Amino acid dipepetide frequency for Cyclobacterium lianum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.171AlaAla: 6.171 ± 0.076
0.656AlaCys: 0.656 ± 0.022
4.154AlaAsp: 4.154 ± 0.053
4.578AlaGlu: 4.578 ± 0.058
3.717AlaPhe: 3.717 ± 0.049
5.926AlaGly: 5.926 ± 0.072
1.279AlaHis: 1.279 ± 0.03
4.979AlaIle: 4.979 ± 0.061
3.356AlaLys: 3.356 ± 0.052
7.142AlaLeu: 7.142 ± 0.074
1.813AlaMet: 1.813 ± 0.038
3.07AlaAsn: 3.07 ± 0.049
2.484AlaPro: 2.484 ± 0.046
2.408AlaGln: 2.408 ± 0.038
3.391AlaArg: 3.391 ± 0.049
4.509AlaSer: 4.509 ± 0.064
3.253AlaThr: 3.253 ± 0.048
4.605AlaVal: 4.605 ± 0.058
0.871AlaTrp: 0.871 ± 0.024
2.795AlaTyr: 2.795 ± 0.044
0.0AlaXaa: 0.0 ± 0.0
Cys
0.418CysAla: 0.418 ± 0.015
0.111CysCys: 0.111 ± 0.009
0.339CysAsp: 0.339 ± 0.014
0.414CysGlu: 0.414 ± 0.017
0.398CysPhe: 0.398 ± 0.02
0.582CysGly: 0.582 ± 0.021
0.23CysHis: 0.23 ± 0.014
0.472CysIle: 0.472 ± 0.017
0.342CysLys: 0.342 ± 0.015
0.74CysLeu: 0.74 ± 0.019
0.17CysMet: 0.17 ± 0.01
0.293CysAsn: 0.293 ± 0.012
0.306CysPro: 0.306 ± 0.014
0.283CysGln: 0.283 ± 0.014
0.347CysArg: 0.347 ± 0.015
0.501CysSer: 0.501 ± 0.017
0.343CysThr: 0.343 ± 0.015
0.349CysVal: 0.349 ± 0.015
0.103CysTrp: 0.103 ± 0.008
0.259CysTyr: 0.259 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
3.626AspAla: 3.626 ± 0.052
0.347AspCys: 0.347 ± 0.017
2.449AspAsp: 2.449 ± 0.051
3.703AspGlu: 3.703 ± 0.053
3.476AspPhe: 3.476 ± 0.048
4.181AspGly: 4.181 ± 0.071
1.24AspHis: 1.24 ± 0.03
3.87AspIle: 3.87 ± 0.047
3.23AspLys: 3.23 ± 0.06
6.016AspLeu: 6.016 ± 0.062
1.298AspMet: 1.298 ± 0.028
2.408AspAsn: 2.408 ± 0.047
3.027AspPro: 3.027 ± 0.048
2.438AspGln: 2.438 ± 0.034
2.835AspArg: 2.835 ± 0.043
2.869AspSer: 2.869 ± 0.044
2.351AspThr: 2.351 ± 0.036
2.885AspVal: 2.885 ± 0.039
1.035AspTrp: 1.035 ± 0.026
2.433AspTyr: 2.433 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
5.042GluAla: 5.042 ± 0.068
0.274GluCys: 0.274 ± 0.012
3.758GluAsp: 3.758 ± 0.05
5.424GluGlu: 5.424 ± 0.073
2.662GluPhe: 2.662 ± 0.04
4.751GluGly: 4.751 ± 0.059
1.046GluHis: 1.046 ± 0.028
5.14GluIle: 5.14 ± 0.061
5.718GluLys: 5.718 ± 0.08
6.166GluLeu: 6.166 ± 0.063
2.018GluMet: 2.018 ± 0.035
4.213GluAsn: 4.213 ± 0.054
1.996GluPro: 1.996 ± 0.036
2.513GluGln: 2.513 ± 0.04
3.186GluArg: 3.186 ± 0.046
3.541GluSer: 3.541 ± 0.047
3.256GluThr: 3.256 ± 0.051
4.462GluVal: 4.462 ± 0.056
0.824GluTrp: 0.824 ± 0.024
2.06GluTyr: 2.06 ± 0.033
0.0GluXaa: 0.0 ± 0.0
Phe
3.182PheAla: 3.182 ± 0.043
0.392PheCys: 0.392 ± 0.016
3.216PheAsp: 3.216 ± 0.047
3.354PheGlu: 3.354 ± 0.046
2.879PhePhe: 2.879 ± 0.052
3.867PheGly: 3.867 ± 0.054
0.935PheHis: 0.935 ± 0.025
3.13PheIle: 3.13 ± 0.051
2.413PheLys: 2.413 ± 0.046
5.057PheLeu: 5.057 ± 0.072
1.112PheMet: 1.112 ± 0.025
2.485PheAsn: 2.485 ± 0.043
2.139PhePro: 2.139 ± 0.034
1.832PheGln: 1.832 ± 0.034
2.422PheArg: 2.422 ± 0.038
4.004PheSer: 4.004 ± 0.055
2.797PheThr: 2.797 ± 0.044
2.904PheVal: 2.904 ± 0.046
0.717PheTrp: 0.717 ± 0.024
2.007PheTyr: 2.007 ± 0.034
0.0PheXaa: 0.0 ± 0.0
Gly
4.828GlyAla: 4.828 ± 0.065
0.56GlyCys: 0.56 ± 0.021
3.793GlyAsp: 3.793 ± 0.053
4.752GlyGlu: 4.752 ± 0.057
3.939GlyPhe: 3.939 ± 0.058
5.247GlyGly: 5.247 ± 0.08
1.425GlyHis: 1.425 ± 0.032
5.543GlyIle: 5.543 ± 0.063
5.04GlyLys: 5.04 ± 0.066
7.279GlyLeu: 7.279 ± 0.073
2.188GlyMet: 2.188 ± 0.04
3.856GlyAsn: 3.856 ± 0.066
2.184GlyPro: 2.184 ± 0.038
2.674GlyGln: 2.674 ± 0.039
3.434GlyArg: 3.434 ± 0.048
4.678GlySer: 4.678 ± 0.059
3.953GlyThr: 3.953 ± 0.07
4.405GlyVal: 4.405 ± 0.055
1.105GlyTrp: 1.105 ± 0.029
3.03GlyTyr: 3.03 ± 0.042
0.0GlyXaa: 0.0 ± 0.0
His
1.303HisAla: 1.303 ± 0.027
0.202HisCys: 0.202 ± 0.012
0.857HisAsp: 0.857 ± 0.024
1.125HisGlu: 1.125 ± 0.031
1.258HisPhe: 1.258 ± 0.031
1.311HisGly: 1.311 ± 0.029
0.617HisHis: 0.617 ± 0.022
1.249HisIle: 1.249 ± 0.03
0.922HisLys: 0.922 ± 0.023
2.215HisLeu: 2.215 ± 0.036
0.413HisMet: 0.413 ± 0.017
0.732HisAsn: 0.732 ± 0.022
1.26HisPro: 1.26 ± 0.031
0.931HisGln: 0.931 ± 0.024
0.966HisArg: 0.966 ± 0.026
1.168HisSer: 1.168 ± 0.025
0.934HisThr: 0.934 ± 0.026
1.08HisVal: 1.08 ± 0.026
0.365HisTrp: 0.365 ± 0.015
0.838HisTyr: 0.838 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
4.956IleAla: 4.956 ± 0.061
0.578IleCys: 0.578 ± 0.019
3.878IleAsp: 3.878 ± 0.046
4.026IleGlu: 4.026 ± 0.06
3.186IlePhe: 3.186 ± 0.056
4.813IleGly: 4.813 ± 0.064
1.45IleHis: 1.45 ± 0.032
4.223IleIle: 4.223 ± 0.071
3.684IleLys: 3.684 ± 0.057
6.425IleLeu: 6.425 ± 0.075
1.286IleMet: 1.286 ± 0.032
3.596IleAsn: 3.596 ± 0.056
3.416IlePro: 3.416 ± 0.039
2.649IleGln: 2.649 ± 0.04
3.833IleArg: 3.833 ± 0.055
5.205IleSer: 5.205 ± 0.062
3.409IleThr: 3.409 ± 0.04
3.554IleVal: 3.554 ± 0.05
0.826IleTrp: 0.826 ± 0.023
2.357IleTyr: 2.357 ± 0.039
0.0IleXaa: 0.0 ± 0.0
Lys
4.301LysAla: 4.301 ± 0.064
0.277LysCys: 0.277 ± 0.012
3.282LysAsp: 3.282 ± 0.048
4.436LysGlu: 4.436 ± 0.072
2.145LysPhe: 2.145 ± 0.037
4.07LysGly: 4.07 ± 0.057
1.006LysHis: 1.006 ± 0.024
4.42LysIle: 4.42 ± 0.062
4.554LysLys: 4.554 ± 0.065
5.168LysLeu: 5.168 ± 0.062
1.623LysMet: 1.623 ± 0.037
3.337LysAsn: 3.337 ± 0.043
2.345LysPro: 2.345 ± 0.04
1.854LysGln: 1.854 ± 0.035
2.55LysArg: 2.55 ± 0.046
3.735LysSer: 3.735 ± 0.045
3.153LysThr: 3.153 ± 0.043
3.87LysVal: 3.87 ± 0.057
0.764LysTrp: 0.764 ± 0.023
2.076LysTyr: 2.076 ± 0.04
0.0LysXaa: 0.0 ± 0.0
Leu
7.504LeuAla: 7.504 ± 0.084
0.675LeuCys: 0.675 ± 0.023
5.785LeuAsp: 5.785 ± 0.065
6.86LeuGlu: 6.86 ± 0.077
4.921LeuPhe: 4.921 ± 0.063
6.74LeuGly: 6.74 ± 0.08
1.838LeuHis: 1.838 ± 0.037
6.619LeuIle: 6.619 ± 0.075
5.986LeuLys: 5.986 ± 0.069
10.308LeuLeu: 10.308 ± 0.13
2.5LeuMet: 2.5 ± 0.044
4.708LeuAsn: 4.708 ± 0.06
4.662LeuPro: 4.662 ± 0.055
3.623LeuGln: 3.623 ± 0.049
4.239LeuArg: 4.239 ± 0.051
7.315LeuSer: 7.315 ± 0.082
4.954LeuThr: 4.954 ± 0.056
6.261LeuVal: 6.261 ± 0.067
1.092LeuTrp: 1.092 ± 0.028
3.262LeuTyr: 3.262 ± 0.053
0.0LeuXaa: 0.0 ± 0.0
Met
2.189MetAla: 2.189 ± 0.036
0.128MetCys: 0.128 ± 0.01
1.61MetAsp: 1.61 ± 0.036
1.955MetGlu: 1.955 ± 0.038
0.74MetPhe: 0.74 ± 0.02
1.929MetGly: 1.929 ± 0.034
0.467MetHis: 0.467 ± 0.017
1.492MetIle: 1.492 ± 0.035
1.833MetLys: 1.833 ± 0.037
2.143MetLeu: 2.143 ± 0.035
0.678MetMet: 0.678 ± 0.026
1.187MetAsn: 1.187 ± 0.021
1.081MetPro: 1.081 ± 0.03
0.954MetGln: 0.954 ± 0.024
1.049MetArg: 1.049 ± 0.024
1.297MetSer: 1.297 ± 0.026
1.1MetThr: 1.1 ± 0.026
1.838MetVal: 1.838 ± 0.037
0.201MetTrp: 0.201 ± 0.012
0.661MetTyr: 0.661 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
3.292AsnAla: 3.292 ± 0.05
0.325AsnCys: 0.325 ± 0.013
2.331AsnAsp: 2.331 ± 0.04
3.089AsnGlu: 3.089 ± 0.046
2.625AsnPhe: 2.625 ± 0.049
3.644AsnGly: 3.644 ± 0.071
0.988AsnHis: 0.988 ± 0.024
3.333AsnIle: 3.333 ± 0.044
2.596AsnLys: 2.596 ± 0.047
4.968AsnLeu: 4.968 ± 0.061
1.148AsnMet: 1.148 ± 0.029
2.427AsnAsn: 2.427 ± 0.053
2.818AsnPro: 2.818 ± 0.042
2.224AsnGln: 2.224 ± 0.04
2.612AsnArg: 2.612 ± 0.048
2.925AsnSer: 2.925 ± 0.042
2.599AsnThr: 2.599 ± 0.047
2.621AsnVal: 2.621 ± 0.05
0.777AsnTrp: 0.777 ± 0.021
2.062AsnTyr: 2.062 ± 0.039
0.0AsnXaa: 0.0 ± 0.0
Pro
3.061ProAla: 3.061 ± 0.047
0.224ProCys: 0.224 ± 0.011
3.187ProAsp: 3.187 ± 0.05
4.185ProGlu: 4.185 ± 0.053
2.168ProPhe: 2.168 ± 0.036
3.483ProGly: 3.483 ± 0.05
0.844ProHis: 0.844 ± 0.021
2.433ProIle: 2.433 ± 0.037
1.964ProLys: 1.964 ± 0.041
3.963ProLeu: 3.963 ± 0.05
0.891ProMet: 0.891 ± 0.027
1.931ProAsn: 1.931 ± 0.037
1.26ProPro: 1.26 ± 0.033
1.386ProGln: 1.386 ± 0.029
1.524ProArg: 1.524 ± 0.032
2.486ProSer: 2.486 ± 0.038
1.767ProThr: 1.767 ± 0.033
3.323ProVal: 3.323 ± 0.046
0.522ProTrp: 0.522 ± 0.02
1.567ProTyr: 1.567 ± 0.031
0.0ProXaa: 0.0 ± 0.0
Gln
2.822GlnAla: 2.822 ± 0.044
0.185GlnCys: 0.185 ± 0.011
1.853GlnAsp: 1.853 ± 0.033
2.801GlnGlu: 2.801 ± 0.041
1.618GlnPhe: 1.618 ± 0.027
2.442GlnGly: 2.442 ± 0.043
0.751GlnHis: 0.751 ± 0.019
2.43GlnIle: 2.43 ± 0.038
2.374GlnLys: 2.374 ± 0.042
3.906GlnLeu: 3.906 ± 0.057
1.025GlnMet: 1.025 ± 0.021
1.909GlnAsn: 1.909 ± 0.036
1.508GlnPro: 1.508 ± 0.03
1.812GlnGln: 1.812 ± 0.039
1.643GlnArg: 1.643 ± 0.035
2.281GlnSer: 2.281 ± 0.04
1.926GlnThr: 1.926 ± 0.037
2.793GlnVal: 2.793 ± 0.038
0.528GlnTrp: 0.528 ± 0.016
1.376GlnTyr: 1.376 ± 0.027
0.0GlnXaa: 0.0 ± 0.0
Arg
2.84ArgAla: 2.84 ± 0.043
0.252ArgCys: 0.252 ± 0.014
2.594ArgAsp: 2.594 ± 0.04
3.63ArgGlu: 3.63 ± 0.052
2.432ArgPhe: 2.432 ± 0.038
2.796ArgGly: 2.796 ± 0.045
0.953ArgHis: 0.953 ± 0.028
3.459ArgIle: 3.459 ± 0.047
3.386ArgLys: 3.386 ± 0.049
4.77ArgLeu: 4.77 ± 0.059
1.291ArgMet: 1.291 ± 0.031
2.511ArgAsn: 2.511 ± 0.044
1.802ArgPro: 1.802 ± 0.03
1.996ArgGln: 1.996 ± 0.037
2.062ArgArg: 2.062 ± 0.042
2.793ArgSer: 2.793 ± 0.046
2.15ArgThr: 2.15 ± 0.035
2.76ArgVal: 2.76 ± 0.041
0.65ArgTrp: 0.65 ± 0.019
2.104ArgTyr: 2.104 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
4.14SerAla: 4.14 ± 0.058
0.61SerCys: 0.61 ± 0.021
3.33SerAsp: 3.33 ± 0.052
3.879SerGlu: 3.879 ± 0.052
3.588SerPhe: 3.588 ± 0.054
5.847SerGly: 5.847 ± 0.07
1.291SerHis: 1.291 ± 0.03
4.286SerIle: 4.286 ± 0.057
3.273SerLys: 3.273 ± 0.044
6.941SerLeu: 6.941 ± 0.064
1.494SerMet: 1.494 ± 0.032
2.91SerAsn: 2.91 ± 0.047
2.847SerPro: 2.847 ± 0.045
2.261SerGln: 2.261 ± 0.039
3.341SerArg: 3.341 ± 0.052
4.275SerSer: 4.275 ± 0.057
3.03SerThr: 3.03 ± 0.046
3.604SerVal: 3.604 ± 0.047
0.923SerTrp: 0.923 ± 0.027
2.5SerTyr: 2.5 ± 0.042
0.001SerXaa: 0.001 ± 0.0
Thr
3.806ThrAla: 3.806 ± 0.053
0.356ThrCys: 0.356 ± 0.014
3.014ThrAsp: 3.014 ± 0.048
2.887ThrGlu: 2.887 ± 0.048
2.644ThrPhe: 2.644 ± 0.042
4.546ThrGly: 4.546 ± 0.059
0.987ThrHis: 0.987 ± 0.027
3.384ThrIle: 3.384 ± 0.047
2.163ThrLys: 2.163 ± 0.032
4.837ThrLeu: 4.837 ± 0.055
0.951ThrMet: 0.951 ± 0.026
2.172ThrAsn: 2.172 ± 0.041
2.111ThrPro: 2.111 ± 0.035
1.608ThrGln: 1.608 ± 0.032
2.107ThrArg: 2.107 ± 0.034
3.062ThrSer: 3.062 ± 0.049
2.397ThrThr: 2.397 ± 0.049
3.385ThrVal: 3.385 ± 0.058
0.658ThrTrp: 0.658 ± 0.021
1.996ThrTyr: 1.996 ± 0.044
0.0ThrXaa: 0.0 ± 0.0
Val
4.305ValAla: 4.305 ± 0.058
0.482ValCys: 0.482 ± 0.017
3.424ValAsp: 3.424 ± 0.048
3.716ValGlu: 3.716 ± 0.052
3.505ValPhe: 3.505 ± 0.054
3.999ValGly: 3.999 ± 0.054
1.157ValHis: 1.157 ± 0.028
3.991ValIle: 3.991 ± 0.047
3.465ValLys: 3.465 ± 0.051
6.308ValLeu: 6.308 ± 0.068
1.458ValMet: 1.458 ± 0.029
3.257ValAsn: 3.257 ± 0.051
2.758ValPro: 2.758 ± 0.036
2.051ValGln: 2.051 ± 0.039
2.909ValArg: 2.909 ± 0.039
4.537ValSer: 4.537 ± 0.064
2.978ValThr: 2.978 ± 0.054
3.864ValVal: 3.864 ± 0.063
0.758ValTrp: 0.758 ± 0.022
2.35ValTyr: 2.35 ± 0.041
0.0ValXaa: 0.0 ± 0.0
Trp
0.83TrpAla: 0.83 ± 0.025
0.08TrpCys: 0.08 ± 0.007
0.814TrpAsp: 0.814 ± 0.023
0.978TrpGlu: 0.978 ± 0.026
0.585TrpPhe: 0.585 ± 0.018
0.935TrpGly: 0.935 ± 0.027
0.317TrpHis: 0.317 ± 0.015
0.891TrpIle: 0.891 ± 0.024
0.875TrpLys: 0.875 ± 0.023
1.303TrpLeu: 1.303 ± 0.028
0.43TrpMet: 0.43 ± 0.014
0.661TrpAsn: 0.661 ± 0.021
0.444TrpPro: 0.444 ± 0.016
0.624TrpGln: 0.624 ± 0.019
0.628TrpArg: 0.628 ± 0.021
0.758TrpSer: 0.758 ± 0.02
0.748TrpThr: 0.748 ± 0.022
0.904TrpVal: 0.904 ± 0.024
0.204TrpTrp: 0.204 ± 0.011
0.496TrpTyr: 0.496 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.543TyrAla: 2.543 ± 0.037
0.283TyrCys: 0.283 ± 0.013
2.049TyrAsp: 2.049 ± 0.037
2.257TyrGlu: 2.257 ± 0.044
2.357TyrPhe: 2.357 ± 0.044
2.807TyrGly: 2.807 ± 0.046
0.926TyrHis: 0.926 ± 0.027
2.002TyrIle: 2.002 ± 0.037
1.795TyrLys: 1.795 ± 0.034
4.197TyrLeu: 4.197 ± 0.052
0.743TyrMet: 0.743 ± 0.022
1.74TyrAsn: 1.74 ± 0.042
1.723TyrPro: 1.723 ± 0.035
1.864TyrGln: 1.864 ± 0.033
2.151TyrArg: 2.151 ± 0.036
2.432TyrSer: 2.432 ± 0.042
1.974TyrThr: 1.974 ± 0.041
1.805TyrVal: 1.805 ± 0.035
0.581TyrTrp: 0.581 ± 0.018
1.642TyrTyr: 1.642 ± 0.037
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.001XaaMet: 0.001 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.002XaaXaa: 0.002 ± 0.001
Statistics based on 4679 proteins (1677476 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski