Amino acid dipepetide frequency for Bellilinea caldifistulae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.173AlaAla: 10.173 ± 0.156	0.868AlaCys: 0.868 ± 0.031	4.353AlaAsp: 4.353 ± 0.069	6.32AlaGlu: 6.32 ± 0.098	3.635AlaPhe: 3.635 ± 0.073	7.672AlaGly: 7.672 ± 0.115	1.58AlaHis: 1.58 ± 0.041	5.603AlaIle: 5.603 ± 0.079	2.46AlaLys: 2.46 ± 0.055	10.877AlaLeu: 10.877 ± 0.126	2.108AlaMet: 2.108 ± 0.047	2.6AlaAsn: 2.6 ± 0.056	3.3AlaPro: 3.3 ± 0.059	3.7AlaGln: 3.7 ± 0.068	5.804AlaArg: 5.804 ± 0.089	4.495AlaSer: 4.495 ± 0.075	3.666AlaThr: 3.666 ± 0.074	7.283AlaVal: 7.283 ± 0.104	1.324AlaTrp: 1.324 ± 0.039	2.776AlaTyr: 2.776 ± 0.062	0.0AlaXaa: 0.0 ± 0.0
Cys	0.681CysAla: 0.681 ± 0.03	0.07CysCys: 0.07 ± 0.008	0.442CysAsp: 0.442 ± 0.021	0.435CysGlu: 0.435 ± 0.021	0.294CysPhe: 0.294 ± 0.019	0.868CysGly: 0.868 ± 0.037	0.225CysHis: 0.225 ± 0.021	0.357CysIle: 0.357 ± 0.019	0.243CysLys: 0.243 ± 0.017	0.752CysLeu: 0.752 ± 0.026	0.122CysMet: 0.122 ± 0.013	0.31CysAsn: 0.31 ± 0.018	0.549CysPro: 0.549 ± 0.031	0.347CysGln: 0.347 ± 0.02	0.515CysArg: 0.515 ± 0.024	0.429CysSer: 0.429 ± 0.023	0.449CysThr: 0.449 ± 0.024	0.492CysVal: 0.492 ± 0.022	0.129CysTrp: 0.129 ± 0.011	0.223CysTyr: 0.223 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.805AspAla: 3.805 ± 0.071	0.403AspCys: 0.403 ± 0.024	2.118AspAsp: 2.118 ± 0.055	3.586AspGlu: 3.586 ± 0.069	2.086AspPhe: 2.086 ± 0.049	3.602AspGly: 3.602 ± 0.065	0.992AspHis: 0.992 ± 0.034	2.496AspIle: 2.496 ± 0.055	1.288AspLys: 1.288 ± 0.035	5.792AspLeu: 5.792 ± 0.085	0.901AspMet: 0.901 ± 0.033	1.274AspAsn: 1.274 ± 0.043	3.026AspPro: 3.026 ± 0.062	2.084AspGln: 2.084 ± 0.053	2.79AspArg: 2.79 ± 0.05	1.99AspSer: 1.99 ± 0.046	1.995AspThr: 1.995 ± 0.046	3.279AspVal: 3.279 ± 0.054	0.968AspTrp: 0.968 ± 0.034	1.701AspTyr: 1.701 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	5.744GluAla: 5.744 ± 0.098	0.395GluCys: 0.395 ± 0.02	2.874GluAsp: 2.874 ± 0.054	5.14GluGlu: 5.14 ± 0.107	2.147GluPhe: 2.147 ± 0.051	4.099GluGly: 4.099 ± 0.072	1.041GluHis: 1.041 ± 0.032	4.781GluIle: 4.781 ± 0.086	3.526GluLys: 3.526 ± 0.067	5.872GluLeu: 5.872 ± 0.103	1.884GluMet: 1.884 ± 0.049	2.747GluAsn: 2.747 ± 0.061	2.476GluPro: 2.476 ± 0.057	2.947GluGln: 2.947 ± 0.064	4.633GluArg: 4.633 ± 0.086	3.057GluSer: 3.057 ± 0.061	3.294GluThr: 3.294 ± 0.064	4.869GluVal: 4.869 ± 0.088	1.167GluTrp: 1.167 ± 0.034	1.777GluTyr: 1.777 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	3.465PheAla: 3.465 ± 0.061	0.394PheCys: 0.394 ± 0.02	2.18PheAsp: 2.18 ± 0.052	2.487PheGlu: 2.487 ± 0.049	2.003PhePhe: 2.003 ± 0.055	3.305PheGly: 3.305 ± 0.069	0.778PheHis: 0.778 ± 0.029	2.461PheIle: 2.461 ± 0.058	1.121PheLys: 1.121 ± 0.035	4.808PheLeu: 4.808 ± 0.089	0.772PheMet: 0.772 ± 0.031	1.502PheAsn: 1.502 ± 0.037	2.064PhePro: 2.064 ± 0.045	1.561PheGln: 1.561 ± 0.043	2.207PheArg: 2.207 ± 0.049	2.914PheSer: 2.914 ± 0.065	2.242PheThr: 2.242 ± 0.054	2.822PheVal: 2.822 ± 0.059	0.783PheTrp: 0.783 ± 0.034	1.44PheTyr: 1.44 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	5.59GlyAla: 5.59 ± 0.09	0.739GlyCys: 0.739 ± 0.032	3.303GlyAsp: 3.303 ± 0.067	4.98GlyGlu: 4.98 ± 0.079	3.389GlyPhe: 3.389 ± 0.056	6.086GlyGly: 6.086 ± 0.114	1.284GlyHis: 1.284 ± 0.035	5.054GlyIle: 5.054 ± 0.079	3.749GlyLys: 3.749 ± 0.068	8.908GlyLeu: 8.908 ± 0.14	2.242GlyMet: 2.242 ± 0.051	2.385GlyAsn: 2.385 ± 0.063	1.95GlyPro: 1.95 ± 0.047	2.953GlyGln: 2.953 ± 0.056	4.2GlyArg: 4.2 ± 0.074	4.298GlySer: 4.298 ± 0.075	3.376GlyThr: 3.376 ± 0.063	6.048GlyVal: 6.048 ± 0.084	1.787GlyTrp: 1.787 ± 0.048	2.544GlyTyr: 2.544 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	1.556HisAla: 1.556 ± 0.045	0.176HisCys: 0.176 ± 0.014	0.733HisAsp: 0.733 ± 0.027	0.933HisGlu: 0.933 ± 0.033	0.829HisPhe: 0.829 ± 0.027	1.277HisGly: 1.277 ± 0.043	0.553HisHis: 0.553 ± 0.029	1.058HisIle: 1.058 ± 0.035	0.518HisLys: 0.518 ± 0.023	2.443HisLeu: 2.443 ± 0.051	0.308HisMet: 0.308 ± 0.015	0.631HisAsn: 0.631 ± 0.024	1.545HisPro: 1.545 ± 0.042	0.886HisGln: 0.886 ± 0.03	1.218HisArg: 1.218 ± 0.039	0.952HisSer: 0.952 ± 0.035	1.018HisThr: 1.018 ± 0.035	1.061HisVal: 1.061 ± 0.034	0.356HisTrp: 0.356 ± 0.019	0.619HisTyr: 0.619 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.745IleAla: 5.745 ± 0.081	0.549IleCys: 0.549 ± 0.025	2.582IleAsp: 2.582 ± 0.055	4.332IleGlu: 4.332 ± 0.078	2.702IlePhe: 2.702 ± 0.059	5.305IleGly: 5.305 ± 0.087	1.358IleHis: 1.358 ± 0.044	3.585IleIle: 3.585 ± 0.079	1.85IleLys: 1.85 ± 0.045	7.332IleLeu: 7.332 ± 0.108	0.952IleMet: 0.952 ± 0.037	2.195IleAsn: 2.195 ± 0.043	3.655IlePro: 3.655 ± 0.057	2.856IleGln: 2.856 ± 0.055	4.213IleArg: 4.213 ± 0.074	3.867IleSer: 3.867 ± 0.071	3.426IleThr: 3.426 ± 0.071	4.017IleVal: 4.017 ± 0.08	0.869IleTrp: 0.869 ± 0.036	1.826IleTyr: 1.826 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	3.191LysAla: 3.191 ± 0.058	0.208LysCys: 0.208 ± 0.013	1.7LysAsp: 1.7 ± 0.05	2.343LysGlu: 2.343 ± 0.058	1.089LysPhe: 1.089 ± 0.037	2.477LysGly: 2.477 ± 0.053	0.595LysHis: 0.595 ± 0.022	2.664LysIle: 2.664 ± 0.062	1.699LysLys: 1.699 ± 0.049	3.079LysLeu: 3.079 ± 0.071	0.935LysMet: 0.935 ± 0.028	1.409LysAsn: 1.409 ± 0.043	2.17LysPro: 2.17 ± 0.053	1.342LysGln: 1.342 ± 0.035	2.185LysArg: 2.185 ± 0.058	1.869LysSer: 1.869 ± 0.047	2.103LysThr: 2.103 ± 0.045	2.75LysVal: 2.75 ± 0.058	0.454LysTrp: 0.454 ± 0.02	0.914LysTyr: 0.914 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	11.255LeuAla: 11.255 ± 0.14	0.751LeuCys: 0.751 ± 0.028	5.351LeuAsp: 5.351 ± 0.084	6.841LeuGlu: 6.841 ± 0.104	4.601LeuPhe: 4.601 ± 0.084	8.004LeuGly: 8.004 ± 0.118	1.978LeuHis: 1.978 ± 0.049	7.506LeuIle: 7.506 ± 0.124	4.285LeuLys: 4.285 ± 0.069	12.791LeuLeu: 12.791 ± 0.176	2.442LeuMet: 2.442 ± 0.058	4.138LeuAsn: 4.138 ± 0.059	7.157LeuPro: 7.157 ± 0.1	4.519LeuGln: 4.519 ± 0.079	7.405LeuArg: 7.405 ± 0.101	7.069LeuSer: 7.069 ± 0.086	6.311LeuThr: 6.311 ± 0.097	7.88LeuVal: 7.88 ± 0.104	1.553LeuTrp: 1.553 ± 0.052	2.953LeuTyr: 2.953 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	2.239MetAla: 2.239 ± 0.057	0.111MetCys: 0.111 ± 0.01	1.213MetAsp: 1.213 ± 0.04	1.425MetGlu: 1.425 ± 0.045	0.704MetPhe: 0.704 ± 0.024	1.677MetGly: 1.677 ± 0.041	0.285MetHis: 0.285 ± 0.015	1.528MetIle: 1.528 ± 0.034	0.997MetLys: 0.997 ± 0.035	2.266MetLeu: 2.266 ± 0.059	0.606MetMet: 0.606 ± 0.026	0.961MetAsn: 0.961 ± 0.031	1.19MetPro: 1.19 ± 0.037	0.879MetGln: 0.879 ± 0.029	1.37MetArg: 1.37 ± 0.042	1.266MetSer: 1.266 ± 0.036	1.368MetThr: 1.368 ± 0.039	1.719MetVal: 1.719 ± 0.046	0.202MetTrp: 0.202 ± 0.015	0.417MetTyr: 0.417 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.802AsnAla: 2.802 ± 0.055	0.278AsnCys: 0.278 ± 0.018	1.459AsnAsp: 1.459 ± 0.044	1.811AsnGlu: 1.811 ± 0.043	1.386AsnPhe: 1.386 ± 0.04	2.808AsnGly: 2.808 ± 0.06	0.809AsnHis: 0.809 ± 0.028	1.887AsnIle: 1.887 ± 0.048	0.895AsnLys: 0.895 ± 0.029	4.453AsnLeu: 4.453 ± 0.079	0.609AsnMet: 0.609 ± 0.024	1.156AsnAsn: 1.156 ± 0.044	2.787AsnPro: 2.787 ± 0.061	1.717AsnGln: 1.717 ± 0.045	2.459AsnArg: 2.459 ± 0.047	1.634AsnSer: 1.634 ± 0.042	1.72AsnThr: 1.72 ± 0.044	1.939AsnVal: 1.939 ± 0.052	0.626AsnTrp: 0.626 ± 0.026	1.042AsnTyr: 1.042 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	5.484ProAla: 5.484 ± 0.088	0.298ProCys: 0.298 ± 0.019	3.044ProAsp: 3.044 ± 0.066	3.917ProGlu: 3.917 ± 0.069	2.284ProPhe: 2.284 ± 0.053	3.642ProGly: 3.642 ± 0.065	1.079ProHis: 1.079 ± 0.038	2.819ProIle: 2.819 ± 0.057	1.443ProLys: 1.443 ± 0.037	6.007ProLeu: 6.007 ± 0.094	1.081ProMet: 1.081 ± 0.034	1.77ProAsn: 1.77 ± 0.046	3.422ProPro: 3.422 ± 0.078	2.566ProGln: 2.566 ± 0.056	2.652ProArg: 2.652 ± 0.05	2.785ProSer: 2.785 ± 0.058	3.083ProThr: 3.083 ± 0.101	4.339ProVal: 4.339 ± 0.075	0.687ProTrp: 0.687 ± 0.026	1.688ProTyr: 1.688 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	4.565GlnAla: 4.565 ± 0.091	0.237GlnCys: 0.237 ± 0.018	1.615GlnAsp: 1.615 ± 0.042	2.458GlnGlu: 2.458 ± 0.046	1.416GlnPhe: 1.416 ± 0.037	2.519GlnGly: 2.519 ± 0.058	0.73GlnHis: 0.73 ± 0.027	3.221GlnIle: 3.221 ± 0.065	1.869GlnLys: 1.869 ± 0.049	3.663GlnLeu: 3.663 ± 0.066	1.095GlnMet: 1.095 ± 0.035	1.751GlnAsn: 1.751 ± 0.041	3.097GlnPro: 3.097 ± 0.063	2.285GlnGln: 2.285 ± 0.06	3.171GlnArg: 3.171 ± 0.064	2.497GlnSer: 2.497 ± 0.057	2.496GlnThr: 2.496 ± 0.052	3.368GlnVal: 3.368 ± 0.07	0.58GlnTrp: 0.58 ± 0.03	1.105GlnTyr: 1.105 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	5.125ArgAla: 5.125 ± 0.073	0.5ArgCys: 0.5 ± 0.026	2.716ArgAsp: 2.716 ± 0.053	4.17ArgGlu: 4.17 ± 0.084	2.917ArgPhe: 2.917 ± 0.06	4.009ArgGly: 4.009 ± 0.064	1.128ArgHis: 1.128 ± 0.032	3.911ArgIle: 3.911 ± 0.07	2.605ArgLys: 2.605 ± 0.055	8.266ArgLeu: 8.266 ± 0.12	1.666ArgMet: 1.666 ± 0.044	2.048ArgAsn: 2.048 ± 0.042	2.842ArgPro: 2.842 ± 0.056	3.472ArgGln: 3.472 ± 0.068	4.935ArgArg: 4.935 ± 0.101	3.298ArgSer: 3.298 ± 0.058	2.811ArgThr: 2.811 ± 0.056	4.561ArgVal: 4.561 ± 0.068	1.231ArgTrp: 1.231 ± 0.042	2.044ArgTyr: 2.044 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	4.915SerAla: 4.915 ± 0.061	0.368SerCys: 0.368 ± 0.02	2.412SerAsp: 2.412 ± 0.05	3.186SerGlu: 3.186 ± 0.071	2.277SerPhe: 2.277 ± 0.052	5.12SerGly: 5.12 ± 0.083	1.007SerHis: 1.007 ± 0.032	3.26SerIle: 3.26 ± 0.059	1.638SerLys: 1.638 ± 0.043	6.587SerLeu: 6.587 ± 0.09	1.188SerMet: 1.188 ± 0.032	1.814SerAsn: 1.814 ± 0.047	3.547SerPro: 3.547 ± 0.06	2.388SerGln: 2.388 ± 0.051	3.638SerArg: 3.638 ± 0.063	3.145SerSer: 3.145 ± 0.068	2.718SerThr: 2.718 ± 0.057	3.683SerVal: 3.683 ± 0.068	0.671SerTrp: 0.671 ± 0.025	1.363SerTyr: 1.363 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	4.977ThrAla: 4.977 ± 0.084	0.43ThrCys: 0.43 ± 0.022	2.243ThrAsp: 2.243 ± 0.052	2.419ThrGlu: 2.419 ± 0.051	2.243ThrPhe: 2.243 ± 0.047	4.047ThrGly: 4.047 ± 0.061	1.022ThrHis: 1.022 ± 0.03	3.375ThrIle: 3.375 ± 0.07	1.189ThrLys: 1.189 ± 0.035	6.23ThrLeu: 6.23 ± 0.087	0.938ThrMet: 0.938 ± 0.034	1.505ThrAsn: 1.505 ± 0.044	3.879ThrPro: 3.879 ± 0.091	1.873ThrGln: 1.873 ± 0.05	3.03ThrArg: 3.03 ± 0.057	2.851ThrSer: 2.851 ± 0.061	2.737ThrThr: 2.737 ± 0.053	3.612ThrVal: 3.612 ± 0.068	0.665ThrTrp: 0.665 ± 0.026	1.476ThrTyr: 1.476 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	5.789ValAla: 5.789 ± 0.078	0.712ValCys: 0.712 ± 0.028	3.591ValAsp: 3.591 ± 0.069	5.123ValGlu: 5.123 ± 0.083	3.2ValPhe: 3.2 ± 0.06	4.919ValGly: 4.919 ± 0.085	1.212ValHis: 1.212 ± 0.037	5.188ValIle: 5.188 ± 0.082	2.421ValLys: 2.421 ± 0.062	8.425ValLeu: 8.425 ± 0.098	1.724ValMet: 1.724 ± 0.04	2.544ValAsn: 2.544 ± 0.05	3.239ValPro: 3.239 ± 0.057	2.85ValGln: 2.85 ± 0.052	4.49ValArg: 4.49 ± 0.058	4.147ValSer: 4.147 ± 0.078	3.684ValThr: 3.684 ± 0.067	5.996ValVal: 5.996 ± 0.101	1.189ValTrp: 1.189 ± 0.035	2.169ValTyr: 2.169 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	1.138TrpAla: 1.138 ± 0.033	0.127TrpCys: 0.127 ± 0.012	0.736TrpAsp: 0.736 ± 0.028	0.945TrpGlu: 0.945 ± 0.031	0.659TrpPhe: 0.659 ± 0.03	1.155TrpGly: 1.155 ± 0.04	0.272TrpHis: 0.272 ± 0.019	1.002TrpIle: 1.002 ± 0.038	0.616TrpLys: 0.616 ± 0.026	2.476TrpLeu: 2.476 ± 0.064	0.475TrpMet: 0.475 ± 0.022	0.542TrpAsn: 0.542 ± 0.023	0.428TrpPro: 0.428 ± 0.02	1.036TrpGln: 1.036 ± 0.031	1.034TrpArg: 1.034 ± 0.038	0.769TrpSer: 0.769 ± 0.035	0.632TrpThr: 0.632 ± 0.03	1.258TrpVal: 1.258 ± 0.039	0.317TrpTrp: 0.317 ± 0.019	0.474TrpTyr: 0.474 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.354TyrAla: 2.354 ± 0.05	0.318TyrCys: 0.318 ± 0.019	1.512TyrAsp: 1.512 ± 0.064	1.622TyrGlu: 1.622 ± 0.039	1.446TyrPhe: 1.446 ± 0.04	2.272TyrGly: 2.272 ± 0.051	0.741TyrHis: 0.741 ± 0.028	1.46TyrIle: 1.46 ± 0.039	0.763TyrLys: 0.763 ± 0.029	3.762TyrLeu: 3.762 ± 0.064	0.374TyrMet: 0.374 ± 0.02	0.997TyrAsn: 0.997 ± 0.035	1.77TyrPro: 1.77 ± 0.045	1.473TyrGln: 1.473 ± 0.037	2.308TyrArg: 2.308 ± 0.042	1.597TyrSer: 1.597 ± 0.04	1.609TyrThr: 1.609 ± 0.044	1.639TyrVal: 1.639 ± 0.043	0.532TyrTrp: 0.532 ± 0.024	1.099TyrTyr: 1.099 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2990 proteins (974906 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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