Amino acid dipepetide frequency for Bacteroides luti

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.973AlaAla: 4.973 ± 0.089	0.845AlaCys: 0.845 ± 0.024	3.78AlaAsp: 3.78 ± 0.063	4.098AlaGlu: 4.098 ± 0.075	3.101AlaPhe: 3.101 ± 0.048	4.758AlaGly: 4.758 ± 0.07	1.096AlaHis: 1.096 ± 0.031	4.935AlaIle: 4.935 ± 0.073	4.818AlaLys: 4.818 ± 0.061	6.116AlaLeu: 6.116 ± 0.089	1.66AlaMet: 1.66 ± 0.04	3.474AlaAsn: 3.474 ± 0.058	2.116AlaPro: 2.116 ± 0.05	2.5AlaGln: 2.5 ± 0.05	2.396AlaArg: 2.396 ± 0.047	4.384AlaSer: 4.384 ± 0.065	3.586AlaThr: 3.586 ± 0.065	4.132AlaVal: 4.132 ± 0.07	0.731AlaTrp: 0.731 ± 0.026	2.765AlaTyr: 2.765 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.626CysAla: 0.626 ± 0.025	0.198CysCys: 0.198 ± 0.014	0.606CysAsp: 0.606 ± 0.023	0.668CysGlu: 0.668 ± 0.024	0.622CysPhe: 0.622 ± 0.024	0.969CysGly: 0.969 ± 0.029	0.264CysHis: 0.264 ± 0.018	0.903CysIle: 0.903 ± 0.027	0.79CysLys: 0.79 ± 0.03	1.027CysLeu: 1.027 ± 0.029	0.312CysMet: 0.312 ± 0.019	0.625CysAsn: 0.625 ± 0.022	0.493CysPro: 0.493 ± 0.021	0.283CysGln: 0.283 ± 0.017	0.472CysArg: 0.472 ± 0.023	0.823CysSer: 0.823 ± 0.028	0.655CysThr: 0.655 ± 0.023	0.694CysVal: 0.694 ± 0.024	0.141CysTrp: 0.141 ± 0.011	0.493CysTyr: 0.493 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.595AspAla: 3.595 ± 0.061	0.603AspCys: 0.603 ± 0.021	2.533AspAsp: 2.533 ± 0.052	3.6AspGlu: 3.6 ± 0.053	3.032AspPhe: 3.032 ± 0.053	3.892AspGly: 3.892 ± 0.068	0.793AspHis: 0.793 ± 0.027	4.222AspIle: 4.222 ± 0.061	4.516AspLys: 4.516 ± 0.066	4.785AspLeu: 4.785 ± 0.074	1.421AspMet: 1.421 ± 0.039	3.125AspAsn: 3.125 ± 0.056	1.812AspPro: 1.812 ± 0.044	1.353AspGln: 1.353 ± 0.037	2.05AspArg: 2.05 ± 0.048	3.398AspSer: 3.398 ± 0.06	2.42AspThr: 2.42 ± 0.048	3.42AspVal: 3.42 ± 0.058	0.836AspTrp: 0.836 ± 0.031	2.921AspTyr: 2.921 ± 0.055	0.0AspXaa: 0.0 ± 0.0
Glu	4.232GluAla: 4.232 ± 0.078	0.58GluCys: 0.58 ± 0.024	3.148GluAsp: 3.148 ± 0.058	4.546GluGlu: 4.546 ± 0.082	2.634GluPhe: 2.634 ± 0.047	3.689GluGly: 3.689 ± 0.063	1.045GluHis: 1.045 ± 0.035	4.754GluIle: 4.754 ± 0.067	5.537GluLys: 5.537 ± 0.08	5.961GluLeu: 5.961 ± 0.08	1.9GluMet: 1.9 ± 0.036	3.822GluAsn: 3.822 ± 0.056	1.586GluPro: 1.586 ± 0.037	2.217GluGln: 2.217 ± 0.05	2.547GluArg: 2.547 ± 0.044	3.43GluSer: 3.43 ± 0.054	3.155GluThr: 3.155 ± 0.054	4.005GluVal: 4.005 ± 0.062	0.781GluTrp: 0.781 ± 0.03	2.692GluTyr: 2.692 ± 0.05	0.0GluXaa: 0.0 ± 0.0
Phe	3.036PheAla: 3.036 ± 0.052	0.678PheCys: 0.678 ± 0.023	2.814PheAsp: 2.814 ± 0.046	2.579PheGlu: 2.579 ± 0.044	2.395PhePhe: 2.395 ± 0.056	3.275PheGly: 3.275 ± 0.05	0.807PheHis: 0.807 ± 0.03	3.608PheIle: 3.608 ± 0.058	3.005PheLys: 3.005 ± 0.053	4.132PheLeu: 4.132 ± 0.072	1.228PheMet: 1.228 ± 0.035	2.852PheAsn: 2.852 ± 0.057	1.739PhePro: 1.739 ± 0.042	1.373PheGln: 1.373 ± 0.035	1.868PheArg: 1.868 ± 0.039	3.839PheSer: 3.839 ± 0.056	2.955PheThr: 2.955 ± 0.044	3.007PheVal: 3.007 ± 0.05	0.621PheTrp: 0.621 ± 0.026	2.124PheTyr: 2.124 ± 0.045	0.0PheXaa: 0.0 ± 0.0
Gly	4.232GlyAla: 4.232 ± 0.066	0.874GlyCys: 0.874 ± 0.032	3.4GlyAsp: 3.4 ± 0.055	3.8GlyGlu: 3.8 ± 0.059	3.247GlyPhe: 3.247 ± 0.054	4.651GlyGly: 4.651 ± 0.075	1.149GlyHis: 1.149 ± 0.033	5.362GlyIle: 5.362 ± 0.073	5.611GlyLys: 5.611 ± 0.072	5.7GlyLeu: 5.7 ± 0.077	1.947GlyMet: 1.947 ± 0.045	3.855GlyAsn: 3.855 ± 0.063	1.279GlyPro: 1.279 ± 0.033	1.874GlyGln: 1.874 ± 0.042	2.441GlyArg: 2.441 ± 0.048	4.126GlySer: 4.126 ± 0.072	4.162GlyThr: 4.162 ± 0.062	4.661GlyVal: 4.661 ± 0.068	0.955GlyTrp: 0.955 ± 0.035	3.28GlyTyr: 3.28 ± 0.064	0.0GlyXaa: 0.0 ± 0.0
His	0.978HisAla: 0.978 ± 0.034	0.246HisCys: 0.246 ± 0.014	0.825HisAsp: 0.825 ± 0.026	0.912HisGlu: 0.912 ± 0.033	0.965HisPhe: 0.965 ± 0.026	1.071HisGly: 1.071 ± 0.036	0.394HisHis: 0.394 ± 0.021	1.296HisIle: 1.296 ± 0.037	1.086HisLys: 1.086 ± 0.033	1.622HisLeu: 1.622 ± 0.038	0.335HisMet: 0.335 ± 0.015	0.923HisAsn: 0.923 ± 0.029	0.959HisPro: 0.959 ± 0.03	0.583HisGln: 0.583 ± 0.023	0.721HisArg: 0.721 ± 0.024	1.091HisSer: 1.091 ± 0.03	0.888HisThr: 0.888 ± 0.028	0.828HisVal: 0.828 ± 0.024	0.225HisTrp: 0.225 ± 0.014	0.836HisTyr: 0.836 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.27IleAla: 5.27 ± 0.07	0.984IleCys: 0.984 ± 0.032	4.429IleAsp: 4.429 ± 0.062	4.76IleGlu: 4.76 ± 0.075	3.203IlePhe: 3.203 ± 0.056	4.794IleGly: 4.794 ± 0.062	1.296IleHis: 1.296 ± 0.038	5.485IleIle: 5.485 ± 0.086	5.498IleLys: 5.498 ± 0.073	6.469IleLeu: 6.469 ± 0.097	1.506IleMet: 1.506 ± 0.036	4.579IleAsn: 4.579 ± 0.072	3.311IlePro: 3.311 ± 0.056	2.256IleGln: 2.256 ± 0.042	3.059IleArg: 3.059 ± 0.056	5.59IleSer: 5.59 ± 0.085	4.28IleThr: 4.28 ± 0.059	4.57IleVal: 4.57 ± 0.072	0.74IleTrp: 0.74 ± 0.027	2.979IleTyr: 2.979 ± 0.048	0.0IleXaa: 0.0 ± 0.0
Lys	5.142LysAla: 5.142 ± 0.073	0.615LysCys: 0.615 ± 0.024	4.698LysAsp: 4.698 ± 0.069	6.318LysGlu: 6.318 ± 0.081	2.655LysPhe: 2.655 ± 0.042	5.009LysGly: 5.009 ± 0.068	1.265LysHis: 1.265 ± 0.032	5.291LysIle: 5.291 ± 0.071	6.214LysLys: 6.214 ± 0.077	6.242LysLeu: 6.242 ± 0.075	2.322LysMet: 2.322 ± 0.044	4.596LysAsn: 4.596 ± 0.062	2.227LysPro: 2.227 ± 0.046	2.745LysGln: 2.745 ± 0.046	3.036LysArg: 3.036 ± 0.047	4.475LysSer: 4.475 ± 0.065	4.013LysThr: 4.013 ± 0.059	4.904LysVal: 4.904 ± 0.069	0.84LysTrp: 0.84 ± 0.03	3.431LysTyr: 3.431 ± 0.056	0.0LysXaa: 0.0 ± 0.0
Leu	5.896LeuAla: 5.896 ± 0.089	1.143LeuCys: 1.143 ± 0.031	4.489LeuAsp: 4.489 ± 0.059	4.775LeuGlu: 4.775 ± 0.068	4.755LeuPhe: 4.755 ± 0.075	5.499LeuGly: 5.499 ± 0.072	1.512LeuHis: 1.512 ± 0.044	6.331LeuIle: 6.331 ± 0.096	7.013LeuLys: 7.013 ± 0.074	8.636LeuLeu: 8.636 ± 0.118	2.322LeuMet: 2.322 ± 0.045	5.429LeuAsn: 5.429 ± 0.079	3.765LeuPro: 3.765 ± 0.056	2.978LeuGln: 2.978 ± 0.056	3.504LeuArg: 3.504 ± 0.057	7.064LeuSer: 7.064 ± 0.083	5.175LeuThr: 5.175 ± 0.079	5.018LeuVal: 5.018 ± 0.072	0.975LeuTrp: 0.975 ± 0.031	3.672LeuTyr: 3.672 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	1.846MetAla: 1.846 ± 0.04	0.228MetCys: 0.228 ± 0.013	1.398MetAsp: 1.398 ± 0.033	1.613MetGlu: 1.613 ± 0.039	1.057MetPhe: 1.057 ± 0.03	1.717MetGly: 1.717 ± 0.043	0.448MetHis: 0.448 ± 0.021	1.77MetIle: 1.77 ± 0.043	2.647MetLys: 2.647 ± 0.044	2.202MetLeu: 2.202 ± 0.044	0.718MetMet: 0.718 ± 0.023	1.724MetAsn: 1.724 ± 0.034	1.077MetPro: 1.077 ± 0.032	0.918MetGln: 0.918 ± 0.028	1.093MetArg: 1.093 ± 0.036	1.427MetSer: 1.427 ± 0.03	1.288MetThr: 1.288 ± 0.034	1.448MetVal: 1.448 ± 0.039	0.247MetTrp: 0.247 ± 0.015	0.853MetTyr: 0.853 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.661AsnAla: 3.661 ± 0.054	0.641AsnCys: 0.641 ± 0.025	2.972AsnAsp: 2.972 ± 0.051	3.535AsnGlu: 3.535 ± 0.064	2.697AsnPhe: 2.697 ± 0.053	4.206AsnGly: 4.206 ± 0.067	0.936AsnHis: 0.936 ± 0.03	4.681AsnIle: 4.681 ± 0.073	4.464AsnLys: 4.464 ± 0.06	4.973AsnLeu: 4.973 ± 0.073	1.442AsnMet: 1.442 ± 0.033	3.591AsnAsn: 3.591 ± 0.067	2.665AsnPro: 2.665 ± 0.047	1.827AsnGln: 1.827 ± 0.039	2.298AsnArg: 2.298 ± 0.054	3.757AsnSer: 3.757 ± 0.065	3.11AsnThr: 3.11 ± 0.055	3.556AsnVal: 3.556 ± 0.058	0.804AsnTrp: 0.804 ± 0.029	2.965AsnTyr: 2.965 ± 0.047	0.0AsnXaa: 0.0 ± 0.0
Pro	2.5ProAla: 2.5 ± 0.049	0.349ProCys: 0.349 ± 0.019	2.339ProAsp: 2.339 ± 0.045	2.967ProGlu: 2.967 ± 0.051	1.86ProPhe: 1.86 ± 0.043	2.273ProGly: 2.273 ± 0.045	0.617ProHis: 0.617 ± 0.024	2.486ProIle: 2.486 ± 0.045	2.23ProLys: 2.23 ± 0.042	3.043ProLeu: 3.043 ± 0.051	0.862ProMet: 0.862 ± 0.027	1.815ProAsn: 1.815 ± 0.039	0.712ProPro: 0.712 ± 0.026	1.266ProGln: 1.266 ± 0.03	1.108ProArg: 1.108 ± 0.03	2.465ProSer: 2.465 ± 0.046	1.865ProThr: 1.865 ± 0.04	2.757ProVal: 2.757 ± 0.05	0.441ProTrp: 0.441 ± 0.023	1.63ProTyr: 1.63 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	2.08GlnAla: 2.08 ± 0.048	0.279GlnCys: 0.279 ± 0.017	1.467GlnAsp: 1.467 ± 0.043	1.978GlnGlu: 1.978 ± 0.043	1.374GlnPhe: 1.374 ± 0.031	1.843GlnGly: 1.843 ± 0.035	0.549GlnHis: 0.549 ± 0.023	2.545GlnIle: 2.545 ± 0.05	2.573GlnLys: 2.573 ± 0.05	3.189GlnLeu: 3.189 ± 0.059	0.92GlnMet: 0.92 ± 0.023	1.943GlnAsn: 1.943 ± 0.04	1.087GlnPro: 1.087 ± 0.032	1.279GlnGln: 1.279 ± 0.039	1.279GlnArg: 1.279 ± 0.035	2.061GlnSer: 2.061 ± 0.046	1.904GlnThr: 1.904 ± 0.037	1.974GlnVal: 1.974 ± 0.045	0.405GlnTrp: 0.405 ± 0.019	1.379GlnTyr: 1.379 ± 0.043	0.0GlnXaa: 0.0 ± 0.0
Arg	2.313ArgAla: 2.313 ± 0.047	0.409ArgCys: 0.409 ± 0.019	1.9ArgAsp: 1.9 ± 0.043	2.418ArgGlu: 2.418 ± 0.051	2.041ArgPhe: 2.041 ± 0.044	2.147ArgGly: 2.147 ± 0.047	0.649ArgHis: 0.649 ± 0.025	3.311ArgIle: 3.311 ± 0.051	3.052ArgLys: 3.052 ± 0.057	3.616ArgLeu: 3.616 ± 0.058	1.19ArgMet: 1.19 ± 0.031	2.32ArgAsn: 2.32 ± 0.043	1.323ArgPro: 1.323 ± 0.036	1.253ArgGln: 1.253 ± 0.034	1.496ArgArg: 1.496 ± 0.038	2.264ArgSer: 2.264 ± 0.05	2.083ArgThr: 2.083 ± 0.045	2.27ArgVal: 2.27 ± 0.047	0.548ArgTrp: 0.548 ± 0.022	1.847ArgTyr: 1.847 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	4.364SerAla: 4.364 ± 0.071	0.86SerCys: 0.86 ± 0.026	3.603SerAsp: 3.603 ± 0.062	3.76SerGlu: 3.76 ± 0.067	3.853SerPhe: 3.853 ± 0.057	4.855SerGly: 4.855 ± 0.07	1.104SerHis: 1.104 ± 0.033	5.106SerIle: 5.106 ± 0.065	4.506SerLys: 4.506 ± 0.064	6.477SerLeu: 6.477 ± 0.08	1.561SerMet: 1.561 ± 0.031	3.557SerAsn: 3.557 ± 0.062	2.341SerPro: 2.341 ± 0.041	2.058SerGln: 2.058 ± 0.042	2.413SerArg: 2.413 ± 0.05	4.873SerSer: 4.873 ± 0.086	3.646SerThr: 3.646 ± 0.054	4.513SerVal: 4.513 ± 0.065	0.86SerTrp: 0.86 ± 0.032	3.097SerTyr: 3.097 ± 0.073	0.0SerXaa: 0.0 ± 0.0
Thr	3.718ThrAla: 3.718 ± 0.06	0.512ThrCys: 0.512 ± 0.024	3.255ThrAsp: 3.255 ± 0.052	3.196ThrGlu: 3.196 ± 0.051	2.789ThrPhe: 2.789 ± 0.057	4.17ThrGly: 4.17 ± 0.057	0.893ThrHis: 0.893 ± 0.03	4.297ThrIle: 4.297 ± 0.066	3.527ThrLys: 3.527 ± 0.054	5.089ThrLeu: 5.089 ± 0.065	1.101ThrMet: 1.101 ± 0.029	2.987ThrAsn: 2.987 ± 0.059	2.582ThrPro: 2.582 ± 0.046	1.669ThrGln: 1.669 ± 0.037	1.917ThrArg: 1.917 ± 0.037	3.67ThrSer: 3.67 ± 0.06	3.17ThrThr: 3.17 ± 0.064	3.679ThrVal: 3.679 ± 0.058	0.611ThrTrp: 0.611 ± 0.023	2.464ThrTyr: 2.464 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	4.331ValAla: 4.331 ± 0.062	0.891ValCys: 0.891 ± 0.027	3.499ValAsp: 3.499 ± 0.052	3.743ValGlu: 3.743 ± 0.049	2.83ValPhe: 2.83 ± 0.049	3.892ValGly: 3.892 ± 0.063	0.959ValHis: 0.959 ± 0.028	4.637ValIle: 4.637 ± 0.081	4.686ValLys: 4.686 ± 0.064	5.579ValLeu: 5.579 ± 0.077	1.542ValMet: 1.542 ± 0.039	3.718ValAsn: 3.718 ± 0.059	2.424ValPro: 2.424 ± 0.047	1.761ValGln: 1.761 ± 0.034	2.394ValArg: 2.394 ± 0.049	4.612ValSer: 4.612 ± 0.066	3.673ValThr: 3.673 ± 0.057	4.181ValVal: 4.181 ± 0.069	0.68ValTrp: 0.68 ± 0.025	2.661ValTyr: 2.661 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.806TrpAla: 0.806 ± 0.025	0.162TrpCys: 0.162 ± 0.012	0.744TrpAsp: 0.744 ± 0.029	0.721TrpGlu: 0.721 ± 0.023	0.533TrpPhe: 0.533 ± 0.024	0.945TrpGly: 0.945 ± 0.035	0.217TrpHis: 0.217 ± 0.017	0.865TrpIle: 0.865 ± 0.035	0.98TrpLys: 0.98 ± 0.035	1.039TrpLeu: 1.039 ± 0.032	0.369TrpMet: 0.369 ± 0.019	0.884TrpAsn: 0.884 ± 0.029	0.283TrpPro: 0.283 ± 0.019	0.424TrpGln: 0.424 ± 0.019	0.491TrpArg: 0.491 ± 0.02	0.758TrpSer: 0.758 ± 0.029	0.63TrpThr: 0.63 ± 0.025	0.688TrpVal: 0.688 ± 0.026	0.204TrpTrp: 0.204 ± 0.015	0.484TrpTyr: 0.484 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.665TyrAla: 2.665 ± 0.044	0.569TyrCys: 0.569 ± 0.024	2.43TyrAsp: 2.43 ± 0.049	2.274TyrGlu: 2.274 ± 0.043	2.288TyrPhe: 2.288 ± 0.048	2.951TyrGly: 2.951 ± 0.061	0.793TyrHis: 0.793 ± 0.024	3.174TyrIle: 3.174 ± 0.051	3.284TyrLys: 3.284 ± 0.054	4.056TyrLeu: 4.056 ± 0.065	1.059TyrMet: 1.059 ± 0.033	2.961TyrAsn: 2.961 ± 0.056	1.805TyrPro: 1.805 ± 0.043	1.488TyrGln: 1.488 ± 0.039	1.87TyrArg: 1.87 ± 0.043	3.3TyrSer: 3.3 ± 0.065	2.637TyrThr: 2.637 ± 0.057	2.387TyrVal: 2.387 ± 0.041	0.583TyrTrp: 0.583 ± 0.022	2.279TyrTyr: 2.279 ± 0.056	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3225 proteins (1209947 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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