Amino acid dipepetide frequency for Vibrio nereis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.632AlaAla: 7.632 ± 0.111
0.962AlaCys: 0.962 ± 0.036
4.477AlaAsp: 4.477 ± 0.063
5.828AlaGlu: 5.828 ± 0.089
3.462AlaPhe: 3.462 ± 0.056
5.949AlaGly: 5.949 ± 0.081
1.629AlaHis: 1.629 ± 0.038
5.989AlaIle: 5.989 ± 0.081
5.153AlaLys: 5.153 ± 0.084
9.929AlaLeu: 9.929 ± 0.106
2.811AlaMet: 2.811 ± 0.056
3.483AlaAsn: 3.483 ± 0.055
2.903AlaPro: 2.903 ± 0.061
3.873AlaGln: 3.873 ± 0.06
3.696AlaArg: 3.696 ± 0.058
5.368AlaSer: 5.368 ± 0.072
4.422AlaThr: 4.422 ± 0.06
5.908AlaVal: 5.908 ± 0.075
0.942AlaTrp: 0.942 ± 0.034
2.318AlaTyr: 2.318 ± 0.05
0.0AlaXaa: 0.0 ± 0.0
Cys
0.834CysAla: 0.834 ± 0.028
0.162CysCys: 0.162 ± 0.013
0.679CysAsp: 0.679 ± 0.025
0.671CysGlu: 0.671 ± 0.024
0.48CysPhe: 0.48 ± 0.021
0.974CysGly: 0.974 ± 0.031
0.338CysHis: 0.338 ± 0.019
0.584CysIle: 0.584 ± 0.024
0.457CysLys: 0.457 ± 0.02
0.917CysLeu: 0.917 ± 0.032
0.228CysMet: 0.228 ± 0.013
0.366CysAsn: 0.366 ± 0.018
0.441CysPro: 0.441 ± 0.02
0.468CysGln: 0.468 ± 0.022
0.465CysArg: 0.465 ± 0.021
0.74CysSer: 0.74 ± 0.026
0.48CysThr: 0.48 ± 0.021
0.689CysVal: 0.689 ± 0.026
0.132CysTrp: 0.132 ± 0.011
0.321CysTyr: 0.321 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
4.371AspAla: 4.371 ± 0.074
0.558AspCys: 0.558 ± 0.024
2.929AspAsp: 2.929 ± 0.058
3.951AspGlu: 3.951 ± 0.065
2.414AspPhe: 2.414 ± 0.044
3.616AspGly: 3.616 ± 0.07
1.093AspHis: 1.093 ± 0.037
3.977AspIle: 3.977 ± 0.064
3.262AspLys: 3.262 ± 0.053
5.276AspLeu: 5.276 ± 0.073
1.445AspMet: 1.445 ± 0.039
2.316AspAsn: 2.316 ± 0.045
2.017AspPro: 2.017 ± 0.042
1.967AspGln: 1.967 ± 0.041
2.258AspArg: 2.258 ± 0.048
3.316AspSer: 3.316 ± 0.055
2.673AspThr: 2.673 ± 0.051
4.087AspVal: 4.087 ± 0.067
0.854AspTrp: 0.854 ± 0.026
1.949AspTyr: 1.949 ± 0.048
0.0AspXaa: 0.0 ± 0.0
Glu
5.443GluAla: 5.443 ± 0.085
0.586GluCys: 0.586 ± 0.025
3.057GluAsp: 3.057 ± 0.054
4.405GluGlu: 4.405 ± 0.076
2.662GluPhe: 2.662 ± 0.05
3.832GluGly: 3.832 ± 0.063
1.729GluHis: 1.729 ± 0.038
3.798GluIle: 3.798 ± 0.06
4.083GluLys: 4.083 ± 0.072
7.532GluLeu: 7.532 ± 0.088
1.888GluMet: 1.888 ± 0.037
2.753GluAsn: 2.753 ± 0.051
2.22GluPro: 2.22 ± 0.048
4.272GluGln: 4.272 ± 0.073
3.554GluArg: 3.554 ± 0.064
4.147GluSer: 4.147 ± 0.063
3.172GluThr: 3.172 ± 0.051
4.671GluVal: 4.671 ± 0.07
0.889GluTrp: 0.889 ± 0.026
1.876GluTyr: 1.876 ± 0.042
0.0GluXaa: 0.0 ± 0.0
Phe
3.698PheAla: 3.698 ± 0.063
0.514PheCys: 0.514 ± 0.02
2.616PheAsp: 2.616 ± 0.051
2.676PheGlu: 2.676 ± 0.047
1.619PhePhe: 1.619 ± 0.04
3.252PheGly: 3.252 ± 0.062
0.836PheHis: 0.836 ± 0.031
2.744PheIle: 2.744 ± 0.056
1.978PheLys: 1.978 ± 0.046
3.407PheLeu: 3.407 ± 0.061
1.018PheMet: 1.018 ± 0.031
1.932PheAsn: 1.932 ± 0.043
1.451PhePro: 1.451 ± 0.035
1.256PheGln: 1.256 ± 0.031
1.476PheArg: 1.476 ± 0.032
3.326PheSer: 3.326 ± 0.056
2.373PheThr: 2.373 ± 0.05
2.891PheVal: 2.891 ± 0.055
0.524PheTrp: 0.524 ± 0.027
1.312PheTyr: 1.312 ± 0.034
0.0PheXaa: 0.0 ± 0.0
Gly
5.428GlyAla: 5.428 ± 0.08
0.928GlyCys: 0.928 ± 0.035
3.632GlyAsp: 3.632 ± 0.062
4.681GlyGlu: 4.681 ± 0.069
3.296GlyPhe: 3.296 ± 0.052
4.923GlyGly: 4.923 ± 0.083
1.594GlyHis: 1.594 ± 0.035
4.769GlyIle: 4.769 ± 0.07
4.042GlyLys: 4.042 ± 0.058
7.012GlyLeu: 7.012 ± 0.074
2.079GlyMet: 2.079 ± 0.045
2.533GlyAsn: 2.533 ± 0.049
1.63GlyPro: 1.63 ± 0.04
2.795GlyGln: 2.795 ± 0.052
3.065GlyArg: 3.065 ± 0.058
4.07GlySer: 4.07 ± 0.057
3.457GlyThr: 3.457 ± 0.052
5.463GlyVal: 5.463 ± 0.075
0.994GlyTrp: 0.994 ± 0.034
2.587GlyTyr: 2.587 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
1.619HisAla: 1.619 ± 0.038
0.335HisCys: 0.335 ± 0.016
1.146HisAsp: 1.146 ± 0.032
1.127HisGlu: 1.127 ± 0.035
1.065HisPhe: 1.065 ± 0.029
1.535HisGly: 1.535 ± 0.038
0.689HisHis: 0.689 ± 0.031
1.458HisIle: 1.458 ± 0.038
1.099HisLys: 1.099 ± 0.029
2.261HisLeu: 2.261 ± 0.049
0.502HisMet: 0.502 ± 0.021
0.927HisAsn: 0.927 ± 0.027
1.184HisPro: 1.184 ± 0.032
1.243HisGln: 1.243 ± 0.036
1.047HisArg: 1.047 ± 0.031
1.467HisSer: 1.467 ± 0.04
1.102HisThr: 1.102 ± 0.03
1.301HisVal: 1.301 ± 0.033
0.354HisTrp: 0.354 ± 0.016
0.861HisTyr: 0.861 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
6.428IleAla: 6.428 ± 0.081
0.667IleCys: 0.667 ± 0.025
4.036IleAsp: 4.036 ± 0.053
4.891IleGlu: 4.891 ± 0.067
2.163IlePhe: 2.163 ± 0.043
4.718IleGly: 4.718 ± 0.067
1.251IleHis: 1.251 ± 0.034
3.445IleIle: 3.445 ± 0.061
3.161IleLys: 3.161 ± 0.052
5.248IleLeu: 5.248 ± 0.077
1.327IleMet: 1.327 ± 0.034
2.775IleAsn: 2.775 ± 0.051
2.627IlePro: 2.627 ± 0.05
2.335IleGln: 2.335 ± 0.046
2.78IleArg: 2.78 ± 0.047
4.431IleSer: 4.431 ± 0.063
3.515IleThr: 3.515 ± 0.051
4.271IleVal: 4.271 ± 0.067
0.628IleTrp: 0.628 ± 0.025
1.649IleTyr: 1.649 ± 0.041
0.0IleXaa: 0.0 ± 0.0
Lys
4.973LysAla: 4.973 ± 0.077
0.34LysCys: 0.34 ± 0.019
2.697LysAsp: 2.697 ± 0.049
3.672LysGlu: 3.672 ± 0.061
1.601LysPhe: 1.601 ± 0.038
3.543LysGly: 3.543 ± 0.054
1.309LysHis: 1.309 ± 0.031
2.716LysIle: 2.716 ± 0.051
2.997LysLys: 2.997 ± 0.054
5.634LysLeu: 5.634 ± 0.076
1.514LysMet: 1.514 ± 0.036
2.039LysAsn: 2.039 ± 0.052
2.488LysPro: 2.488 ± 0.048
3.07LysGln: 3.07 ± 0.054
2.781LysArg: 2.781 ± 0.046
3.15LysSer: 3.15 ± 0.054
2.781LysThr: 2.781 ± 0.046
4.156LysVal: 4.156 ± 0.056
0.639LysTrp: 0.639 ± 0.025
1.455LysTyr: 1.455 ± 0.037
0.0LysXaa: 0.0 ± 0.0
Leu
9.886LeuAla: 9.886 ± 0.098
1.076LeuCys: 1.076 ± 0.033
5.804LeuAsp: 5.804 ± 0.069
6.698LeuGlu: 6.698 ± 0.083
4.208LeuPhe: 4.208 ± 0.07
7.112LeuGly: 7.112 ± 0.079
2.019LeuHis: 2.019 ± 0.042
6.141LeuIle: 6.141 ± 0.085
5.45LeuLys: 5.45 ± 0.078
10.304LeuLeu: 10.304 ± 0.135
2.81LeuMet: 2.81 ± 0.055
4.481LeuAsn: 4.481 ± 0.065
4.719LeuPro: 4.719 ± 0.067
3.535LeuGln: 3.535 ± 0.062
4.275LeuArg: 4.275 ± 0.069
7.964LeuSer: 7.964 ± 0.093
6.011LeuThr: 6.011 ± 0.076
7.291LeuVal: 7.291 ± 0.1
1.057LeuTrp: 1.057 ± 0.036
2.63LeuTyr: 2.63 ± 0.051
0.0LeuXaa: 0.0 ± 0.0
Met
2.653MetAla: 2.653 ± 0.048
0.23MetCys: 0.23 ± 0.015
1.374MetAsp: 1.374 ± 0.035
1.511MetGlu: 1.511 ± 0.038
1.004MetPhe: 1.004 ± 0.029
1.9MetGly: 1.9 ± 0.042
0.513MetHis: 0.513 ± 0.02
1.551MetIle: 1.551 ± 0.038
1.583MetLys: 1.583 ± 0.034
2.88MetLeu: 2.88 ± 0.048
0.887MetMet: 0.887 ± 0.027
1.177MetAsn: 1.177 ± 0.033
1.287MetPro: 1.287 ± 0.036
1.114MetGln: 1.114 ± 0.03
1.192MetArg: 1.192 ± 0.03
2.057MetSer: 2.057 ± 0.044
1.619MetThr: 1.619 ± 0.032
1.966MetVal: 1.966 ± 0.038
0.249MetTrp: 0.249 ± 0.017
0.565MetTyr: 0.565 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
3.373AsnAla: 3.373 ± 0.056
0.397AsnCys: 0.397 ± 0.019
2.191AsnAsp: 2.191 ± 0.048
2.429AsnGlu: 2.429 ± 0.051
1.546AsnPhe: 1.546 ± 0.035
2.918AsnGly: 2.918 ± 0.051
1.004AsnHis: 1.004 ± 0.025
2.632AsnIle: 2.632 ± 0.055
2.185AsnLys: 2.185 ± 0.039
3.912AsnLeu: 3.912 ± 0.059
1.029AsnMet: 1.029 ± 0.027
1.758AsnAsn: 1.758 ± 0.046
2.123AsnPro: 2.123 ± 0.043
2.152AsnGln: 2.152 ± 0.044
1.933AsnArg: 1.933 ± 0.04
2.422AsnSer: 2.422 ± 0.046
2.171AsnThr: 2.171 ± 0.044
2.809AsnVal: 2.809 ± 0.05
0.557AsnTrp: 0.557 ± 0.022
1.341AsnTyr: 1.341 ± 0.038
0.0AsnXaa: 0.0 ± 0.0
Pro
3.045ProAla: 3.045 ± 0.063
0.339ProCys: 0.339 ± 0.016
2.248ProAsp: 2.248 ± 0.041
3.409ProGlu: 3.409 ± 0.061
1.68ProPhe: 1.68 ± 0.041
2.26ProGly: 2.26 ± 0.043
0.872ProHis: 0.872 ± 0.028
2.495ProIle: 2.495 ± 0.043
2.058ProLys: 2.058 ± 0.045
3.98ProLeu: 3.98 ± 0.066
1.114ProMet: 1.114 ± 0.028
1.738ProAsn: 1.738 ± 0.038
1.122ProPro: 1.122 ± 0.036
1.682ProGln: 1.682 ± 0.04
1.364ProArg: 1.364 ± 0.038
2.55ProSer: 2.55 ± 0.048
2.219ProThr: 2.219 ± 0.05
3.167ProVal: 3.167 ± 0.053
0.518ProTrp: 0.518 ± 0.019
1.248ProTyr: 1.248 ± 0.039
0.0ProXaa: 0.0 ± 0.0
Gln
4.243GlnAla: 4.243 ± 0.068
0.397GlnCys: 0.397 ± 0.019
2.142GlnAsp: 2.142 ± 0.044
2.681GlnGlu: 2.681 ± 0.062
1.725GlnPhe: 1.725 ± 0.038
3.059GlnGly: 3.059 ± 0.059
1.143GlnHis: 1.143 ± 0.029
2.535GlnIle: 2.535 ± 0.05
2.128GlnLys: 2.128 ± 0.041
5.153GlnLeu: 5.153 ± 0.065
1.167GlnMet: 1.167 ± 0.03
1.626GlnAsn: 1.626 ± 0.04
1.747GlnPro: 1.747 ± 0.04
2.832GlnGln: 2.832 ± 0.062
2.258GlnArg: 2.258 ± 0.045
2.782GlnSer: 2.782 ± 0.054
2.191GlnThr: 2.191 ± 0.043
3.293GlnVal: 3.293 ± 0.053
0.634GlnTrp: 0.634 ± 0.027
1.363GlnTyr: 1.363 ± 0.033
0.0GlnXaa: 0.0 ± 0.0
Arg
3.483ArgAla: 3.483 ± 0.06
0.452ArgCys: 0.452 ± 0.018
2.509ArgAsp: 2.509 ± 0.049
3.163ArgGlu: 3.163 ± 0.06
2.21ArgPhe: 2.21 ± 0.043
2.589ArgGly: 2.589 ± 0.054
1.09ArgHis: 1.09 ± 0.031
2.987ArgIle: 2.987 ± 0.052
2.503ArgLys: 2.503 ± 0.045
4.753ArgLeu: 4.753 ± 0.067
1.209ArgMet: 1.209 ± 0.03
1.846ArgAsn: 1.846 ± 0.042
1.448ArgPro: 1.448 ± 0.034
2.017ArgGln: 2.017 ± 0.039
2.292ArgArg: 2.292 ± 0.051
2.685ArgSer: 2.685 ± 0.042
2.126ArgThr: 2.126 ± 0.044
3.241ArgVal: 3.241 ± 0.056
0.592ArgTrp: 0.592 ± 0.027
1.669ArgTyr: 1.669 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
5.483SerAla: 5.483 ± 0.064
0.599SerCys: 0.599 ± 0.024
3.649SerAsp: 3.649 ± 0.057
4.314SerGlu: 4.314 ± 0.067
2.793SerPhe: 2.793 ± 0.054
4.959SerGly: 4.959 ± 0.065
1.578SerHis: 1.578 ± 0.037
4.141SerIle: 4.141 ± 0.06
3.322SerLys: 3.322 ± 0.049
6.853SerLeu: 6.853 ± 0.089
1.898SerMet: 1.898 ± 0.04
2.653SerAsn: 2.653 ± 0.052
2.472SerPro: 2.472 ± 0.053
2.996SerGln: 2.996 ± 0.048
2.882SerArg: 2.882 ± 0.054
4.338SerSer: 4.338 ± 0.062
3.263SerThr: 3.263 ± 0.057
4.799SerVal: 4.799 ± 0.069
0.818SerTrp: 0.818 ± 0.028
2.056SerTyr: 2.056 ± 0.045
0.0SerXaa: 0.0 ± 0.0
Thr
4.427ThrAla: 4.427 ± 0.062
0.473ThrCys: 0.473 ± 0.023
2.777ThrAsp: 2.777 ± 0.051
3.15ThrGlu: 3.15 ± 0.053
2.138ThrPhe: 2.138 ± 0.048
3.925ThrGly: 3.925 ± 0.065
1.218ThrHis: 1.218 ± 0.031
3.298ThrIle: 3.298 ± 0.058
2.414ThrLys: 2.414 ± 0.05
6.316ThrLeu: 6.316 ± 0.084
1.217ThrMet: 1.217 ± 0.032
1.949ThrAsn: 1.949 ± 0.037
2.665ThrPro: 2.665 ± 0.045
2.438ThrGln: 2.438 ± 0.047
2.247ThrArg: 2.247 ± 0.05
3.235ThrSer: 3.235 ± 0.052
2.834ThrThr: 2.834 ± 0.051
3.712ThrVal: 3.712 ± 0.061
0.589ThrTrp: 0.589 ± 0.022
1.469ThrTyr: 1.469 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
6.549ValAla: 6.549 ± 0.084
0.863ValCys: 0.863 ± 0.029
4.182ValAsp: 4.182 ± 0.064
5.147ValGlu: 5.147 ± 0.07
2.885ValPhe: 2.885 ± 0.051
5.01ValGly: 5.01 ± 0.066
1.321ValHis: 1.321 ± 0.033
4.757ValIle: 4.757 ± 0.074
3.765ValLys: 3.765 ± 0.065
7.008ValLeu: 7.008 ± 0.075
2.116ValMet: 2.116 ± 0.042
2.939ValAsn: 2.939 ± 0.054
2.757ValPro: 2.757 ± 0.048
2.271ValGln: 2.271 ± 0.04
3.007ValArg: 3.007 ± 0.051
5.117ValSer: 5.117 ± 0.066
4.102ValThr: 4.102 ± 0.065
5.835ValVal: 5.835 ± 0.08
0.798ValTrp: 0.798 ± 0.029
1.885ValTyr: 1.885 ± 0.041
0.0ValXaa: 0.0 ± 0.0
Trp
0.857TrpAla: 0.857 ± 0.027
0.157TrpCys: 0.157 ± 0.01
0.612TrpAsp: 0.612 ± 0.023
0.585TrpGlu: 0.585 ± 0.024
0.646TrpPhe: 0.646 ± 0.027
0.801TrpGly: 0.801 ± 0.025
0.353TrpHis: 0.353 ± 0.018
0.709TrpIle: 0.709 ± 0.025
0.573TrpLys: 0.573 ± 0.026
1.729TrpLeu: 1.729 ± 0.044
0.38TrpMet: 0.38 ± 0.019
0.5TrpAsn: 0.5 ± 0.022
0.448TrpPro: 0.448 ± 0.018
0.889TrpGln: 0.889 ± 0.026
0.623TrpArg: 0.623 ± 0.029
0.704TrpSer: 0.704 ± 0.026
0.485TrpThr: 0.485 ± 0.022
0.86TrpVal: 0.86 ± 0.03
0.211TrpTrp: 0.211 ± 0.015
0.366TrpTyr: 0.366 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.311TyrAla: 2.311 ± 0.043
0.389TyrCys: 0.389 ± 0.018
1.57TyrAsp: 1.57 ± 0.038
1.579TyrGlu: 1.579 ± 0.036
1.302TyrPhe: 1.302 ± 0.033
2.1TyrGly: 2.1 ± 0.044
0.744TyrHis: 0.744 ± 0.025
1.618TyrIle: 1.618 ± 0.038
1.344TyrLys: 1.344 ± 0.032
3.369TyrLeu: 3.369 ± 0.061
0.671TyrMet: 0.671 ± 0.027
1.09TyrAsn: 1.09 ± 0.029
1.359TyrPro: 1.359 ± 0.038
1.896TyrGln: 1.896 ± 0.045
1.669TyrArg: 1.669 ± 0.037
1.996TyrSer: 1.996 ± 0.042
1.496TyrThr: 1.496 ± 0.038
1.904TyrVal: 1.904 ± 0.044
0.511TyrTrp: 0.511 ± 0.02
1.024TyrTyr: 1.024 ± 0.034
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3660 proteins (1178257 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski