6.175LysGlu: 6.175 ± 0.09	2.301LysPhe: 2.301 ± 0.045	4.667LysGly: 4.667 ± 0.066	1.303LysHis: 1.303 ± 0.029	4.279LysIle: 4.279 ± 0.067	5.301LysLys: 5.301 ± 0.077	5.526LysLeu: 5.526 ± 0.068	2.119LysMet: 2.119 ± 0.046	3.707LysAsn: 3.707 ± 0.061	2.152LysPro: 2.152 ± 0.038	2.625LysGln: 2.625 ± 0.05	3.281LysArg: 3.281 ± 0.058	3.318LysSer: 3.318 ± 0.056	3.624LysThr: 3.624 ± 0.052	4.438LysVal: 4.438 ± 0.065	0.803LysTrp: 0.803 ± 0.024	3.017LysTyr: 3.017 ± 0.047	0.0LysXaa: 0.0 ± 0.0
Leu	6.279LeuAla: 6.279 ± 0.081	1.412LeuCys: 1.412 ± 0.033	4.513LeuAsp: 4.513 ± 0.062	5.253LeuGlu: 5.253 ± 0.084	4.509LeuPhe: 4.509 ± 0.085	5.528LeuGly: 5.528 ± 0.077	1.841LeuHis: 1.841 ± 0.04	5.485LeuIle: 5.485 ± 0.096	6.485LeuLys: 6.485 ± 0.08	8.734LeuLeu: 8.734 ± 0.122	2.462LeuMet: 2.462 ± 0.045	4.78LeuAsn: 4.78 ± 0.06	4.015LeuPro: 4.015 ± 0.055	3.26LeuGln: 3.26 ± 0.055	4.01LeuArg: 4.01 ± 0.056	6.512LeuSer: 6.512 ± 0.089	4.982LeuThr: 4.982 ± 0.062	5.068LeuVal: 5.068 ± 0.072	1.084LeuTrp: 1.084 ± 0.03	3.797LeuTyr: 3.797 ± 0.066	0.0LeuXaa: 0.0 ± 0.0
Met	2.135MetAla: 2.135 ± 0.041	0.281MetCys: 0.281 ± 0.018	1.613MetAsp: 1.613 ± 0.04	1.997MetGlu: 1.997 ± 0.044	1.013MetPhe: 1.013 ± 0.032	1.886MetGly: 1.886 ± 0.04	0.48MetHis: 0.48 ± 0.019	1.713MetIle: 1.713 ± 0.043	2.691MetLys: 2.691 ± 0.044	2.499MetLeu: 2.499 ± 0.047	0.876MetMet: 0.876 ± 0.028	1.712MetAsn: 1.712 ± 0.033	1.213MetPro: 1.213 ± 0.03	1.098MetGln: 1.098 ± 0.028	1.338MetArg: 1.338 ± 0.036	1.528MetSer: 1.528 ± 0.032	1.507MetThr: 1.507 ± 0.039	1.687MetVal: 1.687 ± 0.039	0.274MetTrp: 0.274 ± 0.014	0.947MetTyr: 0.947 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	3.473AsnAla: 3.473 ± 0.063	0.581AsnCys: 0.581 ± 0.024	2.58AsnAsp: 2.58 ± 0.047	3.297AsnGlu: 3.297 ± 0.053	2.226AsnPhe: 2.226 ± 0.044	4.05AsnGly: 4.05 ± 0.061	1.048AsnHis: 1.048 ± 0.028	3.863AsnIle: 3.863 ± 0.068	3.375AsnLys: 3.375 ± 0.054	4.376AsnLeu: 4.376 ± 0.064	1.431AsnMet: 1.431 ± 0.033	2.721AsnAsn: 2.721 ± 0.06	2.481AsnPro: 2.481 ± 0.043	1.638AsnGln: 1.638 ± 0.039	2.565AsnArg: 2.565 ± 0.047	2.794AsnSer: 2.794 ± 0.054	2.725AsnThr: 2.725 ± 0.047	3.161AsnVal: 3.161 ± 0.06	0.679AsnTrp: 0.679 ± 0.028	2.44AsnTyr: 2.44 ± 0.053	0.0AsnXaa: 0.0 ± 0.0
Pro	2.825ProAla: 2.825 ± 0.055	0.452ProCys: 0.452 ± 0.02	2.57ProAsp: 2.57 ± 0.051	3.308ProGlu: 3.308 ± 0.049	1.81ProPhe: 1.81 ± 0.037	2.466ProGly: 2.466 ± 0.052	0.778ProHis: 0.778 ± 0.023	2.096ProIle: 2.096 ± 0.045	1.986ProLys: 1.986 ± 0.043	3.172ProLeu: 3.172 ± 0.052	0.965ProMet: 0.965 ± 0.031	1.606ProAsn: 1.606 ± 0.041	0.804ProPro: 0.804 ± 0.029	1.471ProGln: 1.471 ± 0.038	1.357ProArg: 1.357 ± 0.036	2.106ProSer: 2.106 ± 0.047	1.842ProThr: 1.842 ± 0.041	3.082ProVal: 3.082 ± 0.056	0.484ProTrp: 0.484 ± 0.018	1.773ProTyr: 1.773 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	2.492GlnAla: 2.492 ± 0.052	0.337GlnCys: 0.337 ± 0.019	1.688GlnAsp: 1.688 ± 0.039	2.362GlnGlu: 2.362 ± 0.055	1.354GlnPhe: 1.354 ± 0.034	2.113GlnGly: 2.113 ± 0.046	0.681GlnHis: 0.681 ± 0.022	2.345GlnIle: 2.345 ± 0.046	2.509GlnLys: 2.509 ± 0.041	3.225GlnLeu: 3.225 ± 0.051	1.018GlnMet: 1.018 ± 0.03	1.679GlnAsn: 1.679 ± 0.034	1.2GlnPro: 1.2 ± 0.031	1.492GlnGln: 1.492 ± 0.038	1.669GlnArg: 1.669 ± 0.038	1.866GlnSer: 1.866 ± 0.036	2.006GlnThr: 2.006 ± 0.043	2.154GlnVal: 2.154 ± 0.039	0.523GlnTrp: 0.523 ± 0.021	1.497GlnTyr: 1.497 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	2.757ArgAla: 2.757 ± 0.044	0.522ArgCys: 0.522 ± 0.025	2.158ArgAsp: 2.158 ± 0.043	3.045ArgGlu: 3.045 ± 0.056	2.358ArgPhe: 2.358 ± 0.038	2.442ArgGly: 2.442 ± 0.051	1.019ArgHis: 1.019 ± 0.032	3.672ArgIle: 3.672 ± 0.06	3.659ArgLys: 3.659 ± 0.054	4.407ArgLeu: 4.407 ± 0.059	1.631ArgMet: 1.631 ± 0.036	2.466ArgAsn: 2.466 ± 0.043	1.624ArgPro: 1.624 ± 0.038	1.896ArgGln: 1.896 ± 0.041	2.29ArgArg: 2.29 ± 0.052	2.395ArgSer: 2.395 ± 0.043	2.453ArgThr: 2.453 ± 0.049	2.684ArgVal: 2.684 ± 0.051	0.687ArgTrp: 0.687 ± 0.023	2.303ArgTyr: 2.303 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	3.912SerAla: 3.912 ± 0.06	0.842SerCys: 0.842 ± 0.028	3.254SerAsp: 3.254 ± 0.053	3.422SerGlu: 3.422 ± 0.06	3.304SerPhe: 3.304 ± 0.048	4.351SerGly: 4.351 ± 0.073	1.161SerHis: 1.161 ± 0.032	4.221SerIle: 4.221 ± 0.066	3.368SerLys: 3.368 ± 0.049	5.868SerLeu: 5.868 ± 0.073	1.489SerMet: 1.489 ± 0.041	2.638SerAsn: 2.638 ± 0.049	2.181SerPro: 2.181 ± 0.042	1.86SerGln: 1.86 ± 0.043	2.658SerArg: 2.658 ± 0.052	3.683SerSer: 3.683 ± 0.062	2.998SerThr: 2.998 ± 0.053	4.256SerVal: 4.256 ± 0.068	0.803SerTrp: 0.803 ± 0.028	2.69SerTyr: 2.69 ± 0.054	0.0SerXaa: 0.0 ± 0.0
Thr	3.907ThrAla: 3.907 ± 0.063	0.595ThrCys: 0.595 ± 0.025	3.366ThrAsp: 3.366 ± 0.056	3.332ThrGlu: 3.332 ± 0.056	2.753ThrPhe: 2.753 ± 0.048	4.417ThrGly: 4.417 ± 0.069	1.125ThrHis: 1.125 ± 0.032	3.77ThrIle: 3.77 ± 0.064	2.765ThrLys: 2.765 ± 0.052	5.338ThrLeu: 5.338 ± 0.07	1.217ThrMet: 1.217 ± 0.034	2.499ThrAsn: 2.499 ± 0.054	2.709ThrPro: 2.709 ± 0.045	1.769ThrGln: 1.769 ± 0.037	2.287ThrArg: 2.287 ± 0.045	3.149ThrSer: 3.149 ± 0.054	3.047ThrThr: 3.047 ± 0.055	3.856ThrVal: 3.856 ± 0.059	0.701ThrTrp: 0.701 ± 0.025	2.367ThrTyr: 2.367 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	4.619ValAla: 4.619 ± 0.068	1.013ValCys: 1.013 ± 0.03	3.584ValAsp: 3.584 ± 0.058	4.099ValGlu: 4.099 ± 0.054	2.936ValPhe: 2.936 ± 0.05	3.95ValGly: 3.95 ± 0.061	1.176ValHis: 1.176 ± 0.031	4.321ValIle: 4.321 ± 0.066	4.34ValLys: 4.34 ± 0.052	5.756ValLeu: 5.756 ± 0.084	1.793ValMet: 1.793 ± 0.043	3.392ValAsn: 3.392 ± 0.051	2.622ValPro: 2.622 ± 0.05	1.861ValGln: 1.861 ± 0.039	3.015ValArg: 3.015 ± 0.054	4.341ValSer: 4.341 ± 0.063	3.758ValThr: 3.758 ± 0.06	4.374ValVal: 4.374 ± 0.078	0.79ValTrp: 0.79 ± 0.028	2.642ValTyr: 2.642 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.838TrpAla: 0.838 ± 0.03	0.207TrpCys: 0.207 ± 0.014	0.692TrpAsp: 0.692 ± 0.029	0.864TrpGlu: 0.864 ± 0.028	0.624TrpPhe: 0.624 ± 0.025	1.03TrpGly: 1.03 ± 0.034	0.294TrpHis: 0.294 ± 0.018	0.845TrpIle: 0.845 ± 0.029	0.966TrpLys: 0.966 ± 0.031	1.187TrpLeu: 1.187 ± 0.036	0.467TrpMet: 0.467 ± 0.021	0.885TrpAsn: 0.885 ± 0.032	0.289TrpPro: 0.289 ± 0.016	0.523TrpGln: 0.523 ± 0.022	0.573TrpArg: 0.573 ± 0.023	0.74TrpSer: 0.74 ± 0.026	0.697TrpThr: 0.697 ± 0.027	0.748TrpVal: 0.748 ± 0.023	0.215TrpTrp: 0.215 ± 0.016	0.556TrpTyr: 0.556 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.06TyrAla: 3.06 ± 0.053	0.617TyrCys: 0.617 ± 0.022	2.538TyrAsp: 2.538 ± 0.049	2.526TyrGlu: 2.526 ± 0.051	2.177TyrPhe: 2.177 ± 0.041	3.068TyrGly: 3.068 ± 0.06	1.025TyrHis: 1.025 ± 0.03	2.972TyrIle: 2.972 ± 0.053	2.906TyrLys: 2.906 ± 0.053	4.06TyrLeu: 4.06 ± 0.063	1.195TyrMet: 1.195 ± 0.034	2.514TyrAsn: 2.514 ± 0.055	1.882TyrPro: 1.882 ± 0.038	1.667TyrGln: 1.667 ± 0.036	2.288TyrArg: 2.288 ± 0.042	2.659TyrSer: 2.659 ± 0.046	2.65TyrThr: 2.65 ± 0.049	2.522TyrVal: 2.522 ± 0.05	0.637TyrTrp: 0.637 ± 0.024	2.229TyrTyr: 2.229 ± 0.05	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3558 proteins (1234531 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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