Amino acid dipepetide frequency for Nocardia terpenica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.16AlaAla: 22.16 ± 0.168	1.011AlaCys: 1.011 ± 0.021	8.996AlaAsp: 8.996 ± 0.069	8.393AlaGlu: 8.393 ± 0.073	3.35AlaPhe: 3.35 ± 0.042	11.759AlaGly: 11.759 ± 0.093	2.897AlaHis: 2.897 ± 0.035	4.882AlaIle: 4.882 ± 0.05	2.475AlaLys: 2.475 ± 0.046	13.925AlaLeu: 13.925 ± 0.103	2.65AlaMet: 2.65 ± 0.039	2.244AlaAsn: 2.244 ± 0.029	6.406AlaPro: 6.406 ± 0.062	3.914AlaGln: 3.914 ± 0.049	10.171AlaArg: 10.171 ± 0.077	5.294AlaSer: 5.294 ± 0.043	7.631AlaThr: 7.631 ± 0.061	12.125AlaVal: 12.125 ± 0.084	1.813AlaTrp: 1.813 ± 0.028	2.449AlaTyr: 2.449 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	1.136CysAla: 1.136 ± 0.023	0.091CysCys: 0.091 ± 0.007	0.526CysAsp: 0.526 ± 0.017	0.41CysGlu: 0.41 ± 0.012	0.238CysPhe: 0.238 ± 0.01	0.931CysGly: 0.931 ± 0.019	0.2CysHis: 0.2 ± 0.009	0.218CysIle: 0.218 ± 0.009	0.108CysLys: 0.108 ± 0.007	0.738CysLeu: 0.738 ± 0.02	0.122CysMet: 0.122 ± 0.007	0.138CysAsn: 0.138 ± 0.007	0.491CysPro: 0.491 ± 0.016	0.167CysGln: 0.167 ± 0.008	0.676CysArg: 0.676 ± 0.018	0.46CysSer: 0.46 ± 0.016	0.494CysThr: 0.494 ± 0.014	0.633CysVal: 0.633 ± 0.015	0.135CysTrp: 0.135 ± 0.008	0.205CysTyr: 0.205 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.569AspAla: 7.569 ± 0.074	0.465AspCys: 0.465 ± 0.015	3.683AspAsp: 3.683 ± 0.04	3.552AspGlu: 3.552 ± 0.041	1.672AspPhe: 1.672 ± 0.025	5.707AspGly: 5.707 ± 0.047	1.585AspHis: 1.585 ± 0.025	2.575AspIle: 2.575 ± 0.032	1.085AspLys: 1.085 ± 0.026	6.56AspLeu: 6.56 ± 0.057	0.926AspMet: 0.926 ± 0.019	1.158AspAsn: 1.158 ± 0.022	4.985AspPro: 4.985 ± 0.052	1.704AspGln: 1.704 ± 0.027	5.805AspArg: 5.805 ± 0.051	2.997AspSer: 2.997 ± 0.033	3.587AspThr: 3.587 ± 0.04	4.253AspVal: 4.253 ± 0.044	0.988AspTrp: 0.988 ± 0.022	1.501AspTyr: 1.501 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	5.765GluAla: 5.765 ± 0.056	0.403GluCys: 0.403 ± 0.012	2.201GluAsp: 2.201 ± 0.033	2.22GluGlu: 2.22 ± 0.032	1.935GluPhe: 1.935 ± 0.029	3.005GluGly: 3.005 ± 0.036	1.579GluHis: 1.579 ± 0.027	2.707GluIle: 2.707 ± 0.03	1.102GluLys: 1.102 ± 0.023	6.911GluLeu: 6.911 ± 0.063	0.958GluMet: 0.958 ± 0.019	1.055GluAsn: 1.055 ± 0.022	3.182GluPro: 3.182 ± 0.035	2.298GluGln: 2.298 ± 0.034	4.99GluArg: 4.99 ± 0.052	2.765GluSer: 2.765 ± 0.033	2.763GluThr: 2.763 ± 0.031	4.186GluVal: 4.186 ± 0.045	0.832GluTrp: 0.832 ± 0.018	1.203GluTyr: 1.203 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	4.097PheAla: 4.097 ± 0.044	0.266PheCys: 0.266 ± 0.011	2.504PheAsp: 2.504 ± 0.041	1.521PheGlu: 1.521 ± 0.025	0.844PhePhe: 0.844 ± 0.023	3.401PheGly: 3.401 ± 0.042	0.649PheHis: 0.649 ± 0.016	0.786PheIle: 0.786 ± 0.018	0.385PheLys: 0.385 ± 0.013	2.514PheLeu: 2.514 ± 0.034	0.38PheMet: 0.38 ± 0.013	0.525PheAsn: 0.525 ± 0.015	1.435PhePro: 1.435 ± 0.029	0.67PheGln: 0.67 ± 0.017	1.905PheArg: 1.905 ± 0.028	1.443PheSer: 1.443 ± 0.026	2.024PheThr: 2.024 ± 0.031	2.485PheVal: 2.485 ± 0.033	0.421PheTrp: 0.421 ± 0.013	0.61PheTyr: 0.61 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	10.236GlyAla: 10.236 ± 0.077	0.833GlyCys: 0.833 ± 0.02	4.902GlyAsp: 4.902 ± 0.051	4.443GlyGlu: 4.443 ± 0.051	2.922GlyPhe: 2.922 ± 0.041	7.878GlyGly: 7.878 ± 0.08	2.203GlyHis: 2.203 ± 0.031	4.159GlyIle: 4.159 ± 0.043	2.122GlyLys: 2.122 ± 0.037	8.716GlyLeu: 8.716 ± 0.071	2.049GlyMet: 2.049 ± 0.032	1.841GlyAsn: 1.841 ± 0.026	4.703GlyPro: 4.703 ± 0.05	2.492GlyGln: 2.492 ± 0.039	7.016GlyArg: 7.016 ± 0.053	4.902GlySer: 4.902 ± 0.055	5.633GlyThr: 5.633 ± 0.06	7.317GlyVal: 7.317 ± 0.06	1.714GlyTrp: 1.714 ± 0.028	2.435GlyTyr: 2.435 ± 0.034	0.0GlyXaa: 0.0 ± 0.0
His	2.765HisAla: 2.765 ± 0.036	0.236HisCys: 0.236 ± 0.009	1.428HisAsp: 1.428 ± 0.025	1.144HisGlu: 1.144 ± 0.02	0.648HisPhe: 0.648 ± 0.017	2.303HisGly: 2.303 ± 0.033	0.693HisHis: 0.693 ± 0.02	0.903HisIle: 0.903 ± 0.019	0.299HisLys: 0.299 ± 0.011	2.362HisLeu: 2.362 ± 0.033	0.37HisMet: 0.37 ± 0.013	0.481HisAsn: 0.481 ± 0.014	1.867HisPro: 1.867 ± 0.028	0.592HisGln: 0.592 ± 0.015	2.312HisArg: 2.312 ± 0.034	1.105HisSer: 1.105 ± 0.022	1.458HisThr: 1.458 ± 0.027	1.547HisVal: 1.547 ± 0.024	0.388HisTrp: 0.388 ± 0.014	0.556HisTyr: 0.556 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	6.304IleAla: 6.304 ± 0.064	0.339IleCys: 0.339 ± 0.013	3.311IleAsp: 3.311 ± 0.041	2.547IleGlu: 2.547 ± 0.035	0.882IlePhe: 0.882 ± 0.021	4.484IleGly: 4.484 ± 0.047	0.801IleHis: 0.801 ± 0.019	1.206IleIle: 1.206 ± 0.025	0.666IleLys: 0.666 ± 0.017	3.059IleLeu: 3.059 ± 0.038	0.546IleMet: 0.546 ± 0.014	0.85IleAsn: 0.85 ± 0.017	2.45IlePro: 2.45 ± 0.031	0.845IleGln: 0.845 ± 0.019	2.944IleArg: 2.944 ± 0.037	2.011IleSer: 2.011 ± 0.03	2.719IleThr: 2.719 ± 0.035	3.652IleVal: 3.652 ± 0.044	0.45IleTrp: 0.45 ± 0.014	0.716IleTyr: 0.716 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	2.199LysAla: 2.199 ± 0.035	0.099LysCys: 0.099 ± 0.007	0.894LysAsp: 0.894 ± 0.025	0.716LysGlu: 0.716 ± 0.022	0.526LysPhe: 0.526 ± 0.016	1.292LysGly: 1.292 ± 0.03	0.411LysHis: 0.411 ± 0.016	0.866LysIle: 0.866 ± 0.02	0.529LysLys: 0.529 ± 0.019	1.865LysLeu: 1.865 ± 0.032	0.396LysMet: 0.396 ± 0.012	0.454LysAsn: 0.454 ± 0.015	1.227LysPro: 1.227 ± 0.026	0.69LysGln: 0.69 ± 0.02	1.315LysArg: 1.315 ± 0.025	1.055LysSer: 1.055 ± 0.023	1.209LysThr: 1.209 ± 0.023	1.568LysVal: 1.568 ± 0.026	0.249LysTrp: 0.249 ± 0.009	0.435LysTyr: 0.435 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	15.15LeuAla: 15.15 ± 0.095	0.851LeuCys: 0.851 ± 0.022	6.905LeuAsp: 6.905 ± 0.065	4.596LeuGlu: 4.596 ± 0.047	2.738LeuPhe: 2.738 ± 0.036	9.149LeuGly: 9.149 ± 0.057	2.361LeuHis: 2.361 ± 0.034	4.039LeuIle: 4.039 ± 0.046	1.355LeuLys: 1.355 ± 0.031	10.527LeuLeu: 10.527 ± 0.094	1.587LeuMet: 1.587 ± 0.028	1.765LeuAsn: 1.765 ± 0.031	6.33LeuPro: 6.33 ± 0.054	2.172LeuGln: 2.172 ± 0.031	8.955LeuArg: 8.955 ± 0.065	5.479LeuSer: 5.479 ± 0.056	6.764LeuThr: 6.764 ± 0.065	8.361LeuVal: 8.361 ± 0.069	1.313LeuTrp: 1.313 ± 0.022	1.75LeuTyr: 1.75 ± 0.032	0.0LeuXaa: 0.0 ± 0.0
Met	2.258MetAla: 2.258 ± 0.033	0.15MetCys: 0.15 ± 0.007	0.857MetAsp: 0.857 ± 0.019	0.635MetGlu: 0.635 ± 0.017	0.59MetPhe: 0.59 ± 0.016	1.284MetGly: 1.284 ± 0.026	0.408MetHis: 0.408 ± 0.013	0.881MetIle: 0.881 ± 0.019	0.363MetLys: 0.363 ± 0.012	1.992MetLeu: 1.992 ± 0.024	0.346MetMet: 0.346 ± 0.013	0.511MetAsn: 0.511 ± 0.015	1.204MetPro: 1.204 ± 0.023	0.511MetGln: 0.511 ± 0.014	1.581MetArg: 1.581 ± 0.028	1.374MetSer: 1.374 ± 0.024	1.611MetThr: 1.611 ± 0.026	1.498MetVal: 1.498 ± 0.025	0.241MetTrp: 0.241 ± 0.01	0.346MetTyr: 0.346 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.369AsnAla: 2.369 ± 0.032	0.163AsnCys: 0.163 ± 0.008	1.047AsnAsp: 1.047 ± 0.022	0.804AsnGlu: 0.804 ± 0.017	0.573AsnPhe: 0.573 ± 0.017	1.865AsnGly: 1.865 ± 0.028	0.456AsnHis: 0.456 ± 0.014	0.833AsnIle: 0.833 ± 0.018	0.373AsnLys: 0.373 ± 0.013	1.914AsnLeu: 1.914 ± 0.031	0.364AsnMet: 0.364 ± 0.011	0.443AsnAsn: 0.443 ± 0.014	1.643AsnPro: 1.643 ± 0.025	0.57AsnGln: 0.57 ± 0.016	1.511AsnArg: 1.511 ± 0.022	1.065AsnSer: 1.065 ± 0.022	1.248AsnThr: 1.248 ± 0.026	1.387AsnVal: 1.387 ± 0.03	0.314AsnTrp: 0.314 ± 0.011	0.484AsnTyr: 0.484 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	7.913ProAla: 7.913 ± 0.07	0.349ProCys: 0.349 ± 0.012	4.825ProAsp: 4.825 ± 0.049	3.988ProGlu: 3.988 ± 0.044	1.541ProPhe: 1.541 ± 0.026	6.107ProGly: 6.107 ± 0.061	1.381ProHis: 1.381 ± 0.025	2.305ProIle: 2.305 ± 0.029	1.13ProLys: 1.13 ± 0.022	5.082ProLeu: 5.082 ± 0.05	1.122ProMet: 1.122 ± 0.022	1.286ProAsn: 1.286 ± 0.025	3.492ProPro: 3.492 ± 0.053	1.791ProGln: 1.791 ± 0.03	3.94ProArg: 3.94 ± 0.042	2.747ProSer: 2.747 ± 0.037	3.683ProThr: 3.683 ± 0.042	5.235ProVal: 5.235 ± 0.043	0.874ProTrp: 0.874 ± 0.019	1.137ProTyr: 1.137 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	3.607GlnAla: 3.607 ± 0.052	0.19GlnCys: 0.19 ± 0.009	1.18GlnAsp: 1.18 ± 0.023	1.037GlnGlu: 1.037 ± 0.023	0.827GlnPhe: 0.827 ± 0.019	1.933GlnGly: 1.933 ± 0.03	0.731GlnHis: 0.731 ± 0.019	1.34GlnIle: 1.34 ± 0.026	0.498GlnLys: 0.498 ± 0.015	3.389GlnLeu: 3.389 ± 0.045	0.549GlnMet: 0.549 ± 0.015	0.525GlnAsn: 0.525 ± 0.013	1.793GlnPro: 1.793 ± 0.033	1.344GlnGln: 1.344 ± 0.031	2.794GlnArg: 2.794 ± 0.038	1.308GlnSer: 1.308 ± 0.027	1.421GlnThr: 1.421 ± 0.028	2.496GlnVal: 2.496 ± 0.034	0.542GlnTrp: 0.542 ± 0.016	0.609GlnTyr: 0.609 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	10.078ArgAla: 10.078 ± 0.075	0.658ArgCys: 0.658 ± 0.018	4.602ArgAsp: 4.602 ± 0.049	4.485ArgGlu: 4.485 ± 0.048	2.599ArgPhe: 2.599 ± 0.032	5.624ArgGly: 5.624 ± 0.058	2.037ArgHis: 2.037 ± 0.03	4.057ArgIle: 4.057 ± 0.045	1.564ArgLys: 1.564 ± 0.029	8.702ArgLeu: 8.702 ± 0.075	2.061ArgMet: 2.061 ± 0.031	1.633ArgAsn: 1.633 ± 0.025	4.707ArgPro: 4.707 ± 0.05	2.419ArgGln: 2.419 ± 0.034	7.78ArgArg: 7.78 ± 0.07	4.138ArgSer: 4.138 ± 0.045	5.052ArgThr: 5.052 ± 0.046	6.168ArgVal: 6.168 ± 0.052	1.611ArgTrp: 1.611 ± 0.027	2.098ArgTyr: 2.098 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	6.746SerAla: 6.746 ± 0.062	0.412SerCys: 0.412 ± 0.014	2.935SerAsp: 2.935 ± 0.033	2.399SerGlu: 2.399 ± 0.034	1.504SerPhe: 1.504 ± 0.028	5.707SerGly: 5.707 ± 0.056	1.0SerHis: 1.0 ± 0.022	2.001SerIle: 2.001 ± 0.028	0.954SerLys: 0.954 ± 0.025	4.432SerLeu: 4.432 ± 0.043	1.201SerMet: 1.201 ± 0.023	0.925SerAsn: 0.925 ± 0.019	2.973SerPro: 2.973 ± 0.036	1.227SerGln: 1.227 ± 0.025	3.643SerArg: 3.643 ± 0.043	2.614SerSer: 2.614 ± 0.038	3.169SerThr: 3.169 ± 0.038	4.173SerVal: 4.173 ± 0.042	0.868SerTrp: 0.868 ± 0.02	1.106SerTyr: 1.106 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	8.715ThrAla: 8.715 ± 0.071	0.41ThrCys: 0.41 ± 0.014	4.005ThrAsp: 4.005 ± 0.044	3.273ThrGlu: 3.273 ± 0.035	1.685ThrPhe: 1.685 ± 0.031	6.357ThrGly: 6.357 ± 0.057	1.269ThrHis: 1.269 ± 0.024	2.402ThrIle: 2.402 ± 0.031	1.079ThrLys: 1.079 ± 0.023	5.81ThrLeu: 5.81 ± 0.063	1.107ThrMet: 1.107 ± 0.023	1.102ThrAsn: 1.102 ± 0.025	4.05ThrPro: 4.05 ± 0.04	1.358ThrGln: 1.358 ± 0.024	4.228ThrArg: 4.228 ± 0.045	2.842ThrSer: 2.842 ± 0.039	4.078ThrThr: 4.078 ± 0.057	6.307ThrVal: 6.307 ± 0.05	0.828ThrTrp: 0.828 ± 0.017	1.245ThrTyr: 1.245 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	11.426ValAla: 11.426 ± 0.089	0.81ValCys: 0.81 ± 0.018	5.395ValAsp: 5.395 ± 0.048	4.192ValGlu: 4.192 ± 0.05	2.556ValPhe: 2.556 ± 0.032	6.732ValGly: 6.732 ± 0.059	1.896ValHis: 1.896 ± 0.025	3.321ValIle: 3.321 ± 0.04	1.278ValLys: 1.278 ± 0.029	9.374ValLeu: 9.374 ± 0.079	1.317ValMet: 1.317 ± 0.024	1.645ValAsn: 1.645 ± 0.031	4.905ValPro: 4.905 ± 0.048	2.078ValGln: 2.078 ± 0.029	6.888ValArg: 6.888 ± 0.058	4.273ValSer: 4.273 ± 0.043	5.421ValThr: 5.421 ± 0.053	8.143ValVal: 8.143 ± 0.071	1.058ValTrp: 1.058 ± 0.021	1.52ValTyr: 1.52 ± 0.027	0.0ValXaa: 0.0 ± 0.0
Trp	1.618TrpAla: 1.618 ± 0.028	0.162TrpCys: 0.162 ± 0.009	0.809TrpAsp: 0.809 ± 0.02	0.696TrpGlu: 0.696 ± 0.019	0.525TrpPhe: 0.525 ± 0.014	1.016TrpGly: 1.016 ± 0.023	0.4TrpHis: 0.4 ± 0.014	0.643TrpIle: 0.643 ± 0.018	0.315TrpLys: 0.315 ± 0.011	1.817TrpLeu: 1.817 ± 0.033	0.331TrpMet: 0.331 ± 0.012	0.425TrpAsn: 0.425 ± 0.012	0.833TrpPro: 0.833 ± 0.02	0.628TrpGln: 0.628 ± 0.016	1.41TrpArg: 1.41 ± 0.023	0.978TrpSer: 0.978 ± 0.02	0.945TrpThr: 0.945 ± 0.02	1.15TrpVal: 1.15 ± 0.02	0.369TrpTrp: 0.369 ± 0.014	0.323TrpTyr: 0.323 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.435TyrAla: 2.435 ± 0.032	0.214TyrCys: 0.214 ± 0.009	1.351TyrAsp: 1.351 ± 0.026	1.01TyrGlu: 1.01 ± 0.023	0.712TyrPhe: 0.712 ± 0.018	1.98TyrGly: 1.98 ± 0.029	0.503TyrHis: 0.503 ± 0.014	0.659TyrIle: 0.659 ± 0.017	0.317TyrLys: 0.317 ± 0.012	2.457TyrLeu: 2.457 ± 0.03	0.26TyrMet: 0.26 ± 0.011	0.421TyrAsn: 0.421 ± 0.012	1.254TyrPro: 1.254 ± 0.021	0.643TyrGln: 0.643 ± 0.018	2.208TyrArg: 2.208 ± 0.035	1.139TyrSer: 1.139 ± 0.024	1.236TyrThr: 1.236 ± 0.023	1.545TyrVal: 1.545 ± 0.028	0.386TyrTrp: 0.386 ± 0.013	0.494TyrTyr: 0.494 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8083 proteins (2507138 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---