Amino acid dipepetide frequency for Tepidicella xavieri

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.491AlaAla: 17.491 ± 0.215	1.412AlaCys: 1.412 ± 0.046	6.568AlaAsp: 6.568 ± 0.095	7.467AlaGlu: 7.467 ± 0.103	4.066AlaPhe: 4.066 ± 0.072	9.771AlaGly: 9.771 ± 0.111	3.262AlaHis: 3.262 ± 0.058	5.163AlaIle: 5.163 ± 0.096	3.352AlaLys: 3.352 ± 0.073	15.555AlaLeu: 15.555 ± 0.171	3.53AlaMet: 3.53 ± 0.07	2.416AlaAsn: 2.416 ± 0.058	6.241AlaPro: 6.241 ± 0.11	6.963AlaGln: 6.963 ± 0.106	9.471AlaArg: 9.471 ± 0.115	5.998AlaSer: 5.998 ± 0.084	5.687AlaThr: 5.687 ± 0.076	9.28AlaVal: 9.28 ± 0.117	2.427AlaTrp: 2.427 ± 0.064	2.589AlaTyr: 2.589 ± 0.062	0.0AlaXaa: 0.0 ± 0.0
Cys	1.167CysAla: 1.167 ± 0.042	0.11CysCys: 0.11 ± 0.013	0.528CysAsp: 0.528 ± 0.023	0.572CysGlu: 0.572 ± 0.024	0.255CysPhe: 0.255 ± 0.017	0.945CysGly: 0.945 ± 0.034	0.349CysHis: 0.349 ± 0.018	0.423CysIle: 0.423 ± 0.024	0.222CysLys: 0.222 ± 0.018	0.93CysLeu: 0.93 ± 0.032	0.233CysMet: 0.233 ± 0.016	0.229CysAsn: 0.229 ± 0.016	0.647CysPro: 0.647 ± 0.028	0.34CysGln: 0.34 ± 0.02	0.671CysArg: 0.671 ± 0.027	0.403CysSer: 0.403 ± 0.025	0.477CysThr: 0.477 ± 0.027	0.713CysVal: 0.713 ± 0.032	0.141CysTrp: 0.141 ± 0.012	0.203CysTyr: 0.203 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.074AspAla: 7.074 ± 0.103	0.453AspCys: 0.453 ± 0.026	2.659AspAsp: 2.659 ± 0.064	3.396AspGlu: 3.396 ± 0.065	1.955AspPhe: 1.955 ± 0.052	4.345AspGly: 4.345 ± 0.081	1.146AspHis: 1.146 ± 0.038	2.468AspIle: 2.468 ± 0.06	1.56AspLys: 1.56 ± 0.043	5.277AspLeu: 5.277 ± 0.087	1.243AspMet: 1.243 ± 0.036	1.079AspAsn: 1.079 ± 0.034	3.148AspPro: 3.148 ± 0.064	1.649AspGln: 1.649 ± 0.044	3.568AspArg: 3.568 ± 0.066	1.864AspSer: 1.864 ± 0.042	2.417AspThr: 2.417 ± 0.046	4.115AspVal: 4.115 ± 0.068	1.173AspTrp: 1.173 ± 0.039	1.257AspTyr: 1.257 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	8.011GluAla: 8.011 ± 0.116	0.402GluCys: 0.402 ± 0.023	2.31GluAsp: 2.31 ± 0.052	2.715GluGlu: 2.715 ± 0.063	1.719GluPhe: 1.719 ± 0.047	4.063GluGly: 4.063 ± 0.069	1.527GluHis: 1.527 ± 0.045	2.626GluIle: 2.626 ± 0.062	1.704GluLys: 1.704 ± 0.052	5.986GluLeu: 5.986 ± 0.082	1.288GluMet: 1.288 ± 0.038	1.095GluAsn: 1.095 ± 0.038	2.872GluPro: 2.872 ± 0.062	2.944GluGln: 2.944 ± 0.071	5.44GluArg: 5.44 ± 0.097	2.231GluSer: 2.231 ± 0.047	2.58GluThr: 2.58 ± 0.056	4.344GluVal: 4.344 ± 0.081	0.868GluTrp: 0.868 ± 0.032	1.044GluTyr: 1.044 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.836PheAla: 3.836 ± 0.073	0.379PheCys: 0.379 ± 0.022	2.431PheAsp: 2.431 ± 0.055	2.198PheGlu: 2.198 ± 0.048	1.328PhePhe: 1.328 ± 0.053	3.01PheGly: 3.01 ± 0.05	0.801PheHis: 0.801 ± 0.034	1.427PheIle: 1.427 ± 0.039	1.049PheLys: 1.049 ± 0.035	2.949PheLeu: 2.949 ± 0.066	0.796PheMet: 0.796 ± 0.033	1.02PheAsn: 1.02 ± 0.038	1.418PhePro: 1.418 ± 0.04	1.169PheGln: 1.169 ± 0.038	1.925PheArg: 1.925 ± 0.042	1.7PheSer: 1.7 ± 0.046	1.753PheThr: 1.753 ± 0.048	2.699PheVal: 2.699 ± 0.065	0.552PheTrp: 0.552 ± 0.023	0.832PheTyr: 0.832 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	8.38GlyAla: 8.38 ± 0.113	0.988GlyCys: 0.988 ± 0.034	3.674GlyAsp: 3.674 ± 0.067	4.425GlyGlu: 4.425 ± 0.073	3.011GlyPhe: 3.011 ± 0.063	6.345GlyGly: 6.345 ± 0.11	2.243GlyHis: 2.243 ± 0.056	3.674GlyIle: 3.674 ± 0.075	2.826GlyLys: 2.826 ± 0.067	9.28GlyLeu: 9.28 ± 0.12	2.432GlyMet: 2.432 ± 0.056	1.786GlyAsn: 1.786 ± 0.055	3.218GlyPro: 3.218 ± 0.065	3.964GlyGln: 3.964 ± 0.066	5.892GlyArg: 5.892 ± 0.09	3.786GlySer: 3.786 ± 0.068	3.823GlyThr: 3.823 ± 0.075	6.721GlyVal: 6.721 ± 0.091	1.809GlyTrp: 1.809 ± 0.054	2.102GlyTyr: 2.102 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	3.361HisAla: 3.361 ± 0.07	0.308HisCys: 0.308 ± 0.018	1.358HisAsp: 1.358 ± 0.046	1.338HisGlu: 1.338 ± 0.041	0.919HisPhe: 0.919 ± 0.033	2.449HisGly: 2.449 ± 0.049	0.82HisHis: 0.82 ± 0.035	1.136HisIle: 1.136 ± 0.041	0.619HisLys: 0.619 ± 0.027	2.6HisLeu: 2.6 ± 0.054	0.531HisMet: 0.531 ± 0.026	0.507HisAsn: 0.507 ± 0.024	1.881HisPro: 1.881 ± 0.048	0.907HisGln: 0.907 ± 0.033	1.884HisArg: 1.884 ± 0.056	1.044HisSer: 1.044 ± 0.034	1.241HisThr: 1.241 ± 0.041	1.703HisVal: 1.703 ± 0.04	0.518HisTrp: 0.518 ± 0.023	0.698HisTyr: 0.698 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	5.411IleAla: 5.411 ± 0.086	0.407IleCys: 0.407 ± 0.023	3.183IleAsp: 3.183 ± 0.06	3.434IleGlu: 3.434 ± 0.062	1.11IlePhe: 1.11 ± 0.038	4.077IleGly: 4.077 ± 0.075	1.024IleHis: 1.024 ± 0.036	1.537IleIle: 1.537 ± 0.048	1.353IleLys: 1.353 ± 0.048	3.359IleLeu: 3.359 ± 0.068	0.772IleMet: 0.772 ± 0.037	1.294IleAsn: 1.294 ± 0.041	2.005IlePro: 2.005 ± 0.051	1.475IleGln: 1.475 ± 0.05	2.866IleArg: 2.866 ± 0.06	1.894IleSer: 1.894 ± 0.038	2.415IleThr: 2.415 ± 0.049	3.496IleVal: 3.496 ± 0.063	0.481IleTrp: 0.481 ± 0.023	0.953IleTyr: 0.953 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	3.79LysAla: 3.79 ± 0.088	0.174LysCys: 0.174 ± 0.015	1.457LysAsp: 1.457 ± 0.046	1.366LysGlu: 1.366 ± 0.046	0.765LysPhe: 0.765 ± 0.031	2.253LysGly: 2.253 ± 0.059	0.713LysHis: 0.713 ± 0.03	1.272LysIle: 1.272 ± 0.045	1.232LysLys: 1.232 ± 0.053	3.02LysLeu: 3.02 ± 0.062	0.665LysMet: 0.665 ± 0.033	0.811LysAsn: 0.811 ± 0.034	1.847LysPro: 1.847 ± 0.05	1.023LysGln: 1.023 ± 0.04	2.137LysArg: 2.137 ± 0.058	1.407LysSer: 1.407 ± 0.041	1.668LysThr: 1.668 ± 0.052	2.311LysVal: 2.311 ± 0.064	0.314LysTrp: 0.314 ± 0.019	0.562LysTyr: 0.562 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	15.051LeuAla: 15.051 ± 0.167	1.049LeuCys: 1.049 ± 0.037	6.121LeuAsp: 6.121 ± 0.085	5.446LeuGlu: 5.446 ± 0.09	3.269LeuPhe: 3.269 ± 0.074	8.643LeuGly: 8.643 ± 0.114	2.652LeuHis: 2.652 ± 0.062	4.522LeuIle: 4.522 ± 0.084	3.489LeuLys: 3.489 ± 0.07	11.325LeuLeu: 11.325 ± 0.138	2.639LeuMet: 2.639 ± 0.06	2.637LeuAsn: 2.637 ± 0.052	6.561LeuPro: 6.561 ± 0.098	5.115LeuGln: 5.115 ± 0.088	8.424LeuArg: 8.424 ± 0.126	5.755LeuSer: 5.755 ± 0.088	5.539LeuThr: 5.539 ± 0.079	7.331LeuVal: 7.331 ± 0.094	1.646LeuTrp: 1.646 ± 0.05	2.08LeuTyr: 2.08 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	3.367MetAla: 3.367 ± 0.068	0.173MetCys: 0.173 ± 0.014	1.16MetAsp: 1.16 ± 0.037	1.161MetGlu: 1.161 ± 0.037	0.66MetPhe: 0.66 ± 0.031	2.037MetGly: 2.037 ± 0.052	0.535MetHis: 0.535 ± 0.028	0.959MetIle: 0.959 ± 0.032	0.936MetLys: 0.936 ± 0.033	2.452MetLeu: 2.452 ± 0.06	0.612MetMet: 0.612 ± 0.03	0.856MetAsn: 0.856 ± 0.032	1.519MetPro: 1.519 ± 0.044	1.099MetGln: 1.099 ± 0.038	1.762MetArg: 1.762 ± 0.04	1.508MetSer: 1.508 ± 0.04	1.433MetThr: 1.433 ± 0.042	1.725MetVal: 1.725 ± 0.036	0.236MetTrp: 0.236 ± 0.015	0.399MetTyr: 0.399 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	2.826AsnAla: 2.826 ± 0.054	0.224AsnCys: 0.224 ± 0.017	1.224AsnAsp: 1.224 ± 0.035	1.165AsnGlu: 1.165 ± 0.036	0.72AsnPhe: 0.72 ± 0.029	1.916AsnGly: 1.916 ± 0.052	0.521AsnHis: 0.521 ± 0.024	1.033AsnIle: 1.033 ± 0.037	0.639AsnLys: 0.639 ± 0.029	2.424AsnLeu: 2.424 ± 0.056	0.489AsnMet: 0.489 ± 0.023	0.611AsnAsn: 0.611 ± 0.031	1.779AsnPro: 1.779 ± 0.046	0.893AsnGln: 0.893 ± 0.035	1.752AsnArg: 1.752 ± 0.05	0.886AsnSer: 0.886 ± 0.031	1.222AsnThr: 1.222 ± 0.035	1.703AsnVal: 1.703 ± 0.049	0.352AsnTrp: 0.352 ± 0.019	0.512AsnTyr: 0.512 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	7.522ProAla: 7.522 ± 0.135	0.449ProCys: 0.449 ± 0.023	3.4ProAsp: 3.4 ± 0.062	3.639ProGlu: 3.639 ± 0.062	1.761ProPhe: 1.761 ± 0.047	4.813ProGly: 4.813 ± 0.08	1.46ProHis: 1.46 ± 0.045	1.964ProIle: 1.964 ± 0.055	1.395ProLys: 1.395 ± 0.047	5.614ProLeu: 5.614 ± 0.087	1.344ProMet: 1.344 ± 0.033	1.242ProAsn: 1.242 ± 0.041	3.294ProPro: 3.294 ± 0.083	2.58ProGln: 2.58 ± 0.056	3.308ProArg: 3.308 ± 0.062	2.72ProSer: 2.72 ± 0.067	2.738ProThr: 2.738 ± 0.051	4.447ProVal: 4.447 ± 0.075	0.998ProTrp: 0.998 ± 0.04	1.151ProTyr: 1.151 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	7.628GlnAla: 7.628 ± 0.126	0.329GlnCys: 0.329 ± 0.02	1.741GlnAsp: 1.741 ± 0.045	1.958GlnGlu: 1.958 ± 0.051	1.183GlnPhe: 1.183 ± 0.035	3.673GlnGly: 3.673 ± 0.062	1.088GlnHis: 1.088 ± 0.032	1.782GlnIle: 1.782 ± 0.043	1.019GlnLys: 1.019 ± 0.04	4.011GlnLeu: 4.011 ± 0.077	1.056GlnMet: 1.056 ± 0.033	0.778GlnAsn: 0.778 ± 0.029	2.743GlnPro: 2.743 ± 0.062	2.188GlnGln: 2.188 ± 0.057	4.797GlnArg: 4.797 ± 0.097	1.819GlnSer: 1.819 ± 0.047	2.311GlnThr: 2.311 ± 0.055	3.311GlnVal: 3.311 ± 0.057	0.853GlnTrp: 0.853 ± 0.032	0.745GlnTyr: 0.745 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	8.327ArgAla: 8.327 ± 0.104	0.657ArgCys: 0.657 ± 0.027	3.66ArgAsp: 3.66 ± 0.078	4.544ArgGlu: 4.544 ± 0.076	2.935ArgPhe: 2.935 ± 0.06	4.736ArgGly: 4.736 ± 0.076	2.492ArgHis: 2.492 ± 0.064	3.644ArgIle: 3.644 ± 0.073	1.934ArgLys: 1.934 ± 0.057	9.645ArgLeu: 9.645 ± 0.125	1.966ArgMet: 1.966 ± 0.048	1.643ArgAsn: 1.643 ± 0.045	3.879ArgPro: 3.879 ± 0.064	4.132ArgGln: 4.132 ± 0.084	6.089ArgArg: 6.089 ± 0.096	3.161ArgSer: 3.161 ± 0.058	3.139ArgThr: 3.139 ± 0.057	5.533ArgVal: 5.533 ± 0.08	1.604ArgTrp: 1.604 ± 0.045	1.89ArgTyr: 1.89 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	5.92SerAla: 5.92 ± 0.089	0.38SerCys: 0.38 ± 0.024	2.384SerAsp: 2.384 ± 0.052	2.241SerGlu: 2.241 ± 0.047	1.608SerPhe: 1.608 ± 0.043	4.468SerGly: 4.468 ± 0.081	1.151SerHis: 1.151 ± 0.04	1.953SerIle: 1.953 ± 0.049	1.207SerLys: 1.207 ± 0.04	4.93SerLeu: 4.93 ± 0.073	1.144SerMet: 1.144 ± 0.035	1.021SerAsn: 1.021 ± 0.032	2.878SerPro: 2.878 ± 0.061	1.671SerGln: 1.671 ± 0.047	3.422SerArg: 3.422 ± 0.063	2.313SerSer: 2.313 ± 0.054	2.365SerThr: 2.365 ± 0.051	3.331SerVal: 3.331 ± 0.07	0.619SerTrp: 0.619 ± 0.026	0.991SerTyr: 0.991 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	5.668ThrAla: 5.668 ± 0.091	0.414ThrCys: 0.414 ± 0.024	2.433ThrAsp: 2.433 ± 0.05	2.548ThrGlu: 2.548 ± 0.054	1.682ThrPhe: 1.682 ± 0.045	4.388ThrGly: 4.388 ± 0.073	1.304ThrHis: 1.304 ± 0.04	1.933ThrIle: 1.933 ± 0.052	1.048ThrLys: 1.048 ± 0.037	6.3ThrLeu: 6.3 ± 0.077	0.977ThrMet: 0.977 ± 0.036	1.013ThrAsn: 1.013 ± 0.038	3.758ThrPro: 3.758 ± 0.069	1.999ThrGln: 1.999 ± 0.054	3.23ThrArg: 3.23 ± 0.063	2.051ThrSer: 2.051 ± 0.043	2.463ThrThr: 2.463 ± 0.06	4.236ThrVal: 4.236 ± 0.062	0.699ThrTrp: 0.699 ± 0.029	1.038ThrTyr: 1.038 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	9.493ValAla: 9.493 ± 0.115	0.81ValCys: 0.81 ± 0.032	3.756ValAsp: 3.756 ± 0.067	4.336ValGlu: 4.336 ± 0.079	2.868ValPhe: 2.868 ± 0.06	5.429ValGly: 5.429 ± 0.077	1.709ValHis: 1.709 ± 0.043	3.563ValIle: 3.563 ± 0.064	2.223ValLys: 2.223 ± 0.062	8.678ValLeu: 8.678 ± 0.108	1.954ValMet: 1.954 ± 0.05	1.936ValAsn: 1.936 ± 0.054	4.011ValPro: 4.011 ± 0.069	3.132ValGln: 3.132 ± 0.058	5.587ValArg: 5.587 ± 0.083	3.695ValSer: 3.695 ± 0.067	3.966ValThr: 3.966 ± 0.075	6.418ValVal: 6.418 ± 0.1	1.209ValTrp: 1.209 ± 0.038	1.5ValTyr: 1.5 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.829TrpAla: 1.829 ± 0.056	0.216TrpCys: 0.216 ± 0.015	0.656TrpAsp: 0.656 ± 0.03	0.665TrpGlu: 0.665 ± 0.026	0.589TrpPhe: 0.589 ± 0.029	1.147TrpGly: 1.147 ± 0.04	0.461TrpHis: 0.461 ± 0.023	0.653TrpIle: 0.653 ± 0.033	0.404TrpLys: 0.404 ± 0.026	2.633TrpLeu: 2.633 ± 0.071	0.505TrpMet: 0.505 ± 0.027	0.382TrpAsn: 0.382 ± 0.022	1.027TrpPro: 1.027 ± 0.043	0.921TrpGln: 0.921 ± 0.032	1.629TrpArg: 1.629 ± 0.05	0.802TrpSer: 0.802 ± 0.035	0.748TrpThr: 0.748 ± 0.023	1.303TrpVal: 1.303 ± 0.04	0.403TrpTrp: 0.403 ± 0.021	0.298TrpTyr: 0.298 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.559TyrAla: 2.559 ± 0.063	0.223TyrCys: 0.223 ± 0.017	1.143TyrAsp: 1.143 ± 0.034	1.155TyrGlu: 1.155 ± 0.04	0.868TyrPhe: 0.868 ± 0.029	1.869TyrGly: 1.869 ± 0.054	0.565TyrHis: 0.565 ± 0.024	0.813TyrIle: 0.813 ± 0.03	0.577TyrLys: 0.577 ± 0.025	2.327TyrLeu: 2.327 ± 0.054	0.41TyrMet: 0.41 ± 0.023	0.533TyrAsn: 0.533 ± 0.027	1.111TyrPro: 1.111 ± 0.038	0.85TyrGln: 0.85 ± 0.033	1.755TyrArg: 1.755 ± 0.049	0.962TyrSer: 0.962 ± 0.036	1.198TyrThr: 1.198 ± 0.036	1.553TyrVal: 1.553 ± 0.045	0.371TyrTrp: 0.371 ± 0.022	0.507TyrTyr: 0.507 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2634 proteins (865519 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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