Amino acid dipepetide frequency for Paenibacillus stellifer

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.603AlaAla: 10.603 ± 0.147
0.792AlaCys: 0.792 ± 0.026
4.524AlaAsp: 4.524 ± 0.065
6.404AlaGlu: 6.404 ± 0.091
3.349AlaPhe: 3.349 ± 0.053
8.199AlaGly: 8.199 ± 0.103
1.422AlaHis: 1.422 ± 0.034
5.018AlaIle: 5.018 ± 0.062
4.223AlaLys: 4.223 ± 0.058
8.922AlaLeu: 8.922 ± 0.088
2.283AlaMet: 2.283 ± 0.042
2.361AlaAsn: 2.361 ± 0.047
2.999AlaPro: 2.999 ± 0.062
2.658AlaGln: 2.658 ± 0.049
4.086AlaArg: 4.086 ± 0.064
5.611AlaSer: 5.611 ± 0.088
3.329AlaThr: 3.329 ± 0.068
7.256AlaVal: 7.256 ± 0.083
0.91AlaTrp: 0.91 ± 0.028
2.781AlaTyr: 2.781 ± 0.044
0.0AlaXaa: 0.0 ± 0.0
Cys
0.59CysAla: 0.59 ± 0.024
0.125CysCys: 0.125 ± 0.01
0.411CysAsp: 0.411 ± 0.018
0.441CysGlu: 0.441 ± 0.021
0.307CysPhe: 0.307 ± 0.016
0.897CysGly: 0.897 ± 0.026
0.173CysHis: 0.173 ± 0.012
0.475CysIle: 0.475 ± 0.017
0.323CysLys: 0.323 ± 0.015
0.849CysLeu: 0.849 ± 0.027
0.214CysMet: 0.214 ± 0.012
0.279CysAsn: 0.279 ± 0.016
0.411CysPro: 0.411 ± 0.02
0.243CysGln: 0.243 ± 0.012
0.58CysArg: 0.58 ± 0.022
0.596CysSer: 0.596 ± 0.019
0.417CysThr: 0.417 ± 0.018
0.473CysVal: 0.473 ± 0.019
0.092CysTrp: 0.092 ± 0.007
0.273CysTyr: 0.273 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
3.945AspAla: 3.945 ± 0.055
0.428AspCys: 0.428 ± 0.017
2.45AspAsp: 2.45 ± 0.049
3.881AspGlu: 3.881 ± 0.063
2.19AspPhe: 2.19 ± 0.045
4.074AspGly: 4.074 ± 0.066
1.065AspHis: 1.065 ± 0.024
3.686AspIle: 3.686 ± 0.055
2.628AspLys: 2.628 ± 0.047
5.094AspLeu: 5.094 ± 0.066
1.446AspMet: 1.446 ± 0.032
1.733AspAsn: 1.733 ± 0.037
2.333AspPro: 2.333 ± 0.041
1.65AspGln: 1.65 ± 0.039
2.959AspArg: 2.959 ± 0.056
3.029AspSer: 3.029 ± 0.048
2.521AspThr: 2.521 ± 0.042
3.384AspVal: 3.384 ± 0.053
0.758AspTrp: 0.758 ± 0.025
2.089AspTyr: 2.089 ± 0.042
0.0AspXaa: 0.0 ± 0.0
Glu
6.592GluAla: 6.592 ± 0.088
0.424GluCys: 0.424 ± 0.018
3.457GluAsp: 3.457 ± 0.058
5.82GluGlu: 5.82 ± 0.102
2.183GluPhe: 2.183 ± 0.04
4.832GluGly: 4.832 ± 0.061
1.5GluHis: 1.5 ± 0.039
4.394GluIle: 4.394 ± 0.067
3.684GluLys: 3.684 ± 0.059
7.646GluLeu: 7.646 ± 0.092
2.078GluMet: 2.078 ± 0.046
2.429GluAsn: 2.429 ± 0.041
2.312GluPro: 2.312 ± 0.04
3.29GluGln: 3.29 ± 0.06
4.398GluArg: 4.398 ± 0.073
3.751GluSer: 3.751 ± 0.056
3.283GluThr: 3.283 ± 0.056
4.449GluVal: 4.449 ± 0.06
0.885GluTrp: 0.885 ± 0.029
1.96GluTyr: 1.96 ± 0.04
0.0GluXaa: 0.0 ± 0.0
Phe
3.338PheAla: 3.338 ± 0.048
0.388PheCys: 0.388 ± 0.015
2.139PheAsp: 2.139 ± 0.039
2.316PheGlu: 2.316 ± 0.044
1.713PhePhe: 1.713 ± 0.048
3.46PheGly: 3.46 ± 0.059
0.832PheHis: 0.832 ± 0.023
2.585PheIle: 2.585 ± 0.05
1.845PheLys: 1.845 ± 0.042
3.822PheLeu: 3.822 ± 0.063
1.123PheMet: 1.123 ± 0.034
1.417PheAsn: 1.417 ± 0.034
1.567PhePro: 1.567 ± 0.039
1.251PheGln: 1.251 ± 0.031
2.135PheArg: 2.135 ± 0.039
2.684PheSer: 2.684 ± 0.049
2.263PheThr: 2.263 ± 0.043
2.658PheVal: 2.658 ± 0.05
0.539PheTrp: 0.539 ± 0.02
1.395PheTyr: 1.395 ± 0.034
0.0PheXaa: 0.0 ± 0.0
Gly
6.373GlyAla: 6.373 ± 0.083
0.758GlyCys: 0.758 ± 0.026
3.82GlyAsp: 3.82 ± 0.06
5.071GlyGlu: 5.071 ± 0.06
3.332GlyPhe: 3.332 ± 0.056
6.49GlyGly: 6.49 ± 0.094
1.544GlyHis: 1.544 ± 0.035
5.836GlyIle: 5.836 ± 0.07
4.379GlyLys: 4.379 ± 0.063
8.094GlyLeu: 8.094 ± 0.088
2.465GlyMet: 2.465 ± 0.043
2.578GlyAsn: 2.578 ± 0.053
2.163GlyPro: 2.163 ± 0.048
2.691GlyGln: 2.691 ± 0.042
4.574GlyArg: 4.574 ± 0.07
5.369GlySer: 5.369 ± 0.066
4.57GlyThr: 4.57 ± 0.073
5.545GlyVal: 5.545 ± 0.076
1.055GlyTrp: 1.055 ± 0.031
3.065GlyTyr: 3.065 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
1.528HisAla: 1.528 ± 0.039
0.196HisCys: 0.196 ± 0.012
0.968HisAsp: 0.968 ± 0.028
1.246HisGlu: 1.246 ± 0.033
0.94HisPhe: 0.94 ± 0.028
1.521HisGly: 1.521 ± 0.034
0.558HisHis: 0.558 ± 0.024
1.29HisIle: 1.29 ± 0.037
0.813HisLys: 0.813 ± 0.025
2.019HisLeu: 2.019 ± 0.046
0.549HisMet: 0.549 ± 0.019
0.67HisAsn: 0.67 ± 0.021
1.213HisPro: 1.213 ± 0.035
0.662HisGln: 0.662 ± 0.022
1.1HisArg: 1.1 ± 0.031
1.232HisSer: 1.232 ± 0.028
1.093HisThr: 1.093 ± 0.028
1.31HisVal: 1.31 ± 0.03
0.24HisTrp: 0.24 ± 0.016
0.808HisTyr: 0.808 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
5.978IleAla: 5.978 ± 0.077
0.623IleCys: 0.623 ± 0.021
3.399IleAsp: 3.399 ± 0.049
3.955IleGlu: 3.955 ± 0.065
2.208IlePhe: 2.208 ± 0.051
5.499IleGly: 5.499 ± 0.069
1.347IleHis: 1.347 ± 0.032
3.881IleIle: 3.881 ± 0.055
2.744IleLys: 2.744 ± 0.053
5.72IleLeu: 5.72 ± 0.077
1.586IleMet: 1.586 ± 0.035
2.132IleAsn: 2.132 ± 0.04
3.114IlePro: 3.114 ± 0.046
2.192IleGln: 2.192 ± 0.045
3.908IleArg: 3.908 ± 0.066
4.348IleSer: 4.348 ± 0.058
3.57IleThr: 3.57 ± 0.054
4.846IleVal: 4.846 ± 0.071
0.654IleTrp: 0.654 ± 0.022
1.966IleTyr: 1.966 ± 0.038
0.0IleXaa: 0.0 ± 0.0
Lys
4.314LysAla: 4.314 ± 0.068
0.286LysCys: 0.286 ± 0.015
2.807LysAsp: 2.807 ± 0.05
4.115LysGlu: 4.115 ± 0.058
1.418LysPhe: 1.418 ± 0.035
3.75LysGly: 3.75 ± 0.059
0.931LysHis: 0.931 ± 0.025
2.911LysIle: 2.911 ± 0.056
2.889LysLys: 2.889 ± 0.056
5.378LysLeu: 5.378 ± 0.061
1.475LysMet: 1.475 ± 0.038
1.876LysAsn: 1.876 ± 0.043
2.2LysPro: 2.2 ± 0.039
2.02LysGln: 2.02 ± 0.036
2.787LysArg: 2.787 ± 0.049
2.995LysSer: 2.995 ± 0.049
2.676LysThr: 2.676 ± 0.047
3.499LysVal: 3.499 ± 0.059
0.659LysTrp: 0.659 ± 0.023
1.617LysTyr: 1.617 ± 0.036
0.0LysXaa: 0.0 ± 0.0
Leu
9.196LeuAla: 9.196 ± 0.096
0.837LeuCys: 0.837 ± 0.026
5.362LeuAsp: 5.362 ± 0.065
6.811LeuGlu: 6.811 ± 0.088
4.408LeuPhe: 4.408 ± 0.08
7.438LeuGly: 7.438 ± 0.088
2.137LeuHis: 2.137 ± 0.043
6.488LeuIle: 6.488 ± 0.086
5.524LeuLys: 5.524 ± 0.071
11.665LeuLeu: 11.665 ± 0.144
2.693LeuMet: 2.693 ± 0.046
3.849LeuAsn: 3.849 ± 0.062
4.818LeuPro: 4.818 ± 0.067
3.768LeuGln: 3.768 ± 0.058
5.631LeuArg: 5.631 ± 0.088
7.281LeuSer: 7.281 ± 0.094
5.772LeuThr: 5.772 ± 0.063
6.248LeuVal: 6.248 ± 0.077
1.029LeuTrp: 1.029 ± 0.027
3.227LeuTyr: 3.227 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
2.276MetAla: 2.276 ± 0.041
0.165MetCys: 0.165 ± 0.012
1.46MetAsp: 1.46 ± 0.033
1.978MetGlu: 1.978 ± 0.035
0.962MetPhe: 0.962 ± 0.025
1.765MetGly: 1.765 ± 0.04
0.437MetHis: 0.437 ± 0.017
1.82MetIle: 1.82 ± 0.039
1.911MetLys: 1.911 ± 0.043
3.03MetLeu: 3.03 ± 0.05
0.823MetMet: 0.823 ± 0.03
1.395MetAsn: 1.395 ± 0.035
1.14MetPro: 1.14 ± 0.025
0.922MetGln: 0.922 ± 0.028
1.347MetArg: 1.347 ± 0.027
1.828MetSer: 1.828 ± 0.042
1.711MetThr: 1.711 ± 0.041
1.648MetVal: 1.648 ± 0.038
0.195MetTrp: 0.195 ± 0.012
0.684MetTyr: 0.684 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
2.828AsnAla: 2.828 ± 0.051
0.27AsnCys: 0.27 ± 0.017
1.665AsnAsp: 1.665 ± 0.031
2.283AsnGlu: 2.283 ± 0.042
1.225AsnPhe: 1.225 ± 0.033
2.968AsnGly: 2.968 ± 0.055
0.706AsnHis: 0.706 ± 0.025
2.168AsnIle: 2.168 ± 0.042
1.692AsnLys: 1.692 ± 0.039
3.304AsnLeu: 3.304 ± 0.048
0.95AsnMet: 0.95 ± 0.029
1.296AsnAsn: 1.296 ± 0.032
2.013AsnPro: 2.013 ± 0.04
1.204AsnGln: 1.204 ± 0.031
2.168AsnArg: 2.168 ± 0.041
1.956AsnSer: 1.956 ± 0.042
1.785AsnThr: 1.785 ± 0.036
2.409AsnVal: 2.409 ± 0.048
0.479AsnTrp: 0.479 ± 0.021
1.219AsnTyr: 1.219 ± 0.034
0.0AsnXaa: 0.0 ± 0.0
Pro
3.854ProAla: 3.854 ± 0.067
0.294ProCys: 0.294 ± 0.016
2.689ProAsp: 2.689 ± 0.045
3.788ProGlu: 3.788 ± 0.058
1.828ProPhe: 1.828 ± 0.037
3.604ProGly: 3.604 ± 0.055
0.845ProHis: 0.845 ± 0.024
2.112ProIle: 2.112 ± 0.043
1.751ProLys: 1.751 ± 0.037
4.156ProLeu: 4.156 ± 0.054
0.911ProMet: 0.911 ± 0.027
1.27ProAsn: 1.27 ± 0.029
1.404ProPro: 1.404 ± 0.041
1.394ProGln: 1.394 ± 0.032
1.631ProArg: 1.631 ± 0.035
2.641ProSer: 2.641 ± 0.05
1.702ProThr: 1.702 ± 0.046
3.611ProVal: 3.611 ± 0.055
0.502ProTrp: 0.502 ± 0.019
1.521ProTyr: 1.521 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
3.224GlnAla: 3.224 ± 0.051
0.198GlnCys: 0.198 ± 0.013
1.665GlnAsp: 1.665 ± 0.032
2.521GlnGlu: 2.521 ± 0.048
1.296GlnPhe: 1.296 ± 0.03
2.607GlnGly: 2.607 ± 0.043
0.726GlnHis: 0.726 ± 0.024
2.224GlnIle: 2.224 ± 0.042
1.762GlnLys: 1.762 ± 0.042
3.692GlnLeu: 3.692 ± 0.061
1.065GlnMet: 1.065 ± 0.03
1.227GlnAsn: 1.227 ± 0.031
1.466GlnPro: 1.466 ± 0.035
1.499GlnGln: 1.499 ± 0.035
1.905GlnArg: 1.905 ± 0.039
2.166GlnSer: 2.166 ± 0.04
1.804GlnThr: 1.804 ± 0.041
2.305GlnVal: 2.305 ± 0.04
0.437GlnTrp: 0.437 ± 0.019
1.216GlnTyr: 1.216 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
3.84ArgAla: 3.84 ± 0.06
0.427ArgCys: 0.427 ± 0.019
2.729ArgAsp: 2.729 ± 0.051
4.509ArgGlu: 4.509 ± 0.076
2.256ArgPhe: 2.256 ± 0.04
3.463ArgGly: 3.463 ± 0.065
1.225ArgHis: 1.225 ± 0.038
3.722ArgIle: 3.722 ± 0.047
3.227ArgLys: 3.227 ± 0.054
6.169ArgLeu: 6.169 ± 0.079
1.705ArgMet: 1.705 ± 0.035
1.984ArgAsn: 1.984 ± 0.039
1.985ArgPro: 1.985 ± 0.04
2.206ArgGln: 2.206 ± 0.045
3.595ArgArg: 3.595 ± 0.072
3.665ArgSer: 3.665 ± 0.052
2.9ArgThr: 2.9 ± 0.049
3.29ArgVal: 3.29 ± 0.052
0.624ArgTrp: 0.624 ± 0.023
2.055ArgTyr: 2.055 ± 0.044
0.0ArgXaa: 0.0 ± 0.0
Ser
5.704SerAla: 5.704 ± 0.078
0.5SerCys: 0.5 ± 0.022
3.182SerAsp: 3.182 ± 0.051
3.874SerGlu: 3.874 ± 0.048
2.876SerPhe: 2.876 ± 0.048
6.237SerGly: 6.237 ± 0.09
1.19SerHis: 1.19 ± 0.028
3.994SerIle: 3.994 ± 0.064
2.952SerLys: 2.952 ± 0.052
6.877SerLeu: 6.877 ± 0.078
1.701SerMet: 1.701 ± 0.034
1.959SerAsn: 1.959 ± 0.039
2.813SerPro: 2.813 ± 0.048
1.957SerGln: 1.957 ± 0.039
3.802SerArg: 3.802 ± 0.058
4.387SerSer: 4.387 ± 0.08
2.969SerThr: 2.969 ± 0.058
4.575SerVal: 4.575 ± 0.06
0.795SerTrp: 0.795 ± 0.025
2.177SerTyr: 2.177 ± 0.045
0.0SerXaa: 0.0 ± 0.0
Thr
4.909ThrAla: 4.909 ± 0.075
0.349ThrCys: 0.349 ± 0.015
2.681ThrAsp: 2.681 ± 0.046
3.246ThrGlu: 3.246 ± 0.049
2.045ThrPhe: 2.045 ± 0.036
5.021ThrGly: 5.021 ± 0.063
0.949ThrHis: 0.949 ± 0.023
3.216ThrIle: 3.216 ± 0.046
2.158ThrLys: 2.158 ± 0.043
5.442ThrLeu: 5.442 ± 0.071
1.225ThrMet: 1.225 ± 0.03
1.608ThrAsn: 1.608 ± 0.037
2.583ThrPro: 2.583 ± 0.052
1.374ThrGln: 1.374 ± 0.036
2.433ThrArg: 2.433 ± 0.04
3.025ThrSer: 3.025 ± 0.05
2.614ThrThr: 2.614 ± 0.057
4.612ThrVal: 4.612 ± 0.077
0.542ThrTrp: 0.542 ± 0.021
1.688ThrTyr: 1.688 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
5.204ValAla: 5.204 ± 0.066
0.68ValCys: 0.68 ± 0.025
3.473ValAsp: 3.473 ± 0.061
4.169ValGlu: 4.169 ± 0.069
2.938ValPhe: 2.938 ± 0.048
4.362ValGly: 4.362 ± 0.068
1.401ValHis: 1.401 ± 0.032
4.962ValIle: 4.962 ± 0.062
3.833ValLys: 3.833 ± 0.056
7.653ValLeu: 7.653 ± 0.087
1.925ValMet: 1.925 ± 0.04
2.624ValAsn: 2.624 ± 0.046
3.142ValPro: 3.142 ± 0.052
2.463ValGln: 2.463 ± 0.044
3.742ValArg: 3.742 ± 0.061
4.965ValSer: 4.965 ± 0.071
4.307ValThr: 4.307 ± 0.066
4.827ValVal: 4.827 ± 0.079
0.803ValTrp: 0.803 ± 0.026
2.35ValTyr: 2.35 ± 0.047
0.0ValXaa: 0.0 ± 0.0
Trp
0.793TrpAla: 0.793 ± 0.025
0.095TrpCys: 0.095 ± 0.008
0.639TrpAsp: 0.639 ± 0.022
0.743TrpGlu: 0.743 ± 0.026
0.487TrpPhe: 0.487 ± 0.018
0.823TrpGly: 0.823 ± 0.03
0.24TrpHis: 0.24 ± 0.013
0.851TrpIle: 0.851 ± 0.026
0.713TrpLys: 0.713 ± 0.024
1.336TrpLeu: 1.336 ± 0.034
0.403TrpMet: 0.403 ± 0.018
0.65TrpAsn: 0.65 ± 0.024
0.331TrpPro: 0.331 ± 0.015
0.421TrpGln: 0.421 ± 0.019
0.601TrpArg: 0.601 ± 0.022
0.806TrpSer: 0.806 ± 0.026
0.606TrpThr: 0.606 ± 0.023
0.718TrpVal: 0.718 ± 0.023
0.166TrpTrp: 0.166 ± 0.012
0.358TrpTyr: 0.358 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.64TyrAla: 2.64 ± 0.048
0.332TyrCys: 0.332 ± 0.015
1.825TyrAsp: 1.825 ± 0.043
2.197TyrGlu: 2.197 ± 0.041
1.511TyrPhe: 1.511 ± 0.038
2.758TyrGly: 2.758 ± 0.044
0.727TyrHis: 0.727 ± 0.026
2.037TyrIle: 2.037 ± 0.037
1.552TyrLys: 1.552 ± 0.034
3.316TyrLeu: 3.316 ± 0.054
0.875TyrMet: 0.875 ± 0.024
1.25TyrAsn: 1.25 ± 0.034
1.499TyrPro: 1.499 ± 0.034
1.142TyrGln: 1.142 ± 0.032
2.195TyrArg: 2.195 ± 0.042
2.185TyrSer: 2.185 ± 0.045
1.829TyrThr: 1.829 ± 0.039
2.162TyrVal: 2.162 ± 0.039
0.417TyrTrp: 0.417 ± 0.019
1.262TyrTyr: 1.262 ± 0.035
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4417 proteins (1351556 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski