Amino acid dipepetide frequency for Alkalicoccus saliphilus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.187AlaAla: 9.187 ± 0.13
0.688AlaCys: 0.688 ± 0.028
4.26AlaAsp: 4.26 ± 0.07
7.122AlaGlu: 7.122 ± 0.114
3.62AlaPhe: 3.62 ± 0.072
7.567AlaGly: 7.567 ± 0.115
1.401AlaHis: 1.401 ± 0.038
3.786AlaIle: 3.786 ± 0.078
3.338AlaLys: 3.338 ± 0.077
7.844AlaLeu: 7.844 ± 0.107
2.204AlaMet: 2.204 ± 0.049
1.957AlaAsn: 1.957 ± 0.052
2.48AlaPro: 2.48 ± 0.051
2.019AlaGln: 2.019 ± 0.051
3.259AlaArg: 3.259 ± 0.064
4.882AlaSer: 4.882 ± 0.077
2.638AlaThr: 2.638 ± 0.056
8.048AlaVal: 8.048 ± 0.115
0.793AlaTrp: 0.793 ± 0.031
2.313AlaTyr: 2.313 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
0.447CysAla: 0.447 ± 0.022
0.093CysCys: 0.093 ± 0.012
0.318CysAsp: 0.318 ± 0.017
0.368CysGlu: 0.368 ± 0.022
0.284CysPhe: 0.284 ± 0.016
0.719CysGly: 0.719 ± 0.025
0.166CysHis: 0.166 ± 0.011
0.392CysIle: 0.392 ± 0.019
0.165CysLys: 0.165 ± 0.015
0.578CysLeu: 0.578 ± 0.023
0.162CysMet: 0.162 ± 0.013
0.182CysAsn: 0.182 ± 0.015
0.352CysPro: 0.352 ± 0.022
0.17CysGln: 0.17 ± 0.014
0.497CysArg: 0.497 ± 0.024
0.485CysSer: 0.485 ± 0.027
0.387CysThr: 0.387 ± 0.017
0.348CysVal: 0.348 ± 0.019
0.066CysTrp: 0.066 ± 0.009
0.198CysTyr: 0.198 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
3.431AspAla: 3.431 ± 0.067
0.298AspCys: 0.298 ± 0.019
2.544AspAsp: 2.544 ± 0.069
4.785AspGlu: 4.785 ± 0.078
2.357AspPhe: 2.357 ± 0.057
3.668AspGly: 3.668 ± 0.08
1.246AspHis: 1.246 ± 0.042
3.806AspIle: 3.806 ± 0.061
2.97AspLys: 2.97 ± 0.068
4.934AspLeu: 4.934 ± 0.083
1.597AspMet: 1.597 ± 0.041
1.894AspAsn: 1.894 ± 0.057
2.456AspPro: 2.456 ± 0.054
1.751AspGln: 1.751 ± 0.046
2.624AspArg: 2.624 ± 0.051
2.552AspSer: 2.552 ± 0.052
2.745AspThr: 2.745 ± 0.051
3.771AspVal: 3.771 ± 0.069
0.633AspTrp: 0.633 ± 0.029
2.097AspTyr: 2.097 ± 0.046
0.0AspXaa: 0.0 ± 0.0
Glu
7.747GluAla: 7.747 ± 0.125
0.339GluCys: 0.339 ± 0.019
5.014GluAsp: 5.014 ± 0.085
10.746GluGlu: 10.746 ± 0.175
2.532GluPhe: 2.532 ± 0.053
5.573GluGly: 5.573 ± 0.094
1.667GluHis: 1.667 ± 0.041
5.238GluIle: 5.238 ± 0.079
7.308GluLys: 7.308 ± 0.121
7.265GluLeu: 7.265 ± 0.098
2.674GluMet: 2.674 ± 0.062
4.168GluAsn: 4.168 ± 0.088
2.39GluPro: 2.39 ± 0.06
3.341GluGln: 3.341 ± 0.07
4.052GluArg: 4.052 ± 0.068
3.997GluSer: 3.997 ± 0.071
4.803GluThr: 4.803 ± 0.072
5.589GluVal: 5.589 ± 0.09
1.008GluTrp: 1.008 ± 0.034
2.187GluTyr: 2.187 ± 0.046
0.0GluXaa: 0.0 ± 0.0
Phe
3.13PheAla: 3.13 ± 0.059
0.31PheCys: 0.31 ± 0.018
2.306PheAsp: 2.306 ± 0.051
2.845PheGlu: 2.845 ± 0.054
2.413PhePhe: 2.413 ± 0.069
3.34PheGly: 3.34 ± 0.067
1.09PheHis: 1.09 ± 0.035
3.407PheIle: 3.407 ± 0.077
1.717PheLys: 1.717 ± 0.042
4.661PheLeu: 4.661 ± 0.089
1.254PheMet: 1.254 ± 0.036
1.444PheAsn: 1.444 ± 0.037
1.795PhePro: 1.795 ± 0.045
1.673PheGln: 1.673 ± 0.037
1.88PheArg: 1.88 ± 0.049
3.13PheSer: 3.13 ± 0.056
2.74PheThr: 2.74 ± 0.065
2.864PheVal: 2.864 ± 0.068
0.477PheTrp: 0.477 ± 0.022
1.705PheTyr: 1.705 ± 0.048
0.0PheXaa: 0.0 ± 0.0
Gly
5.994GlyAla: 5.994 ± 0.092
0.559GlyCys: 0.559 ± 0.024
3.449GlyAsp: 3.449 ± 0.064
5.675GlyGlu: 5.675 ± 0.082
3.463GlyPhe: 3.463 ± 0.062
5.726GlyGly: 5.726 ± 0.111
1.467GlyHis: 1.467 ± 0.042
5.454GlyIle: 5.454 ± 0.093
4.354GlyLys: 4.354 ± 0.076
6.742GlyLeu: 6.742 ± 0.096
2.438GlyMet: 2.438 ± 0.044
2.536GlyAsn: 2.536 ± 0.058
2.108GlyPro: 2.108 ± 0.055
1.962GlyGln: 1.962 ± 0.045
3.828GlyArg: 3.828 ± 0.064
4.624GlySer: 4.624 ± 0.077
4.474GlyThr: 4.474 ± 0.072
5.361GlyVal: 5.361 ± 0.084
0.912GlyTrp: 0.912 ± 0.035
2.588GlyTyr: 2.588 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
1.472HisAla: 1.472 ± 0.041
0.182HisCys: 0.182 ± 0.014
1.074HisAsp: 1.074 ± 0.037
1.591HisGlu: 1.591 ± 0.039
1.085HisPhe: 1.085 ± 0.036
1.675HisGly: 1.675 ± 0.045
0.651HisHis: 0.651 ± 0.028
1.452HisIle: 1.452 ± 0.037
0.971HisLys: 0.971 ± 0.03
2.127HisLeu: 2.127 ± 0.049
0.579HisMet: 0.579 ± 0.026
0.689HisAsn: 0.689 ± 0.031
1.293HisPro: 1.293 ± 0.035
0.772HisGln: 0.772 ± 0.028
1.113HisArg: 1.113 ± 0.035
1.147HisSer: 1.147 ± 0.033
1.164HisThr: 1.164 ± 0.039
1.584HisVal: 1.584 ± 0.04
0.238HisTrp: 0.238 ± 0.016
0.794HisTyr: 0.794 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
5.085IleAla: 5.085 ± 0.091
0.454IleCys: 0.454 ± 0.024
3.797IleAsp: 3.797 ± 0.068
4.805IleGlu: 4.805 ± 0.077
2.909IlePhe: 2.909 ± 0.076
5.316IleGly: 5.316 ± 0.091
1.566IleHis: 1.566 ± 0.039
4.849IleIle: 4.849 ± 0.095
3.123IleLys: 3.123 ± 0.068
5.844IleLeu: 5.844 ± 0.098
1.605IleMet: 1.605 ± 0.046
2.529IleAsn: 2.529 ± 0.055
3.093IlePro: 3.093 ± 0.066
2.347IleGln: 2.347 ± 0.04
2.998IleArg: 2.998 ± 0.058
4.208IleSer: 4.208 ± 0.078
3.904IleThr: 3.904 ± 0.053
4.706IleVal: 4.706 ± 0.084
0.564IleTrp: 0.564 ± 0.027
2.068IleTyr: 2.068 ± 0.054
0.0IleXaa: 0.0 ± 0.0
Lys
4.592LysAla: 4.592 ± 0.079
0.252LysCys: 0.252 ± 0.018
3.088LysAsp: 3.088 ± 0.059
6.603LysGlu: 6.603 ± 0.101
1.566LysPhe: 1.566 ± 0.039
3.645LysGly: 3.645 ± 0.059
1.244LysHis: 1.244 ± 0.035
3.41LysIle: 3.41 ± 0.065
5.543LysLys: 5.543 ± 0.096
5.03LysLeu: 5.03 ± 0.078
1.929LysMet: 1.929 ± 0.041
2.595LysAsn: 2.595 ± 0.055
2.015LysPro: 2.015 ± 0.046
2.718LysGln: 2.718 ± 0.064
2.918LysArg: 2.918 ± 0.061
2.861LysSer: 2.861 ± 0.062
3.226LysThr: 3.226 ± 0.058
3.691LysVal: 3.691 ± 0.073
0.606LysTrp: 0.606 ± 0.024
1.719LysTyr: 1.719 ± 0.046
0.0LysXaa: 0.0 ± 0.0
Leu
7.467LeuAla: 7.467 ± 0.103
0.535LeuCys: 0.535 ± 0.02
4.736LeuAsp: 4.736 ± 0.08
7.359LeuGlu: 7.359 ± 0.104
4.66LeuPhe: 4.66 ± 0.082
6.354LeuGly: 6.354 ± 0.105
2.233LeuHis: 2.233 ± 0.053
6.362LeuIle: 6.362 ± 0.099
5.655LeuLys: 5.655 ± 0.085
10.183LeuLeu: 10.183 ± 0.161
2.538LeuMet: 2.538 ± 0.057
3.456LeuAsn: 3.456 ± 0.065
4.382LeuPro: 4.382 ± 0.075
3.756LeuGln: 3.756 ± 0.066
4.136LeuArg: 4.136 ± 0.074
6.202LeuSer: 6.202 ± 0.084
5.614LeuThr: 5.614 ± 0.095
5.764LeuVal: 5.764 ± 0.082
0.832LeuTrp: 0.832 ± 0.032
3.05LeuTyr: 3.05 ± 0.062
0.0LeuXaa: 0.0 ± 0.0
Met
2.222MetAla: 2.222 ± 0.053
0.14MetCys: 0.14 ± 0.015
1.584MetAsp: 1.584 ± 0.043
2.691MetGlu: 2.691 ± 0.056
1.15MetPhe: 1.15 ± 0.038
1.728MetGly: 1.728 ± 0.05
0.574MetHis: 0.574 ± 0.021
2.051MetIle: 2.051 ± 0.048
2.539MetLys: 2.539 ± 0.05
2.691MetLeu: 2.691 ± 0.052
0.932MetMet: 0.932 ± 0.034
1.518MetAsn: 1.518 ± 0.041
1.108MetPro: 1.108 ± 0.033
1.115MetGln: 1.115 ± 0.031
1.211MetArg: 1.211 ± 0.032
1.619MetSer: 1.619 ± 0.041
1.862MetThr: 1.862 ± 0.038
1.649MetVal: 1.649 ± 0.041
0.207MetTrp: 0.207 ± 0.016
0.78MetTyr: 0.78 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
2.488AsnAla: 2.488 ± 0.057
0.231AsnCys: 0.231 ± 0.016
1.978AsnAsp: 1.978 ± 0.052
3.168AsnGlu: 3.168 ± 0.075
1.474AsnPhe: 1.474 ± 0.045
2.718AsnGly: 2.718 ± 0.06
0.764AsnHis: 0.764 ± 0.03
2.691AsnIle: 2.691 ± 0.059
2.155AsnLys: 2.155 ± 0.055
3.084AsnLeu: 3.084 ± 0.064
1.119AsnMet: 1.119 ± 0.03
1.886AsnAsn: 1.886 ± 0.098
1.814AsnPro: 1.814 ± 0.045
1.316AsnGln: 1.316 ± 0.04
1.833AsnArg: 1.833 ± 0.048
1.87AsnSer: 1.87 ± 0.044
1.982AsnThr: 1.982 ± 0.048
2.703AsnVal: 2.703 ± 0.047
0.427AsnTrp: 0.427 ± 0.021
1.316AsnTyr: 1.316 ± 0.037
0.0AsnXaa: 0.0 ± 0.0
Pro
3.245ProAla: 3.245 ± 0.066
0.216ProCys: 0.216 ± 0.016
2.487ProAsp: 2.487 ± 0.058
4.394ProGlu: 4.394 ± 0.073
2.02ProPhe: 2.02 ± 0.047
3.076ProGly: 3.076 ± 0.066
0.934ProHis: 0.934 ± 0.032
1.964ProIle: 1.964 ± 0.053
1.765ProLys: 1.765 ± 0.044
3.814ProLeu: 3.814 ± 0.066
0.948ProMet: 0.948 ± 0.028
1.117ProAsn: 1.117 ± 0.033
1.342ProPro: 1.342 ± 0.045
1.117ProGln: 1.117 ± 0.038
1.298ProArg: 1.298 ± 0.035
2.346ProSer: 2.346 ± 0.054
1.472ProThr: 1.472 ± 0.039
3.789ProVal: 3.789 ± 0.062
0.438ProTrp: 0.438 ± 0.023
1.37ProTyr: 1.37 ± 0.04
0.0ProXaa: 0.0 ± 0.0
Gln
2.8GlnAla: 2.8 ± 0.051
0.167GlnCys: 0.167 ± 0.014
1.551GlnAsp: 1.551 ± 0.036
3.377GlnGlu: 3.377 ± 0.063
1.344GlnPhe: 1.344 ± 0.038
2.195GlnGly: 2.195 ± 0.049
0.751GlnHis: 0.751 ± 0.029
1.984GlnIle: 1.984 ± 0.045
2.447GlnLys: 2.447 ± 0.053
3.618GlnLeu: 3.618 ± 0.059
1.075GlnMet: 1.075 ± 0.034
1.263GlnAsn: 1.263 ± 0.034
1.219GlnPro: 1.219 ± 0.033
1.564GlnGln: 1.564 ± 0.048
1.577GlnArg: 1.577 ± 0.04
1.898GlnSer: 1.898 ± 0.049
1.841GlnThr: 1.841 ± 0.045
2.189GlnVal: 2.189 ± 0.045
0.409GlnTrp: 0.409 ± 0.021
1.026GlnTyr: 1.026 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
3.004ArgAla: 3.004 ± 0.056
0.27ArgCys: 0.27 ± 0.016
2.245ArgAsp: 2.245 ± 0.047
4.242ArgGlu: 4.242 ± 0.078
2.088ArgPhe: 2.088 ± 0.046
2.93ArgGly: 2.93 ± 0.06
1.027ArgHis: 1.027 ± 0.03
3.157ArgIle: 3.157 ± 0.057
3.38ArgLys: 3.38 ± 0.064
4.558ArgLeu: 4.558 ± 0.069
1.561ArgMet: 1.561 ± 0.042
1.769ArgAsn: 1.769 ± 0.046
1.781ArgPro: 1.781 ± 0.041
1.698ArgGln: 1.698 ± 0.049
3.005ArgArg: 3.005 ± 0.069
2.79ArgSer: 2.79 ± 0.054
2.654ArgThr: 2.654 ± 0.056
2.808ArgVal: 2.808 ± 0.055
0.538ArgTrp: 0.538 ± 0.022
1.516ArgTyr: 1.516 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
4.332SerAla: 4.332 ± 0.083
0.438SerCys: 0.438 ± 0.023
2.754SerAsp: 2.754 ± 0.056
4.329SerGlu: 4.329 ± 0.076
3.168SerPhe: 3.168 ± 0.059
5.201SerGly: 5.201 ± 0.086
1.248SerHis: 1.248 ± 0.039
3.942SerIle: 3.942 ± 0.07
2.635SerLys: 2.635 ± 0.055
5.955SerLeu: 5.955 ± 0.087
1.886SerMet: 1.886 ± 0.045
1.747SerAsn: 1.747 ± 0.063
2.36SerPro: 2.36 ± 0.053
1.724SerGln: 1.724 ± 0.047
3.403SerArg: 3.403 ± 0.062
4.217SerSer: 4.217 ± 0.074
2.88SerThr: 2.88 ± 0.055
4.197SerVal: 4.197 ± 0.061
0.739SerTrp: 0.739 ± 0.027
2.131SerTyr: 2.131 ± 0.054
0.0SerXaa: 0.0 ± 0.0
Thr
5.51ThrAla: 5.51 ± 0.078
0.334ThrCys: 0.334 ± 0.02
2.835ThrAsp: 2.835 ± 0.055
4.028ThrGlu: 4.028 ± 0.06
2.507ThrPhe: 2.507 ± 0.059
4.999ThrGly: 4.999 ± 0.065
1.022ThrHis: 1.022 ± 0.032
3.596ThrIle: 3.596 ± 0.064
2.725ThrLys: 2.725 ± 0.053
4.86ThrLeu: 4.86 ± 0.075
1.525ThrMet: 1.525 ± 0.034
1.905ThrAsn: 1.905 ± 0.042
2.339ThrPro: 2.339 ± 0.048
1.214ThrGln: 1.214 ± 0.034
1.917ThrArg: 1.917 ± 0.043
3.213ThrSer: 3.213 ± 0.056
2.584ThrThr: 2.584 ± 0.061
4.38ThrVal: 4.38 ± 0.072
0.547ThrTrp: 0.547 ± 0.025
1.844ThrTyr: 1.844 ± 0.047
0.0ThrXaa: 0.0 ± 0.0
Val
4.262ValAla: 4.262 ± 0.088
0.55ValCys: 0.55 ± 0.023
3.748ValAsp: 3.748 ± 0.067
5.761ValGlu: 5.761 ± 0.093
3.306ValPhe: 3.306 ± 0.068
4.211ValGly: 4.211 ± 0.083
1.552ValHis: 1.552 ± 0.042
5.323ValIle: 5.323 ± 0.086
4.095ValLys: 4.095 ± 0.068
7.323ValLeu: 7.323 ± 0.105
2.067ValMet: 2.067 ± 0.047
2.733ValAsn: 2.733 ± 0.05
3.129ValPro: 3.129 ± 0.069
2.534ValGln: 2.534 ± 0.052
3.274ValArg: 3.274 ± 0.062
4.708ValSer: 4.708 ± 0.074
4.526ValThr: 4.526 ± 0.065
4.981ValVal: 4.981 ± 0.071
0.668ValTrp: 0.668 ± 0.03
2.384ValTyr: 2.384 ± 0.047
0.0ValXaa: 0.0 ± 0.0
Trp
0.682TrpAla: 0.682 ± 0.029
0.066TrpCys: 0.066 ± 0.008
0.526TrpAsp: 0.526 ± 0.027
0.917TrpGlu: 0.917 ± 0.033
0.481TrpPhe: 0.481 ± 0.023
0.673TrpGly: 0.673 ± 0.024
0.237TrpHis: 0.237 ± 0.018
0.807TrpIle: 0.807 ± 0.027
0.789TrpLys: 0.789 ± 0.029
1.152TrpLeu: 1.152 ± 0.042
0.392TrpMet: 0.392 ± 0.023
0.508TrpAsn: 0.508 ± 0.024
0.308TrpPro: 0.308 ± 0.017
0.423TrpGln: 0.423 ± 0.022
0.449TrpArg: 0.449 ± 0.022
0.566TrpSer: 0.566 ± 0.025
0.585TrpThr: 0.585 ± 0.028
0.585TrpVal: 0.585 ± 0.027
0.15TrpTrp: 0.15 ± 0.012
0.309TrpTyr: 0.309 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.308TyrAla: 2.308 ± 0.046
0.252TyrCys: 0.252 ± 0.016
1.866TyrAsp: 1.866 ± 0.054
2.828TyrGlu: 2.828 ± 0.063
1.756TyrPhe: 1.756 ± 0.042
2.398TyrGly: 2.398 ± 0.047
0.816TyrHis: 0.816 ± 0.029
2.098TyrIle: 2.098 ± 0.055
1.576TyrLys: 1.576 ± 0.046
3.011TyrLeu: 3.011 ± 0.056
0.886TyrMet: 0.886 ± 0.025
1.124TyrAsn: 1.124 ± 0.041
1.389TyrPro: 1.389 ± 0.042
1.081TyrGln: 1.081 ± 0.04
1.751TyrArg: 1.751 ± 0.037
1.973TyrSer: 1.973 ± 0.045
1.802TyrThr: 1.802 ± 0.042
2.127TyrVal: 2.127 ± 0.049
0.353TyrTrp: 0.353 ± 0.02
1.409TyrTyr: 1.409 ± 0.044
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3323 proteins (966463 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski