Amino acid dipepetide frequency for Streptococcus phage Javan10

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.114AlaAla: 3.114 ± 0.614
0.0AlaCys: 0.0 ± 0.0
4.762AlaAsp: 4.762 ± 0.687
4.304AlaGlu: 4.304 ± 0.808
2.473AlaPhe: 2.473 ± 0.493
4.304AlaGly: 4.304 ± 0.776
0.824AlaHis: 0.824 ± 0.313
5.861AlaIle: 5.861 ± 0.979
6.593AlaLys: 6.593 ± 0.882
4.853AlaLeu: 4.853 ± 0.591
1.282AlaMet: 1.282 ± 0.329
4.762AlaAsn: 4.762 ± 0.545
1.282AlaPro: 1.282 ± 0.406
2.381AlaGln: 2.381 ± 0.325
2.198AlaArg: 2.198 ± 0.472
4.396AlaSer: 4.396 ± 0.592
3.846AlaThr: 3.846 ± 0.746
3.48AlaVal: 3.48 ± 0.573
0.916AlaTrp: 0.916 ± 0.299
3.48AlaTyr: 3.48 ± 0.615
0.0AlaXaa: 0.0 ± 0.0
Cys
0.092CysAla: 0.092 ± 0.083
0.183CysCys: 0.183 ± 0.125
0.733CysAsp: 0.733 ± 0.346
0.641CysGlu: 0.641 ± 0.245
0.092CysPhe: 0.092 ± 0.09
0.275CysGly: 0.275 ± 0.169
0.366CysHis: 0.366 ± 0.179
0.275CysIle: 0.275 ± 0.16
0.092CysLys: 0.092 ± 0.097
0.458CysLeu: 0.458 ± 0.232
0.275CysMet: 0.275 ± 0.171
0.183CysAsn: 0.183 ± 0.122
0.092CysPro: 0.092 ± 0.11
0.366CysGln: 0.366 ± 0.152
0.549CysArg: 0.549 ± 0.218
0.366CysSer: 0.366 ± 0.201
0.183CysThr: 0.183 ± 0.125
0.366CysVal: 0.366 ± 0.171
0.092CysTrp: 0.092 ± 0.09
0.641CysTyr: 0.641 ± 0.275
0.0CysXaa: 0.0 ± 0.0
Asp
3.48AspAla: 3.48 ± 0.633
0.733AspCys: 0.733 ± 0.244
4.121AspAsp: 4.121 ± 0.705
4.487AspGlu: 4.487 ± 0.551
3.297AspPhe: 3.297 ± 0.433
5.495AspGly: 5.495 ± 1.001
0.641AspHis: 0.641 ± 0.212
4.762AspIle: 4.762 ± 0.63
5.586AspLys: 5.586 ± 0.813
4.945AspLeu: 4.945 ± 0.688
1.007AspMet: 1.007 ± 0.293
5.22AspAsn: 5.22 ± 0.494
1.557AspPro: 1.557 ± 0.417
1.465AspGln: 1.465 ± 0.426
2.198AspArg: 2.198 ± 0.305
3.755AspSer: 3.755 ± 0.777
3.846AspThr: 3.846 ± 0.612
3.388AspVal: 3.388 ± 0.662
1.465AspTrp: 1.465 ± 0.361
3.938AspTyr: 3.938 ± 0.811
0.0AspXaa: 0.0 ± 0.0
Glu
5.678GluAla: 5.678 ± 0.863
0.366GluCys: 0.366 ± 0.196
3.755GluAsp: 3.755 ± 0.483
5.128GluGlu: 5.128 ± 0.695
2.564GluPhe: 2.564 ± 0.497
2.289GluGly: 2.289 ± 0.385
1.007GluHis: 1.007 ± 0.295
5.769GluIle: 5.769 ± 0.862
6.227GluLys: 6.227 ± 1.031
6.96GluLeu: 6.96 ± 1.069
2.564GluMet: 2.564 ± 0.579
4.029GluAsn: 4.029 ± 0.906
1.465GluPro: 1.465 ± 0.419
3.205GluGln: 3.205 ± 0.641
3.48GluArg: 3.48 ± 0.747
3.571GluSer: 3.571 ± 0.569
3.755GluThr: 3.755 ± 0.549
3.48GluVal: 3.48 ± 0.543
0.641GluTrp: 0.641 ± 0.245
2.473GluTyr: 2.473 ± 0.441
0.0GluXaa: 0.0 ± 0.0
Phe
2.473PheAla: 2.473 ± 0.464
0.092PheCys: 0.092 ± 0.096
3.388PheAsp: 3.388 ± 0.573
3.297PheGlu: 3.297 ± 0.707
1.099PhePhe: 1.099 ± 0.294
2.747PheGly: 2.747 ± 0.486
0.275PheHis: 0.275 ± 0.157
2.93PheIle: 2.93 ± 0.63
4.67PheLys: 4.67 ± 0.668
2.289PheLeu: 2.289 ± 0.462
1.374PheMet: 1.374 ± 0.398
2.289PheAsn: 2.289 ± 0.546
1.007PhePro: 1.007 ± 0.369
0.641PheGln: 0.641 ± 0.236
1.465PheArg: 1.465 ± 0.35
2.473PheSer: 2.473 ± 0.487
2.381PheThr: 2.381 ± 0.538
3.297PheVal: 3.297 ± 0.541
0.366PheTrp: 0.366 ± 0.176
1.374PheTyr: 1.374 ± 0.356
0.0PheXaa: 0.0 ± 0.0
Gly
4.212GlyAla: 4.212 ± 1.075
0.366GlyCys: 0.366 ± 0.187
3.846GlyAsp: 3.846 ± 0.564
3.48GlyGlu: 3.48 ± 0.745
3.48GlyPhe: 3.48 ± 0.652
4.487GlyGly: 4.487 ± 0.834
0.824GlyHis: 0.824 ± 0.218
4.762GlyIle: 4.762 ± 0.634
6.136GlyLys: 6.136 ± 0.797
4.396GlyLeu: 4.396 ± 0.567
1.648GlyMet: 1.648 ± 0.586
3.48GlyAsn: 3.48 ± 0.492
1.19GlyPro: 1.19 ± 0.521
2.198GlyGln: 2.198 ± 0.516
2.473GlyArg: 2.473 ± 0.394
3.755GlySer: 3.755 ± 0.713
4.67GlyThr: 4.67 ± 0.754
2.747GlyVal: 2.747 ± 0.576
1.557GlyTrp: 1.557 ± 0.347
4.029GlyTyr: 4.029 ± 0.646
0.0GlyXaa: 0.0 ± 0.0
His
0.641HisAla: 0.641 ± 0.223
0.366HisCys: 0.366 ± 0.218
0.824HisAsp: 0.824 ± 0.326
1.282HisGlu: 1.282 ± 0.376
0.824HisPhe: 0.824 ± 0.271
0.824HisGly: 0.824 ± 0.289
0.275HisHis: 0.275 ± 0.2
1.374HisIle: 1.374 ± 0.392
1.282HisLys: 1.282 ± 0.308
1.648HisLeu: 1.648 ± 0.491
0.092HisMet: 0.092 ± 0.089
0.549HisAsn: 0.549 ± 0.248
0.458HisPro: 0.458 ± 0.257
1.007HisGln: 1.007 ± 0.273
0.733HisArg: 0.733 ± 0.232
0.458HisSer: 0.458 ± 0.206
0.458HisThr: 0.458 ± 0.235
0.733HisVal: 0.733 ± 0.316
0.275HisTrp: 0.275 ± 0.168
0.916HisTyr: 0.916 ± 0.254
0.0HisXaa: 0.0 ± 0.0
Ile
5.586IleAla: 5.586 ± 0.76
0.366IleCys: 0.366 ± 0.208
7.326IleAsp: 7.326 ± 0.803
4.945IleGlu: 4.945 ± 0.863
2.473IlePhe: 2.473 ± 0.532
3.846IleGly: 3.846 ± 0.801
1.374IleHis: 1.374 ± 0.346
5.128IleIle: 5.128 ± 0.768
7.234IleLys: 7.234 ± 0.862
5.678IleLeu: 5.678 ± 0.758
2.289IleMet: 2.289 ± 0.575
4.853IleAsn: 4.853 ± 0.744
2.747IlePro: 2.747 ± 0.658
2.564IleGln: 2.564 ± 0.368
2.381IleArg: 2.381 ± 0.609
5.037IleSer: 5.037 ± 0.85
3.755IleThr: 3.755 ± 0.556
4.396IleVal: 4.396 ± 0.728
0.549IleTrp: 0.549 ± 0.245
2.106IleTyr: 2.106 ± 0.453
0.0IleXaa: 0.0 ± 0.0
Lys
6.777LysAla: 6.777 ± 0.941
0.366LysCys: 0.366 ± 0.18
5.586LysAsp: 5.586 ± 0.978
6.227LysGlu: 6.227 ± 1.067
1.832LysPhe: 1.832 ± 0.347
4.396LysGly: 4.396 ± 0.684
1.099LysHis: 1.099 ± 0.385
5.678LysIle: 5.678 ± 0.845
7.234LysLys: 7.234 ± 1.005
6.96LysLeu: 6.96 ± 0.797
2.656LysMet: 2.656 ± 0.66
5.128LysAsn: 5.128 ± 0.627
3.205LysPro: 3.205 ± 0.65
3.297LysGln: 3.297 ± 0.534
4.579LysArg: 4.579 ± 0.925
5.403LysSer: 5.403 ± 0.886
6.685LysThr: 6.685 ± 0.812
5.311LysVal: 5.311 ± 0.644
1.465LysTrp: 1.465 ± 0.32
3.663LysTyr: 3.663 ± 0.55
0.0LysXaa: 0.0 ± 0.0
Leu
5.403LeuAla: 5.403 ± 0.592
0.275LeuCys: 0.275 ± 0.143
4.487LeuAsp: 4.487 ± 0.721
4.945LeuGlu: 4.945 ± 0.765
2.656LeuPhe: 2.656 ± 0.492
5.403LeuGly: 5.403 ± 0.806
0.916LeuHis: 0.916 ± 0.365
5.22LeuIle: 5.22 ± 0.735
8.516LeuLys: 8.516 ± 1.144
7.051LeuLeu: 7.051 ± 1.063
1.19LeuMet: 1.19 ± 0.295
6.044LeuAsn: 6.044 ± 0.779
2.473LeuPro: 2.473 ± 0.447
3.297LeuGln: 3.297 ± 0.657
3.114LeuArg: 3.114 ± 0.614
6.685LeuSer: 6.685 ± 0.76
5.586LeuThr: 5.586 ± 0.759
4.67LeuVal: 4.67 ± 0.732
1.282LeuTrp: 1.282 ± 0.32
2.289LeuTyr: 2.289 ± 0.466
0.0LeuXaa: 0.0 ± 0.0
Met
2.106MetAla: 2.106 ± 0.537
0.183MetCys: 0.183 ± 0.15
1.648MetAsp: 1.648 ± 0.551
1.74MetGlu: 1.74 ± 0.589
0.733MetPhe: 0.733 ± 0.277
0.733MetGly: 0.733 ± 0.276
0.183MetHis: 0.183 ± 0.115
2.015MetIle: 2.015 ± 0.598
1.557MetLys: 1.557 ± 0.323
1.648MetLeu: 1.648 ± 0.332
0.549MetMet: 0.549 ± 0.219
1.099MetAsn: 1.099 ± 0.39
0.733MetPro: 0.733 ± 0.246
1.557MetGln: 1.557 ± 0.384
0.824MetArg: 0.824 ± 0.302
1.74MetSer: 1.74 ± 0.447
1.557MetThr: 1.557 ± 0.435
1.832MetVal: 1.832 ± 0.317
0.183MetTrp: 0.183 ± 0.134
0.916MetTyr: 0.916 ± 0.312
0.0MetXaa: 0.0 ± 0.0
Asn
3.297AsnAla: 3.297 ± 0.639
0.183AsnCys: 0.183 ± 0.125
3.205AsnAsp: 3.205 ± 0.607
4.304AsnGlu: 4.304 ± 0.725
3.022AsnPhe: 3.022 ± 0.431
4.945AsnGly: 4.945 ± 0.907
0.916AsnHis: 0.916 ± 0.34
4.762AsnIle: 4.762 ± 0.695
5.037AsnLys: 5.037 ± 0.726
5.861AsnLeu: 5.861 ± 0.978
1.19AsnMet: 1.19 ± 0.365
3.663AsnAsn: 3.663 ± 0.763
2.381AsnPro: 2.381 ± 0.454
2.473AsnGln: 2.473 ± 0.664
2.839AsnArg: 2.839 ± 0.594
3.022AsnSer: 3.022 ± 0.632
3.48AsnThr: 3.48 ± 0.659
3.48AsnVal: 3.48 ± 0.539
0.824AsnTrp: 0.824 ± 0.281
2.564AsnTyr: 2.564 ± 0.301
0.0AsnXaa: 0.0 ± 0.0
Pro
1.923ProAla: 1.923 ± 0.433
0.092ProCys: 0.092 ± 0.105
2.106ProAsp: 2.106 ± 0.395
1.74ProGlu: 1.74 ± 0.46
1.19ProPhe: 1.19 ± 0.378
1.465ProGly: 1.465 ± 0.42
0.458ProHis: 0.458 ± 0.249
2.198ProIle: 2.198 ± 0.465
3.663ProLys: 3.663 ± 0.64
2.015ProLeu: 2.015 ± 0.416
0.733ProMet: 0.733 ± 0.258
1.282ProAsn: 1.282 ± 0.386
1.099ProPro: 1.099 ± 0.244
1.465ProGln: 1.465 ± 0.381
0.916ProArg: 0.916 ± 0.275
2.656ProSer: 2.656 ± 0.508
1.74ProThr: 1.74 ± 0.589
1.007ProVal: 1.007 ± 0.268
0.0ProTrp: 0.0 ± 0.0
1.19ProTyr: 1.19 ± 0.442
0.0ProXaa: 0.0 ± 0.0
Gln
2.839GlnAla: 2.839 ± 0.751
0.549GlnCys: 0.549 ± 0.231
1.648GlnAsp: 1.648 ± 0.372
3.022GlnGlu: 3.022 ± 0.699
1.832GlnPhe: 1.832 ± 0.377
2.564GlnGly: 2.564 ± 0.708
0.733GlnHis: 0.733 ± 0.221
2.564GlnIle: 2.564 ± 0.48
4.121GlnLys: 4.121 ± 0.524
3.755GlnLeu: 3.755 ± 0.538
0.824GlnMet: 0.824 ± 0.39
2.106GlnAsn: 2.106 ± 0.462
0.549GlnPro: 0.549 ± 0.289
1.74GlnGln: 1.74 ± 0.475
1.648GlnArg: 1.648 ± 0.457
2.015GlnSer: 2.015 ± 0.464
1.74GlnThr: 1.74 ± 0.392
1.648GlnVal: 1.648 ± 0.391
0.458GlnTrp: 0.458 ± 0.204
1.19GlnTyr: 1.19 ± 0.322
0.0GlnXaa: 0.0 ± 0.0
Arg
2.473ArgAla: 2.473 ± 0.441
0.275ArgCys: 0.275 ± 0.162
2.198ArgAsp: 2.198 ± 0.387
3.114ArgGlu: 3.114 ± 0.615
1.374ArgPhe: 1.374 ± 0.366
2.289ArgGly: 2.289 ± 0.414
0.733ArgHis: 0.733 ± 0.331
3.388ArgIle: 3.388 ± 0.476
2.839ArgLys: 2.839 ± 0.452
3.846ArgLeu: 3.846 ± 0.815
0.733ArgMet: 0.733 ± 0.252
2.564ArgAsn: 2.564 ± 0.49
1.648ArgPro: 1.648 ± 0.326
1.557ArgGln: 1.557 ± 0.37
1.832ArgArg: 1.832 ± 0.403
1.282ArgSer: 1.282 ± 0.468
2.656ArgThr: 2.656 ± 0.529
2.198ArgVal: 2.198 ± 0.465
0.275ArgTrp: 0.275 ± 0.126
2.473ArgTyr: 2.473 ± 0.489
0.0ArgXaa: 0.0 ± 0.0
Ser
3.114SerAla: 3.114 ± 0.774
0.366SerCys: 0.366 ± 0.201
4.762SerAsp: 4.762 ± 0.555
4.212SerGlu: 4.212 ± 0.677
3.755SerPhe: 3.755 ± 0.658
5.311SerGly: 5.311 ± 1.067
1.099SerHis: 1.099 ± 0.284
4.304SerIle: 4.304 ± 0.587
4.212SerLys: 4.212 ± 0.63
4.762SerLeu: 4.762 ± 0.842
1.374SerMet: 1.374 ± 0.342
4.121SerAsn: 4.121 ± 0.662
1.19SerPro: 1.19 ± 0.288
1.74SerGln: 1.74 ± 0.441
2.289SerArg: 2.289 ± 0.396
5.311SerSer: 5.311 ± 0.714
4.487SerThr: 4.487 ± 0.959
3.938SerVal: 3.938 ± 0.791
0.641SerTrp: 0.641 ± 0.217
2.656SerTyr: 2.656 ± 0.425
0.0SerXaa: 0.0 ± 0.0
Thr
4.121ThrAla: 4.121 ± 0.605
0.366ThrCys: 0.366 ± 0.195
4.304ThrAsp: 4.304 ± 0.491
3.022ThrGlu: 3.022 ± 0.526
2.564ThrPhe: 2.564 ± 0.583
4.945ThrGly: 4.945 ± 0.638
0.916ThrHis: 0.916 ± 0.273
5.037ThrIle: 5.037 ± 0.85
4.67ThrLys: 4.67 ± 0.601
5.769ThrLeu: 5.769 ± 0.754
1.465ThrMet: 1.465 ± 0.386
3.48ThrAsn: 3.48 ± 0.729
2.381ThrPro: 2.381 ± 0.454
1.74ThrGln: 1.74 ± 0.375
1.648ThrArg: 1.648 ± 0.351
4.487ThrSer: 4.487 ± 0.875
4.212ThrThr: 4.212 ± 0.55
5.769ThrVal: 5.769 ± 1.032
0.458ThrTrp: 0.458 ± 0.22
2.656ThrTyr: 2.656 ± 0.565
0.0ThrXaa: 0.0 ± 0.0
Val
3.48ValAla: 3.48 ± 0.422
0.458ValCys: 0.458 ± 0.205
3.938ValAsp: 3.938 ± 0.565
4.396ValGlu: 4.396 ± 0.6
1.74ValPhe: 1.74 ± 0.425
4.212ValGly: 4.212 ± 0.847
0.824ValHis: 0.824 ± 0.238
4.304ValIle: 4.304 ± 0.614
4.029ValLys: 4.029 ± 0.485
4.762ValLeu: 4.762 ± 0.688
0.916ValMet: 0.916 ± 0.342
3.388ValAsn: 3.388 ± 0.607
1.832ValPro: 1.832 ± 0.367
2.473ValGln: 2.473 ± 0.454
2.564ValArg: 2.564 ± 0.531
4.121ValSer: 4.121 ± 0.587
4.945ValThr: 4.945 ± 0.696
4.487ValVal: 4.487 ± 0.751
0.458ValTrp: 0.458 ± 0.21
1.465ValTyr: 1.465 ± 0.255
0.0ValXaa: 0.0 ± 0.0
Trp
1.19TrpAla: 1.19 ± 0.414
0.092TrpCys: 0.092 ± 0.082
0.183TrpAsp: 0.183 ± 0.118
1.007TrpGlu: 1.007 ± 0.36
0.549TrpPhe: 0.549 ± 0.197
0.824TrpGly: 0.824 ± 0.322
0.275TrpHis: 0.275 ± 0.145
1.374TrpIle: 1.374 ± 0.285
0.641TrpLys: 0.641 ± 0.238
0.549TrpLeu: 0.549 ± 0.219
0.275TrpMet: 0.275 ± 0.187
0.549TrpAsn: 0.549 ± 0.224
0.183TrpPro: 0.183 ± 0.137
0.824TrpGln: 0.824 ± 0.234
0.458TrpArg: 0.458 ± 0.195
1.007TrpSer: 1.007 ± 0.284
1.099TrpThr: 1.099 ± 0.296
0.641TrpVal: 0.641 ± 0.226
0.275TrpTrp: 0.275 ± 0.145
0.458TrpTyr: 0.458 ± 0.183
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.114TyrAla: 3.114 ± 0.635
0.641TyrCys: 0.641 ± 0.188
2.564TyrAsp: 2.564 ± 0.461
3.114TyrGlu: 3.114 ± 0.618
2.381TyrPhe: 2.381 ± 0.486
2.381TyrGly: 2.381 ± 0.338
1.282TyrHis: 1.282 ± 0.349
2.93TyrIle: 2.93 ± 0.403
3.205TyrLys: 3.205 ± 0.591
3.297TyrLeu: 3.297 ± 0.494
1.007TyrMet: 1.007 ± 0.325
2.656TyrAsn: 2.656 ± 0.531
1.465TyrPro: 1.465 ± 0.416
1.557TyrGln: 1.557 ± 0.339
1.557TyrArg: 1.557 ± 0.344
2.106TyrSer: 2.106 ± 0.446
2.93TyrThr: 2.93 ± 0.459
1.923TyrVal: 1.923 ± 0.362
0.366TyrTrp: 0.366 ± 0.215
1.832TyrTyr: 1.832 ± 0.432
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 57 proteins (10921 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski